Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15054 - 15054

Published: Nov. 30, 2022

Flavonoids are a category of plant-derived compounds which exhibit large number health-related effects. One the most well-known and studied flavonoids is kaempferol, can be found in wide variety herbs plant families. Apart from their anticarcinogenic anti-inflammatory effects, kaempferol its associated also antibacterial, antifungal, antiprotozoal activities. The development drugs treatment schemes based on these becoming increasingly important face emerging resistance numerous pathogens as well complex molecular interactions between various drug therapies. In addition, many kaempferol-containing plants used traditional systems all over world for centuries to treat conditions. Due sources compounds, some mechanisms antimicrobial activity known while others still under analysis. This paper thoroughly documents vegetal food recent significant studies regarding applications.

Language: Английский

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Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Biomimetics, Journal Year: 2024, Volume and Issue: 9(3), P. 154 - 154

Published: March 1, 2024

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one the major complications such medical interventions. emergence novel technologies, especially 3D printing, represents promising avenue development for reducing risk eventualities. There are already host biomaterials, suitable being tested antimicrobial properties when they coated with bioactive compounds, as antibiotics, or combined hydrogels antioxidant properties, chitosan metal nanoparticles, among others. materials discussed context this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), zirconia. While recent research results promising, further required to address increasing antibiotic resistance exhibited by several common pathogens, potential fungal infections, toxicity some nanoparticles. Other solutions, like incorporation phytochemicals, should also be explored. Incorporating artificial intelligence (AI) certain implants use AI against bacterial might represent viable solutions these problems. Finally, there legal considerations associated biomaterials widespread which must taken into account.

Language: Английский

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Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4097 - 4097

Published: Sept. 22, 2023

Capsaicin is a phytochemical derived from plants of the genus Capsicum and subject intensive research due to its numerous physiological therapeutical effects, including important antimicrobial properties. Depending on concentration strain bacterium, capsaicin can exert either bacteriostatic or even bactericidal effects against wide range both Gram-positive Gram-negative bacteria, while in certain cases it reduce their pathogenicity by variety mechanisms such as mitigating release toxins inhibiting biofilm formation. Likewise, has been shown be effective fungal pathogens, particularly Candida spp., where once again interferes with The parasites Toxoplasma gondi Trypanosoma cruzi have found susceptible action this compound too there are also viruses whose invasiveness significantly dampened it. Among most encouraging findings prospects for future development, especially using new formulations drug delivery mechanisms. Finally, influence somatostatin substance P secretion action, offers an interesting array possibilities given that these physiologically secreted compounds modulate inflammation immune response significant extent.

Language: Английский

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Screening the release of chemicals and microplastic particles from diverse plastic consumer products into water under accelerated UV weathering conditions

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 477, P. 135256 - 135256

Published: July 19, 2024

Photodegradation of plastic consumer products is known to accelerate weathering and facilitate the release chemicals particles into aquatic environment. However, these processes are complex. In our presented pilot study, eight were leached in distilled water under strong ultraviolet (UV) light simulating months Central European climate compared their respective dark controls (DCs). The leachates formed exploratorily characterized using a range chemical analytical tools describe degradation leaching processes. These techniques covered (a) microplastic analysis, showing substantial liberation further increased UV exposure, (b) non-targeted mass spectrometric characterization leachates, revealing several hundreds features with typically only minor agreement between exposure corresponding DCs, (c) target analysis 71 organic analytes, which 15 could be detected at least one sample, (d) metal(loid) revealed toxic metal(loid)s enhanced exposure. A data comparison US-EPA's ToxVal ToxCast databases showed that metals additives might pose health environmental concerns, requiring study comprehensive impact assessments.

Language: Английский

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Capsaicin: Emerging Pharmacological and Therapeutic Insights

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 7895 - 7943

Published: July 24, 2024

Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already a number established clinical and industrial applications. Capsaicin is known to act through TRPV1 receptor, which exists various tissues; capsaicin hepatically metabolised, having half-life correlated with method application. Research on applications different formulations still ongoing. Thus, local have pronounced anti-inflammatory effect, while systemic multitude effects because their increased lipophilic character ensures augmented bioavailability. Furthermore, teams documented capsaicin's anti-cancer effects, proven both vivo vitro designs. A notable constraint therapeutic its toxicity, especially sensitive tissues. Regarding capsaicin, apart from all recorded as medicinal application acupuncture points demonstrated be effective combination warrants further research. Finally, antimicrobial can supplement anti-carcinogenic actions.

Language: Английский

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Kaempferol: A Review of Current Evidence of Its Antiviral Potential

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16299 - 16299

Published: Nov. 14, 2023

Kaempferol and its derivatives are flavonoids found in various plants, a considerable number of these have been used medical applications worldwide. compounds well-known antioxidant, anti-inflammatory antimicrobial properties among other health benefits. However, the antiviral kaempferol notable, there is significant experimental studies on this topic. were effective against DNA viruses such as hepatitis B virus, alphaherpesvirinae family, African swine fever pseudorabies virus; they also RNA viruses, namely feline SARS coronavirus, dengue Japanese encephalitis influenza enterovirus 71, poliovirus, respiratory syncytial human immunodeficiency calicivirus, chikungunya virus. On hand, no effectiveness murine norovirus A virus could be determined. The action mechanisms various, inhibition viral polymerases attachment entry into host cells. Future research should focused further elucidating from different plants assessing their potential use to complement drugs.

Language: Английский

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Dermal bioaccessibility and health risk assessment associated with mining production of metals (Pb-Zn-Ag) and critical raw materials (Sb-W) in the Iberian Peninsula

Environmental Chemistry and Ecotoxicology, Journal Year: 2025, Volume and Issue: 7, P. 506 - 515

Published: Jan. 1, 2025

Language: Английский

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Assessment of gold endowment and exploration maturity in selected South African goldfields using Zipf’s law, deposit density regression, and the USGS three-part quantitative mineral resource assessment: Toward sustaining gold production

Ore Geology Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106513 - 106513

Published: Feb. 1, 2025

Language: Английский

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Environmentally relevant concentrations of antimony pose potential risks to human health: An evaluation on human umbilical vein endothelial cells

Toxicology in Vitro, Journal Year: 2025, Volume and Issue: 106, P. 106054 - 106054

Published: March 13, 2025

Language: Английский

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Metallic trace elements in pancreatic tissue are associated with higher risk of pancreatic adenocarcinoma - METAPANDA study.

Pancreatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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