Effects of exercise on chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review and meta-analysis

Journal of Cancer Survivorship, Journal Year: 2022, Volume and Issue: 17(2), P. 318 - 331

Published: Feb. 11, 2022

Language: Английский

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Harms of exercise training in patients with cancer undergoing systemic treatment: a systematic review and meta-analysis of published and unpublished controlled trials

EClinicalMedicine, Journal Year: 2023, Volume and Issue: 59, P. 101937 - 101937

Published: April 6, 2023

Exercise is recommended for people with cancer. The aim of this study was to evaluate the harms exercise in patients cancer undergoing systemic treatment.

Language: Английский

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Assessment of Integrative Therapeutic Methods for Improving the Quality of Life and Functioning in Cancer Patients—A Systematic Review

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(5), P. 1190 - 1190

Published: Feb. 20, 2024

Background: Cancer rehabilitation represents a series of measures adopted for the recovery psychological, emotional, social, and financial functioning in case cancer patients. The purpose this study is to identify main elements therapeutic management field medical rehabilitation, as well integrative, complementary medicine holistic approaches that can be performed on oncological patient. Methods: This systematic literature review follows methodology outlined “Preferred Reporting Items Systematic Reviews Meta-Analysis” (“PRISMA”) statement, which an internationally recognized widely accepted standard. Results: Active rehabilitative therapies offer options improving quality life patients; these comprehensively address both physical psychological aspects disease. also includes latest novelties nanotechnologies applied example, drugs (or supplements) inspired by nature. Conclusions: Physical medicine, mostly using stimulating methods, was recently added list contraindications patients, approach pathological concept itself clinical consequences functional therapies. Integrative, presents important resource Advanced studies are needed future further ascertain role

Language: Английский

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Translation, Cross-Cultural Adaptation, and Validation of the Kannada Version of the Exercise Adherence Rating Scale (EARS-Kn) Among Head and Neck Cancer (HNC) Survivors in a Tertiary Care Setup in India

Integrative Cancer Therapies, Journal Year: 2025, Volume and Issue: 24

Published: Jan. 1, 2025

Background: Adherence in rehabilitation services includes attending appointments, regularly performing prescribed exercises, and correct exercise execution. The Exercise Rating Scale (EARS) has been adapted into several languages, but there is lack of a standardized tool for various Indian languages cultural contexts, particularly use with cancer survivors. With the anticipated 57.7% rise cases by 2040, this study aims to address gap. Aims objectives: To cross-culturally adapt EARS Kannada (EARS-Kn) evaluate its validity reliability amongst HNC survivors enrolled Multimodal Oncology Rehabilitation Exercise—MORE © Program. Methodology: Following Beaton guidelines, was Kannada. 34 engaged MORE program. Internal consistency (Cronbach’s ⍺) construct (Exploratory Factor Analysis, EFA) were assessed. Receiver Operating Curve (ROC) determined cut-off scores, sensitivity specificity EARS-Kn. Results: EARS-Kn demonstrated Cronbach’s-⍺ value .93. EFA revealed one-factor solution eigenvalues exceeding one 70.1% loading. area under curve (AUC) 0.908. A score 17 established, 95.83% 80% specificity. Conclusion: version showed strong among Kannada-speaking survivors, indicating potential enhance understanding adherence them. Future studies could explore diverse populations regimes. Studies also further investigate psychometric properties different which would help improve survivorship outcomes.

Language: Английский

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Capsaicin alleviates cisplatin‐induced muscle loss and atrophy in vitro and in vivo

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 14(1), P. 182 - 197

Published: Nov. 18, 2022

Abstract Background Cisplatin (CP) is a widely used chemotherapeutic drug with subsequent adverse effects on different organs and tissues including skeletal muscle loss atrophy as the most common clinical symptoms. The molecular mechanism of cisplatin‐induced not clearly understood. However, recent significant advances indicate that it related to an imbalance in both protein status apoptosis. Capsaicin (CAP) one major ingredients chilli peppers. It valuable pharmacological agent several therapeutic applications controlling pain inflammation particular potential atrophy. mechanisms underlying its protective against remain largely unknown. This study aims investigate capsaicin's beneficial vitro vivo. Methods anti‐muscle‐atrophic effect capsaicin was investigated using vivo studies. By pretreatment model, pretreated for 24 h treated cisplatin 48 h, we utilized C 2 12 myotube formation model where cell viability analysis, immunofluorescence, expression were measured hampering C57BL/6 mice administered (10, 40 mg/kg BW) 5 weeks (3 seven consecutively days assess animal oxidative stress examination, grip strength tested evaluate strength. Results Our results indicated caused lower showed subset hallmark signs typically recognized during atrophy, severe reduction diameter, repression Akt, mTOR expression. could ameliorate by up‐regulating synthesis well down‐regulating markers degradation. Additionally, able downregulate apoptosis‐related markers, activated TRPV1 autophagy progress modulation recovery lysosome function. In vivo, relieve cytokine secretion while modulating autophagy‐related fusion, improving strength, alleviating body weight gastrocnemius Conclusions These findings suggest can restore between degradation pathways may have

Language: Английский

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State of Rehabilitation Research in the Head and Neck Cancer Population: Functional Impact vs. Impairment-Focused Outcomes

Current Oncology Reports, Journal Year: 2022, Volume and Issue: 24(4), P. 517 - 532

Published: Feb. 19, 2022

Language: Английский

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The Effect of Exercise on Pain in People with Cancer: A Systematic Review with Meta-analysis

Sports Medicine, Journal Year: 2023, Volume and Issue: 53(9), P. 1737 - 1752

Published: May 22, 2023

Cancer-related pain is common and undertreated. Exercise known to have a pain-relieving effect in non-cancer pain.This systematic review aimed evaluate (1) the of exercise on cancer-related all cancers, (2) whether differed according mode, degree supervision, intervention duration timing (during or after cancer treatment), types, measurement tool type.Electronic searches were undertaken six databases identify studies evaluating people with cancer, published prior 11 January 2023. All stages screening data extraction conducted independently by two authors. The Cochrane risk bias for randomised trials (RoB 2) was used overall strength evidence assessed using GRADE approach. Meta-analyses performed study design, characteristics.In total, 71 reported 74 papers eligible inclusion. meta-analysis included 5877 participants showed reductions favouring (standardised mean difference - 0.45; 95% confidence interval 0.62, 0.28). For most (> 82%) subgroup analyses, direction favoured compared usual care, sizes ranging from small large (median size 0.35; range 0.03 1.17). very low.The findings provide support that participation does not worsen it may be beneficial. Better categorisation inclusion more diverse populations future research would improve understanding extent benefit whom.CRD42021266826.

Language: Английский

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Effect of exercise across the head and neck cancer continuum: a systematic review of randomized controlled trials

Supportive Care in Cancer, Journal Year: 2023, Volume and Issue: 31(12)

Published: Nov. 4, 2023

Abstract Purpose This study aims to systematically explore the impact of physical exercise as supportive therapy for head and neck cancer. Methods A systematic search on PubMed/MEDLINE, Cochrane, SPORTDiscus was conducted. Randomized controlled trials exploring effects a intervention in comparison with usual care outcomes patients cancer were selected. The RoB 2 tool used determine quality. extracted data are reported qualitative synthesis. Results Among 527 records examined, nine studies included. No investigating prehabilitation found, whereas eight involving 452 conducted during anticancer treatment. Most did not report improvements body mass index or composition, while 2/4 3/5 investigations found significant increase muscle strength cardiorespiratory fitness, respectively. Regarding patients’ outcomes, 4 out 7 observed enhancements some domains quality life, two 3 detected an amelioration fatigue following intervention. Analyzing programs, it seems that combining aerobic resistance training could be more beneficial compared single type full-body counteracting decline controlling symptoms phase. One trial has investigated effect who had terminated treatments, reporting lean mass, strength, life. Conclusion Exercise may promising approach Future needed consolidate these results.

Language: Английский

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Physical activity and pain in people with cancer: a systematic review and meta-analysis

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(3)

Published: Feb. 6, 2024

Abstract Purpose Physical activity can provide analgesic benefit but its effect on cancer-related pain is unclear. This review synthesised and appraised the evidence for of physical in people living with or beyond cancer. Methods A systematic search Ovid Medline Embase was performed to identify randomised controlled trials (RCTs), cross-over studies (RXTs), prospective observational that examined outcomes adults Meta-analyses were generate estimates. Risk bias assessed, GRADE system used assess quality. Results One hundred twenty-one ( n = 13,806), including 102 RCTs, 6 RXTs, 13 studies, met criteria inclusion. RCTs identified a decrease intensity 3734; standardised mean difference (SMD) − 0.30; 95% confidence interval (CI) 0.45, 0.15) bodily 1170; SMD 0.28; CI 0.01, 0.56) not interference 207; 0.13, 0.42, following interventions. Individual also reduction sensitivity use, although meta-analysis possible these outcomes. High heterogeneity between low certainty some estimates, publication meant quality graded as very low. Conclusion may cancer; however, high limits ability generalise this finding all cancer specific types pain.

Language: Английский

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Effectiveness of Therapeutic Exercise Models on Cancer-Related Fatigue in Patients With Cancer Undergoing Chemotherapy: A Systematic Review and Network Meta-analysis

Archives of Physical Medicine and Rehabilitation, Journal Year: 2023, Volume and Issue: 104(8), P. 1331 - 1342

Published: Jan. 31, 2023

ObjectiveTo assess and compare the effectiveness of different exercise modalities in reducing cancer-related fatigue (CRF) patients with cancer undergoing chemotherapy. Exercise intensities for selected types were also compared.Data SourcesWe conducted a search MEDLINE, Embase, CINAHL, Scopus, SPORTDiscus, Web Science from inception to October 15, 2021.Study SelectionRandomized controlled trials concerning on CRF chemotherapy included.Data ExtractionStudy characteristics extracted using structured protocol. Methodological quality was assessed employing PEDro scale risk bias Revised Cochrane Risk Bias Tool Randomized Trials. The certainty evidence based Grading Recommendations, Assessment, Development Evaluation. measure effect used adjusted standardized mean difference (SMD) or Hedge's g, together corresponding 95% confidence intervals (CI).Data SynthesisForty-seven studies included. Data pooled random-effects model. There trend that adding low-intensity aerobic resistance (SMD=1.28, CI -0.18; 2.75, P=.086), moderate-intensity (SMD=0.85; -0.12; 1.82, P=.087), more effective than flexibility training usual care (UC). UC alone less (SMD=-0.47, -0.96, 0.02, P=.060) UC.ConclusionsThe addition low- and/or demonstrated positive improvement chemotherapy, when compared training.

Language: Английский

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