Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics–instigated testicular toxicity in rats: A biochemical, spermatological, and histopathological assessment DOI

Ali Akbar,

Muhammad Umar Ijaz

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(6), P. 9031 - 9044

Published: Jan. 6, 2024

Language: Английский

Effects of Microplastics on Fish and in Human Health DOI Creative Commons
Md. Simul Bhuyan

Frontiers in Environmental Science, Journal Year: 2022, Volume and Issue: 10

Published: March 16, 2022

Microplastics (MPs) are regarded as a global issue due to their toxicity effects on fish and humans. Fish is vital origin of human protein, which necessary for body growth. Contamination by MPs major hazard that requires special focus. After exposure alone or in combination with other pollutants, may experience variety health issues. can cause tissue damage, oxidative stress, changes immune-related gene expression well antioxidant status fish. being exposed MPs, suffer from neurotoxicity, growth retardation, behavioral abnormalities. The consequences poorly understood. Due the abundance environment, occur via consumption, inhalation, skin contact. Humans cytotoxicity, immune system disruption, transfer tissues after them. toxic both still unknown. This detailed review has potential add existing knowledge about ecotoxicity humans, will be useful forthcoming study.

Language: Английский

Citations

326

The Burden of Microplastics Pollution and Contending Policies and Regulations DOI Open Access
Sunusi Usman, Ahmad Faizal Abdull Razis, Khozirah Shaari

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(11), P. 6773 - 6773

Published: June 1, 2022

The relationship between humans and plastics has become intricate due to their versatile nature low production cost. Plastics generation surpassed that of other manufactured products, which, coupled with the prevailing poor waste management systems, makes it a serious problem for terrestrial aquatic environments as its final destination. Their extensive presence continued pose significant threat, not only ecosystem but also approximately 3 billion people relying on livelihood. Even more disturbing were recent findings these in food drinking water evidence human exposure, long-term health effects which are largely unknown. This ubiquitous phenomenon over time put under critical observation, leading development many local international policies, resolutions, directives aimed at addressing reversing menace. review provided first snapshot global governance strategies currently mitigating plastic pollution, limitations, future directions. revealed several aspects microplastics (MPs) pollution be overlooked policy formulation, laxity implementation, an apparent lack indices ascertain impact regulations. Furthermore, there is no regulation MPs contamination funding research into alternatives. This, therefore, necessitates need well-coordinated approach national levels scale up policies all countries translate them from paper measurable, holistic, realizable actions will address forms pollution.

Language: Английский

Citations

88

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism DOI Creative Commons
Udayadharshini Subaramaniyam,

Rethi Saliya Allimuthu,

Shanu Vappu

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: June 26, 2023

Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially fish. Fish is a staple affordable food source, rich animal protein, along with various vitamins, essential amino acids, minerals. Exposure of fish to microplastics, pesticides, nanoparticles generates ROS induces oxidative stress, inflammation, immunotoxicity, genotoxicity, DNA damage alters gut microbiota, thus reducing growth quality Changes behavioral patterns, swimming, feeding habits were also observed under exposures above contaminants. These affect Nrf-2, JNK, ERK, NF-κB, MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes Effects found modulate antioxidant enzymes, including superoxide dismutase, catalase, glutathione system. So, protect health from contribution nano-technology or nano-formulations was researched. A decrease nutritional population significantly impacts human diet, influencing traditions economics worldwide. On other hand, traces microplastics habitat water can enter humans by consuming contaminated may result serious hazards. This review summarizes stress caused due nano-particle contamination exposure their impact health. As rescue mechanism, use management disease discussed.

Language: Английский

Citations

80

Microplastics induce neurotoxicity in aquatic animals at environmentally realistic concentrations: A meta-analysis DOI
Fei Xiong,

Jinyan Liu,

Kai Xu

et al.

Environmental Pollution, Journal Year: 2022, Volume and Issue: 318, P. 120939 - 120939

Published: Dec. 26, 2022

Language: Английский

Citations

74

The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways DOI

Huiwen Kang,

Wei Zhang, Jiaru Jing

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 458, P. 131949 - 131949

Published: June 29, 2023

Language: Английский

Citations

46

Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases DOI
Shuang Liu,

Yinling He,

Yin Jia

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 134054 - 134054

Published: March 15, 2024

Language: Английский

Citations

34

The histopathological and functional consequences of microplastic exposure DOI Creative Commons

Yujeong Lee,

Min Kyung Sung, Soo‐Eun Sung

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Language: Английский

Citations

2

A review on source, occurrence, and impacts of microplastics in freshwater aquaculture systems in China DOI Creative Commons
Chenxi Wu, Xiong Xiong, Amir Hossein Hamidian

et al.

Water Biology and Security, Journal Year: 2022, Volume and Issue: 1(3), P. 100040 - 100040

Published: May 4, 2022

Microplastic pollution has become an increasingly important environmental issue worldwide in recent years because of its ubiquitous presence different media and potential to affect the health organisms ecosystems. Aquaculture contributes significantly world's food production nutritional supply, especially developing countries. Widespread occurrence microplastics aquaculture systems raised great concern regarding safety issues products. China is a world leader production, with freshwater accounting for 59.1% total 2020. Therefore, this review mainly focuses on research progress related microplastic China. Results from literature show that are present at abundances comparable natural waterbodies Microplastics can be ingested remain body Exposure adversely aquatic ecosystem functions. However, risks real environment uncertain. Consumption products not major pathway human exposure microplastics. To provide scientific guidance governmental decision-making control, future work should focus toxicological methodology understanding impacts community levels.

Language: Английский

Citations

50

Nanoplastics and Microplastics May Be Damaging Our Livers DOI Creative Commons
Jianli Yin,

Ye Ju,

Honghao Qian

et al.

Toxics, Journal Year: 2022, Volume and Issue: 10(10), P. 586 - 586

Published: Oct. 4, 2022

Plastics in the environment can be degraded and even broken into pieces under action of natural factors, products with a particle size less than 5 mm are called microplastics (MPs). MPs exist variety environmental media that come contact human body. It enter body through food chains. At present, there many studies investigating damage to marine organisms mammals. The liver is largest metabolizing organ plays an important role metabolism However, no available systematic review on toxic effects liver. This paper summarizes adverse mechanisms liver, by searching literature highlighting have been published date, provides scenario for toxicity caused MPs.

Language: Английский

Citations

46

Photoaged microplastics induce neurotoxicity via oxidative stress and abnormal neurotransmission in zebrafish larvae (Danio rerio) DOI

Ping Ding,

Chongdan Xiang,

Xintong Li

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 881, P. 163480 - 163480

Published: April 15, 2023

Language: Английский

Citations

33