Perspectives in MicroRNA Therapeutics for Cystic Fibrosis
Non-Coding RNA,
Journal Year:
2025,
Volume and Issue:
11(1), P. 3 - 3
Published: Jan. 12, 2025
The
discovery
of
the
involvement
microRNAs
(miRNAs)
in
cystic
fibrosis
(CF)
has
generated
increasing
interest
past
years,
due
to
their
possible
employment
as
a
novel
class
drugs
be
studied
pre-clinical
settings
therapeutic
protocols
for
fibrosis.
In
this
narrative
review
article,
consider
and
comparatively
evaluate
published
laboratory
information
development
miRNA-based
We
miRNAs
involved
upregulation
CFTR,
inhibition
inflammation
and,
finally,
exhibiting
antibacterial
activity.
suggest
that
antago-miRNAs
ago-miRNAs
(miRNA
mimics)
can
proposed
validation
settings.
Language: Английский
Hepatic isomiR landscaping reveals new biological insights into metabolic dysfunction in steatotic liver disease
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Abstract
Post-transcriptionally
modified
microRNA
(miRNA),
called
isomiRs,
expand
the
repertoire
of
transcripts
that
can
leveraged
for
therapeutic
targets
and
biological
insights.
However,
expression
isomiRs
has
not
been
characterized
in
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD).
Therefore,
we
assessed
isomiR
profile
biopsies
from
79
patients
with
MASLD
modeled
their
potential
role
biology.
MiRNAs
represented
75%
sequencing
reads
over
65%
them
were
attributed
to
demonstrating
higher
diversity
compared
canonically
annotated
miRNAs.
Differential
machine-learning
analyses
used
identify
173
associated
severity
58
fibrosis
score.
Candidate
target
mRNAs
identified
each
based
on
sequence
complementarity.
Using
matched
mRNA
data,
supported
by
data
an
independent
study,
proposed
key
dysregulated
involved
a
selection
33
disease-associated
pathways.
Importantly,
offered
novel
unique
canonical
miRNA,
e.g.
isomiR-122
targeting
INSIG1
(insulin
cholesterol
metabolism),
isomiR-21
HMGCS2
PPARA
(PARR
TGF-beta
signaling).
Our
work
advances
knowledge
regarding
lays
foundation
identification.
Highlights
results
provide
comprehensive
analysis
(isomiRs)
tissue.
Machine
learning
whose
is
MASLD.
Multi-omic
uncovered
regulatory
mechanisms
Language: Английский
Gut Microbiota–microRNA Interactions and Obesity Pathophysiology: A Systematic Review of Integrated Studies
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12836 - 12836
Published: Nov. 29, 2024
Obesity
is
the
fifth
leading
cause
of
death
globally
and
its
comorbidities
put
a
high
burden
on
societies
disability.
In
this
review,
we
aim
to
summarize
interactions
crosstalk
between
gut
microbiota
micro-RNA
(miRNA)
in
obesity.
We
searched
for
relevant
literature
through
PubMed,
Web
Science,
Scopus,
Science
Direct.
The
study
design
registered
international
prospective
register
systematic
reviews
(Prospero).
According
inclusion
criteria,
eight
studies
were
eligible
assessment
(two
including
human
subjects
six
animal
subjects).
report
that
miRNA
context
obesity
are
diverse
some
cases
tissue
specific.
However,
mediate
obesity-associated
pathways
inflammatory
response,
oxidative
stress,
insulin
signaling,
permeability,
lipogenesis.
To
mention
most
meaningful
results,
expression
adipose
miRNA-378a-3p/5p
was
associated
with
Language: Английский