Polymers,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2021 - 2021
Published: July 15, 2024
Poly(vinyl
alcohol)
(PVA)
is
a
versatile
synthetic
polymer,
used
for
the
design
of
hydrogels,
porous
membranes
and
films.
Its
solubility
in
water,
film-
hydrogel-forming
capabilities,
non-toxicity,
crystallinity
excellent
mechanical
properties,
chemical
inertness
stability
towards
biological
fluids,
superior
oxygen
gas
barrier
good
printability
availability
(relatively
low
production
cost)
are
main
aspects
that
make
PVA
suitable
variety
applications,
from
biomedical
pharmaceutical
uses
to
sensing
devices,
packaging
materials
or
wastewater
treatment.
However,
pure
present
limited
flexibility
poor
biocompatibility
biodegradability,
which
restrict
its
use
alone
various
applications.
mixed
with
other
polymers
biomolecules
(polysaccharides,
proteins,
peptides,
amino
acids
etc.),
as
well
inorganic/organic
compounds,
generates
wide
PVA’s
shortcomings
considerably
improved,
new
functionalities
obtained.
Also,
transformation
brings
features
opens
door
unexpected
uses.
The
review
focused
on
recent
advances
PVA-based
hydrogels.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1388 - 1388
Published: Oct. 28, 2024
:
Hydrogels
produced
using
the
freeze-thaw
method
have
demonstrated
significant
potential
for
wound
management
applications.
However,
their
production
requires
precise
control
over
critical
factors
including
freezing
temperature
and
choice
of
matrix-forming
excipients,
which
no
consensus
on
optimal
conditions
currently
exists.
This
study
aimed
to
address
this
gap
by
evaluating
effects
above-mentioned
variables
cryogel
performance.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(5), P. 675 - 675
Published: March 1, 2024
Poly(vinyl
alcohol)
(PVA)
physical
cryogels
that
contained
the
additives
of
o-,
m-,
and
p-bis-phenols
or
phenol
were
prepared,
their
physico-chemical
characteristics
macroporous
morphology
solute
release
dynamics
evaluated.
These
phenolic
caused
changes
in
viscosity
initial
PVA
solutions
before
freeze–thaw
processing
facilitated
growth
rigidity
resultant
cryogels,
while
heat
endurance
decreased.
The
magnitude
effects
depended
on
interposition
hydroxyls
molecules
used
was
stipulated
by
H-bonding
with
OH-groups.
Subsequent
rinsing
such
“primary”
pure
water
led
to
lowering
rigidity.
average
size
macropores
inside
these
heterophase
gels
also
additive
type.
It
found
substances
from
additive-containing
occurred
via
virtually
a
free
diffusion
mechanism;
therefore,
drug
delivery
systems
as
loaded
either
pyrocatechol,
resorcinol,
hydroquinone,
phenol,
upon
vitro
agar
tests,
exhibited
antibacterial
activity
typical
phenols.
promising
biomedical
potential
studied
nanocomposite
gel
materials
is
supposed.
Frontiers in Bioscience-Elite,
Journal Year:
2024,
Volume and Issue:
16(3)
Published: Aug. 7, 2024
Monoclonal
antibodies
(mAbs)
are
pioneers
in
the
diagnosis
and
treatment
of
many
diseases,
such
as
cancer,
asthma,
poisoning,
viral
infections,
etc.
As
market
value
mAbs
increases
biopharma
industry,
demand
for
high
quantities
is
met
by
upscaled
production
using
bioreactor
systems.
Thus,
disposable,
porous
matrices
called
cryogels
have
gained
primary
focus
adherent
support
proliferation
hybridoma
cells.
Gels,
Journal Year:
2024,
Volume and Issue:
10(11), P. 734 - 734
Published: Nov. 13, 2024
Poly(3-hydroxybutyric
acid)-based
microspheres
of
two
types,
with
and
without
macropores,
were
prepared;
their
morphology
particle
size
evaluated.
These
entrapped
as
disperse
fillers
into
the
bulk
macroporous
cryogels
based
on
poly(vinyl
alcohol)
(PVA).
It
was
found
that
rigidity
resultant
composite
increased
markedly
compared
to
unfilled
same
PVA
concentration.
The
resulting
composites
further
tested
for
potential
act
drug
carriers.
With
that,
simvastatin
included
filler
particles
directly
in
course
preparation,
followed
by
entrapment
such
drug-loaded
cryogel.
In
turn,
ibuprofen
sodium
salt
introduced
preliminary
prepared
filled
drug-free
microspheres.
experimental
study
release
kinetics
showed
due
non-covalent
interactions
both
discrete
phase,
prolongation
processes
observed.
