Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(16), P. 5761 - 5761

Published: Aug. 11, 2020

Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, dental materials. BPA can contaminate food, beverage, air, soil. It accumulates several human tissues organs potentially harmful health through different molecular mechanisms. Due its hormone-like properties, may bind estrogen receptors, thereby affecting both body weight tumorigenesis. also affect metabolism cancer progression, by interacting with GPR30, impair male reproductive function, binding androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, HAND2, are involved action on fat liver homeostasis, cardiovascular system, cancer. Finally, epigenetic changes, such DNA methylation, histones modification, changes microRNAs expression contribute pathological effects. This review aims provide extensive comprehensive analysis of most recent evidence about potential mechanisms which affects health.

Language: Английский

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Layered double hydroxide based materials applied in persulfate based advanced oxidation processes: Property, mechanism, application and perspectives

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 424, P. 127612 - 127612

Published: Nov. 8, 2021

Language: Английский

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BPA and BPA alternatives BPS, BPAF, and TMBPF, induce cytotoxicity and apoptosis in rat and human stem cells

Ecotoxicology and Environmental Safety, Journal Year: 2021, Volume and Issue: 216, P. 112210 - 112210

Published: April 16, 2021

Bisphenol A (BPA) is a ubiquitous industrial chemical found in everyday plastic products and materials. Due to scientific findings on the reproductive, developmental, cellular defects caused by BPA heightened public awareness, manufacturers have begun use new chemicals place of "BPA-free" products. These alternatives are analogs include dozens compounds that undergone relatively little testing oversight, including: bisphenol S (BPS), AF (BPAF), recently developed tetramethyl F (TMBPF; monomer valPure V70). Here, we used adult female rat adipose-derived stem cells (rASCs) human mesenchymal (hMSCs) compare toxicities potencies these vitro. Rat were exposed (1–10 μM), 17β-estradiol (E2; 10 BPS (1–100 BPAF (3 × 10−4–30 TMBPF (0.01–50 or control media alone (with 0.01% ethanol) for varying time intervals from min 24 h. We significantly decreased cell viability massive apoptosis treated with each analog, as early exposure, at low, physiologically relevant doses. showed extreme cytotoxicity dose-dependent manner (LC50 = 0.014 μM 0.009 (hMSCs)), whereas bimodal response, low high concentrations being most toxic 0.88 0.06 (hMSCs)). Activated caspase-6 levels increased nearly all indicating majority death was due caspase-6-mediated apoptosis. results both underscore toxicity potency analogs, establish rank order of: > BPS. Further, other recent indicate newer may be 'regrettable substitutions,' worse than original parent compound lacking proper regulation. This work brings light need further toxicological characterization, better regulation, greater development safer, more sustainable non-plastic

Language: Английский

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Bisphenol A and Type 2 Diabetes Mellitus: A Review of Epidemiologic, Functional, and Early Life Factors

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(2), P. 716 - 716

Published: Jan. 15, 2021

Type 2 diabetes mellitus (T2DM) is characterised by insulin resistance and eventual pancreatic β-cell dysfunction, resulting in persistent high blood glucose levels. Endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) are currently under scrutiny they implicated the development of metabolic diseases, including T2DM. BPA a pervasive EDC, being main constituent polycarbonate plastics. It can enter human body ingestion, through skin, cross from mother to offspring via placenta or breast milk. xenoestrogen that alters various aspects beta cell metabolism modulation oestrogen receptor signalling. In vivo vitro models reveal varying concentrations disrupt homeostasis function altering gene expression mitochondrial morphology. also plays role has been linked long-term adverse effects following foetal perinatal exposure. Several epidemiological studies significant association between impaired homeostasis, although conflicting findings driven multiple confounding factors have reported. this review, functional summarised compared, their respective strengths limitations discussed. Further research essential for understanding exact mechanism action tissues extent its on humans at environmentally relevant doses.

Language: Английский

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Endocrine-disrupting chemicals (EDCs) and cancer: new perspectives on an old relationship

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 46(4), P. 667 - 677

Published: Dec. 16, 2022

Language: Английский

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Endocrine Disrupting Chemicals’ Effects in Children: What We Know and What We Need to Learn?

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11899 - 11899

Published: Oct. 7, 2022

Thousands of natural or manufactured chemicals were defined as endocrine-disrupting (EDCs) because they can interfere with hormone activity and the endocrine system. We summarize discuss what we know still need to learn about EDCs' pathogenic mechanisms action, well effects most common EDCs on system health in childhood. The MEDLINE database (PubMed) was searched 13 May 2022, filtering for EDCs, diseases, children. are a group compounds high heterogeneity, but usually disrupt by mimicking interfering hormones body's hormonal balance through other mechanisms. Individual studied detail, while humans' "cocktail effect" is unclear. In utero, early postnatal life, and/or pubertal development highly susceptible periods exposure. Human epidemiological studies suggest that affect prenatal growth, thyroid function, glucose metabolism, obesity, puberty, fertility several Further needed clarify which mainly act epigenetic processes. A better understanding human crucial developing future regulatory strategies prevent exposure ensure children today, generations, environment.

Language: Английский

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Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work

Environment International, Journal Year: 2023, Volume and Issue: 176, P. 107976 - 107976

Published: May 16, 2023

Bisphenol A (BPA) is the most simple and predominant component of family. BPA widely present in environment human body as a result its extensive usage plastic epoxy resins consumer goods like water bottles, food containers, tableware. Since 1930s, when BPA's estrogenic activity was first observed, it labeled "mimic hormone E2", studies on endocrine-disrupting effects then have been conducted. As top vertebrate model for genetic developmental studies, zebrafish has caught tremendous attention past two decades. By using zebrafish, negative either through signaling pathways or non-estrogenic were largely found. In this review, we tried to draw full picture current state knowledge with their mechanisms action decades, which may help fully understand mechanism, give direction future studies.

Language: Английский

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Thyroid dysfunction caused by exposure to environmental endocrine disruptors and the underlying mechanism: A review

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 391, P. 110909 - 110909

Published: Feb. 8, 2024

Language: Английский

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Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 814 - 814

Published: Jan. 19, 2025

Bisphenol A (BPA) is a prevalent environmental contaminant found in plastics and known for its endocrine-disrupting properties, posing risks to both human health the environment. Despite widespread presence, impact of BPA on papillary thyroid cancer (PTC) progression, especially under realistic conditions, not well understood. This study examined effects PTC using 3D tumor spheroid model, which better mimicked complex interactions within tissues compared traditional 2D models. Our findings demonstrated that BPA, at environmentally relevant concentrations, could induce significant changes cells, including decrease E-cadherin expression, an increase vimentin reduced thyroglobulin (TG) secretion. These suggest exposure may promote epithelial–mesenchymal transition (EMT), enhance invasiveness, reduce cell differentiation, potentially complicating treatment, by increasing resistance radioiodine therapy. research highlights BPA’s hazardous nature as emphasizes need advanced vitro models, like spheroids, assess posed such chemicals. It provides valuable insights into implications role enhancing our understanding

Language: Английский

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Endocrine-disrupting chemicals and child health

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2021, Volume and Issue: 35(5), P. 101516 - 101516

Published: March 11, 2021

Language: Английский

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