Gels, Journal Year: 2023, Volume and Issue: 9(10), P. 789 - 789
Published: Oct. 1, 2023
Smart hydrogels possess both intelligent and responsive properties, which are designed to exhibit specific responses external stimuli such as changes in temperature, pH, or the presence of ions/counterions, making them “smart” “responsive” materials [...]
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10143 - 10143
Published: Sept. 21, 2024
Xanthan gum (XG) is an exopolysaccharide synthesized by the aerobic fermentation of simple sugars using Xanthomonas bacteria. It comprises a cellulosic backbone with trisaccharide side chain connected to alternative glucose residues in main through α (1→3) linkage. XG dissolves readily cold and hot water produce viscous solution that behaves like pseudoplastic fluid. shows excellent resistance enzymatic degradation great stability throughout broad temperature, pH, or salt concentration range. Additionally, nontoxic, biocompatible, biodegradable, making it suitable carrier for drug delivery. Furthermore, carboxylic functions pyruvate glucuronic acid offer considerable opportunity chemical modification meet desired criteria specific application. Therefore, its derivatives conjunction other polymers have frequently been studied as matrices tablets, nanoparticles, microparticles, hydrogels. This review primarily focuses on applications various oral delivery systems over past decade, including sustained-release formulations, gastroretentive dosage forms, colon-targeted Source, production methods, physicochemical properties relevant also discussed.
Language: Английский
Citations
4
Biosensors and Bioelectronics X, Journal Year: 2025, Volume and Issue: unknown, P. 100594 - 100594
Published: Feb. 1, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 445 - 445
Published: March 31, 2025
Background/Objectives. Central nervous system (CNS)-related diseases such as Alzheimer’s and Parkinson’s, Attention Deficit Hyperactive Disorder (ADHD), stroke, epilepsy, migraines are leading causes of morbidity disability worldwide. New solutions for drug delivery increasingly needed. In this context, three-dimensional (3D) printing technology has introduced innovative alternatives to produce more efficient medicines with diverse features, patterns, consistencies, particularly oral medications. Even though research in area is growing rapidly, no study thoroughly analyzed 3D progress the CNS. To fill gap pursues determine a technological landscape field. Methods. For aim, Competitive Technology Intelligence (CTI) methodology was applied, examining 747 publications from 1 January 2019 20 May 2024 published Scopus database. Results. The main advances identified comprise six categories: techniques, characteristics applications, materials, design factors, user acceptance, quality processes. FDM technique pharmaceutical use. applications include pills, polypills, caplets, gel caps, multitablets, orodispersible films, tablets, featuring external patterns internal structures one or active substances. Insights show that most utilized materials thermoplastic polymers like PLA, PVA, PCL, ABS, HIPS. A novel factor involves release using compartments varying thicknesses volumes core. Additionally, specialized software have enabled creation highly complex designs. acceptance category, drugs dosages tailored specific needs preferences neurological patients. Finally, aspect, precision Active Pharmaceutical Ingredient (API) dosage controlled-release mechanisms critical, given narrow margin between therapeutic doses toxicity CNS diseases. Conclusions. Revealing these advancements allows researchers, academics, decision-makers identify opportunities allocate resources efficiently, promising enhanced medicaments health well-being individuals suffering disorders.
Language: Английский
Citations
0
Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Abstract Currently, new cancer treatment options are being developed following tumor resection surgery, with a focus on minimizing invasiveness and reducing systemic toxicity to lower the risk of recurrence. In this context, thermosensitive poloxamer Pluronic Acid F‐127 (PF‐127) is modified by incorporating polysaccharides varying structures—xanthan gum (XG), alginate (ALG), gellan (GG), levan (LEV). Hydrogels synthesized using different ratios PF‐127. Rheological results reveal that adding hydrogel matrix increases storage moduli from 8 11–18 kPa viscosity 4.5 6.1–7.1 Pa s. Additionally, micellar aggregation capacity (MAC) gelation temperature shift 34 °C between 22 31 °C. Studies 5‐fluorouracil (5‐FU) release these composites indicate enhanced MAC prolongs drug 4 times longer compared made PF‐127 alone. A mathematical model applied analyze experimental results, taking into account polymer chain release. Hydrogel's degradation rate primary determinants duration. Thus, modifying composition, MAC, thermosensitivity, profile can be finely controlled based polysaccharide used.
Language: Английский
Citations
0
Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(9), P. 4133 - 4145
Published: April 20, 2024
Language: Английский
Citations
3
Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(11), P. 5414 - 5427
Published: Oct. 26, 2023
Light-based three-dimensional (3D) bioprinting has been widely studied in tissue engineering. Despite the fact that free-radical chain polymerization-based bioinks like hyaluronic acid methacrylate (HAMA) and gelatin methacryloyl (GelMA) have extensively explored 3D bioprinting, thiol-ene hydrogel system attracted increasing attention for its ability building scaffolds an oxygen-tolerant cell-friendly way. Herein, we report a superfast curing bioink composed of norbornene-modified (NorHA) thiolated (GelSH) bioprinting. A new facile approach was first introduced synthesis NorHA, which circumvented cumbersome steps involved previous works. Additionally, after mixing NorHA with macro-cross-linker GelSH, customized NorHA/GelSH exhibited fascinating superiorities over gold standard GelMA bioinks, such as ultrafast rate (1-5 s), much lowered photoinitiator concentration (0.03% w/v), flexible physical performances. Moreover, greatly avoided excess ROS generation, is important survival encapsulated cells. Last, compared scaffold, 3D-printed scaffold not only excellent cell viability but also guaranteed proliferation, revealing superior bioactivity. In conclusion, promising candidate engineering applications.
Language: Английский
Citations
8
Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 466 - 466
Published: July 16, 2024
In this study, a functional nanostructured lipid carriers (NLCs)-based hydrogel was developed to repair the damaged epidermal skin barrier. NLCs were prepared via high-energy approach, using argan oil and beeswax as liquid solid lipids, respectively, loaded with ceramides cholesterol at physiologically relevant ratio, acting structural compounds. Employing series of surfactants optimizing preparation conditions, 215.5 ± 0.9 nm in size negative zeta potential -42.7 obtained, showing acceptable physical microbial stability. Solid state characterization by differential scanning calorimetry X-ray powder diffraction revealed formation imperfect crystal NLC-type. The optimized NLC dispersion into gel based on sodium hyaluronate xanthan gum. gels obtained presented shear thinning thixotropic behavior, which is suitable for dermal application. Incorporating enhanced rheological, viscoelastic, textural properties formed while retaining spreadability required comfortable application patient compliance. NLC-loaded noticeable occlusion effect vitro. It provided 2.8-fold higher hydration levels ex vivo porcine ear model than NLC-free gel, barrier nourish actively.
Language: Английский
Citations
2
Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e28561 - e28561
Published: March 1, 2024
This study concentrated on developing a novel sprayable hydrogel by the combination of thermosensitive (Pluronic F-127, PF-127) and an inclusion complex glabridin (GLD) sulfobutylether-β-cyclodextrin (SBE-β-CD). GLD was encapsulated into SBE-β-CD freeze-drying method. The successful encapsulation verified Fourier transform infrared (FT-IR), X-ray diffractometer (XRD), scanning electron microscope (SEM), nuclear magnetic resonance spectroscopy (NMR). prepared GLD/SBE-β-CD exhibited 93.24%~96.46% efficiency 11.24%~11.93% loading capacity, showed excellent biocompatibility human vascular endothelial cells (HUVECs) erythrocytes. exerts higher antioxidant antibacterial activity than alone. well dispersed within 20% PF-127 solution to form PF-127/GLD/SBE-β-CD hydrogel. Introducing did not influence its loose porous structure, while demonstrated controlled release in sustained manner. full-thickness skin wound model that accelerated healing traumatic defects. In one aspect, biocompatible structure provides favorable conditions for cell adhesion proliferation. another respect, therapeutic markedly promotes angiogenesis cells, migration keratinocytes. It also presents properties surface. Taken together, this work established (PF-127/GLD/SBE-β-CD) proved it is effective strategy healing.
Language: Английский
Citations
0
Gels, Journal Year: 2023, Volume and Issue: 9(10), P. 789 - 789
Published: Oct. 1, 2023
Smart hydrogels possess both intelligent and responsive properties, which are designed to exhibit specific responses external stimuli such as changes in temperature, pH, or the presence of ions/counterions, making them “smart” “responsive” materials [...]
Language: Английский
Citations
0