Age-stratified seroprevalence of antibodies against SARS-CoV-2 in the pre- and post-vaccination era, February 2020–March 2022, Japan DOI Creative Commons
Seiya Yamayoshi, Kiyoko Iwatsuki‐Horimoto,

Moe Okuda

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 12, 2022

Abstract Japan has reported a small number of COVID-19 cases relative to other countries. Because not all infected people receive diagnostic tests for COVID-19, the must be lower than actual infections. Assessments presence antibodies against spike protein SARS-CoV-2 can retrospectively determine history natural infection and vaccination. In this study, we assessed seroprevalence by analyzing over 60,000 samples collected in from February 2020 March 2022. The results showed that about 5% Japanese population had been with virus January 2021. increased administration vaccinations adults; however, among elderly, it was as high vaccination rate, probably due poor immune responses vaccines waning immunity. spread during epidemic waves caused Delta Omicron variants children who were eligible Nevertheless, their low 10% Our study underscores incidence effects on immunity at level.

Language: Английский

What do we know about pathological mechanism and pattern of lung injury related to SARS-CoV-2 Omicron variant? DOI Creative Commons

Roberto Scendoni,

Mariano Cingolani

Diagnostic Pathology, Journal Year: 2023, Volume and Issue: 18(1)

Published: Feb. 10, 2023

Abstract Pulmonary damage in SARS-CoV-2 is characterized pathologically by diffuse alveolar (DAD) and thrombosis. In addition, nosocomial bacterial superinfections ventilator-induced lung injury (VILI) are likely to occur. The Omicron variant have manifested itself as a more diffusive virus which mainly affects the upper airways, such nose pharynx. mechanism leading with complex clinical course for remains unclear. A key question whether organ due direct targeting of or downstream effects an altered immune response. An escape process being studied, could lead prolonged viral shedding increase hospitalization times patients comorbidities, increased risk pulmonary co-infections/superinfections damage. This brief commentary reports current knowledge on provides some useful suggestions scientific community.

Language: Английский

Citations

9
The trade‐off between deaths by infection and socio‐economic costs in the emerging infectious disease DOI
Akira Watanabe, Hiroyuki Matsuda

Population Ecology, Journal Year: 2024, Volume and Issue: 66(3), P. 158 - 170

Published: Jan. 15, 2024

Abstract COVID‐19, caused by the novel coronavirus (SARS‐CoV‐2), is an emerging infectious disease (EID) with a relatively high infectivity and mortality rate. During state of emergency announced Japanese government in spring 2020, citizens were requested to stay home, number infected people was drastically reduced without legally‐binding lockdown. It well‐acknowledged that there trade‐off between maintaining economic activity preventing spread diseases. We aimed reduce total loss epidemic EID like COVID‐19 present study. focused on early late stages proposed framework resulted from damage infection cost for countermeasure. Mathematical models used estimate effect interventions deaths infection. The converted into monetary base different policies compared. In stage, we calculated when behavioral restrictions implemented. favorable intensity intervention depended basic reproduction number, fatality rate, impact. indicators showed it ratio maintain hospitalization system per determine which strategy should be adopted.

Language: Английский

Citations

2
Age-Stratified Seroprevalence of SARS-CoV-2 Antibodies before and during the Vaccination Era, Japan, February 2020–March 2022 DOI Creative Commons
Seiya Yamayoshi, Kiyoko Iwatsuki‐Horimoto,

Moe Okuda

et al.

Emerging infectious diseases, Journal Year: 2022, Volume and Issue: 28(11), P. 2198 - 2205

Published: Oct. 26, 2022

Abstract Japan has reported a relatively small number of COVID-19 cases. Because not all infected persons receive diagnostic tests for COVID-19, the must be lower than actual infections. We assessed SARS-CoV-2 seroprevalence by analyzing >60,000 samples collected in (Tokyo Metropolitan Area and Hokkaido Prefecture) during February 2020–March 2022. The results showed that ≈3.8% population had become seropositive January 2021. increased with administration vaccinations; however, among elderly, was as high vaccination rate. Among children, who were eligible vaccination, infection spread epidemic waves caused Delta Omicron variants. Nevertheless, unvaccinated children <5 years age low 10% March Our study underscores incidence effects on immunity at level.

Language: Английский

Citations

5
Molecular Epidemiology of SARS-CoV-2 Genome Sentinel Surveillance in Commercial COVID-19 Testing Sites Targeting Asymptomatic Individuals During Japan’s Seventh Epidemic Wave DOI Creative Commons
Teiichiro Shiino, Junko S. Takeuchi,

Hajime Ohyanagi

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 7, 2024

Abstract Eight peaks of coronavirus disease 2019 (COVID-19) outbreak occurred in Japan, each associated with severe acute respiratory syndrome 2 (SARS-CoV-2) variants concern. The National Epidemiological Surveillance Infectious Diseases (NESID) analyzed viral genome sequences from symptomatic patients and submitted the results to GISAID. Meanwhile, commercial testing services occasionally sequence samples asymptomatic individuals. We compared a total 1,248 SARS-CoV-2 full-genome obtained SB Coronavirus Inspection Center Corp. (SBCVIC) during Japan’s seventh wave, which was dominated by Omicron variants, 1,764 Japan GISAID same period using chronological phylogenies molecular transmission networks. number SBCVIC consistent cases reported NESID. detected shift PANGO lineage BA.2 BA.5 earlier than that lineages were distributed at different locations network entries, whereas often formed distinct subclusters. Test-based sentinel surveillance individuals may be more manageable approach notifiable surveillance; however, it not necessarily capture all infection populations throughout Japan.

Language: Английский

Citations

0
Molecular epidemiology of SARS-CoV-2 genome sentinel surveillance in commercial COVID-19 testing sites targeting asymptomatic individuals during Japan’s seventh epidemic wave DOI Creative Commons
Teiichiro Shiino, Junko S. Takeuchi,

Hajime Ohyanagi

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 9, 2024

Language: Английский

Citations

0
Exploring spatiotemporal patterns of COVID-19 infection in Nagasaki Prefecture in Japan using prospective space-time scan statistics from April 2020 to April 2022 DOI Creative Commons
Yixiao Lu, Guoxi Cai, Zhijian Hu

et al.

Archives of Public Health, Journal Year: 2022, Volume and Issue: 80(1)

Published: July 26, 2022

Abstract Background Up to April 2022, there were six waves of infection coronavirus disease 2019 (COVID-19) in Japan. As the outbreaks continue grow, it is critical detect COVID-19’s clusters allocate health resources and improve decision-making substantially. This study aimed identify active COVID-19 Nagasaki Prefecture form spatiotemporal pattern high-risk areas different periods. Methods We used prospective space-time scan statistic emerging examine relative risk five consecutive periods from 1, 2020 7, Prefecture. Results The densely inhabited districts (DIDs) City have remained most affected since December 2020. Most confirmed cases early period each wave had a history travelling other prefectures. Community-level transmissions are suggested by quick expansion spatial urban rural remote islands. Moreover, welfare facilities schools may lead an cluster Prefecture’s areas. Conclusions gives overall analysis transmission dynamics pandemic Prefecture, based on number machi-level daily cases. Furthermore, findings can serve as references for subsequent prevention control. method helps authorities track investigate that specific these environments, especially where healthcare scarce.

Language: Английский

Citations

1
The trade-off between deaths by infection and socio-economic costs in the emerging infectious disease DOI Open Access
Akira Watanabe, Hiroyuki Matsuda

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 17, 2023

COVID-19, caused by the novel coronavirus (SARS-CoV-2), is an emerging infectious disease (EID) with a relatively high infectivity and mortality rate. During state of emergency announced Japanese government in spring 2020, citizens were requested to stay home, number infected people was drastically reduced without legally-binding lockdown. It well-acknowledged that there trade-off between maintaining economic activity preventing spread diseases. We aimed reduce total loss epidemic EID like COVID-19 present study. focused on early late stages proposed framework resulted from damage infection cost for countermeasure. Mathematical models used estimate effect interventions deaths infection. The converted into monetary base different policies compared. In stage, we calculated when behavioral restrictions implemented. favorable intensity intervention depended basic reproduction number, fatality rate, impact. indicators showed it ratio maintain hospitalization system per which strategies should be adopted.

Language: Английский

Citations

0
Age-stratified seroprevalence of antibodies against SARS-CoV-2 in the pre- and post-vaccination era, February 2020–March 2022, Japan DOI Creative Commons
Seiya Yamayoshi, Kiyoko Iwatsuki‐Horimoto,

Moe Okuda

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 12, 2022

Abstract Japan has reported a small number of COVID-19 cases relative to other countries. Because not all infected people receive diagnostic tests for COVID-19, the must be lower than actual infections. Assessments presence antibodies against spike protein SARS-CoV-2 can retrospectively determine history natural infection and vaccination. In this study, we assessed seroprevalence by analyzing over 60,000 samples collected in from February 2020 March 2022. The results showed that about 5% Japanese population had been with virus January 2021. increased administration vaccinations adults; however, among elderly, it was as high vaccination rate, probably due poor immune responses vaccines waning immunity. spread during epidemic waves caused Delta Omicron variants children who were eligible Nevertheless, their low 10% Our study underscores incidence effects on immunity at level.

Language: Английский

Citations

0