Kaempferol: Paving the path for advanced treatments in aging-related diseases

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 188, P. 112389 - 112389

Published: March 8, 2024

Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, flavonoid found in several plants, has emerged as promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, pharmacokinetics, highlights its potential therapeutic utility against underpinned by distinctive structure, which confers antioxidative anti-inflammatory properties. Kaempferol counteracts reactive oxygen species (ROS) modulates crucial cellular pathways, thereby combating oxidative stress inflammation, hallmarks low toxicity wide margins, demonstrated preclinical clinical studies, further substantiate potential. Compelling evidence supports substantial addressing ARDs through mechanisms, notably anti-inflammatory, antioxidant, anti-apoptotic actions. exhibits versatile neuroprotective effect modulating various proinflammatory signaling including NF-kB, p38MAPK, AKT, β-catenin cascade. Additionally, it hinders formation aggregation beta-amyloid protein regulates brain-derived neurotrophic factors. In terms anticancer potential, kaempferol acts diverse inducing apoptosis, arresting cell cycle at G2/M phase, suppressing epithelial-mesenchymal transition (EMT)-related markers, affecting phosphoinositide 3-kinase/protein kinase B pathways. Subsequent studies should focus on refining dosage regimens, exploring innovative delivery systems, conducting trials to translate these findings into applications.

Language: Английский

---

Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2023, Volume and Issue: 12(1)

Published: May 15, 2023

Abstract Background Flavonols are phytoconstituents of biological and medicinal importance. In addition to functioning as antioxidants, flavonols may play a role in antagonizing diabetes, cancer, cardiovascular disease, viral bacterial diseases. Quercetin, myricetin, kaempferol, fisetin the major dietary flavonols. Quercetin is potent scavenger free radicals, providing protection from radical damage oxidation-associated Main body abstract An extensive literature review specific databases (e.g., Pubmed, google scholar, science direct) were conducted using keywords “flavonol,” “quercetin,” “antidiabetic,” “antiviral,” “anticancer,” “myricetin.” Some studies concluded that quercetin promising antioxidant agent while kaempferol could be effective against human gastric cancer. addition, prevents apoptosis pancreatic beta-cells via boosting function survival rate beta-cells, leading increased insulin secretion. also show potential alternatives conventional antibiotics, restricting infection by envelope proteins block entry. Short conclusion There substantial scientific evidence high consumption associated with reduced risk cancer coronary diseases, alleviation, tumor growth prevention, secretion improvement, among other diverse health benefits. Nevertheless, more required determine appropriate concentration, dose, type flavonol for particular condition prevent any adverse side effects.

Language: Английский

---

Kaempferol efficacy in metabolic diseases: Molecular mechanisms of action in diabetes mellitus, obesity, non-alcoholic fatty liver disease, steatohepatitis, and atherosclerosis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116694 - 116694

Published: May 6, 2024

The incidence of metabolic diseases has progressively increased, which a negative impact on human health and life safety globally. Due to the good efficacy limited side effects, there is growing interest in developing effective drugs treat from natural compounds. Kaempferol (KMP), an important flavonoid, exists many vegetables, fruits, traditional medicinal plants. Recently, KMP received widespread attention worldwide due its potential treatment diseases. To promote basic research clinical application KMP, this review provides timely comprehensive summary pharmacological advances four molecular mechanisms action, including diabetes mellitus, obesity, non-alcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), atherosclerosis. According research, shows remarkable therapeutic effects by regulating multiple signaling transduction pathways such as NF-κB, Nrf2, AMPK, PI3K/AKT, TLR4, ER stress. In addition, most recent literature KMP's source, pharmacokinetics studies, well toxicity are also discussed review, thus providing foundation evidence for further studies develop novel Collectively, our manuscript strongly suggested that could be promising candidate

Language: Английский

---

Nature’s Arsenal: Uncovering Antibacterial Agents Against Antimicrobial Resistance

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 253 - 253

Published: March 1, 2025

Background/Objectives: Antimicrobial resistance (AMR) poses a significant public health threat, leading to increased mortality. The World Health Organization has established priority list highlighting critical multidrug-resistant (MDR) pathogens that demand urgent research on antimicrobial treatments. Considering this and the fact new antibiotics are only sporadically approved, natural antibacterial agents have seen resurgence in interest as potential alternatives conventional chemotherapeutics. Natural antibacterials, derived from microorganisms, higher fungi, plants, animals, minerals, food sources, offer diverse mechanisms of action against MDR pathogens. Here, we present comprehensive summary including brief history their application key strategies for using microorganisms (microbiopredators, such bacteriophages), plant extracts essential oils, minerals (e.g., silver copper), well compounds animal origin, milk or even venoms. review also addresses role prebiotics, probiotics, peptides, novel formulations nanoparticles. these compounds, terpenoids, alkaloids, phenolic explored alongside challenges application, e.g., extraction, formulation, pharmacokinetics. Conclusions: Future should focus developing eco-friendly, sustainable validating safety efficacy through clinical trials. Clear regulatory frameworks integrating into practice. Despite challenges, sources transformative combating AMR promoting solutions.

Language: Английский

---

Research progress on pharmacokinetics, anti-inflammatory and immunomodulatory effects of kaempferol

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114387 - 114387

Published: March 6, 2025

Language: Английский

---

Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety

Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 16

Published: Feb. 27, 2023

The liver is the body’s most critical organ that performs vital functions. Hepatic disorders can affect physiological and biochemical functions of body. disorder a condition describes damage to cells, tissues, structures, liver, which cause fibrosis ultimately result in cirrhosis. These diseases include hepatitis, ALD, NAFLD, fibrosis, cirrhosis, hepatic failure, HCC. are caused by cell membrane rupture, immune response, altered drug metabolism, accumulation reactive oxygen species, lipid peroxidation, death. Despite breakthrough modern medicine, there no effective stimulating function, offering complete protection, aiding regeneration. Furthermore, some drugs create adverse side effects, natural medicines carefully selected as new therapeutic strategies for managing disease. Kaempferol polyphenol contained many vegetables, fruits, herbal remedies. We use it manage various such diabetes, cardiovascular disorders, cancers. potent antioxidant has anti-inflammatory therefore possesses hepatoprotective properties. previous research studied effect kaempferol hepatotoxicity protocols, including acetaminophen (APAP)-induced hepatotoxicity, CCl4, HCC, lipopolysaccharide (LPS)-induced acute injury. Therefore, this report aims provide recent brief overview literature concerning its possible molecular mechanism action. It also provides on kaempferol’s chemical structure, source, bioavailability, safety.

Language: Английский

---

Antimicrobial Properties of Capsaicin: Available Data and Future Research Perspectives

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4097 - 4097

Published: Sept. 22, 2023

Capsaicin is a phytochemical derived from plants of the genus Capsicum and subject intensive research due to its numerous physiological therapeutical effects, including important antimicrobial properties. Depending on concentration strain bacterium, capsaicin can exert either bacteriostatic or even bactericidal effects against wide range both Gram-positive Gram-negative bacteria, while in certain cases it reduce their pathogenicity by variety mechanisms such as mitigating release toxins inhibiting biofilm formation. Likewise, has been shown be effective fungal pathogens, particularly Candida spp., where once again interferes with The parasites Toxoplasma gondi Trypanosoma cruzi have found susceptible action this compound too there are also viruses whose invasiveness significantly dampened it. Among most encouraging findings prospects for future development, especially using new formulations drug delivery mechanisms. Finally, influence somatostatin substance P secretion action, offers an interesting array possibilities given that these physiologically secreted compounds modulate inflammation immune response significant extent.

Language: Английский

---

Exploring the efficacious constituents and underlying mechanisms of sini decoction for sepsis treatment through network pharmacology and multi-omics

Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155212 - 155212

Published: Nov. 12, 2023

Language: Английский

---

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Biomimetics, Journal Year: 2024, Volume and Issue: 9(3), P. 154 - 154

Published: March 1, 2024

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one the major complications such medical interventions. emergence novel technologies, especially 3D printing, represents promising avenue development for reducing risk eventualities. There are already host biomaterials, suitable being tested antimicrobial properties when they coated with bioactive compounds, as antibiotics, or combined hydrogels antioxidant properties, chitosan metal nanoparticles, among others. materials discussed context this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), zirconia. While recent research results promising, further required to address increasing antibiotic resistance exhibited by several common pathogens, potential fungal infections, toxicity some nanoparticles. Other solutions, like incorporation phytochemicals, should also be explored. Incorporating artificial intelligence (AI) certain implants use AI against bacterial might represent viable solutions these problems. Finally, there legal considerations associated biomaterials widespread which must taken into account.

Language: Английский

---

Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 163 - 205

Published: April 18, 2024

Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)

Language: Английский

---