Cells,
Journal Year:
2023,
Volume and Issue:
12(19), P. 2350 - 2350
Published: Sept. 25, 2023
Silk
has
a
long
history
as
an
exclusive
textile,
but
also
suture
thread
in
medicine;
nowadays,
diverse
cell
carriers
are
manufactured
from
silk.
Its
advantages
manifold,
including
high
biocompatibility,
biomechanical
strength
and
processability
(approved
for
nearly
all
manufacturing
techniques).
Silk’s
limitations,
such
scarcity
batch
to
variations,
overcome
by
gene
technology,
which
allows
the
upscaled
production
of
recombinant
“designed”
silk
proteins.
For
processing
thin
fibroin
filaments,
sericin
component
is
generally
removed
(degumming).
In
contrast
many
synthetic
biomaterials,
superior
adherence
growth.
addition,
grafts
demonstrate
mechanical
performance
long-term
stability,
making
them
attractive
anterior
cruciate
ligament
(ACL)
tissue
engineering.
Looking
at
these
promising
properties,
this
review
focusses
on
responses
types
variants,
well
their
relevant
ACL
Meanwhile,
attracted
increasing
interest
been
proposed
bioactive
biomaterial
with
antimicrobial
properties.
But
so
far,
was
exclusively
used
experimental
engineering
approaches,
spider
seems
not
have
applied.
To
improve
bone
integration
grafts,
scaffolds
osteogenic
functionalization,
silk-based
tunnel
fillers
interference
screws
developed.
Nevertheless,
signaling
pathways
stimulated
components
remain
barely
elucidated,
need
be
considered
during
development
optimized
Journal of Applied Polymer Science,
Journal Year:
2024,
Volume and Issue:
141(15)
Published: Jan. 18, 2024
Abstract
Biocompatible,
tough,
and
photoluminescent
hydrogels
are
highly
desirable
for
biomedical
applications
in
vivo.
Herein,
hybrid
prepared
from
silk
fibroin
(SF)
polyacrylic
acid
(PAA)
complexed
with
europium,
named
as
SF‐PAA‐Eu
3+
hydrogels,
exhibit
good
comprehensive
properties.
Owing
to
the
intensive
molecular
interactions
among
SF,
PAA,
Eu
,
show
a
greatest
tensile
strength
of
0.58
MPa,
elongation
443%,
work
fracture
1.65
MJ/m.
In
vivo
imaging
experiment
mouse
subcutaneous
implantation
model
revealed
excellent
sustained
photoluminescence
24
h.
The
provides
strategy
designing
functional
SF‐based
Materials,
Journal Year:
2024,
Volume and Issue:
17(16), P. 3924 - 3924
Published: Aug. 7, 2024
Silk
fibroin
(SF)
extracted
from
silk
is
non-toxic
and
has
excellent
biocompatibility
biodegradability,
making
it
an
biomedical
material.
SF-based
soft
materials,
including
porous
scaffolds
hydrogels,
play
important
role
in
accurately
delivering
drugs
to
wounds,
creating
microenvironments
for
the
adhesion
proliferation
of
support
cells,
tissue
remodeling,
repair,
wound
healing.
This
article
focuses
on
study
SF
protein-based
summarizing
their
preparation
methods
basic
applications,
as
well
regenerative
effects,
such
drug
delivery
carriers
various
aspects
engineering
bone,
blood
vessels,
nerves,
skin
recent
years,
promoting
effects
healing
repair
processes.
The
authors
expect
materials
field
repair.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Natural
resource
based
polymers,
especially
those
derived
from
proteins,
have
attracted
significant
attention
for
their
potential
utilization
in
advanced
wound
care
applications.
Protein
materials
provide
superior
biocompatibility,
biodegradability,
and
other
functionalities
compared
to
conventional
dressings.
The
effectiveness
of
various
fabrication
techniques,
such
as
electrospinning,
phase
separation,
self-assembly,
ball
milling,
is
examined
the
context
developing
protein-based
healing.
These
methods
produce
a
wide
range
forms,
including
hydrogels,
scaffolds,
sponges,
films,
bioinspired
nanomaterials,
each
designed
specific
types
wounds
different
stages
This
review
presents
comprehensive
analysis
recent
research
that
investigates
transformation
proteins
into
healing
Our
focus
on
essential
keratin,
collagen,
gelatin,
silk,
zein,
albumin,
we
emphasize
distinct
traits
roles
management.
Protein-based
show
promising
biomedical
engineering,
offering
improved
capabilities
reduced
risks
infection.
It
crucial
explore
use
these
clinical
settings
while
also
addressing
challenges
may
arise
commercialization
future.
BMC Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 13, 2024
Human
artificial
corneas
(HAC)
generated
by
tissue
engineering
recently
demonstrated
clinical
usefulness
in
the
management
of
complex
corneal
diseases.
However,
biological
mechanisms
associated
to
their
regenerative
potential
need
be
elucidated.
In
present
work,
we
HAC
using
nanostructured
fibrin-agarose
biomaterials
with
cultured
epithelial
and
stromal
cells,
compared
structure
histochemical
immunohistochemical
profiles
control
native
(CTR-C)
limbus
(CTR-L)
determine
level
biomimicry
these
two
organs.
tissues
consisted
a
stratified
epithelium
cellular
substitute.
The
interface
between
stroma
was
similar
that
CTR-C,
without
finger-shaped
palisades
Vogt
found
CTR-L,
contained
poorly
developed
basement
membrane
as
determined
PAS
histochemistry.
Analysis
layer
revealed
significantly
lower
amounts
extracellular
matrix
components
(collagen,
proteoglycans,
decorin,
keratocan,
lumican)
than
CTR-C
all
samples
being
devoid
elastic
reticular
fibers.
At
level,
were
strongly
positive
for
several
cytokeratins,
although
KRT5
CTR-L.
expression
crystallin
lambda
tissues,
whereas
alpha-a
CTR-C.
No
differences
among
controls
cell–cell
junction
proteins
CX43
TJP1.
When
specific
markers
analyzed,
profile
KRT3,
KRT19,
KRT15,
ΔNp63
more
CTR-L
These
results
suggest
laboratory
could
structurally
functionally
biomimetic
at
central
cornea,
open
door
use
patients
limbal
deficiency.
Cells,
Journal Year:
2023,
Volume and Issue:
12(19), P. 2350 - 2350
Published: Sept. 25, 2023
Silk
has
a
long
history
as
an
exclusive
textile,
but
also
suture
thread
in
medicine;
nowadays,
diverse
cell
carriers
are
manufactured
from
silk.
Its
advantages
manifold,
including
high
biocompatibility,
biomechanical
strength
and
processability
(approved
for
nearly
all
manufacturing
techniques).
Silk’s
limitations,
such
scarcity
batch
to
variations,
overcome
by
gene
technology,
which
allows
the
upscaled
production
of
recombinant
“designed”
silk
proteins.
For
processing
thin
fibroin
filaments,
sericin
component
is
generally
removed
(degumming).
In
contrast
many
synthetic
biomaterials,
superior
adherence
growth.
addition,
grafts
demonstrate
mechanical
performance
long-term
stability,
making
them
attractive
anterior
cruciate
ligament
(ACL)
tissue
engineering.
Looking
at
these
promising
properties,
this
review
focusses
on
responses
types
variants,
well
their
relevant
ACL
Meanwhile,
attracted
increasing
interest
been
proposed
bioactive
biomaterial
with
antimicrobial
properties.
But
so
far,
was
exclusively
used
experimental
engineering
approaches,
spider
seems
not
have
applied.
To
improve
bone
integration
grafts,
scaffolds
osteogenic
functionalization,
silk-based
tunnel
fillers
interference
screws
developed.
Nevertheless,
signaling
pathways
stimulated
components
remain
barely
elucidated,
need
be
considered
during
development
optimized
