Can a physical activity program improve functional capacity and fatigue in people with cancer? A retrospective analysis

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 6, 2025

Abstract Purpose The primary aim was to determine the effect of a physical activity (PA) program with education sessions on walking capacity and fatigue in people cancer. secondary objective assess factors that moderated program’s among sociodemographic, symptom-related factors. Satisfaction also evaluated. Method A retrospective, observational study data from 12-week twice-weekly group PA combined conducted. 6-min walk test (6MWT), Multidimensional Fatigue Inventory (MFI-20) satisfaction were assessed. Paired t-tests applied changes 6MWT MFI-20. Multiple linear regressions influence age, gender, initial effects program. Results Among 264 participants (age 57.36 ± 12.43 years; 189 women; 134 breast cancer), 125 (47%) completed Walking (+ 41.63 91.00 m) (-2.01 3.77) improved after ( p < 0.001). Age gender did not effect; however, lower higher scores associated larger improvements high who it. Conclusions significantly program, but drop-out rate high. could be individualized based an individual's or score enhance its effectiveness.

Language: Английский

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Effects of high-intensity interval training on functional performance and maximal oxygen uptake in comparison with moderate intensity continuous training in cancer patients: a systematic review and meta-analysis

Supportive Care in Cancer, Journal Year: 2023, Volume and Issue: 31(11)

Published: Oct. 18, 2023

Abstract Introduction High-intensity interval training (HIIT) is an appropriate modality to improve endurance and therefore contributes physical performance. This review investigates the effect of HIIT on functional performance in cancer patients. We reviewed relative peak oxygen uptake (relV̇O 2PEAK ) meta-analytical compared with moderate intensity continuous (MICT). Furthermore, we took various parameters under consideration. Methods A systematic literature search was conducted Scopus, PubMed, Cochrane Library databases. For review, included randomized controlled trials containing From this, filtered interventions additional MICT for meta-analysis. Outcomes interest were assessments V̇O 2MAX . Results The research yielded 584 records which fit inclusion criteria, 31 studies n =1555 patients (57.4±8.6 years) could be overall 8 meta-analysis ( =268, 59.11±5.11 regarding relV̇O Different outcomes found, walking distance (+8.63±6.91% meters 6-min walk test) mobility (+2.7cm sit reach improved significantly due HIIT. In terms , by (10.68±6.48%) (7.4±4.29%). can favored increase (SMD 0.37; 95% CI 0.09–0.65; I 2 =0%; p =0.009). Effect sizes improvements correlate moderately total volume (Spearman’s ρ=0.49; =0.03), whereas percentage increases do not ρ=0.24; =0.14). Conclusion Functional positively altered different protocols forms implementation, a tendency toward more effectiveness vs. found Future should include often, finally allow comparison between both this regard.

Language: Английский

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Keep calm and keep rowing: the psychophysical effects of dragon boat program in breast cancer survivors

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(4)

Published: March 8, 2024

Abstract Purpose Dragon Boat discipline has become a popular type of physical exercise among women with breast cancer. The present study aims to investigate the effects activity on body composition, function, and psychosocial aspects (i.e., appreciation quality life [QoL]) in operated for Methods Thirty-one (age, 57.88 ± 7.88 years; BMI, 27.86 6.38 kg·m −2 ) previous removal surgery were recruited randomized into two groups: group (DB, N = 18) or home-based non-supervised training program (home group; HG, 13). All participants underwent handgrip test, 30-s chair stand test (30CST), 6-min walking (6MWT), shoulder mobility measurements at baseline after 12 weeks intervention. Participants also filled out Body Appreciation Scale-2 (BAS-2) Short Form Health Survey-12 (SF-12) self-report questionnaires. Results significantly improved 30CST (+ 6%, p .011) 6MWT performance 30%, compared program. Moreover, 20% (3/15 women) DB obtained reliable change from pre- post-intervention BAS-2 mental QoL component SF-12 ( vs 15% 0% HC group). No emerged SF-12. Conclusion is efficient improve lower limb strength Furthermore, some assigned this activity. Importantly, no adverse events documented during Trial registration NCT05206526 (10/02/2022)

Language: Английский

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Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: Sept. 14, 2021

Breast cancer represents the most commonly diagnosed while neoadjuvant and adjuvant chemotherapies are extensively used in order to reduce tumor development improve disease-free survival. However, chemotherapy also leads severe off-target side-effects resulting, together with itself, major skeletal muscle deconditioning. This review first focuses on recent advances both macroscopic changes cellular mechanisms implicated deconditioning of breast patients, particularly as a consequence treatment. To date, only six clinical studies biopsies patients highlighted several important aspects such decrease fibers cross-sectional area, dysregulation protein turnover balance mitochondrial alterations. comparison knowledge accumulated through decades intensive research many different animal human models atrophy, more necessary obtain comprehensive understanding processes cancer-mediated is indeed essential ultimately lead implementation efficient preventive strategies exercise, nutrition or pharmacological treatments. We therefore discuss potential by drawing parallel other cachexia wasting, at pre-clinical levels.

Language: Английский

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Effectiveness of Therapeutic Exercise and Patient Education on Cancer-Related Fatigue in Breast Cancer Survivors: A Randomised, Single-Blind, Controlled Trial with a 6-Month Follow-Up

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(1), P. 269 - 269

Published: Jan. 5, 2022

This study aimed to determine the effectiveness of therapeutic exercise plus patient education on perceived fatigue, functional capacity and pain in breast cancer survivors with cancer-related fatigue. A randomised, single-blind, clinical trial was conducted a total 80 who presented Women were randomised into supervised group (STE-G) (n = 40) or an unsupervised (UE-G) 40). Both interventions included delivered three sessions per week over eight weeks. The main outcome fatigue as assessed by Spanish version Functional Assessment Chronic Illness Therapy-Fatigue subscale (FACIT-F). Other evaluated outcomes measured visual analogue scale, distance using 6-Minute Walk Test. Data collected at baseline, immediately post-intervention, six months after baseline. Significantly greater improvements across all variables observed STE-G throughout entire follow-up period exception pain. Conclusions: program significantly reduce increase suffering from compared physical based individual preferences education.

Language: Английский

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Physical Activity During Breast Cancer Therapy Associates With Preserved Exercise Capacity and Cardiac Function (WF97415)

JACC CardioOncology, Journal Year: 2023, Volume and Issue: 5(5), P. 641 - 652

Published: March 21, 2023

Cancer treatment increases cardiovascular disease risk, but physical activity (PA) may prevent disease.

Language: Английский

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Mechanisms, assessment, and exercise interventions for skeletal muscle dysfunction post-chemotherapy in breast cancer: from inflammation factors to clinical practice

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 4, 2025

Chemotherapy remains a central component of breast cancer treatment, significantly improving patient survival rates. However, its toxic side effects, along with cancer-related paraneoplastic syndromes, can lead to the loss skeletal muscle mass and function, impairing physical abilities increasing risk complications during treatment. Chemotherapeutic agents directly impact cells by promoting protein degradation, inhibiting synthesis, triggering systemic inflammation, all which contribute atrophy. Additionally, these drugs interfere proliferation differentiation stem cells, such as satellite disrupting regeneration repair while inducing abnormal intermuscular tissue, thereby worsening wasting. These effects not only reduce effectiveness chemotherapy but also negatively affect patients’ quality life disease prognosis. Recent studies have emphasized role exercise an effective non-pharmacological strategy for preventing preserving in patients. This review examines clinical manifestations dysfunction following chemotherapy, potential mechanisms underlying changes, evidence supporting therapeutic approach function.

Language: Английский

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Thirty-second sit-to-stand test as an alternative for estimating peak oxygen uptake and 6-min walking distance in women with breast cancer: a cross-sectional study

Supportive Care in Cancer, Journal Year: 2022, Volume and Issue: 30(10), P. 8251 - 8260

Published: July 11, 2022

Abstract Purpose To determine whether the 30-s sit-to-stand (30STS) test can be a valid tool for estimating and stratifying peak oxygen uptake (VO2peak) 6-min walking distance (6MWD) in women with breast cancer. Methods This cross-sectional study uses data from ONCORE randomized controlled trial, including 120 aged 18–70 years early-stage cancer under treatment anthracycline and/or anti-HER2 antibodies. Participant characteristics were collected at baseline pooled functional assessment (30STS test, relative absolute VO2peak, 6MWD) post-intervention (comprehensive cardio-oncology rehabilitation program vs. usual care). Bivariate correlations multivariate linear regression analyses performed to relationship between variables. Results The number of repetitions 30STS showed (i) moderate correlation VO2peak (ml/kg/min) ( r = 0.419; p < 0.001; n 126), (ii) weak (ml/min) 0.241; 0.008; 120), (iii) 6MWD 0.440; 85). equations obtained models allowed estimation 2 0.390; 0.261, respectively) based on its stratification into tertiles (low, moderate, high). Conclusion was found useful estimate Its use may facilitate capacity this population implementation therapeutic exercise programs if cardiopulmonary testing (CPET) or 6MWT are not available. Trial registration ClinicalTrials.gov Identifier: NCT03964142. Registered 28 May 2019. Retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT03964142

Language: Английский

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Reference values for six-minute walk distance and six-minute walk work in Caucasian adults

Pulmonology, Journal Year: 2023, Volume and Issue: 29(5), P. 399 - 409

Published: April 10, 2023

The six-minute walk test (6MWT) is a practical and simple field-based to assess physical capacity. Several reference equations for walking distance (6MWD, m) exist, but have number of limitations that decrease their clinical utility. In addition, no exist the 6MWT-derived outcome work (6MWORK, kg.m).To establish new 6MWD 6MWORK on 20 m course using data from population-based Canadian Cohort Obstructive Lung Disease study.A total 335 participants without obstructive or restrictive pulmonary function, with normal self-reported health status, exercise capacity, <30 pack years cigarette smoking history were selected create representative sample adults aged ≥40 years. All performed two 6MWTs. Reference derived multiple regression analyses.On average, 541±98 41.3 ± 11.2 kg.m, respectively. outcomes significantly greater in males than females. Sex-specific results an explained variance 24 35%.This study established Caucasian females status These newly add value assessment functional capacity practice.

Language: Английский

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The Effect of a Home-Based Tele-Exercise Training Program on the Quality of Life and Physical Performance in Breast Cancer Survivors

Sports, Journal Year: 2023, Volume and Issue: 11(5), P. 102 - 102

Published: May 10, 2023

The number of breast cancer (BCa) survivors has been steadily increasing due to advances in anti-cancer treatments, though these individuals suffer from various cancer- and treatment-related long-term side effects. present study aimed at investigating the effects a home-based tele-exercise training intervention on physical- mental health-associated parameters BCa survivors. A total 13 female (age: 58.31 ± 3.13 years, BMI: 25.68 0.62 kg/m2, waist circumference: 96.54 1.84 cm) participated two-month group program twice per week which included aerobic, resistance flexibility exercises. results revealed that improved participants' body mass index (BMI) (p < 0.001), circumference cardiorespiratory fitness (6 min walk test) 0.001) muscle function (sit stand 0.01), sit ups push-ups 0.001)). Beneficial were also observed perceived anxiety (Zung Self-Rating Anxiety Scale) post-traumatic stress disorder (PTSD) symptoms (PCL-C) self-reported fatigue quality life (QoL) 0.05) physical 0.05), cognitive 0.01) emotional functioning (EORTQ-QLQ-C30). Our findings suggest common adverse performance, health overall QoL can be ameliorated through programs

Language: Английский

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