State‐of‐the‐Art and Future Challenges of Smart Wound Dressings for Diabetic Foot Ulcer Treatment DOI Creative Commons
Sabine Szunerits, Rabah Boukherroub

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 23, 2024

The slow healing process of diabetic wound due to persisting infections in bed, owing hyperglycemia, makes the search for efficient treatments pending. While it is complicated increase closure rate diabetic‐related wounds complex pathology, treatment such with hydrogels seen as a promising approach and pursued over years. However, where this research currently standing terms clinical translation these different multifunctional stimuli‐responsive hydrogel bandages accelerate foot ulcer help improve life patients future management? This perspective article will review some most important advancements field conclude perspectives, considered relevant context.

Language: Английский

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions DOI Creative Commons

Peilin Lu,

Dongxue Ruan,

Meiqi Huang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

Citations

83
Engineered hydrogel platform for diabetic wound healing DOI
Jie Cui, Jianbin Shi, Yanjun Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379

Published: Feb. 1, 2025

Language: Английский

Citations

1
Advances in the development of medical dressings for the treatment of diabetic foot wounds DOI
Ming Cai, Zhao Liu,

Xun Sun

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575

Published: Sept. 7, 2024

Language: Английский

Citations

5
Material Design, Fabrication Strategies, and the Development of Multifunctional Hydrogel Composites Dressings for Skin Wound Management DOI
Zhibin Wu, Dongdong Lu, Shuo Sun

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The skin is fragile, making it very vulnerable to damage and injury. Untreated wounds can pose a serious threat human health. Three-dimensional polymer network hydrogels have broad application prospects in wound dressings due their unique properties structure. therapeutic effect of traditional limited, while multifunctional composite show greater potential. Multifunctional regulate moisture through formula adjustment. Moreover, be combined with bioactive ingredients improve performance healing applications. Stimulus-responsive respond specifically the environment meet needs different stages. This review summarizes material types, structure, properties, design considerations, formulation strategies for hydrogel used healing. We discuss various types recently developed dressings, highlights importance tailoring physicochemical addresses potential challenges preparing dressings.

Language: Английский

Citations

0
Evaluating the Wound Healing Potential of Characterized Bergenia ciliata–Loaded Salvia hispanica Hydrogel in Diabetic Mice DOI
Muhammad Summer,

Shaukat Ali,

Gulzar Muhammad

et al.

Microscopy Research and Technique, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

ABSTRACT The current study assessed the wound healing potential of Bergenia ciliata (BC) extract, BC‐loaded Salvia hispanica hydrogel (CH‐BC) and nanoparticles (NPs)–loaded (CH‐BC AgNPs/NPs‐loaded hydrogel) using in vitro vivo studies. prepared its components were analyzed UV–visible spectrophotometry (UV–vis), scanning electron microscopy (SEM), dynamic light scattering (DLS) analysis/particle size analyzer (PSA), zeta potential, fourier transform infrared spectrometry (FT‐IR), x‐ray diffraction (XRD). Peaks peak shifts at 450–460, 250–260, 270–280 nm UV–vis FT‐IR (500–4000 cm −1 ) confirmed extract loading various functional group presence. DLS nanometric BC AgNP while indicated slightly negative charge hydrogel. SEM average topography –mediated (BC AgNPs) AgNPs loaded AgNPs), XRD peaks 2ϴ (10–70) topographical crystalline porous nature materials. showed higher radical scavenging (74.19% ± 1.84%) iron chelation activity (93.70 2.20) 50 25 μL/mL, respectively, CH‐BC produced lowest (48.97% 3.0%) 75 μL/mL (54.35 3.24). Moreover, Chia (CH) synergistically enhanced (1.30%) DPPH scavenging. contraction percentage augmented as potent candidate for (14th day). These findings further supported by a significant ( p < 0.001) restoration MMP2 (184.6 11.7 pg/mL), TIMPs (184.8 15.7 GPx (153.4 11.5 IL‐6 (10 1 pg/mL) levels compared to those diabetic control. normal reepithelization, angiogenesis, maturation wounds treatment groups after histological analysis strengthened supposed rationale that CH, along with AgNPs, can act improve therapeutic results. Hence, appeared sustainable, biocompatible, nontoxic agent paved way futuristic biomedical investigations.

Language: Английский

Citations

0
Understanding molecular mechanism of diabetic wound healing: addressing recent advancements in therapeutic managements DOI

Pratyush Porel,

Manpreet Kaur,

Vipul Sharma

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 6, 2025

Language: Английский

Citations

0
Applications and prospects of biomaterials in diabetes management DOI Creative Commons
Wei‐jie Guan, Liang Zhang

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 7, 2025

Diabetes is a widespread metabolic disorder that presents considerable challenges in its management. Recent advancements biomaterial research have shed light on innovative approaches for the treatment of diabetes. This review examines role biomaterials diabetes diagnosis and treatment, as well their application managing diabetic wounds. By evaluating recent developments alongside future obstacles, highlights promising potential care, underscoring importance enhancing patient outcomes refining methodologies.

Language: Английский

Citations

0
Paquinimod‐hydrogel hybrid microneedle array patch alleviates hypertrophic scar via inhibiting M1 polarization DOI Creative Commons
Zi‐Hui Zhang, Peng Wang,

Hengdeng Liu

et al.

Bioengineering & Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Abstract Hypertrophic scar (HS) is one of the most common complications skin injuries, with a lack effective therapeutic approaches to date. Most current research has focused on dysfunction hypertrophic fibroblasts (HSFBs) and dermal vascular endothelial cells (HDVECs), neglecting crucial role inflammatory microenvironment that causes them be abnormal. In this study, we first discovered validated S100A8/9 specific inhibitor Paquinimod could inhibit macrophage polarization toward M1, further suppress proliferation, migration, collagen formation, angiogenesis HSFBs HDVECs in vitro. This mechanism also been rat model HS. Then, developed good biocompatibility penetrability Paquinimod‐Hydrogel Hybrid Microneedle Array Patch (PHMAP) for HS treatment. With advantages excellent penetrability, surface sealing, sustained release, precise uniform distribution, PHMAP exhibited superior efficacy over intravenous intradermal injections. These results suggest can promising advanced solution prevention therapies.

Language: Английский

Citations

0
Cellulose-based hydrogels enhanced with bioactive molecules for optimal chronic diabetic wound management DOI
Mahtab Ghasemi Toudeshkchouei, Hassan Abdoos, Jafar Ai

et al.

Journal of Microencapsulation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 23, 2025

Hydrogels are three-dimensional structures that replicate natural tissues' extracellular matrix (ECM). They essential for transporting exudates, gases, and moisture facilitating cellular interactions in tissue engineering wound healing. The choice of primary material designing the scaffold is necessary to be paid more attention rather than common sources, including plant fibres like cotton, bamboo, algae, as well bacterial marine-derived materials. Among them, cellulose-based polymers especially valued their biocompatibility ability promote Chronic diabetic wounds pose unique treatment challenges, such necrosis infection risks. Consequently, a growing interest incorporating bioactive molecules into hydrogels. This article investigates how these infused hydrogels enhance healing process chronic wounds, examining various loading crosslinking techniques alongside clinical applications. It also discusses benefits limitations with improve strategies.

Language: Английский

Citations

0
Insights into Liposomal and Gel-Based Formulations for Dermatological Treatments DOI Creative Commons
Giovanni Strazzabosco,

A Liboni,

Giulia Pezzi

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 245 - 245

Published: March 26, 2025

Dermatological diseases pose a significant challenge due to their chronic nature, complex pathophysiology, and the need for effective, patient-friendly treatments. Recent advancements in liposomal gel-based formulations have played crucial role improving drug delivery, therapeutic efficacy, patient compliance. Liposomal garnered considerable attention dermatology ability encapsulate both hydrophilic lipophilic compounds, enabling controlled release enhanced skin penetration. However, challenges such as formulation complexity, stability issues, regulatory constraints remain. Similarly, are widely used ease of application, biocompatibility, retain active ingredients. they also face limitations, including restricted penetration depth, susceptibility microbial contamination, achieving sustained release. The integration technologies offers promising strategy overcome current optimize dermatological delivery. This review explores well-established therapies recent innovations, offering comprehensive overview applications treatment prevalent conditions. Ultimately, continued research is essential refine these formulations, expanding clinical utility enhancing effectiveness dermatology.

Language: Английский

Citations

0