Risk factors and severity of functional impairment in long COVID: a single-center experience in Croatia

Croatian Medical Journal, Journal Year: 2022, Volume and Issue: 63(1), P. 27 - 35

Published: Feb. 1, 2022

AimTo determine the frequency of common symptoms in long COVID and their effect on quality life, to factors contributing a more severe COVID.MethodsThe study enrolled 266 patients who were either referred long-COVID outpatient clinic or inpatients undergoing rehabilitation. The data collected between December 2020 May 2021. We evaluated experienced during acute comorbidities. Functional status was assessed with Post Covid Status (PCFS).ResultsThe final sample consisted 261 patients. After COVID-19 period (>4 weeks), almost 80% had impaired functional status. Only 21.5% reported no impairment (0 PCFS scale). A higher score associated female sex (P < 0.001) oxygen therapy requirement disease = 0.001). However, it not having pre-existing lung 0.749). Disease severity did pose risk for developing COVID.ConclusionWomen at greater COVID, although we have explanation why. Malignant hypertension also presented factor impairment. More studies are warranted if certain susceptible COVID.

Language: Английский

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Post-COVID-19 asthenic syndrome

S S Korsakov Journal of Neurology and Psychiatry, Journal Year: 2021, Volume and Issue: 121(4), P. 25 - 25

Published: Jan. 1, 2021

To study the features of asthenic syndrome and possibilities its therapy in patients post-covid period.The included 129 with an average age 49.8±8.9 years who had undergone COVID-19 using a continuous sample method. Patients for were selected at clinical bases outpatient clinics Samara (Russia) July-August 2020. All signed informed consent form prior to enrollment. randomized into two groups: main group (n=64), ethylmethylhydroxypyridine succinate (Neurox) was prescribed 1 tablet (125 mg) 3 times day 4 weeks; comparison (n=65), medical drugs (MD) did not contain substances from pharmacological related antihypoxants/antioxidants/nootropics. Three visits (V) conducted: first (V1) - period inclusion, second (V2) after 14 days, third (V3) on 28th start therapy. The dynamics general state (weakness, fatigue, concentration, dizziness, headache, sleep disorders) evaluated visual-analog scale (VAS), assessment subjective feeling severity asthenia (fatigue, physical mental decreased motivation activity) Multidimensional Fatigue Inventory (MFI-20), cognitive functions Mini-Mental State Examination (MMSE), vegetative tone according Kerdo index.At end (V3), statistically significant changes indicators (VAS, MFI-20) obtained only patients; no differences index. Analysis MMSE data revealed decrease both groups, which may be associated pseudocognitive deficits due asthenia.We have evidence high incidence COVID-19. Against background taking Neurox, there expression symptoms.Изучение особенностей астенического синдрома и возможностей его терапии у больных в постковидный период.Методом сплошной выборки исследование были включены больных, средний возраст 49,8±8,9 года, перенесших Пациентов для исследования отбирали на клинических базах амбулаторно-поликлинических учреждений Самары период июль—август 2020 г. Все пациенты подписали информированное согласие. Методом конвертов рандомизированы две группы: основной группе (n=64) был назначен этилметилгидроксипиридинасукцинат (Нейрокс) по таблетке мг) раза сутки течение нед; сравнения (n=65) лекарственные препараты (ЛП) не содержали веществ из фармакологической группы, относящихся к антигипоксантам/антиоксидантам/ноотропам. Проведено три визита (V): первый — включения, второй через дней, третий 28-й день от начала терапии. Динамику общего состояния (слабость, утомляемость, концентрация внимания, головокружение, головная боль, нарушения сна) оценивали визуально-аналоговой шкале (ВАШ), оценку субъективного ощущения тяжести астении (усталость, физическая умственная снижение мотивации активности) многомерному опроснику усталости (Multidimensional Inventory, MFI-20), когнитивные функции краткой оценки психического статуса (Mini-Mental Examination, MMSE), вегетативный тонус индексу Кердо.В конце статистически значимые изменения показателей (ВАШ, получены только больных; Кердо значимых различий получено. Анализ данных выявил когнитивных функций обеих группах, что может быть связано с псевдокогнитивным дефицитом вследствие астении.Нами получено свидетельство высокой частоты встречаемости после перенесенного На фоне приема Нейрокса отмечено выраженности симптомов астении.

Language: Русский

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Indigenous and Disruptive Remote Patient Monitoring Devices - A Case Study on AI in Healthcare

SDMIMD Journal of Management, Journal Year: 2023, Volume and Issue: unknown, P. 27 - 34

Published: Oct. 9, 2023

The evolution of Industry 4.0 technologies has facilitated the growth technologically driven healthcare solutions, disrupting, and significantly challenging way sector works moving towards Healthcare 4.0. global interest in Artificial Intelligence (AI) is increasing tremendously comparison to other sectors. A rapidly ageing population with health complications led rise AI-driven Remote Patient Monitoring (RPM) devices, where a patient can be monitored comfort home, using latest communication sensor technologies. This study aims understand usage as disruptor, capturing ever-increasing demands concerning remote monitoring industry, making huge improvements, redefining how provided, for timely cost-effective solutions. analysis these devices been done through case approach. For this purpose, two AI-enabled Dozee.ai Qure.ai, have taken which assisting patients doctors diagnosis vitals remotely. Data from secondary sources analyze concept indigenous disruptive innovations. Both apps quite successful their Covid positive assisted both personnel during critical times. Despite advantages RPM they are vulnerable data hacking privacy issues. Any errors pose potential risks patients’ health.

Language: Английский

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Psychological Effects of Social Isolation During the COVID-19 Pandemic 2020

GeroPsych, Journal Year: 2022, Volume and Issue: 35(1), P. 17 - 29

Published: Feb. 10, 2022

Abstract. The SARS-CoV2 pandemic meant considerable restrictions in the social life of many people. Older people belong to high-risk group for a severe fatal course disease, which is why these groups received special protection. This protection included drastic on their personal and contacts, including suspension psychosocial therapies. study examines cognitive emotional effects isolation older A 49 participants who lived nursing homes was tested before after 2020. results present provide empirical evidence negative regarding performance, anxiety, depressive symptoms, quality life.

Language: Английский

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Postcovid-19 Asthenic Syndrome

Neuroscience and Behavioral Physiology, Journal Year: 2022, Volume and Issue: 52(2), P. 191 - 195

Published: Feb. 1, 2022

Language: Английский

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Acquired decrease of the C3b /C4b receptor (CR1, CD35) and C4d deposits on Erythrocytes from ICU COVID-19 Patients

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: Aug. 14, 2020

ABSTRACT We determined CR1, CD35 the C3b, C4b receptor density, C3b/C3bi and C4d deposits densities on Erythrocytes (E) in 51 COVID-19 patients undergoing O 2 therapy or assisted ventilation ICU units Rheims France. A clear acquired decrease of CR1 density E from was observed, particularly among fatal cases, paralleling several severity parameters. Deposits largely above values observed normal individuals, mostly without C3 deposits, have been more than 80% patients, reminiscent sub endothelial pericapillary organ transplant rejection, already parallel, as well also clinical SLE flares. Conversely, significant were only ¼ patients. The CR1/E detection virus spike, C4 fragment E, are likely to be two aspects same phenomenon immune complexes complement coated cell debris handling clearance. Measurement deposit might represent a way for assessing inflammation activation occurring capillaries. cumulative index Taken together, these original findings stress participation regulatory proteins that disease evidence matter mechanisms use CR1-like molecules with aim down regulating should considered. HIGHLIGHTS Acquired Large most possible Decreased CR1/E,

Language: Английский

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COVID-19: the epidemiology and treatment

British Journal of Hospital Medicine, Journal Year: 2020, Volume and Issue: 81(10), P. 1 - 9

Published: Oct. 2, 2020

After initially emerging in late 2019, coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), has spread rapidly to cause a global pandemic. SARS-CoV-2 is betacoronavirus that closely related and Middle East coronavirus, all of which can lung injury, distress cytokine storm. While mortality rates associated with are lower than those or it more contagious spreads these other viruses. This article summarises epidemiology potential options for treating COVID-19 give foundation future studies diagnosis, treatment prevention this deadly disease.

Language: Английский

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Correlates of psychological distress in epileptic patients during the COVID-19 outbreak

Epilepsy & Behavior, Journal Year: 2020, Volume and Issue: 115, P. 107632 - 107632

Published: Nov. 19, 2020

Following the severe consequences of coronavirus disease 2019 (COVID-19) outbreak, on March 9th, 2020 Italian Government implemented extraordinary measures to limit viral transmission, including restrictive quarantine measures. Psychological distress represents seizure-precipitating factor most often reported by patients with epilepsy. To date, no studies have analyzed role played different dimensions psychological quarantine-induced in epilepsy.We included a total 40 patients, 18 suffered from generalized, and 22 focal The previously seen outpatient clinic during pre-lockdown period between January February were reevaluated after lockdown period. was evaluated using three subscales Impact Event Scale-Revised (IES-R). Finally, we employed logistic regression analyses explore demographic clinical features associated high scores IES-R.Patients higher IES-R Intrusion Avoidance demonstrated an increased number epileptic attacks compared prelockdown Multivariate showed that specific subgroup (i.e., older, female more anxious symptoms) are at risk seizure frequency.Our study confirmed frequency seizures when early identification vulnerable worsening is crucial requiring hospital or treatment COVID-19 outbreak.

Language: Английский

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Suffering and Salutogenesis: A Conceptual Analysis of Lessons for Psychiatry From Existential Positive Psychology (PP2.0) in the Setting of the COVID-19 Pandemic

Frontiers in Psychology, Journal Year: 2021, Volume and Issue: 12

Published: April 9, 2021

The COVID-19 pandemic has had a widespread effect on the thoughts, emotions and behavior of millions people all around world. In this context, large body scientific literature examining mental health impact global crisis emerged. majority these studies have framed in terms pre-defined categories derived from psychiatric nosology, such as anxiety disorders, depression or post-traumatic stress disorder. These constructs often fail to capture complexity actual experiences individuals being studied; more specifically, they describe exclusively disease, while neglecting their potentially adaptive “salutogenic” aspects. Similarly, discussion psychological assistance for largely been confined reiteration “evidence-based” pharmacological techniques which can be delivered using remote access technology. context pandemic, approaches are likely mixed efficacy. Conversely, “negative emotions” distressing may actually functional setting disaster crisis, serving minimize harm, maximize social coherence compliance, facilitate adherence safety measures. limitations “conventional” approach are, certain degree, inherent prevailing medical model health. Beyond considerations lies concept “salutogenesis,” term refers innate capacity create maintain well-being face adversity. Using principles second wave positive psychology (PP2.0), particularly its emphasis totality human experience possibility deriving meaning character growth suffering, paper conceptually analyses relevant aspects salutogenesis PP2.0, proposes an alternate addressing concerns during pandemic. Such approach, acknowledging utility conventional medical-psychotherapeutic specific cases, reduces risk medicalizing experience, provides communities with opportunities adaptation. benefits proposal could extend far beyond current offering opportunity field psychiatry research move away purely “disease-centered” model.

Language: Английский

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Injection of Recombinant Tissue Plasminogen Activator into Extracorporeal Membrane Oxygenators Postpones Oxygenator Exchange in COVID-19

ASAIO Journal, Journal Year: 2022, Volume and Issue: unknown

Published: May 16, 2022

Coronavirus disease 2019 (COVID-19) has drastically increased the number of patients requiring extracorporeal life support. We investigate efficacy and safety low-dose recombinant tissue-type plasminogen activator (rtPA) injection into exhausted oxygenators to delay exchange in critically ill COVID-19 on veno-venous membrane oxygenation (V-V ECMO). Small doses rtPA were injected directly draining section a V-V ECMO circuit. compared transmembrane pressure gradient, pump head efficiency, arterial partial oxygen pressure, carbon dioxide before after procedure. Bleeding was with matched control group 20 receiving standard anticoagulation. Four received 16 oxygenator instillations at 5, 10, or mg per dose. Administration significantly reduced gradient (Δ p m = 54.8 ± 18.1 mmHg vs . 38.3 13.3 after, < 0.001) dose-dependent manner (Pearson’s R −0.63, 0.023), allowing exchange, thus reducing overall consumed oxygenators. blood flow efficiency η (1.20 0.28 ml/revolution 1.24 0.27 ml/r, 0.002). Lysis did not affect gases systemic coagulation. Minor bleeding occurred 2 4 (50%) lysis as well 19 (95%). effectively delays if is indicated by an increase gradient. Application result higher incidences anticoagulated for COVID-19.

Language: Английский

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