Sleep Deprivation-Induced Oxidative Stress in Rat Models: A Scoping Systematic Review

Antioxidants, Journal Year: 2023, Volume and Issue: 12(8), P. 1600 - 1600

Published: Aug. 11, 2023

Sleep deprivation is highly prevalent in the modern world, possibly reaching epidemic proportions. While multiple theories regarding roles of sleep exist (inactivity, energy conservation, restoration, brain plasticity and antioxidant), unknowns still remain proposed antioxidant sleep. The existing experimental evidence often contradicting, with studies pointing both toward against presence oxidative stress after deprivation. main goals this review were to analyze data relationship between stress, attempt further clarify aspects surrounding identify current knowledge gaps. Systematic searches conducted three major online databases for performed on rat models measurements, published 2015 2022. A total 54 included review. Most results seem point changes parameters deprivation, suggesting an role Alterations these observed paradoxical protocols strains. Furthermore, effects extend beyond central nervous system, affecting other body sites periphery. recovery seems be characterized by increased variability, normalizations some long-lasting Surprisingly, most revealed a response following However, origin impact during somewhat unclear. definitive exclusion influence protocol not possible, available suggest that may determined itself as opposed conditions. Due fact, could attributed directly

Language: Английский

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The effects of L-theanine consumption on sleep outcomes: a systematic review and meta-analysis.

Sleep Medicine Reviews, Journal Year: 2025, Volume and Issue: 81, P. 102076 - 102076

Published: Feb. 25, 2025

This systematic review ansd meta-analysis aimed to evaluate the effects of L-theanine, a non-proteinogenic amino acid found in tea, on sleep outcomes. Literature searches were conducted five electronic databases (APA PsycINFO, CINAHL, Medline, Scopus, Web Science), and one register (Cochrane Central Register Controlled Trials) from inception until September 2024. Randomised controlled trials investigating L-theanine supplementation quality humans all ages health status included. Nineteen articles (N = 897 participants) selected 18 included meta-analysis. was shown significantly improve subjective onset latency (SMD 0.15, 95 % CI [0.01, 0.29], p 0.04; n 10 studies), daytime dysfunction 0.33, [0.16, 0.49], < 0.001; 9 overall score 0.43, [0.04, 0.83], 0.03; 12 studies). The findings indicate potential use management disturbances; however, lack studies "pure" warrants further investigation. Future are needed determine adequate dose duration for improving maintaining healthy clinical populations.

Language: Английский

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Mental health symptoms one year after acute COVID-19 infection: Prevalence and risk factors

Revista de Psiquiatría y Salud Mental, Journal Year: 2022, Volume and Issue: 16, P. 38 - 46

Published: June 17, 2022

Emerging evidence suggests that mental health symptoms in COVID-19 survivors are higher than expected, possibly indicating such more likely to develop post-infection just persist as a residual component of the acute phase. It is thus imperative investigate potential development post-COVID syndrome longer-term and identify its risk factors.A prospective study investigated associated with determinants over 12-month period following disease onset all consecutive adult inpatients outpatients attending tertiary referral hospital from March May 2020.A total 479 patients (female, 52.6%) were followed-up for 12 months after onset. Of them, 47.2% still presenting at least one symptom. While most subsided compared (all p < 0.001), significant increase was observed only psychiatric disorders (10.2%) lack concentration focus (20%; 0.001). Patients related multiple body systems contracting ≤ 0.034) suffer domain-related follow-up. Also, post infection found those suffering (p = 0.005).Findings this may have important public implications, they underlie increased need support survivors.Nuevas evidencias sugieren que los síntomas de salud en supervivientes son mayores lo esperado, posiblemente indica es más probable dichos se desarrollen después la infección vez sólo persistir como componente fase aguda. Por tanto, imperativo investigar el posible desarrollo un síndrome largo plazo e identificar sus factores riesgo.Un estudio prospectivo investigó asociados y determinantes durante periodo meses tras inicio enfermedad todos pacientes adultos consecutivos con COVID-19, hospitalizados ambulatorios, acudieron tercer nivel entre marzo mayo 2020.Un (mujeres, 52,6%) fueron seguidos del COVID-19. De ellos, 47,2% seguía presentando al menos síntoma. Mientras mayoría disminuyeron comparación (todos 0,001), observó aumento significativo solamente trastornos psiquiátricos (10,2%) falta concentración enfoque 0,001). Los presentaban relacionados múltiples sistemas cuerpo contraer 0,034) tenían probabilidades sufrir dominio seguimiento. Además, encontró mayor riesgo presentar sufrían 0,005).Los resultados este pueden tener importantes implicaciones para pública, ya subyacen necesidad apoyo

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Impact of 6-months of an advanced hybrid closed-loop system on sleep and psychosocial outcomes in youth with type 1 diabetes and their parents

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 207, P. 111087 - 111087

Published: Jan. 1, 2024

Language: Английский

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Family Resilience and Adolescent Mental Health during COVID-19: A Moderated Mediation Model

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(8), P. 4801 - 4801

Published: April 15, 2022

The COVID-19 pandemic has impacted and is still impacting people's lives, including physical mental health. Family plays an important role in adolescent health due to the long staying at home.This paper aimed investigate impact of family resilience on during pandemic, mediation stress perception moderation meta-mood.A total 2691 Chinese adolescents were recruited using convenient sampling. Their health, resilience, meta-mood surveyed. Multivariate statistics used analyze data.Our results showed that (1) about 36.7% our sample have some problems; (2) can positively predict whereas negatively health; (3) mediates relationship between (4) moderates perception, i.e., first half role.Our indicate one either improve or adolescents' relieve problems.

Language: Английский

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Recent Progress in Long-Term Sleep Monitoring Technology

Biosensors, Journal Year: 2023, Volume and Issue: 13(3), P. 395 - 395

Published: March 17, 2023

Sleep is an essential physiological activity, accounting for about one-third of our lives, which significantly impacts memory, mood, health, and children’s growth. Especially after the COVID-19 epidemic, sleep health issues have attracted more attention. In recent years, with development wearable electronic devices, there been studies, products, or solutions related to monitoring. Many mature technologies, such as polysomnography, applied clinical practice. However, it urgent develop non-contacting devices suitable household continuous This paper first introduces basic knowledge significance Then, according types signals monitored, this describes research progress bioelectrical signals, biomechanical biochemical used not ideal monitor quality whole night based on only one signal. Therefore, reviews multi-signal monitoring systematic schemes. Finally, a conclusion discussion are presented propose potential future directions prospects

Language: Английский

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Long COVID and rheumatology: Clinical, diagnostic, and therapeutic implications

Best Practice & Research Clinical Rheumatology, Journal Year: 2022, Volume and Issue: 36(4), P. 101794 - 101794

Published: Nov. 8, 2022

Language: Английский

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The Impact of the COVID-19 Pandemic on Inpatient Admissions for Psychotic and Affective Disorders: The Experience of a Large Psychiatric Teaching Hospital in Romania

Healthcare, Journal Year: 2022, Volume and Issue: 10(8), P. 1570 - 1570

Published: Aug. 18, 2022

The COVID-19 pandemic resulted in a global sanitary crisis and, addition, elicited serious mental health consequences. utilization of psychiatric hospital-based services acts as an indicator public health. Therefore, this research sought to investigate differences the numbers and characteristics inpatient admissions for psychotic affective disorders at largest Romanian hospital between period lockdown (16 March−15 May 2020) another three corresponding periods: same year pre-lockdown January−15 March 2020), immediate post-lockdown May−15 July two years later 2022). A retrospective analysis was performed. study included total 6604 patients. Inpatient decreased during comparison with (p < 0.001 p 0.001, respectively) respectively). For both disorders, decrease age patients admitted lockdown, compared 0.05 respectively), observed. length stay higher immediately 0.001). Collectively, present findings provide glimpse long-term consequences measures on patients’ access healthcare form hospitalization, these could basis development different approach times crisis.

Language: Английский

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The Effect of Gut Microbiota-Targeted Interventions on Neuroinflammation and Motor Function in Parkinson’s Disease Animal Models—A Systematic Review

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 3946 - 3974

Published: April 26, 2024

Gut microbiome-targeted interventions such as fecal transplant, prebiotics, probiotics, synbiotics, and antibiotic gut depletion are speculated to be of potential use in delaying the onset progression Parkinson’s disease by rebalancing microbiome context gut–brain axis. Our study aims organize recent findings regarding these animal models identify how they affect neuroinflammation motor outcomes. A systematic literature search was applied PubMed, Web Science, Embase, SCOPUS for non-dietary interventions. Studies that investigated gut-targeted using vivo murine PD follow dopaminergic cell loss, tests, neuroinflammatory markers outcomes were considered eligible. total 1335 studies identified databases, out which 29 found narrative systematization resulting data performed, effect direction represented. Quality assessment SYRCLE risk bias tool also performed. Out eligible studies, we a significant majority report intervention reduced loss (82.76%, 95% CI [64.23%, 94.15%]) produced induction model. Also, most reported reduction microglial (87.5%, [61.65%, 98.45%]) astrocytic activation (84,62%, [54.55%, 98.08%]) caused These results mirrored (96.4% [81.65%, 99.91%]) reporting an increase performance behavioral tests. limitation insufficient information assess specific causes bias. show can improve acute models. Further needed clarify if benefits transfer long-term pathogenesis disease, is not yet fully understood. The had no funding source, protocol registered PROSPERO database with ID number CRD42023461495.

Language: Английский

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Sleep and day-to-day PTSD symptom variability: an ecological momentary assessment and actigraphy monitored study in trauma-exposed young adults

European journal of psychotraumatology, Journal Year: 2023, Volume and Issue: 14(2)

Published: April 25, 2023

Background: Disrupted sleep and post-traumatic stress disorder (PTSD) are bi-directionally linked have been found to mutually reinforce each other on a day-to-day basis. However, most of the previous research has focused subjective measures only.Objective: Here, we investigated temporal relationship between PTSD symptoms using both (sleep diary) objective (actigraphy).Methods: Forty-one non-treatment seeking, trauma exposed young adults (age M = 24.68, SD 8.15) with range symptom severities (PTSS, 0–53 PCL-5) were recruited. Participants completed two surveys per day over four weeks measure day-time (i.e. PTSS number intrusions) night-time subjectively, while wearing an actigraphy watch objectively.Results: Linear mixed models revealed that subjectively reported disruptions associated elevated next-day increasing intrusive memories within participants. Similar results for daytime sleep. these associations not data. Exploratory moderator analyses including sex (male vs. female) differed in strength sexes but generally same direction.Discussion: These line our hypothesis regards diary (subjective sleep), (objective sleep). Several factors which implications sleep, such as COVID-19 pandemic and/ or sleep-state misperception, may be potential reasons behind those discrepancies. this study had limited power needs replicated larger samples. Nonetheless, add current literature about bi-directional clinical treatment strategies.

Language: Английский

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