Environmental Science & Technology Letters,
Journal Year:
2024,
Volume and Issue:
11(7), P. 679 - 686
Published: June 12, 2024
Increased
wildfire
activity
increases
the
demands
on
fire
rescue
services
and
firefighters'
contact
with
harmful
chemicals.
This
study
aimed
to
determine
exposure
toxic
metal(loid)s
its
association
lipid
profile.
CELSPAC-FIREexpo
participants
(including
110
firefighters)
provided
urine
blood
samples
quantify
urinary
levels
of
(arsenic,
cadmium
(Cd),
mercury,
lead
(Pb)),
serum
biomarkers
(cholesterol
(CHOL),
low-density
lipoprotein
cholesterol
(LDL),
high-density
(HDL),
triglycerides
(TG)).
The
associations
were
investigated
by
using
multiple
linear
regression
Bayesian
weighted
quantile
sum
(BWQS)
regression.
Higher
Pb
observed
in
firefighters.
was
positively
associated
CHOL
TG.
Cd
negatively
HDL.
In
BWQS
model,
mixture
(β
=
14.75,
95%
CrI
2.45–29.08),
LDL
15.14,
3.39–29.35),
TG
14.79,
0.73–30.42),
while
HDL
−14.96,
−25.78
−1.8).
emerged
as
a
key
component
metal(loid)
mixture.
results
suggest
that
higher
is
alteration
profile,
which
can
result
an
unfavorable
cardiometabolic
especially
occupationally
exposed
Journal of the American Heart Association,
Journal Year:
2023,
Volume and Issue:
12(13)
Published: June 12, 2023
Exposure
to
environmental
pollutants
is
linked
increased
risk
of
cardiovascular
disease.
Beyond
the
extensive
evidence
for
particulate
air
pollution,
accumulating
supports
that
exposure
nonessential
metals
such
as
lead,
cadmium,
and
arsenic
a
significant
contributor
disease
worldwide.
Humans
are
exposed
through
air,
water,
soil,
food
industrial
public
use.
Contaminant
interfere
with
critical
intracellular
reactions
functions
leading
oxidative
stress
chronic
inflammation
result
in
endothelial
dysfunction,
hypertension,
epigenetic
dysregulation,
dyslipidemia,
changes
myocardial
excitation
contractile
function.
Lead,
have
been
subclinical
atherosclerosis,
coronary
artery
stenosis,
calcification
well
ischemic
heart
stroke,
left
ventricular
hypertrophy
failure,
peripheral
Epidemiological
studies
show
or
associated
death
mostly
attributable
Public
health
measures
reducing
metal
reductions
death.
Populations
color
low
socioeconomic
means
more
commonly
therefore
at
greater
metal-induced
Together
strengthening
prevent
exposures,
development
sensitive
selective
measurement
modalities,
clinical
monitoring
chelation
therapies
could
further
diminish
burden
exposure.
Frontiers in Public Health,
Journal Year:
2022,
Volume and Issue:
10
Published: Sept. 9, 2022
Background
Research
on
the
association
between
blood
lead
(Pb)
and
lipid
biomarkers
have
yielded
inconsistent
results,
epidemiological
studies
Pb
levels
hyperlipidemia
are
scarce.
The
present
study
aimed
to
examine
in
adults
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Methods
A
total
of
43,196
participants
NHANES
1999
2018
were
included
final
analysis.
Hyperlipidemia
was
determined
based
Cholesterol
Education
Program
guidelines.
Blood
assessed
using
inductively-coupled
plasma
mass
spectrometry.
Weighted
multivariable
logistic
regression
analysis
subgroup
conducted
determine
correlation
hyperlipidemia.
Results
In
model,
high
significantly
associated
with
after
adjusting
for
confounders
(OR
1.41;
95%CI:
1.18–1.67).
Furthermore,
elevated
an
increased
risk
across
four
quartile
(Q)
groups
(Q1:
OR
1.00;
Q2:
1.16
[95%CI:
1.04–1.29];
Q3:
1.39
1.21–1.59];
Q4:
1.33
1.15–1.54];
P
trend
<0.05).
Significant
moderating
effects
found
stratified
by
age,
education,
hypertension,
diabetes
(
<
0.05).
sensitivity
analysis,
ORs
quartiles
1.00,
1.17
(95%CI:
1.05–1.30),
1.42
1.24–1.62),
1.38
1.19–1.60)
Q1,
Q2,
Q3,
Q4,
respectively
<0.001)
removing
arteriosclerotic
cardiovascular
disease,
1.13
1.01–1.25),
1.21–1.56),
1.32
1.16–1.52)
including
pregnant
women.
Conclusion
current
showed
a
positive
Circulation Research,
Journal Year:
2024,
Volume and Issue:
134(9), P. 1048 - 1060
Published: April 25, 2024
Environmental
stressors
associated
with
human
activities
(eg,
air
and
noise
pollution,
light
disturbance
at
night)
climate
change
heat,
wildfires,
extreme
weather
events)
are
increasingly
recognized
as
contributing
to
cardiovascular
morbidity
mortality.
These
harmful
exposures
have
been
shown
elicit
changes
in
stress
responses,
circadian
rhythms,
immune
cell
activation,
oxidative
stress,
well
traditional
risk
factors
hypertension,
diabetes,
obesity)
that
promote
diseases.
In
this
overview,
we
summarize
evidence
from
animal
studies
of
the
impacts
environmental
on
health.
addition,
discuss
strategies
reduce
impact
current
future
disease
burden,
including
urban
planning,
personal
monitoring,
mitigation
measures.
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Feb. 24, 2024
Abstract
Apolipoprotein
B-100
(APOB)
is
a
component
of
fat-
and
cholesterol-transporting
molecules
in
the
bloodstream.
It
main
lipoprotein
low-density
cholesterol
(LDL)
has
been
implicated
conditions
that
end
healthspan
(the
interval
between
birth
onset
chronic
disease).
However,
APOB’s
direct
relationship
with
remains
uncertain.
With
Mendelian
randomization,
we
show
higher
levels
APOB
LDL
shorten
humans.
Multivariable
randomization
on
suggests
predominant
trait
accounting
for
APOB.
In
addition,
provide
preliminary
evidence
increases
risk
Alzheimer’s
disease,
condition
ends
healthspan.
If
these
relationships
are
causal,
they
suggest
interventions
to
improve
aging
populations
could
include
strategies
targeting
Ultimately,
given
more
than
44
million
people
currently
suffer
from
disease
worldwide,
such
needed.
Toxics,
Journal Year:
2023,
Volume and Issue:
11(8), P. 670 - 670
Published: Aug. 3, 2023
Metabolic
syndrome
(MetS)
is
an
important
public
health
issue
that
affects
millions
of
people
around
the
world
and
growing
to
pandemic-like
proportions.
This
defined
by
World
Health
Organization
(WHO)
as
a
pathologic
condition
characterized
abdominal
obesity,
insulin
resistance,
hypertension,
hyperlipidemia.
Moreover,
etiology
MetS
multifactorial,
involving
many
environmental
factors,
including
toxicant
exposures.
Several
studies
have
associated
with
heavy
metals
exposure,
which
focus
this
review.
Environmental
and/or
occupational
exposure
are
major
risk,
contributing
development
chronic
diseases.
Of
particular
note,
toxic
such
mercury,
lead,
cadmium
may
contribute
altering
oxidative
stress,
IL-6
signaling,
apoptosis,
altered
lipoprotein
metabolism,
fluid
shear
stress
atherosclerosis,
other
mechanisms.
In
review,
we
discuss
known
potential
roles
in
well
targeted
pathways
MetS.
Furthermore,
describe
how
new
approaches
proteomic
transcriptome
analysis,
bioinformatic
tools,
help
bring
about
understanding
involvement
metalloids
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: April 14, 2023
Background
Although
several
studies
have
examined
the
relationships
between
lead
(Pb)
exposure
and
serum
lipid
profiles,
associations
of
metal
mixture,
including
essential
metals
with
remain
unclear.
Objective
To
investigate
mixture
Pb
[magnesium
(Mg),
manganese
(Mn),
copper
(Cu),
iron
(Fe),
zinc
(Zn),
calcium
(Ca)]
profiles
[total
cholesterol
(TC),
triglyceride
(TG),
low-density
lipoprotein
(LDL-C),
high-density
(HDL-C)],
as
well
potential
interactions
among
metals.
Methods
Nine
hundred
ninety-eight
Chinese
community-dwelling
adults
completed
a
questionnaire
underwent
checkups
anthropometric
parameters,
profile
levels
(TC,
TG,
LDL-C,
HDL-C),
blood
concentrations
(Pb,
Mg,
Mn,
Cu,
Fe,
Zn,
Ca).
The
multivariable
linear
regression,
weighted
quantile
sum
(WQS)
Bayesian
kernel
machine
regression
(BKMR)
were
applied
to
evaluate
single
combined
profiles.
Results
In
model,
was
positively
associated
TC,
HDL-C
(
p
<
0.05,
all),
Mg
Ln
TG
all).
WQS
BKMR
models,
all
addition,
an
inverse
U-shaped
association
positive
interactive
effect
on
TC
LDL-C
found.
Conclusion
Pb,
together
metals,
especially
levels,
are
suggested
be
considered
when
assessing
dyslipidemia
risk.
However,
more
evidence
is
still
needed
validate
conclusions.
