A short investigation: the demographic data of pharmacogenomics testing results for asian pediatric perioperative drugs DOI Creative Commons

Anna Surgean Veterini,

Kohar Hari Santoso,

Retti K. Bakti

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Abstract Background: Post-operative pain management for pediatric patients is generally suboptimum. With patients, anesthesiologists are challenged to evaluate whether the administered dosage appropriate and precisely predict potential side effects from drugs. This imperative as genetics also serves a pivotal role in determining individual’s responses Methods: Paediatric aged 1 12 years who underwent surgery received anaesthesia were offered participate study. Participants pharmacogenomic testing so that anaesthesiologist could determine safety effectiveness of drugs given. The genes investigated included CACNA1S RYR1; COMT; CYP2C19; CYP2C9; CYP2D6; G6PD OPRM1. Both descriptive analytical analysis performed investigate if certain genotype phenotype associated with analgesic Results: Of 22 participants, all reported be having “Uncertain Susceptibility” malignant hyperthermia based on RYR1. Most participants COMT Rs4680 GG (n=16, 72.7%), CYP2C19 *1/*1 (n=9, 40.9%), CYP2C9 (n=20, 90.9%), CYP2D6 *1/*10 (n=8, 36.4%), B (Wildtype)/B (Wildtype) (n=21, 95.4%) OPRM1 Rs1799971GG (n=11, 50.0%). Conclusions: The distribution results examinations indicate normal metabolizers CYP2C9, CYP2D, account less than 50% total samples. In contrast, more phenotypes fall into metabolizer category. For RYR1, subjects classified under uncertain susceptibility. Interestingly, gene, exhibit high activity.

Language: Английский

Assessment of Anticancer Properties of Thai Plants DOI
Bancha Yingngam

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 122 - 164

Published: March 11, 2024

Cancer, a critical health concern, necessitates safer, more effective treatments. This chapter explores the anticancer potential of traditional Thai plants, which, despite being underresearched, show significant promise. It focuses on bioactive compounds and their efficacy against various cancer types. The categorizes these plants based active components reviews both laboratory animal studies to understand underlying mechanisms involved in inhibiting cell growth, inducing death, preventing tumor blood vessel formation. Clinical trials supporting findings are also highlighted. Given improve or innovate treatments, present encouraging prospects. However, further research is essential confirm safety approaches. These suggest that could lead development innovative drugs, signaling advancements therapy.

Language: Английский

Citations

13
AI's role in revolutionizing personalized medicine by reshaping pharmacogenomics and drug therapy DOI Creative Commons

Hamed Taherdoost,

Alireza Ghofrani

Intelligent Pharmacy, Journal Year: 2024, Volume and Issue: 2(5), P. 643 - 650

Published: Aug. 20, 2024

Language: Английский

Citations

13
PERSONALIZED MEDICINE IN ORAL CANCER DOI
Shalini Gupta,

Arushi Tomar,

Riya Singh

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104670 - 104670

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advancing frontiers in skin offensive odor management: from innovative diagnostics to cutting-edge treatments and emerging technologies DOI
Majeed M. A. Ali

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 8, 2025

Language: Английский

Citations

0
Robotic-assisted colorectal surgery in colorectal cancer management: a narrative review of clinical efficacy and multidisciplinary integration DOI Creative Commons
Engeng Chen, Li Chen, Wei Zhang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 7, 2025

Colorectal cancer (CRC) remains a formidable global health challenge, ranking among the most prevalent malignancies and principal contributor to cancer-associated mortality. While traditional open surgery has historically been cornerstone of CRC treatment, advent minimally invasive techniques, particularly robotic-assisted colorectal (RACS), garnered significant momentum owing technological advancements in field. Robotic platforms, exemplified by da Vinci Surgical System, offer superior three-dimensional visualization, enhanced dexterity, heightened precision, yielding improved perioperative outcomes, anatomically intricate regions such as pelvis. This review provides critical appraisal current landscape RACS, emphasizing its superiority over conventional laparoscopic approaches. The increased control precision afforded robotic have shown optimize outcomes complex procedures total mesorectal excision, with evidence indicating reduced intraoperative blood loss, shortened hospital stays, functional recovery. Nonetheless, challenges persist, including absence haptic feedback, prohibitive costs, steep learning curve associated systems. Despite these limitations, RACS demonstrated considerable promise sphincter-preserving function-preserving procedures, ultimately enhancing postoperative quality life. Beyond surgical field, this also investigates integration within multidisciplinary treatment strategies for CRC, context locally advanced rectal cancer. combination techniques neoadjuvant therapy immunotherapy-especially tumors characterized mismatch repair deficiency or high microsatellite instability notable clinical efficacy. Furthermore, emerging personalized therapeutic approaches, immunotherapies targeted chemotherapeutic agents, emphasize transformative potential delivering oncologic outcomes. Looking towards future, innovations imaging, artificial intelligence, augmented reality, herald new possibilities further efficacy surgeries. standardization protocols, alongside ongoing training robust research, will be fully realizing benefits across diverse settings. By incorporating cutting-edge technologies methods, is prepared become future management, significantly improve both survival patient

Language: Английский

Citations

0
Personalized medicine: An alternative for Cancer Treatment DOI Creative Commons
Devendra Singh, Vinay Kumar Dhiman,

Minakshi Pandey

et al.

Cancer Treatment and Research Communications, Journal Year: 2024, Volume and Issue: 42, P. 100860 - 100860

Published: Jan. 1, 2024

The incidence of cancer continues to increase worldwide, resulting in significant physical, emotional, and financial challenges for individuals, families, communities, healthcare systems. Cancer is projected be responsible approximately 10 million deaths 2020, accounting one six globally. Prostate, colon, lung, breast cancers are the most common types cancer. In India, it estimated that there will around 2.7 patients by 2020. Personalized medicine has potential offer an alternative approach treatment. Precision medicine, often known as personalized a new treatment technique focuses on tailoring medication each patient's specific genetic, biochemical, lifestyle factors. goal optimize tumor response while minimizing therapy side effects, improved patient care quality life. allows creation focused medicines address gene mutations leveraging knowledge about cancer, including its genetic makeup. Ongoing research seeks detect modifications diverse types, produce novel diagnostic tools, develop treatments particularly target these changes. recent years, achieved major advances solid tumors, with promise improve precision, reduce well enhance outcomes therapy. This review aims objectively evaluate transformation treatment, emphasizing shift towards more precise methodology.

Language: Английский

Citations

3
A comprehensive review on lncRNA LOXL1-AS1: molecular mechanistic pathways of lncRNA LOXL1-AS1 in tumorigenicity of cancer cells DOI Creative Commons
Saghar Yousefnia

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 29, 2024

Long non-coding RNAs (lncRNAs) are versatile that regulate various cellular processes, such as gene regulation, by acting signals, decoys, guides, and scaffolds. A novel recognized lncRNA, LOXL1-antisense RNA 1 (LOXL1-AS1), is dysregulated in some diseases, including cancer, acts an oncogenic lncRNA many types of cancer cells. Upregulation LOXL1-AS1 has been involved proliferation, migration, metastasis, EMT, well inhibiting apoptosis Most importantly, the malignant promoting activity can be mostly mediated sequestering specific miRNAs their binding to 3´UTR target mRNAs, thereby indirectly regulating expression. Additionally, decoy transcription factors proteins prevent regulatory regions, mechanistic on regulation expression signaling pathways. This review presents pathways role modulating its Having information about molecular mechanisms regulated cells open ways find out particular prognostic biomarkers, discover therapeutic approaches for different cancer.

Language: Английский

Citations

1
A Systematic Review of Cardio-Metabolic Properties of Lonicera caerulea L. DOI Creative Commons
Larisa Bora, Adelina Lombrea, Stefan Laurentiu Batrina

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 694 - 694

Published: June 5, 2024

In the light of growing concerns faced by Western societies due to aging, natality decline, and epidemic cardio-metabolic diseases, both preventable treatable, new effective strategical interventions are urgently needed in order decrease their socio-economical encumbrance. The recent focus research has been redirected towards investigating potential haskap (Lonicera caerulea L.) as a novel functional food or superfruit. Therefore, our present review aims highlight latest scientific proofs regarding Lonicera L. (LC), perennial fruit-bearing plant rich polyphenols, reversing dysfunctions. this regard, systematic search on two databases (PubMed Google Scholar) from 1 January 2016 December 2023 was performed, keyword combination being AND searched pharmacological action, with inclusion criteria consisting extenso original articles, written English. health-enhancing characteristics berries have examined through vitro vivo studies 35 included papers. Positive effects cardiovascular diseases metabolic syndrome assigned antioxidant activity, hypolipidemic hypoglycemic effects, well hepatoprotective vasoprotective potential. Latest advances LCF mechanisms action detailed within well. All these cutting-edge data suggest that vegetal product would be good candidate for further clinical studies.

Language: Английский

Citations

0
How pharmacology can aid in the diagnosis of mental disorders DOI Creative Commons

Roland Seifert,

Bastian Schirmer, Johanna Seifert

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

Citations

0
Machine learning in oncological pharmacogenomics: advancing personalized chemotherapy DOI
Çıgır Biray Avci, Bakiye Göker Bağca,

Behrouz Shademan

et al.

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(5)

Published: Oct. 1, 2024

Language: Английский

Citations

0