Ex vivo antiacetylcholinesterase studies on silver nanoparticles synthesized using green approach

Applied Organometallic Chemistry, Journal Year: 2023, Volume and Issue: 37(12)

Published: Oct. 11, 2023

For the green fabrication of silver nanoparticles (AgNPs), scientists are favoring herbal sources to avoid toxic effects synthetic sources. Thus, in this study, AgNPs were generated using extract whole plant Hippeastrum hybridum L. (HH) and 1 mM AgNO 3 aqueous solution. These HH‐AgNPs characterized via UV–Vis Spectroscopy, which showed a maximum absorbance 1.61 at 432 nm sharp peak; FT‐R analysis, confirmed functional groups HH their AgNPs; XRD gives 4‐Bragg's reflections 2θ crystal structure with 13.3 average size; SEM irregular‐shaped morphology 40 mean EDX elemental composition reported that Ag was present 22.75%. After characterization, these tested as anti‐Alzheimer agents against acetylcholinesterase (AChE) ex vivo activity rat brain homogenate source AChE enzyme. 48 ± 0.03 42 0.05% 150 μg concentration HH‐AgNPs, respectively, 145 0.24 124.2 0.14 IC 50 concentration. According enzyme kinetics results, inhibits competitive mode ( K m increased from 166.2% 1,379.2% V max not affected), while mixed inhibition 0.029 0.048, decreased 9 5.4). Iapp maxiapp also calculated (K 39 95.1 μg, remained constant for plant), both maxipp 122.32 325 8.15 9.8 respectively. The , i I found be 0.017 (HH‐plant) 0.2 (HH‐AgNPs); 98 (HH‐plant); 129 (HH‐AgNPs), 53 (HH‐plant), 179 γK (18 mM) HH‐plant, it is applicable. In conclusion, could said HH‐plant plays significant role generation small‐size HH‐AgNPs. exhibited anti‐AChE potential compared proved an treatment AD.

Language: Английский

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Digital Screen Time and the Risk of Female Breast Cancer: A Retrospective Matched Case-Control Study

Journal of Biomedical Physics and Engineering, Journal Year: 2023, Volume and Issue: online

Published: Jan. 1, 2023

Background: As the use of electronic devices such as mobile phones, tablets, and computers continues to rise globally, concerns have been raised about their potential impact on human health. Exposure high energy visible (HEV) blue light, emitted from digital screens, particularly so-called artificial light at night (ALAN), has associated with adverse health effects, ranging disruption circadian rhythms cancer. Breast cancer incidence rates are also increasing worldwide.Objective: This study aimed finding a correlation between breast exposure phone.Material Methods: In this retrospective matched case-control study, we investigate whether phone screens is an increased risk female We interviewed 301 patients (cases) 294 controls using standard questionnaire performed multivariate analysis, chi-square, Fisher’s exact tests for data analysis.Results: Although heavy users in case group our had statistically significant higher mean 10-year cumulative compared control (7089±14985 vs 4052±12515 hours, respectively, P=0.038), did not find strong relationship HEV development Conclusion: Our findings suggest that might constitute factor promoting cancer, but further large-scale cohort studies warranted.

Language: Английский

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TRABALHO NOTURNO E RISCO OCUPACIONAL: PRINCIPAIS TRANSTORNOS À SAÚDE

Editora Coleta Científica eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Desalinhamento circadiano, sono curto e redução da melatonina podem perturbar a saúde pela alteração de processos fisiológicos comportamentais que contribuem para o desenvolvimento/exacerbação doenças, tornando trabalho noturno um fator risco ocupacional. Má qualidade do sono, sonolência diurna excessiva insônia explicar associação entre hipertensão. Para mulheres, ele é preocupante reprodução, pois altera os horários sono/vigília exposição à luz noite atrapalha sistema circadiano liberação hormonal interferem na fertilidade. Trabalho afeta equilíbrio vida pessoal/profissional/social satisfação conjugal, influenciando mental. insuficiente alterar gasto energético, horário conteúdo das refeições, que, somados ao sedentarismo, surgimento síndrome metabólica. O câncer não está relacionado apenas fatores genéticos sua com resulta alterações fisiológicas induzidas circadiana. Estilo pouco saudável, alimentação inadequada sedentarismo são Diabetes Mellitus tipo 2, além noturno, desalinhamento privação prejudicam metabolismo glicose, podendo afetar energético ingestão calórica. Mulheres mais prejudicadas em relação às diferenças gênero nos efeitos noturno. Porém, estudos apresentam resultados controversos poucas associações comprovadas, mas como essas enfermidades custam caro, afetam capacidade laboral vida, programas políticas minimizem importantes.

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Shift and Night Work in Technology Intensive Environment as a Health Hazard

Annals of the Russian academy of medical sciences, Journal Year: 2024, Volume and Issue: 79(2), P. 101 - 111

Published: June 11, 2024

Flexible workday arrangement is a common management practice in the modern technology intensive society. The impact of shift work night hours on human health has been subject broad range fundamental and applied studies occupational medicine other fields. Epidemiological data body research findings suggest that workers are prone to various pathologies. This paper summarizes current views link between risk chronic noncommunicable diseases (NCDs), which leading cause morbidity mortality among working population therefore top priority. Systematic reviews meta-analyses present strong evidence have higher malignant tumors (breast cancer, prostate colorectal cancer), coronary heart disease, type 2 diabetes compared daytime-only workers. There are, however, individual differences NCDs may depend length employment circumstances. Also, factors discussed can modify associated pathologies, such as chronotype, changing shifts, proper rotation, sufficient rest etc. Mechanisms genetic regulation circadian rhythms sleep-wake cycle crucial element conceptual model influence body. Insufficient adaptation plasticity system desynchronization external time inner biorhythms workers; this accompanied with changes genes expression lead If disturbed main factor etiopathogenesis, term “circadian-related disease” should be used. Deep understanding desynchronosis problems important implement ‘circadian safety’ measures, i.e. protect from negative consequences affect their capacities life quality. will require standard protocols study disturbances, tools methods diagnose workers, resolving issues interpretation respect capacity, proneness tolerance circadian-related problems, finding pharmacological physical approaches reduce considering special aspects drug therapy desynchronosis.

Language: Английский

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Circadian Rhythm and Personalized Exercise

Published: Jan. 1, 2022

Almost all physiological and biochemical processes in the human body follow a circadian rhythm. Studies have found that biological rhythms of body, especially rhythms, affect capacity for performance exercise. Exercise also affects rhythms. The rhythm influences core temperature, muscle strength, aerobic anaerobic exercise capacity, flexibility. causes phase shift remodels Research has shown can improve fitness if it is timed to coincide with peak performance. In addition considering diurnal variations, preferences regarding time (day or night) are important studying effects on Furthermore, there differences among different types. Therefore, arranging intensity according characteristics great significance improving training efficiency, reducing occurrence injuries, overcoming clock disorders.

Language: Английский

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