Internal Flames: Metal(loid) Exposure Linked to Alteration of the Lipid Profile in Czech Male Firefighters (CELSPAC-FIREexpo Study) DOI Creative Commons
Nina Pálešová, Katarína Řiháčková, Jan Kuta

et al.

Environmental Science & Technology Letters, Journal Year: 2024, Volume and Issue: 11(7), P. 679 - 686

Published: June 12, 2024

Increased wildfire activity increases the demands on fire rescue services and firefighters' contact with harmful chemicals. This study aimed to determine exposure toxic metal(loid)s its association lipid profile. CELSPAC-FIREexpo participants (including 110 firefighters) provided urine blood samples quantify urinary levels of (arsenic, cadmium (Cd), mercury, lead (Pb)), serum biomarkers (cholesterol (CHOL), low-density lipoprotein cholesterol (LDL), high-density (HDL), triglycerides (TG)). The associations were investigated by using multiple linear regression Bayesian weighted quantile sum (BWQS) regression. Higher Pb observed in firefighters. was positively associated CHOL TG. Cd negatively HDL. In BWQS model, mixture (β = 14.75, 95% CrI 2.45–29.08), LDL 15.14, 3.39–29.35), TG 14.79, 0.73–30.42), while HDL −14.96, −25.78 −1.8). emerged as a key component metal(loid) mixture. results suggest that higher is alteration profile, which can result an unfavorable cardiometabolic especially occupationally exposed

Language: Английский

Do blood metals influence lipid profiles? Findings of a cross-sectional population-based survey DOI Creative Commons
Sabit Cakmak, Kimberly Mitchell,

Anna Lukina

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 231, P. 116107 - 116107

Published: May 13, 2023

Dyslipidemia, an imbalance of lipids and a major risk factor for cardiovascular disease, has been associated with elevated blood urine levels several heavy metals. Using data from Canadian Health Measures Survey (CHMS), we tested associations between cadmium, copper, mercury, lead, manganese, molybdenum, nickel, selenium, zinc, the triglycerides (TG), total cholesterol (TC), low density lipoproteins (LDL), high (HDL) apolipoproteins A1 (APO A1), B B). All adjusted single metals were positive significant, except APO HDL. The joint effect interquartile range increase in was positively percentage increases TC, LDL 8.82% (95%CI: 7.06, 10.57), 7.01% 2.51, 11.51) 7.15% 0.51, 13.78), respectively. Future studies are warranted to determine if reducing environmental exposure favorably influences lipid profiles disease.

Language: Английский

Citations

10
Associations between individual and mixed urinary metal exposure and dyslipidemia among Chinese adults: Data from the China Multi-Ethnic Cohort Study DOI Creative Commons
Jianqin Zhong, Tingting Yang,

Ziyun Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116696 - 116696

Published: July 9, 2024

The prevalence of dyslipidemia is increasing, and it has become a significant global public health concern. Some studies have demonstrated contradictory relationships between urinary metals dyslipidemia, the combined effects mixed metal exposure on remain ambiguous. In this study, we examined how individual are associated with occurrence dyslipidemia. According to data from 2018-2019 baseline survey database China Multi-Ethnic Cohort (CMEC) Study, population 9348 individuals was studied. Inductively coupled plasmamass spectrometry (ICP-MS) used measure 21 concentrations in collected adult samples. associations were analyzed by logistic regression, weighted quantile sum regression (WQS), quantile-based g-computation (qgcomp), controlled for potential confounders examine single effects. Dyslipidemia detected 3231 individuals, which represented approximately 34.6 % total population. single-exposure model, Al Na inversely risk (OR = 0.95, 95 CI: 0.93, 0.98; OR 0.89, 0.83, respectively), whereas Zn, Ca, P positively 1.69, 1.42, 2.01; 1.12, 1.06, 1.18; 1.21, 1.09, 1.34, respectively). Moreover, Zn significantly even after adjusting these metals, Cr negatively results WQS qgcomp analyses showed that mixtures 1.26, 1.15, 1.38; 1.01, 1.19). This positive association primarily driven P, Ca. sensitivity collinearity diagnosis, interaction, stratified analysis, remained, confirming reliability study findings. Ca determined, provided novel insights into link

Language: Английский

Citations

3
Metals and Cardiovascular Disease DOI
Aaron Barchowsky

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Study on the correlation and interaction between metals and dyslipidemia: a case–control study in Chinese community-dwelling elderly DOI
Zhongyuan Zhang, Rui Wang,

Pei He

et al.

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(48), P. 105756 - 105769

Published: Sept. 16, 2023

Language: Английский

Citations

8
Association of cerebral spinal fluid copper imbalance in amyotrophic lateral sclerosis DOI Creative Commons
Qiao Yi Chen, Peng Wu, Ting Wen

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Nov. 17, 2022

A plethora of environmental risk factors has been persistently implicated in the pathogenesis amyotrophic lateral sclerosis (ALS), including metal/metalloids. This study aimed to examine potential associations between cerebral spinal fluid (CSF) metal/metalloids and ALS risks. CSF concentrations copper (Cu), nickel (Ni), mercury (Hg), arsenic (As), manganese (Mn), iron (Fe) (spinal- bulbar-onset) patients controls were measured using inductively coupled plasma mass spectrometry (ICP-MS). Results from this revealed marked differences control, spinal-onset, bulbar-onset groups. We report that Cu levels lower spinal-onset groups compared control group. Ni level higher group In addition, metal/metalloid with disease severity, sex, serum triglycerides also examined broach relevance neurotoxic heterogeneity.

Language: Английский

Citations

14
Association of Urinary Lead and Cadmium Levels, and Serum Lipids with Subclinical Arteriosclerosis: Evidence from Taiwan DOI Open Access
Chien‐Yu Lin, Sandy Huey-Jen Hsu, Ching‐Way Chen

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 571 - 571

Published: Jan. 21, 2023

Exposure to lead and cadmium has been linked changes in lipid metabolism the development of arteriosclerosis, but role lipoprotein profiles this relationship is not well understood, including potential novel biomarkers.In study, we enrolled 736 young Taiwanese subjects aged 12 30 years assess correlation between urine levels cadmium, profiles, carotid intima-media thickness (CIMT).Higher were significantly associated with higher low-density cholesterol (LDL-C), small dense LDL-C (sdLDL-C), LDL-triglyceride (LDL-TG), CIMT. Participants had highest mean values CIMT, LDL-C, sdLDL-C, LDL-TG. In a structural equation model, direct indirect association CIMT through whereas an LDL-C.Our results suggest are abnormal increased These heavy metals could have additive effects on lipids them may be mediated by levels. Further research needed determine causal relationship.

Language: Английский

Citations

7
Adequate Intake of Dietary Fiber May Relieve the Detrimental Impact of Blood Lead on Dyslipidemia among US Adults: A Study of Data from the National Health and Nutrition Examination Survey Database DOI Open Access
Bin Li,

Fengzhan Zhang,

Haoqi Jiang

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4434 - 4434

Published: Oct. 19, 2023

Lead (Pb) exposure is a well-established risk factor for dyslipidemia, and people are exposed to it in multiple ways daily. Dietary fiber presumed improve lipid metabolism disorders, but still unknown whether can relieve the detrimental impact of Pb on dyslipidemia. We used publicly accessible data from 2011–2016 cycles National Health Nutrition Examination Survey (NHANES). A total 2128 US adults were enrolled subsequent analysis. Heavy metal concentrations blood measured using inductively coupled plasma mass spectrometry (ICP-MS). weighted logistic regression was conducted calculate odds ratios (ORs) 95% confidence intervals (CIs). The dose–response relationship between heavy metals dyslipidemia explored restricted cubic spline (RCS) After fully adjusting potential confounding factors (age, gender, race, education level, ratio family income poverty, marital status, body index, physical activity, waist circumference, smoke, alcohol drinking history metabolic syndrome, hypertension, diabetes), positive association levels revealed (OR = 1.20, CI: 1.03–1.40). intake may significantly modify (p-interaction 0.049), with stronger 1.26, 1.05–1.52) being individuals an inadequate dietary (<14 g/1000 kcal/day), null 1.01, 0.72–1.42) observed those adequate (≥14 kcal/day). Moreover, RCS analysis showed that compared average level (4.24 µg/dL), lower (3.08 µg/dL) contribute group intake. Our findings suggest be However, offset caused by exposure. Since avoiding daily life difficult, increasing future might promising approach alleviate

Language: Английский

Citations

7
Metal mixture exposures and serum lipid levels in childhood: the Rhea mother-child cohort in Greece DOI
Gyeyoon Yim, Katerina Margetaki, Megan E. Romano

et al.

Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2024, Volume and Issue: 34(4), P. 688 - 698

Published: May 2, 2024

Language: Английский

Citations

2
Elevated serum lead and cadmium levels associated with increased risk of dyslipidemia in children aged 6 to 9 years in Shenzhen, China DOI
Shufan Li, Ruiguo Liu, Yueyang Wu

et al.

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(27), P. 70558 - 70568

Published: May 6, 2023

Language: Английский

Citations

6
Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study DOI Creative Commons
Oluseyi Ademola Adejumo, Adenike Enikuomehin,

Adeyemi Ogunleye

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(10), P. e0292364 - e0292364

Published: Oct. 11, 2023

Introduction The burden of cardiovascular disease (CVD) is huge due to its associated morbidity, mortality and adverse socio-economic impact. Environmental pollution as a risk factor contributes significantly the CVD, especially in low middle income countries. One effective strategies reduce CVD prevent or detect factors early at-risk population. This study determined some factors, kidney function, their association with heavy metals among automobile mechanics. Method was cross-sectional involving 162 mechanics 81 age sex matched controls. Serum levels lead, cadmium risks were assessed compared two groups. Associations between serum using correlation analysis. P value <0.05 taken significant. Results mean ages controls 47.27±9.99 years 48.94±10.34 years, respectively. prevalence elevated higher (25.9% vs 7.9%; p = <0.001). significant total cholesterol (32.1% 18.5%; 0.017), hyperuricemia (20.4% 1.2%; <0.001), blood glucose (16.0% 4.9% 0.013); alcohol use (55.1% 30.0%; 0.001). Among mechanics, there positive correlations cadmium, atherogenic index plasma (AIP) (p 0.024; r 0.382) triglyceride 0.020; 0.391). Significant found lead neutrophil gelatinase lipocalin (NGAL) <0.001; 0.329). There level, AIP 0.016; 0.373) TG 0.004; 0.439); NGAL all participants 0.005; 0.206). Conclusion Automobile have notable exposure factors. Health education sensitisation well policies that would regulate persons should be implemented Nigeria.

Language: Английский

Citations

4