The Improvement of Physical Function and Caregiver Burden by a Multimodal Intervention: A Case Study of Combined Exercise Therapy, Nutritional Guidance, and Hydrogen Gas Inhalation Therapy

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

The objective of this exploratory case study was to examine the impact a multifaceted intervention, which incorporated exercise therapy, nutritional guidance, and hydrogen gas inhalation, on physical function caregiver burden an older female patient suspected having sarcopenia. methods employed included three-month program group individualized sessions, three times per week, in addition guidance inhalation therapy. primary outcome measures grip strength, walking speed, inflammatory/oxidative stress markers (c-reactive protein (CRP), interleukin-6 (IL-6), 8-hydroxy-2' -deoxyguanosine (8-OHdG)), burden, assessed by Family Caregiver Burden Scale (FCS). results demonstrated that after period months, there improvement strength speed. Concurrently, decrease CRP, IL-6, 8-OHdG levels. FCS score shift from "severe" range "normal" range, suggesting reduction burden. findings suggest multidisciplinary, intervention combining support, may be effective enhancing reducing adults with However, further research is necessary clarify independent effects inhalation.

Language: Английский

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Hydrogen alleviates myocardial infarction by impeding apoptosis via ROS-mediated mitochondrial endogenous pathway

Free Radical Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 5, 2025

Acute myocardial infarction (AMI) is a deadly cardiovascular disease with no effective solution except for percutaneous coronary intervention and artery bypass grafting. Inflammation apoptosis of the injured myocardium after revascularization seriously affect prognosis. Hydrogen possesses anti-inflammatory, anti-oxidative, anti-apoptotic effects may become new treatment AMI. This study explored specific mechanism by which hydrogen operates during AMI treatment. Thirty Sprague-Dawley rats were randomly divided into three groups: control, (MI), + (MI+H2), each containing 10 rats. The MI rat model was established ligation left anterior descending branch. MI+H2 group received 2% inhalation 3 h/Bid. Myocardial infarct size evaluated using triphenyl tetrazolium chloride staining. Transmission electron microscopy showed reduced mitochondrial damage compared group. JC-1 staining, indicates membrane potential, low red/green fluorescence intensity ratio in to that control group, indicating potential loss. After inhalation, this increased, suggesting partial recovery potential. In addition, ATP content, complex I, III activity significantly decreased improved administration. Western blotting analysis Cyt-c protein levels mitochondria increased cytoplasm Following ROS, 8-OHdG, MDA could represent oxidative stress injury decreased. Besides, expression Cyt-C, Bax, cleaved-caspase-9, cleaved-caspase-3 while Bcl-2, TRX2, SOD2 these proteins Overall, reduces size, improves dysfunction, modulates apoptosis-related substances. Importantly, acute downregulating ROS upregulating antioxidant proteins.

Language: Английский

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Pharmacologic and Nonpharmacologic Treatment of Long COVID: A Meta-narrative Review

SN Comprehensive Clinical Medicine, Journal Year: 2025, Volume and Issue: 7(1)

Published: April 14, 2025

Language: Английский

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Molecular Hydrogen in the Treatment of Respiratory Diseases

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4116 - 4116

Published: April 26, 2025

Molecular hydrogen is gaining increasing attention as an antioxidant, anti-inflammatory, and antiapoptotic agent. Once considered inert gas, it reveals current therapeutic potential among others in inflammatory diseases, cancer, sports medicine, others. The present review aims to provide a consistent summary of the findings last twenty years on use molecular major respiratory including allergies, asthma, COPD, pulmonary fibrosis, lung injury various origins, well cancer infections tract. In addition, basic mechanisms through which exercises its biological activity system are described.

Language: Английский

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The Clinical Use of Hydrogen as a Medical Treatment

Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 93 - 111

Published: Jan. 1, 2024

Language: Английский

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Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen

Terapevticheskii arkhiv, Journal Year: 2024, Volume and Issue: 96(3), P. 260 - 265

Published: April 16, 2024

Рost-COVID-19 syndrome (PS) is one of the medical and social problem. According to WHO, 10–20% COVID-19 patients suffer from PS. The use gases – inhaled nitric oxide (iNO) molecular hydrogen (iH2) may influence on mechanisms development PC. Aim. To evaluate safety efficacy combined inhalation NO H2 (iNO/iH2) in with respiratory manifestations PS. Materials methods. 34 PS (11 men/23 women, 60.0±11.7 years) were included prospective open-label controlled study parallel groups: main group (n=17) received iNO/iH2 for 90 minutes once a day 10 days (concentration 60 ppm, H24% gas mixture), control didn’t receive inhalations. period confirmation start was 641.8±230.5 days. groups did not differ baseline parameters. clinical symptoms (from self-observation diary mMRC questionnaires, "dyspnea language"), FAS, HADS, SF-36 scores, 6-minute walk test, blood serum parameters oxidative stress, dynamics microcirculation eye bulbar conjunctiva evaluated. individual dose iNO has chosen during 15-minute test (the positive have indicated that selected correctly). Results. decrease severity, such as dyspnea, cough, fatigue palpitations (p0.005), increase questionnaire scores (p=0.006) reducing FAS score (p=0.001), well anxiety component HADS (p=0.02) revealed at end treatment compared group. We observed an improvement distance walked (p=0.01) values SpO2 (p=0.04) volumetric flow velocity venules (p0.001), date damage (p0.001) antioxidant activity (p=0.03) serum. Conclusion. results demonstrate indicators, stress

Language: Английский

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Infection-Simulator, Immunostimulatory and Immunomodulatory Effects of Interferons I and III in Biological Systems: A New Era in Vaccinology and Therapeutics Possible?

Published: July 10, 2024

The severe acquired respiratory coronavirus–2 (SARS–CoV-2) infection has initiated both acute and chronic COVID–19 disease between 2020 2023, currently evolving with other homologous prior coronavirus strains of the Nidoviridae order, which encompasses prevalent alpha/ beta coronaviruses, but also Middle East Respiratory Syndrome (MERS-CoV) SARS-CoV-1, recent SARS–CoV–2 variants, increasing demands for effective immunogens therapeutic approaches that will reduce global burden further from SARS–CoV-2 affected individuals may experience post sequelae (PASC) or “Long COVID”. Following a worldwide programme prophylactic vaccination, there is still dilemma in efforts to find early would treat novel SARS-CoV-2 variants prevent future epidemics pandemics within host human animal populations, where zoonotic cross species transfer naturally occurs. Concerns about viral immune escape intersect at specific point; gained evolutionary ability several viruses co–infect compete against previous scientific advances since 1796 remain undetected asymptomatic during stages progressing symptomatic via double methylation 5' end eukaryotic DNA RNA-based genomes, 7-MeGpppA2’-O-Me cap, its capping process performed by activated 2’ - O Methyltransferase (MTase) enzyme, complex two non-structural proteins (NSPs) joined together through an activation (NSP10/16) N7-Methyltransferase (N7-MTase/NSP14), respectively. Moreover, it was discovered polymorphic translate NSP1, prevents various Pattern Recognition Receptors (PRRs), consequently, detection Pathogen-Associated Molecular Patterns (PAMPs) Damage-Associated (DAMPs) alike. NSP1 silences important interferon-encoding genes (INGs) interferon-stimulated (ISGs), signalled paracrine manner neighbouring cells, induces apoptosis inducing effect “trace erase” making as immunologically “invisible” possible initial, key replication distribution, all such mechanisms occurring independently cause. Another NSP NSP14, plays functional roles are independent each other; produce new genetic material purpose maintaining validity genome well, not just methyl group 5’ genome. Other NSPs share role 10, 14 16 directly suppressing PRRs ISGs, help virus self-camouflaging first- second-line immunity, thereby often severely impacting quality produced adaptive responses. outcome phenomena sharp decrease Type I III interferons' (IFNs) rate synthesis usually occur affect homeostatic cellular pathways, resulting induced apoptosis. Nonetheless, effects microbial evasion development carcinogenic pathologies widely known. In short, developed proportionate response responses, relying on gaps mostly situated natural system their molecular self-camouflaging. Scientists numerous treatment generally showed good success rates fewer risks adverse events, present COVID-19 research should be taken into consideration whilst filtering most appropriate solutions. For example, administration recombinant interferons nasal mucosa layer, mediators anti–viral activity, can simulate intracellular stimulate activity timely manner, training innate cells develop appropriately adequate B T cells. example could involve lymphocytes low dose IFNs possibly III, insertion lymphatic system, alongside additional recruitment plasmacytoid dendritic (pDCs) interferon “factories”, management. It might focusing offering information genetics protein structure pathogen, rather than first-line faster, excessively increases specificity, reach level brings opportunity evolve previously-developed mechanisms. until community realises this potentially crucial aspect large proportions world population probably continue face serious diseases over coming decades, evidenced dengue fever more recently, monkeypox avian flu. Of note, been indicated IFN / display significant immunising, clinical onset-attenuating many evoked diseases, well number oncological diseases.

Language: Английский

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Current views on the functional role of hydrogen and its kinetics in the human body

PULMONOLOGIYA, Journal Year: 2024, Volume and Issue: 34(1), P. 7 - 18

Published: Feb. 21, 2024

The purpose of this overview was to present historical data on the discovery hydrogen and a brief summary its physical properties that form basis for use in aeronautics. Information is provided hydrogen, biologically neutral molecule, medicine as diagnostic indicator penetrating wounds gastrointestinal tract, determination local blood flow using clearance method, breath test diagnosis malabsorption carbohydrate intolerance, achlorhydria, bacterial overgrowth syndrome, assessment biodegradation magnesium-containing implants, orocecal transit time, during deep-sea diving. reasons sharp increase doctors’ interest studying biological role after antioxidant by group Japanese scientists (2007) are analyzed. In order protection body, from recent research ways concentration body through supply exogenous gas inhalation or administering hydrogen-rich water saline solution presented. Particular attention paid critical analysis studies kinetics different routes, tissues, inhalation, water. Based an publications, molecular relieve oxidative stress tissues intestines, liver lungs most promising, since highest found these tissues. Fermentation carbohydrates has also been shown production intestinal microbiota. Considering large number generators appeared market, requirements their safety summarized. Considerations cardiology, gastroenterology, pulmonology, other areas based modern views mechanisms antioxidant, anti-apoptotic, cytoprotective, anti-inflammatory effects hydrogen. experimental clinical acute chronic lung lesions, therapy COVID-19 infection. Conclusion. literature our own data, conclusion drawn prospects wide range concentrations many diseases with pathogenesis stress. particular, need additional highlighted clarify regimen, frequency, duration used, personalized approach combination endogenous (from microbiota) various diseases.

Language: Английский

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Molecular Hydrogen for Outpatients with COVID-19 (Hydro-COVID): A Phase 3 Randomised, Triple-Blinded, Pragmatic, Placebo-Controlled, Multicentre Trial

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(15), P. 4308 - 4308

Published: July 24, 2024

Background. Due to its antioxidant, anti-inflammatory, anti-apoptosis, and anti-fatigue properties, molecular hydrogen (H2) is potentially a novel therapeutic nutrient for patients with coronavirus acute disease 2019 (COVID-19). We determined the efficacy safety profile of hydrogen-rich water (HRW) reduce risk COVID-19 progression. Methods: also conducted phase 3, triple-blind, randomised, placebo-controlled trial evaluate treatment HRW initiated within 5 days after onset signs or symptoms in primary care mild-to-moderate, laboratory-confirmed COVID-19. Participants were randomised receive placebo twice daily 21 days. The incidence clinical worsening adverse events endpoints. Results: A total 675 participants followed up day 30. was not superior preventing at 14: H2 group, 46.1% 43.5% hazard ratio 1.09, 90% confidence interval [0.90–1.31]. One death reported 30 group two Adverse 91 (27%) 89 (26.2%) participants, respectively. Conclusions: taken from did worsening.

Language: Английский

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A Review Article on Exercise Intolerance in Long COVID: Unmasking the Causes and Optimizing Treatment Strategies

Medical Science Monitor, Journal Year: 2023, Volume and Issue: 29

Published: Sept. 18, 2023

There is a growing body of research on SARS-CoV-2 (PASC), previously known as the post-COVID syndrome, chronic condition characterized by symptoms that persist after infection.Among these symptoms, feelings physical exhaustion and prolonged fatigue are particularly prevalent can significantly impact patients' quality life.These associated with reduced overall capacity, decreased daily activity, malaise intense training, intolerance to activity (IFA).IFA, described ability perform activities typical for patient's age, often lead sedentary lifestyle.Prolonged inactivity cause deterioration in disrupt mitochondrial function, triggering vicious cycle gradual symptom worsening.The underlying causes PASC remain unclear; however, several biochemical mechanisms have been discussed explain body's energy depletion, multidisciplinary approach combines cognitive rehabilitation lifestyle interventions such exercise diet modifications has suggested improve health well-being patients.This critical review aims existing possible links among fatigue, patients PASC.Further into treatment importance developing individualized needed address each unique requirements.

Language: Английский

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