Effects of Turmeric Powder on Aflatoxin M1 and Aflatoxicol Excretion in Milk from Dairy Cows Exposed to Aflatoxin B1 at the EU Maximum Tolerable Levels

Toxins, Journal Year: 2022, Volume and Issue: 14(7), P. 430 - 430

Published: June 24, 2022

Due to the climatic change, an increase in aflatoxin B1 (AFB1) maize contamination has been reported Europe. As alternative mineral binders, natural phytogenic compounds are increasingly used counteract negative effects of AFB1 farm animals. In cows, even low dietary concentrations may result milk excretion genotoxic carcinogen metabolite M1 (AFM1). this study, we tested ability turmeric powder (TP), extract from Curcuma longa (CL) rich curcumin and curcuminoids, reducing AFM1 mammary Holstein–Friesian cows. Both active principles inhibit hepatic synthesis interact with drug transporters involved absorption excretion. A crossover design was applied two groups cows (n = 4 each) a 4-day washout. Animals received diet contaminated levels (5 ± 1 µg/kg) for 10 days TP supplementation (20 g/head/day). treatment had no impact on yield, composition or somatic cell count. Despite tendency toward lower average content last four (below EU limits), statistically significant differences group occurred. Since bioavailability be major issue, further investigations different CL preparations warranted.

Language: Английский

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Aflatoxins in Cereals and Cereal-Based Products: Occurrence, Toxicity, Impact on Human Health, and Their Detoxification and Management Strategies

Toxins, Journal Year: 2022, Volume and Issue: 14(10), P. 687 - 687

Published: Oct. 6, 2022

Cereals and cereal-based products are primary sources of nutrition across the world. However, contamination these foods with aflatoxins (AFs), secondary metabolites produced by several fungal species, has raised serious concerns. AF generation in innate substrates is influenced parameters, including substrate type, fungus moisture content, minerals, humidity, temperature, physical injury to kernels. Consumption AF-contaminated cereals can lead both acute chronic health issues related mental maturity, reproduction, nervous system. Therefore, precise detection methods, detoxification, management strategies AFs cereal crucial for food safety as well consumer health. Hence, this review provides a brief overview occurrence, chemical characteristics, biosynthetic processes, hazards, techniques AFs, along focus on detoxification that could be implemented security.

Language: Английский

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Computational Studies of Aflatoxin B1 (AFB1): A Review

Toxins, Journal Year: 2023, Volume and Issue: 15(2), P. 135 - 135

Published: Feb. 7, 2023

Aflatoxin B1 (AFB1) exhibits the most potent mutagenic and carcinogenic activity among aflatoxins. For this reason, AFB1 is recognized as a human group 1 carcinogen by International Agency of Research on Cancer. Consequently, it essential to determine its properties behavior in different chemical systems. The can be explored using computational chemistry, which has been employed complementarily experimental investigations. present review includes silico studies (semiempirical, Hartree–Fock, DFT, molecular docking, dynamics) conducted from first study 1974 (2022). This work was performed, considering following groups: (a) (structural, energy, solvent effects, ground excited state, atomic charges, others); (b) theoretical investigations (degradation, quantification, reactivity, (c) interactions with inorganic compounds (Ag+, Zn2+, Mg2+); (d) environmentally (clays); (e) biological (DNA, enzymes, cyclodextrins, glucans, others). Accordingly, work, we provide stakeholder knowledge toxicity types AFB1-derivatives, structure–activity relationships manifested bonds between DNA or proteins, strategies that have quantify, detect, eliminate molecule.

Language: Английский

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Fungi and cancer

Gut, Journal Year: 2023, Volume and Issue: 72(7), P. 1410 - 1425

Published: May 5, 2023

The microbiome may impact cancer development, progression and treatment responsiveness, but its fungal components remain insufficiently studied in this context. In review, we highlight accumulating evidence suggesting a possible involvement of commensal pathogenic fungi modulation cancer-related processes. We discuss the mechanisms by which can influence tumour biology, locally activity exerted within microenvironment, or remotely through secretion bioactive metabolites, host immunity communications with neighbouring bacterial commensals. examine prospects utilising fungi-related molecular signatures diagnosis, patient stratification assessment while highlighting challenges limitations faced performing such research. all, demonstrate that likely constitute important members mucosal tumour-residing microbiomes. Exploration inter-kingdom interactions decoding their causal impacts on biology enable harnessing into diagnosis treatment.

Language: Английский

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Current Status of Major Mycotoxins Contamination in Food and Feed in Asia─A Review

ACS Food Science & Technology, Journal Year: 2023, Volume and Issue: 3(2), P. 231 - 244

Published: Jan. 24, 2023

Mycotoxins can cause genotoxic, mutagenic, teratogenic, and carcinogenic effects in humans animals. inevitably exist widely all kinds of food feed commodities, which cereals are the most susceptible. In one largest cereal producing consuming regions world, mycotoxin contamination causes about 1 billion metric tons loss annually, also influences a serious decline Asian economic development. This Review is based on three databases, PubMed, Google Scholar, Web Science, including studies that were published English period from January 1, 2016 to October 2022. Results show current status control strategies aflatoxins, ochratoxin A, zearalenone, deoxynivalenol, fumonisins Asia. Developed countries Asia should maintain strict monitoring establish an effective system for whole production chain, while developing strengthen prevention mycotoxins.

Language: Английский

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