Environmental Pollution, Journal Year: 2024, Volume and Issue: 362, P. 124932 - 124932
Published: Sept. 13, 2024
Language: Английский
Chemosphere, Journal Year: 2024, Volume and Issue: 361, P. 142380 - 142380
Published: May 18, 2024
Due to weather and working/operational conditions, plastic degradation produces toxic non-biodegradable nano microplastics (N/M-Ps, ranging from 10 nm 5 mm), over time these N/M-Ps have integrated with the human cycle through ingestion inhalation. These N/M-Ps, as serious emerging pollutants, are causing considerable adverse health issues due up-taken by cells, tissue, organs, including brain. It has been proven that can cross blood-brain barrier (via olfactory blood vessels) affect secretion of neuroinflammatory (cytokine chemokine), transporters, receptor markers. Neurotoxicity, neuroinflammation, brain injury, which may result in such scenarios a concern cause disorders. However, related pathways pathogenesis not well-explored but focus upcoming research. Therefore, this editorial, well-organized multidisciplinary research is required explore associated pathogenesis, leading mapping nano-enabled therapeutics acute chronic N/M-P exposure.
Language: Английский
Citations
12
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 474, P. 134800 - 134800
Published: June 3, 2024
Language: Английский
Citations
8
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136028 - 136028
Published: Oct. 2, 2024
Language: Английский
Citations
8
Microplastics, Journal Year: 2025, Volume and Issue: 4(1), P. 4 - 4
Published: Jan. 7, 2025
Micro-nano plastics (MNPs) are emerging environmental and food contaminants that raising serious health concerns. Due to the polycontamination of web with pollutants (EPs), now MNPs, co-ingestion EPs MNPs is likely occur, potential synergistic effects such co-ingestions completely unstudied. In this study, we therefore sought determine two model EPs, arsenic boscalid, on uptake toxicity 25 1000 nm polystyrene (PS-25 PS-1000), vice versa, employing a triculture small intestinal epithelium combined simulated digestion. 24 h exposures, neither nor + caused significant toxicity. The presence PS-25 significantly increased (from 0.0 5.8%, p < 0.001) translocation 5.2 9.8%, 0.05) but had no effect boscalid or translocation, whereas PS-1000 either EP. both PS was also by rising from 10.6 19.5% (p 0.01) for 4.8 8.5% PS-1000. These findings highlight need further studies assess MNP-EP interactions possible adverse impacts.
Language: Английский
Citations
1
Journal of Contaminant Hydrology, Journal Year: 2025, Volume and Issue: 269, P. 104514 - 104514
Published: Feb. 1, 2025
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3703 - 3703
Published: Nov. 1, 2024
Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.
Language: Английский
Citations
5
Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109109 - 109109
Published: Nov. 1, 2024
Micro/Nano plastics (MNPs) pollutants are widespread in the environment, raising significant concerns about their biosafety. Emerging studies indicate that urinary system is a primary accumulation site for MNPs, leading to severe tissue and functional damage. This review aims summarize recent research on potential hazards MNPs may pose system, highlighting mechanisms of toxicity current state knowledge. Studies have shown enter human body through drinking water, food chain, inhalation, skin contact. They penetrate bloodstream via digestive, respiratory, systems, subsequently dispersing various organs, including system. The might induce cellular oxidative stress, inflammation, apoptosis, autophagy, "intestine-kidney axis", other possible toxic mechanisms. These processes could disrupt kidney metabolic functions promote fibrosis, thereby potentially increasing risk diseases. Despite ongoing research, understanding MNPs' impact remains limited. Therefore, this provides comprehensive overview highlights key challenges, outlines future directions. It offers theoretical basis development effective protective measures policies.
Language: Английский
Citations
4
Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Nanoplastics (NPs) are ubiquitous in the environment, posing significant threats to biological systems, including nervous across various trophic levels. Nevertheless, molecular mechanisms behind size-dependent neurotoxicity of NPs remain unclear. Here, we investigated 20 and 100 nm polystyrene (PS-NPs) zebrafish. Utilizing dynamics simulations complementary methods, discovered that PS-NPs initiated by promoting dimerization toll-like receptor 4/myeloid differentiation-2 (TLR4/MD-2) complex. This process involves binding hydrophobic pocket MD-2, which induced flipping Phe-126 toward dimer interface bending C-terminal domain TLR-4, bringing two domains into close proximity. Thereafter, astrocytes microglia were activated, initiating a cascade events include neuroinflammation, central system cell apoptosis, inhibition motor neuron development, ultimately alteration swimming behavior Further, elicited more severe than PS-NPs, attributed their higher accumulation brain as determined through 14C-labeled effective interaction with TLR4/MD-2 Overall, our study uncovers underlying NPs, merit attention during risk assessment regulation.
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 382 - 382
Published: Jan. 17, 2025
High-Density Polyethylene (HDPE) and Low-Density (LDPE) films were used to create nanoplastic (NP) models, with the shape of delamination occurring during degradation. In case HDPE, selective degradation occurred not only in amorphous part, but also crystalline part at same time. Some lamellae that extend radially form spherulite structure missing 30-day The length these defects was less than 1 µm. HDPE disintegrated within units by conformational lamellae, size fragments obtained had a wide distribution. LDPE synthesized radical polymerization, so it contained cross-linked part. sufficiently fused, when degraded, delaminated separated preferentially. zeta potential reached minimum value approximately −20 mV time 21 days, then increased. This complex dependence on due NP particle aggregation. addition 1% Triton(R) X-114 surfactant effective stabilizing dispersion. remained constant around 20 nm for times 15–30 days.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114021 - 114021
Published: Jan. 18, 2025
Language: Английский
Citations
0