Distress Symptoms of Old Age and Mild Cognitive Impairment are Two Distinct Dimensions in Older Adults Without Major Depression

Psychology Research and Behavior Management, Journal Year: 2024, Volume and Issue: Volume 17, P. 101 - 116

Published: Jan. 1, 2024

Background: Studies in old adults showed bidirectional interconnections between amnestic mild cognitive impairment (aMCI) and affective symptoms that adverse childhood experiences (ACE) may affect both factors. Nevertheless, these associations be confined to older with clinical depression. Aim: To delineate the relationship of aMCI without major depression (MDD) or dysfunctions activities daily living (ADL). Methods: This case-control study recruited 61 participants (diagnosed using Petersen's criteria) 59 excluded subjects MDD ADL dysfunctions. Results: We uncovered 2 distinct dimensions, namely distress age (DSOA), comprising symptoms, perceived stress neuroticism, dysfunctions, episodic memory test scores, total Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA) scores. A large part variance (37.9%) DSOA scores was explained by ACE, negative life events (health financial problems), a subjective feeling decline, education (all positively). ACE NLE have highly significant impact on score are not associated its severity. Cluster analysis diagnosis is overinclusive because some incorrectly classified as aMCI. Conclusion: The clinicians should carefully screen for after excluding MDD. might misinterpreted Keywords: depression, experiences, impairments, disorders, events, neurocognitive deficits

Language: Английский

The Role of Mesenchymal Stem Cell Exosomes in the Onset and Progression of Alzheimer's Disease

Biomedical Sciences, Journal Year: 2024, Volume and Issue: 10(1), P. 6 - 13

Published: March 13, 2024

Alzheimer's disease (AD) is a neurodegenerative with progressive loss of memory and cognitive function. Because its pathogenesis has not been fully elucidated, there still lack understanding effective treatment. Many studies have shown that Mesenchymal stem cells Exosomes (MSCs-Exo) can promote anti-inflammatory, regulate immune function, enhance amyloid (Aβ) degradation, axon growth nerve cells. effectively cross the blood-brain barrier, better biocompatibility biosafety than nanomaterials, more diverse ways to carry drugs. Adipose cell exosomes only treat AD by their own characteristics, but also other neurological diseases as A drug carrier efficiently freely barrier: they reduce Aβ42 plaques improve neuronal microenvironment through microglia. In model mice, excessive activation microglia demonstrated formation an inflammatory in brain. The erodes healthy neurons certain extent, forcing them overactivate signaling pathways so can't function normally, clear expression factors hypoxia-induced synaptic repair microRNA/ phosphatase tensin homolog (miR-223/PTEN) phosphatidylinositol kinase (PI3K/Akt) pathways. It polarization towards anti-inflammatory phenotype repair. be used dysfunction alleviating Tau phosphating or delaying hippocampus volume decay, targeting core pathological mechanism achieve therapeutic effects. This article mainly introduces role MSC development AD.

Language: Английский

Distress symptoms of old age and mild cognitive impairment are two distinct dimensions in older adults without major depression: effects of adverse childhood experiences and negative life events

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 4, 2023

Abstract Background Studies in old adults showed bidirectional interconnections between amnestic mild cognitive impairment (aMCI) and affective symptoms that adverse childhood experiences (ACE) may affect both factors. Nevertheless, these associations be confined to older with clinical depression. Aims To delineate the relationship of aMCI without major depression (MDD) or dysfunctions activities daily living (ADL). Methods This case-control study recruited 61 participants (diagnosed using Petersen’s criteria) 59 excluded subjects MDD ADL dysfunctions. Results We uncovered 2 distinct dimensions, namely distress age (DSOA) comprising anxiety, depression, perceived stress neuroticism scores, (mCoDy) episodic memory test total Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA) scores. A large part variance (37.9%) DSOA scores was explained by ACE, negative life events (health financial problems), a subjective feeling decline, education (all positively). While ACE NLE have highly significant impact on DSOA, they are not associated mCoDy Cluster analysis diagnosis is overinclusive because some incorrectly classified as aMCI. Conclusions The clinicians should carefully screen for after excluding MDD. might misinterpreted

Language: Английский