Regulation of B-cell function by miRNAs impacting Systemic lupus erythematosus progression DOI Creative Commons
Bevan E. Huang, Fengbiao Guo,

Jiaxuan Chen

et al.

Gene, Journal Year: 2024, Volume and Issue: 933, P. 149011 - 149011

Published: Oct. 18, 2024

Systemic lupus erythematosus (SLE) is a complex autoimmune disease marked by abnormal B-cell proliferation and increased autoantibodies. miRNAs play crucial role in regulating dysfunction SLE pathology. influence DNA methylation, activation, gene expression, contributing to pathogenesis. impact B cells through key processes like proliferation, differentiation, tolerance, apoptosis. also exacerbate inflammation immune responses modulating Interleukin 4 (IL-4), IL-6, interferon cytokines. Autophagy, degradation mechanism, regulated specific that This article explores the of multiple development, survival, responses, influencing miR-23a, miR-17 ∼ 92 family, miR-125b/miR-221 affect development transcription factors, signaling pathways, cell cycle genes. such as miR-181a-5p miR-23a-5p are differentially across developmental stages, emphasizing their regulatory roles biology. synthesizes miRNA-B interactions offer new strategies directions for diagnosis treatment.

Language: Английский

Unlocking novel therapeutic avenues in glioblastoma: Harnessing 4-amino cyanine and miRNA synergy for next-gen treatment convergence DOI

K Sandhanam,

Tamilanban Thamaraikani,

K. Manasa

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 553, P. 1 - 18

Published: June 27, 2024

Language: Английский

Citations

5
Significance of LncRNAs in AKI-to-CKD transition: A therapeutic and diagnostic viewpoint DOI

Bhupendra Puri,

Syamantak Majumder, Anil Bhanudas Gaikwad

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 342, P. 122509 - 122509

Published: Feb. 22, 2024

Language: Английский

Citations

4
Molecular insights into cell signaling pathways in kidney stone formation DOI
Manpreet Kaur, Roja Varanasi, Debadatta Nayak

et al.

Urolithiasis, Journal Year: 2025, Volume and Issue: 53(1)

Published: Feb. 14, 2025

Language: Английский

Citations

0
Quantitative real-time PCR analysis of circulating MicroRNA levels in blood samples from pediatric patients with epilepsy DOI
Haidar J. Muhammed, Marwa M. Al-Attar,

Zainab Fayadh Shubrem

et al.

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102214 - 102214

Published: April 1, 2025

Language: Английский

Citations

0
circKDM1A suppresses bladder cancer progression by sponging miR-889-3p/CPEB3 and stabilizing p53 mRNA DOI Creative Commons
Haotian Chen,

Jing Wen,

Wentao Zhang

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(4), P. 109624 - 109624

Published: March 29, 2024

Circular RNAs (circRNAs) play crucial biological functions in various tumors, including bladder cancer (BCa). However, the roles and underlying molecular mechanisms of circRNAs malignant proliferation BCa are yet unknown. CircKDM1A was observed to be downregulated tissues cells. Knockdown circKDM1A promoted cells xenograft growth, while overexpression exerts opposite effect. The dual-luciferase reporter assay revealed that directly bound miR-889-3p, acting as its sponge downregulate CPEB3. In turn, CPEB3 CPE signal p53 mRNA 3'UTR stabilize expression. Thus, circKDM1A-mediated downregulation inhibits stability promotes progression. conclusion, a tumor suppressor via miR-889-3p/CPEB3/p53 axis. may potential prognostic biomarker therapeutic target BCa.

Language: Английский

Citations

2
Decoding Kidney Pathophysiology: Omics-Driven Approaches in Precision Medicine DOI Open Access
Charlotte Delrue, Marijn M. Speeckaert

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1157 - 1157

Published: Dec. 19, 2024

Chronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic therapeutic approaches usually fail to account for heterogeneity, resulting in low efficacy. Precision medicine offers novel approach studying by combining omics technologies such as genomics, transcriptomics, proteomics, metabolomics, epigenomics. By identifying discrete subtypes, molecular biomarkers, targets, these pave the way personalized treatment approaches. Multi-omics integration has enhanced our understanding CKD revealing intricate linkages pathways that contribute resistance progression. While pharmacogenomics insights into expected responses treatments, single-cell spatial transcriptomics can be utilized investigate biological heterogeneity. Despite significant development, challenges persist, including data concerns, high costs, ethical quandaries. Standardized protocols, collaborative data-sharing frameworks, advanced computational tools machine learning causal inference models are required address challenges. With advancement technology, nephrology may benefit from improved accuracy, risk assessment, care. overcoming barriers, precision potential develop techniques improving patient outcomes treatment.

Language: Английский

Citations

2
Exosomes in renal cell carcinoma: challenges and opportunities DOI
Mahan Mohammadi, Kamran Mansouri, Pantea Mohammadi

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: March 23, 2024

Language: Английский

Citations

1
Regulation of B-cell function by miRNAs impacting Systemic lupus erythematosus progression DOI Creative Commons
Bevan E. Huang, Fengbiao Guo,

Jiaxuan Chen

et al.

Gene, Journal Year: 2024, Volume and Issue: 933, P. 149011 - 149011

Published: Oct. 18, 2024

Systemic lupus erythematosus (SLE) is a complex autoimmune disease marked by abnormal B-cell proliferation and increased autoantibodies. miRNAs play crucial role in regulating dysfunction SLE pathology. influence DNA methylation, activation, gene expression, contributing to pathogenesis. impact B cells through key processes like proliferation, differentiation, tolerance, apoptosis. also exacerbate inflammation immune responses modulating Interleukin 4 (IL-4), IL-6, interferon cytokines. Autophagy, degradation mechanism, regulated specific that This article explores the of multiple development, survival, responses, influencing miR-23a, miR-17 ∼ 92 family, miR-125b/miR-221 affect development transcription factors, signaling pathways, cell cycle genes. such as miR-181a-5p miR-23a-5p are differentially across developmental stages, emphasizing their regulatory roles biology. synthesizes miRNA-B interactions offer new strategies directions for diagnosis treatment.

Language: Английский

Citations

0