Brazilian Journal of Microbiology, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Language: Английский
Current Opinion in Infectious Diseases, Journal Year: 2023, Volume and Issue: 36(6), P. 522 - 528
Published: Oct. 13, 2023
Respiratory syncytial virus (RSV) remains a leading cause of mortality and morbidity worldwide. RSV seasonality was disrupted by COVID-19-associated nonpharmaceutical interventions (NPIs). We review seasonality, molecular epidemiology, clinical manifestations, community awareness to inform future prevention strategies.An initial reduction disease observed with NPIs, subsequent global resurgence associated collapse in genetic diversity. A lack immunity is suggested have contributed the cases experienced post COVID-19. The median age children admitted increased during resurgence, likely secondary expanded cohort RSV-immune naive children. pandemic also played role awareness, which can be utilized as part coordinated public health effort introduce strategies. Further education on signs symptoms still required.mAbs maternal vaccines targeting potential reduce paediatric morbidity, however this new era will require ongoing research facilitate engagement, better respiratory surveillance. Tackling burden measures ensure access affordability
Language: Английский
Citations
13
Journal of Theoretical Biology, Journal Year: 2024, Volume and Issue: 587, P. 111817 - 111817
Published: April 9, 2024
Language: Английский
Citations
5
Vaccines, Journal Year: 2022, Volume and Issue: 10(12), P. 2159 - 2159
Published: Dec. 15, 2022
This study aims to provide comparative data on clinical features and in-hospital outcomes among U.S. adults admitted the hospital with COVID-19 influenza infection using a nationwide inpatient sample (N.I.S.) 2020. Data were collected patient characteristics outcomes, including patient's age, race, sex, insurance status, median income, length of stay, mortality, hospitalization cost, comorbidities, mechanical ventilation, vasopressor support. Additional analysis was performed propensity matching. In propensity-matched cohort analysis, influenza-positive (and COVID-positive) patients had higher mean cost (USD 129,742 vs. USD 68,878, p = 0.04) total stay (9.9 days 8.2 days, 0.01), odds needing ventilation (OR 2.01, 95% CI 1.19-3.39), mortality 2.09, 1.03-4.24) relative COVID-positive influenza-negative cohort. conclusion, lower charges, shorter stays, overall thereby supporting use vaccine in patients.
Language: Английский
Citations
19
Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 491 - 491
Published: Feb. 20, 2023
Respiratory syncytial virus (RSV) is a major healthcare concern, especially for immune-compromised individuals and infants below 5 years of age. Worldwide, it known to be associated with incidences morbidity mortality in infants. Despite the seriousness issue continuous rigorous scientific efforts, no approved vaccine or available drug fully effective against RSV. The purpose this review article provide insights into past ongoing efforts securing vaccines therapeutics readers will able confer mechanism existing therapies loopholes that need overcome future therapeutic development A methodological approach was applied collect latest data updated results regarding We outline throughput vaccination technologies prophylactic linked range approaches already (with limited use) those undergoing trials are included. Moreover, important regimens used alone conjugation adjuvants also briefly discussed. After reading article, audience understand current standing clinical management form vaccine, prophylactic, candidates An understanding biological behavior acting as reason behind lack RSV developed. literature indicates limitations attached management, drugs, could explained by dealing challenges study designs improvement further work approval on novel applications.
Language: Английский
Citations
12
BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)
Published: Dec. 7, 2023
Abstract Background The US confronted a “triple-demic” of influenza, respiratory syncytial virus (RSV), and COVID-19 in the winter 2022, leading to increased infections higher demand for medical supplies. It is urgent analyze these epidemics their spatial-temporal co-occurrence, identifying hotspots informing public health strategies. Methods We employed retrospective prospective space-time scan statistics assess situations COVID-19, RSV 51 states from October 2021 February 2022 2023, respectively. This enabled monitoring spatiotemporal variations each epidemic individually collectively. Results Compared 2021, cases decreased while influenza significantly 2022. found high-risk cluster (not all three) 2021. In late November large triple-demic emerged central US. number at high risk multiple 15 21 January 2023. Conclusions Our study offers novel approach that combines both univariate multivariate surveillance, as well analyses. more comprehensive timely understanding how co-occurrence impacts various regions within United States. findings assist tailor-made strategies mitigate effects infections.
Language: Английский
Citations
12
The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 895, P. 165012 - 165012
Published: June 22, 2023
The quantification of viral genomes in wastewater reflects the prevalence infections within community. Knowledge how spread common enteric viruses community was affected by Swedish COVID-19 interventions is limited. To investigate this, weekly samples collected for monitoring SARS-CoV-2 throughout pandemic at Rya sewage treatment plant Gothenburg were also analyzed adenovirus, norovirus GII, astrovirus, and rotavirus. amount each genome quantified real-time-qPCR compared with quantity these from 2017. results showed that winter seasonality GII rotavirus observed 2017 interrupted shortly after introduction interventions, they remained low level pandemic. circulation pattern astrovirus adenovirus less affected. When restrictions lifted 2022, a dramatic increase rotavirus, wastewater. changes abundance some identified through consistent number patients diagnosed viruses. These findings suggest moderate intervention to prevent significantly reduced show valuable tool detecting outbreaks may cause gastroenteritis when people do not seek medical help, such as during
Language: Английский
Citations
11
Health Science Reports, Journal Year: 2024, Volume and Issue: 7(1)
Published: Jan. 1, 2024
Abstract Background and Aims Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection in infants young children. Given the altered circulation patterns viruses during coronavirus disease pandemic‐2019 (COVID‐19), study aimed to evaluate epidemiology clinical features RSV infections hospitalized children COVID‐19 pandemic Gorgan, northeastern Iran. Molecular studies on viral are necessary monitor circulating viruses, severity, symptoms, addition early warning new outbreaks. Methods Overall, 411 swab samples from October 2021 March 2022 were collected at Taleghani Children's Hospital, The incidence RSV, as well subgroups genotypes, investigated confirmed using PCR methods. Additionally, all tested for severe syndrome‐associated 2 (SARS‐CoV‐2) influenza, demographic data analyzed SPSS software. Results share SARS‐CoV‐2, influenza among with lower (ALRI) 27%, 16.5%, 4.1%, respectively. subgroup A (genotype ON1) was dominant over B BA9), more symptoms. Compared prepandemic era there high numbers SARS‐CoV‐2 positive low other viruses. Despite this, prevalence ALRI‐related RSV‐disease our specialized pediatric center higher than same cohort. Conclusions Studying determining strains can contribute effective control treatment strategies.
Language: Английский
Citations
4
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: Jan. 31, 2024
Respiratory syncytial virus (RSV) is one of the leading causes hospitalization and mortality among children with respiratory tract infections. The non-pharmaceutical preventive measures against severe acute syndrome coronavirus (COVID-19) may have reduced transmission RSV, altering its tropical epidemiological seasonality. Thus, this study represents first attempt to evaluate changes in RSV epidemiology context COVID-19 pandemic Malaysia.
Language: Английский
Citations
4
Indoor Environments, Journal Year: 2025, Volume and Issue: unknown, P. 100079 - 100079
Published: Jan. 1, 2025
Language: Английский
Citations
0
BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 6, 2025
Respiratory syncytial virus (RSV) is an important cause of children's pulmonary infections. However, there are fewer studies on RSV infections in adults. The purpose this study was to describe the clinical manifestations, para-clinical characteristics, and outcome infection among adult patients who were referred Imam Khomeini Hospital Complex during winter spring 2022–2023. From December 21, 2022, May 20, 2023, we conducted a cross-sectional hospitalized adults having positive RT-PCR results for RSV. We further assessed characteristics outcomes groups. screened 1375 with suspected acute respiratory (ARIs) confirmed 59 them (4.3%). Of these, 23 excluded from analysis due outpatient management, leaving 36 (61.01%). mean age 53.28 ± 20.37 years (range: 15–83), slightly higher proportion females (52.80%) compared males (47.20%). Dyspnea, productive cough, fever most common symptoms, symptom duration 10.50 days. Ischemic heart disease, hypertension, liver failure underlying conditions. Notably, biochemical inflammatory markers such as CRP, ESR, LDH significantly elevated beyond normal range. Finally, five (13.9%) received intensive care treatments died. Although rate not high Iranian adults, greater required hospitalization (61%). There significant link between failure, INR, more than 30% bilateral involvement, abdominal pain, longer ICU stays, immunodeficiency cases increased mortality infection. suggest that may act secondary factor decompensating pre-existing which present certain conditions, potentially leading life-threatening consequences.
Language: Английский
Citations
0