Vascular Pharmacology, Journal Year: 2025, Volume and Issue: 159, P. 107496 - 107496
Published: April 14, 2025
Language: Английский
Experimental & Molecular Medicine, Journal Year: 2020, Volume and Issue: 52(3), P. 400 - 408
Published: March 1, 2020
Many studies have highlighted the importance of tight regulation mRNA stability in control gene expression. largely depends on nucleotide sequence, which affects secondary and tertiary structures mRNAs, accessibility various RNA-binding proteins to mRNAs. Recent advances high-throughput RNA-sequencing techniques resulted elucidation important roles played by modifications sequences regulating stability. To date, hundreds different RNA been characterized. Among them, several modifications, including N
Language: Английский
Citations
426
Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)
Published: Feb. 8, 2021
The four major RNA adenosine modifications, i.e., m
Language: Английский
Citations
184
Immunity, Journal Year: 2020, Volume and Issue: 53(1), P. 54 - 77
Published: July 1, 2020
Language: Английский
Citations
152
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Jan. 9, 2023
Abstract The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis the process generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, transformation. mTORC1, Myc, noncoding RNA signaling pathways are primary mediators work jointly with polymerases proteins to control protein synthesis. Activation of mTORC1 required for normal fetal growth development tissue regeneration after birth. Myc implicated cancer by enhancing Pol II activity, leading uncontrolled growth. deregulation RNAs such as microRNAs, long RNAs, circular involved developing blood, neurodegenerative diseases, atherosclerosis. We review similarities differences between eukaryotic bacterial molecular mechanism ribosome-targeting antibiotics resistance. also most recent findings dysfunction COVID-19 other conditions discuss consequences frameshifting, ribosome-stalling, ribosome-collision. summarize various diseases. Furthermore, we current clinical trials, prospective vaccines COVID-19, therapies targeting cancer, cardiovascular disease, aging, disease.
Language: Английский
Citations
147
Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(10), P. 714 - 731
Published: June 27, 2023
Language: Английский
Citations
138
Trends in Genetics, Journal Year: 2022, Volume and Issue: 39(1), P. 74 - 88
Published: Nov. 12, 2022
Cancer was initially considered to be an exclusively genetic disease, but interplay of dysregulated and epigenetic mechanisms is now known contribute the cancer phenotype. More recently, chemical modifications RNA molecules - so-called epitranscriptome have been found regulate various aspects function homeostasis. Specific enzymes, as RNA-modifying proteins (RMPs), are responsible for depositing, removing, reading in RNA. Intensive investigations epitranscriptomic field recent years, conjunction with great technological advances, revealed critical role regulating numerous cellular pathways. Furthermore, growing evidence has that modification machinery often altered human cancers, highlighting enormous potential RMPs pharmacological targets or diagnostic markers.
Language: Английский
Citations
81
Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)
Published: June 22, 2023
Abstract Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined polymeric ribonucleic acid molecules that less than 200 nucleotides in length and serve a variety of essential functions within cells. RNA species include microRNA (miRNA), PIWI-interacting (piRNA), interfering (siRNA), tRNA-derived (tsRNA), etc. Current evidence suggest can also have diverse modifications their nucleotide composition affect stability well capacity for nuclear export, these relevant drive molecular signaling processes biogenesis, cell proliferation differentiation. In this review, we highlight the characteristics cellular modifications, current techniques reliable detection. We discuss how may be clinical applications diagnosis treatment human health conditions such cancer.
Language: Английский
Citations
53
Seminars in Cancer Biology, Journal Year: 2020, Volume and Issue: 75, P. 97 - 115
Published: Nov. 19, 2020
Language: Английский
Citations
136
Trends in biotechnology, Journal Year: 2020, Volume and Issue: 39(1), P. 72 - 89
Published: July 1, 2020
Language: Английский
Citations
134
The Journal of Cell Biology, Journal Year: 2020, Volume and Issue: 219(6)
Published: April 7, 2020
Translation control is critical to regulate protein expression. By directly adjusting levels, cells can quickly respond dynamic transitions during stem cell differentiation and embryonic development. Ribosomes are multisubunit cellular assemblies that mediate translation. Previously seen as invariant machines with the same composition of components in all conditions, recent studies indicate ribosomes heterogeneous different ribosome types preferentially translate specific subsets mRNAs. Such heterogeneity specialized translation functions very important development, they allow stimuli through direct changes abundance. In this review, we discuss arises from multiple features rRNAs, including rRNA variants modifications, ribosomal proteins, their stoichiometry, compositions, paralogues, posttranslational modifications. We also alterations ribosome-associated proteins (RAPs), a particular focus on consequent translational
Language: Английский
Citations
91