The effect of cooper, zinc and selenium on skin condition DOI
Anna Kulik

Polish Hyperbaric Research, Journal Year: 2023, Volume and Issue: 83(2), P. 23 - 30

Published: June 1, 2023

Abstract Trace elements are essential for the maintenance of homeostasis body, and condition proper functioning human organism. Micronutrients influence a number metabolic processes in dermis epidermis. An excess or deficiency trace may represent potential threat to health with implications skin condition. This study reviews literature on effects copper, zinc selenium

Language: Английский

Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases DOI Creative Commons
Leilei Chen, Qingqing Shen, Yingjuan Liu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 2, 2025

Language: Английский

Citations

8
The mechanism of cuproptosis in Parkinson’s disease DOI
Min Huang,

Yong Zhang,

Xuehong Liu

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102214 - 102214

Published: Feb. 2, 2024

Language: Английский

Citations

12
MAMMALIAN COPPER HOMEOSTASIS: PHYSIOLOGIC ROLES AND MOLECULAR MECHANISMS DOI
Svetlana Lutsenko, Shubhrajit Roy, Peter Tsvetkov

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 105(1), P. 441 - 491

Published: Aug. 22, 2024

In the past decade, evidence for numerous roles of copper (Cu) in mammalian physiology has grown exponentially. The discoveries Cu involvement cell signaling, autophagy, motility, differentiation, and regulated death (cuproptosis) have markedly extended list already known functions Cu, such as a cofactor essential metabolic enzymes, protein structural component, regulator trafficking. Novel unexpected transporting proteins enzymes been identified, new disorders homeostasis described. Significant progress made mechanistic studies two classic metabolism, Menkes disease Wilson’s disease, which paved way novel approaches to their treatment. discovery cuproptosis role metastatic growth increased interest targeting homeostatic pathways treat cancer. this review, we summarize established concepts field discuss how decade expand modify these concepts. brain metabolism functional speciation recently discovered attracted significant attention are highlighted review.

Language: Английский

Citations

10
Restoration of metal homeostasis: a potential strategy against neurodegenerative diseases DOI
Yiyue Zhang, Xisheng Li, Kaidi Ren

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 87, P. 101931 - 101931

Published: April 8, 2023

Language: Английский

Citations

19
Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS DOI Creative Commons
Jin Hong Min, Heela Sarlus, Robert A. Harris

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: July 9, 2024

The pathophysiology of ALS involves many signs a disruption in copper homeostasis, with both excess free levels and functional deficiency likely occurring simultaneously. This is crucial, as important physiological functions are performed by cuproenzymes. While it unsurprising that symptoms related to deficiency, resulting vascular, antioxidant system mitochondrial oxidative respiration deficiencies, there also toxicity such ROS generation enhanced protein aggregation. We discuss how plays key role proteostasis interacts either directly or indirectly the aggregate-prone proteins implicated ALS, TDP-43, C9ORF72, SOD1 FUS well effect their aggregation on homeostasis. suggest loss cuproprotein function at core pathology, condition driven combination unbound can initiate and/or accelerate could trigger positive feedback cycle whereby aggregates other chain reaction eventually captures elements proteostatic mechanisms place counteract them. end result an abundance aggregated non-functional cuproproteins chaperones alongside depleted intracellular stores, general lack cuproenzyme function. then possible aetiology illustrate strong risk factors including environmental toxins BMAA heavy metals functionally behave promote disturb metabolism drives this vicious sporadic ALS. From synthesis, we propose restoration balance using delivery agents chaperones/chaperone mimetics, perhaps conjunction neuroprotective amino acid serine, promising strategy treatment incurable disease.

Language: Английский

Citations

8
Copper homeostasis and cuproptosis in health and disease DOI Creative Commons

Yunuo Yang,

Jiaxuan Wu,

Lisheng Wang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 17, 2024

Copper is a vital trace element in human physiology, essential for the synthesis of numerous crucial metabolic enzymes and facilitation various biological processes. Regulation copper levels within narrow range imperative maintaining homeostasis. Numerous studies have demonstrated significant roles homeostasis cuproptosis health disease pathogenesis. However, comprehensive up-to-date systematic review this domain remains absent. This aims to consolidate recent advancements understanding disease, focusing on underlying mechanisms potential therapeutic interventions. Dysregulation homeostasis, manifesting as either excess or deficiency, implicated etiology diseases. Cuproptosis, recently identified form cell death, characterized by intracellular overload. phenomenon mediates diverse array evolutionary processes organisms, spanning from genetic disorders, liver diseases, neurodegenerative cancers. provides summary pathogenic along with associated targeted agents. Furthermore, it explores future research directions yield treatment, management, prevention.

Language: Английский

Citations

7
Role of copper in central nervous system physiology and pathology DOI Creative Commons
Martina Locatelli, Cinthia Farina

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(4), P. 1058 - 1068

Published: May 16, 2024

Copper is a transition metal and an essential element for the organism, as alterations in its homeostasis leading to accumulation or deficiency have pathological effects several organs, including central nervous system. Central copper dysregulations been evidenced two genetic disorders characterized by mutations copper-ATPases ATP7A ATP7B, Menkes disease Wilson's disease, respectively, also multifactorial neurological such Alzheimer's Parkinson's amyotrophic lateral sclerosis, multiple sclerosis. This review summarizes current knowledge about role of system physiology pathology, reports unbalances levels and/or distribution under describes relevant animal models human where metabolism genes are dysregulated, discusses therapeutic approaches modulating availability. Overall, may contribute etiology represent targets restore tissue homeostasis.

Language: Английский

Citations

6
Neuronal regulated cell death in aging-related neurodegenerative diseases: key pathways and therapeutic potentials DOI Creative Commons
Run Song, Shiyi Yin, Jiannan Wu

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(8), P. 2245 - 2263

Published: July 29, 2024

Regulated cell death (such as apoptosis, necroptosis, pyroptosis, autophagy, cuproptosis, ferroptosis, disulfidptosis) involves complex signaling pathways and molecular effectors, has been proven to be an important regulatory mechanism for regulating neuronal aging death. However, excessive activation of regulated may lead the progression aging-related diseases. This review summarizes recent advances in understanding seven forms age-related Notably, newly identified ferroptosis cuproptosis have implicated risk cognitive impairment neurodegenerative These exacerbate disease by promoting inflammation, oxidative stress, pathological protein aggregation. The also provides overview key crosstalk mechanisms among these forms, with a focus on disulfidptosis. For instance, FDX1 directly induces copper ion valency dihydrolipoamide S-acetyltransferase aggregation, while mediates glutathione peroxidase 4 degradation, enhancing sensitivity. Additionally, inhibiting Xc- transport system prevent can increase disulfide formation shift NADP + /NADPH ratio, transitioning insights help uncover potential connections novel differentiate them from traditional mechanisms. In conclusion, identifying targets their points various aid developing specific biomarkers reverse clock treat conditions.

Language: Английский

Citations

4
Copper in human health: from COVID 19 to Neurodegenerative diseases DOI
Roger Deloncle,

Olivier Guillard,

Alain Pineau

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: unknown, P. 127636 - 127636

Published: March 1, 2025

Language: Английский

Citations

0
A new benzil-based chemosensor for colorimetric and fluorometric detection of Cu2+ with high selectivity and sensitivity in living cells DOI Creative Commons
Jinhe Xu, Huan Chen,

Yuekai Wang

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1319, P. 139489 - 139489

Published: July 30, 2024

A novel benzil-based probe DBBQ containing two julolidine Schiff base arms was synthesized and demonstrated for its highly selective sensitive detection of Cu2+ ions in CH3CN: HEPES buffers (3:2, v/v, pH=7.4). Upon the addition ions, absorption exhibited remarkable change color from yellow to brown, which could be easily observed by naked eyes. In addition, displayed fluorescence quenching signal over a wide range competitive substances. The intensity buffer pH=7.4) solution showed good linear response relationship 0–2.5 μΜ low limit 0.41 μM. binding ratio between determined 1:1. Probe potentially used as chemosensor living HepG2 cells.

Language: Английский

Citations

2