Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(5), P. 579 - 579
Published: May 8, 2024
Microplastics
(MPs)
are
plastic
particles
between
0.1
and
5000
µm
in
size
that
have
attracted
considerable
attention
from
the
scientific
community
general
public,
as
they
threaten
environment.
contribute
to
various
harmful
effects,
including
lipid
peroxidation,
DNA
damage,
activation
of
mitogen-activated
protein
kinase
pathways,
cell
membrane
breakages,
mitochondrial
dysfunction,
lysosomal
defects,
inflammation,
apoptosis.
They
affect
cells,
tissues,
organs,
overall
health,
potentially
contributing
conditions
like
cancer
cardiovascular
disease.
pose
a
significant
danger
due
their
widespread
occurrence
food.
In
recent
years,
information
has
emerged
indicating
MPs
can
cause
oxidative
stress
(OS),
known
factor
accelerating
aging
organisms.
This
comprehensive
evaluation
exposed
notable
variability
reported
connection
OS.
work
aims
provide
critical
review
whether
harmfulness
constitute
environmental
contaminants
may
result
OS
through
analysis
research
existing
literature,
well
an
assessment
characteristics
causing
Additionally,
article
covers
analytical
methodology
used
this
field.
The
conclusions
point
necessity
for
further
into
effects
on
Environments,
Journal Year:
2023,
Volume and Issue:
10(11), P. 194 - 194
Published: Nov. 10, 2023
Microplastics
(MPs),
small
plastic
particles
resulting
from
the
degradation
of
larger
items
and
primary
sources
such
as
textiles,
engineered
pellets,
etc.,
have
become
a
ubiquitous
environmental
pollutant.
As
their
prevalence
in
natural
environment
grows,
concerns
about
potential
impacts
on
human
health
escalated.
This
review
discusses
current
research
findings
presence
MPs
organs
liver,
blood,
heart,
placenta,
breast
milk,
sputum,
semen,
testis,
urine,
while
also
exploring
plausible
mechanisms
translocation.
Furthermore,
emphasizes
importance
understanding
toxicological
effects
various
physiological
processes
within
these
broader
implications
for
health.
examines
pathways
through
which
can
enter
accumulate
bodily
fluids,
shedding
light
intricate
routes
exposure
implications.
It
is
worth
noting
that
invasive
medical
procedures
may
permit
direct
access
to
bloodstream
tissues,
serving
contamination
source.
However,
it
evident
comprehensive
MPs’
invasion
into
vital
effective
mitigation
strategies
preservation
both
environment.
Liver International,
Journal Year:
2024,
Volume and Issue:
44(5), P. 1093 - 1105
Published: Feb. 26, 2024
Abstract
Plastics,
while
providing
modern
conveniences,
have
become
an
inescapable
source
of
global
concern
due
to
their
role
in
environmental
pollution.
Particularly,
the
focus
on
bisphenol
A
(BPA)
reveals
its
biohazardous
nature
and
association
with
liver
issues,
specifically
steatosis.
However,
research
indicates
that
BPA
is
just
one
facet
problem,
as
other
analogues,
microplastics,
nanoplastics
additional
plastic
derivatives
also
pose
potential
risks.
Notably,
implicated
every
stage
non‐alcoholic
fatty
disease
(NAFLD)
onset
progression,
surpassing
hepatitis
B
virus
a
primary
cause
chronic
worldwide.
As
contamination
tops
contaminants
list,
urgent
action
needed
assess
causative
factors
mitigate
impact.
This
review
delves
into
molecular
disruptions
linking
pollutant
exposure
diseases,
emphasizing
broader
connection
between
plastics
rising
prevalence
NAFLD.
Environmental Toxicology and Pharmacology,
Journal Year:
2023,
Volume and Issue:
104, P. 104298 - 104298
Published: Oct. 19, 2023
The
crescent
presence
of
nanoplastics
in
the
environment
raises
concerns
regarding
their
potential
impact
on
health.
This
study
exposed
human
colon
adenocarcinoma
cells
(HT29)
and
microglia
(N9)
to
(25
nm,
50
100
nm
Polystyrene)
investigate
inflammatory
responses,
which
are
vital
for
body's
defence.
Although
cytotoxicity
remained
generally
low,
HT29
exhibited
a
notable
upregulation
p50
p38
expression,
concomitant
with
elevated
TLR4
contrast
N9
that
showed
less
pronounced
these
proteins.
Additionally,
nanoplastic
exposure
increased
IL-1ß
levels,
partially
attenuated
by
pre-exposure
or
inhibitors.
Intriguingly,
substantial
increases
iNOS
mRNA.
effect
was
entirely
prevented
inhibitors,
while
TNF-α
mRNA
levels
relatively
stable.
These
findings
underscore
activate
pathways,
response
kinetics
varying
depending
cell
type.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4964 - 4964
Published: May 2, 2024
The
impact
of
microplastics
(MPs)
on
the
metabolic
functions
liver
is
currently
unclear
and
not
completely
understood.
To
investigate
effects
administration
MPs
hepatic
metabolism
normal
obese
mice,
alterations
in
lipid,
glucose
(Glu),
amino
acid
regulation
pathways
were
analyzed
adipose
tissues
C57BL/6Korl
(wild
type,
WT)
or
C57BL/6-Lepem1hwl/Korl
mice
(leptin
knockout,
Lep
KO)
orally
administered
polystyrene
(PS)
for
9
weeks.
Significant
lipid
accumulation,
adipogenesis,
lipogenesis,
lipolysis
detected
tissue
MP-treated
WT
KO
compared
to
vehicle-treated
group.
These
their
accompanied
by
an
upregulation
serum
profile,
as
well
mice.
Specifically,
level
leptin
was
increased
without
any
change
food
intake.
Also,
MP-induced
disruptions
glycogenolysis,
Glu
transporter
type
4
(GLUT4)-5′
AMP-activated
protein
kinase
(AMPK)
signaling
pathway,
levels
intermediates,
insulin
resistance
observed.
Furthermore,
seven
endogenous
metabolites
remarkably
changed
after
MP
administrations.
Finally,
observed
both
types
further
verified
differentiated
3T3-L1
adipocytes
HepG2
cells.
Thus,
these
results
suggest
that
oral
weeks
may
be
associated
with
disruption
Glu,
Sustainability,
Journal Year:
2024,
Volume and Issue:
16(19), P. 8704 - 8704
Published: Oct. 9, 2024
With
nearly
40%
of
the
total
plastics
produced
being
used
for
packaging,
up
to
five
trillion
plastic
bags
are
consumed
in
world
annually.
The
inadequate
disposal
waste
and
its
persistence
has
become
a
serious
challenge/risk
environment,
health,
well-being
living
creatures,
including
humans.
natural
degradation
is
extremely
slow;
large
pieces
may
break
down
into
microplastics
(MPs)
(1
μm–5
mm)
or
nanoplastics
(NPs)
(<1000
nm)
after
protracted
physical,
chemical,
and/or
biological
degradations.
A
brief
overview
transport
micro-
aquatic,
terrestrial,
atmospheric
environments
presented.
Details
provided
on
exposure
routes
these
materials
their
entry
humans
other
biota
through
ingestion,
inhalation,
dermal
contact.
greatest
concern
cumulative
impact
heterogeneous
secondary
MPs
NPs
planetary
human
health.
Inhaled
have
been
shown
affect
upper
respiratory
tract,
lower
alveoli;
prolonged
can
lead
chronic
inflammatory
changes
systemic
disease.
These
also
autoimmune
diseases
health
conditions,
atherosclerosis
malignancy.
Sustainable
mitigation
strategies
reduce
MPs/NPs
include
source
reduction,
material
substitution,
filtration
purification,
transformation
value-added
materials,
technological
innovations,
etc.
Multidisciplinary
collaborations
across
fields
medicine,
public
environmental
science,
economics,
policy
required
help
limit
detrimental
effects
widespread
environment.
