Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project

Journal of Epidemiology and Global Health, Journal Year: 2023, Volume and Issue: 13(3), P. 577 - 588

Published: July 22, 2023

SARS-CoV-2 breakthrough infections (BI) after vaccine booster dose are a relevant public health issue.Multicentric longitudinal cohort study within the ORCHESTRA project, involving 63,516 workers (HW) from 14 European settings. The investigated cumulative incidence of BI and its correlation with age, sex, job title, previous infection, time since third dose.13,093 (20.6%) were observed. was higher in women HW aged < 50 years, but nearly halved 60 years. Nurses experienced highest incidence, administrative staff lowest. immunosuppressed (28.6%) vs others (24.9%). When controlling for gender, title infection before booster, heterologous vaccination reduced respect to BNT162b2 mRNA [Odds Ratio (OR) 0.69, 95% CI 0.63-0.76]. Previous protected against asymptomatic [Relative Risk (RRR) recent no 0.53, 0.23-1.20] even more symptomatic [RRR 0.11, 0.05-0.25]. Symptomatic increased 70.5% receiving 64 days 86.2% when elapsed > 130 days.The risk is significantly by vaccination, older ages. Immunosuppression incidence. Time affects severity, confirming usefulness booster. Further research should focus on trend 4th relationship variables across epidemics.

Language: Английский

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Opportunities and challenges to implementing mRNA-based vaccines and medicines: lessons from COVID-19

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 8, 2024

The messenger RNA (mRNA) platform emerged at the forefront of vaccine development during COVID-19 pandemic, with two mRNA vaccines being among first authorized globally. These were developed rapidly. Informed by decades laboratory research, and proved to be safe efficacious tools for mitigating global impact pandemic. holds promise a broader medical application beyond COVID-19. Herein, we provide an overview this describe lessons learned from pandemic help formulate strategies toward enhancing uptake future mRNA-based interventions. We identify several as vital acceptance expanding array therapeutics, including education, accurate transparent information sharing, targeted engagement campaigns, continued investment in safety surveillance, inclusion diverse participant pools clinical trials, addressing deep-rooted inequalities access healthcare. present findings Global Listening Project (GLP) initiative, which draws on quantitative qualitative approaches capture perceptions experiences design concrete action plans improving societal preparedness emergencies. GLP survey (&gt;70,000 respondents 70 countries) revealed tremendous disparities across countries sociodemographic groups regarding willingness accept novel medicines. comfort innovations medicines was generally low (35%) marginally lower women (33%). learnt actionable insights into designing effective enhance

Language: Английский

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Impact of the COVID-19 Pandemic on Attitudes toward Vaccination: Representative Study of Polish Society

Vaccines, Journal Year: 2023, Volume and Issue: 11(6), P. 1069 - 1069

Published: June 6, 2023

The study explored the association between individuals' attitudes toward vaccination and their actual behavior. We also examined impact of coronavirus disease 2019 (COVID-19) pandemic ongoing debate on changing towards vaccination, specifically within different demographic groups. survey was conducted among a representative sample Poles (N = 805) using computer-assisted web interview (CAWI) technology. As demonstrated, those who identified themselves as strong vaccine supporters were statistically significantly more frequently to be vaccinated with COVID-19 booster doses, follow physician's recommendation any without hesitation, strengthened in confidence vaccines during (p < 0.001 for all). However, over half responders declared moderate supporters/opponents, groups whose further are likely affected by (mis)communication. Importantly, than that weakened pandemic, while 43% not against COVID-19. In addition, demonstrated older better-educated individuals COVID-19-vaccinated p 0.013, respectively). results this imply that, order improve acceptance, it is essential strengthen public health communication avoid errors pandemic.

Language: Английский

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I want to be safe: understanding the main drivers behind vaccination choice throughout the pandemic

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 22, 2024

Abstract Background Despite being a major advancement in modern medicine, vaccines face widespread hesitancy and refusal, posing challenges to immunization campaigns. The COVID-19 pandemic accentuated vaccine hesitancy, emphasizing the pivotal role of beliefs efficacy safety on acceptance rates. This study explores influence perceptions uptake Italy during pandemic. Methods We administered 70-item questionnaire representative sample 600 Italian speakers. Participants were tasked with assessing perceived effectiveness each dose, along providing reasons influencing their vaccination choices. Additionally, we conducted an experimental manipulation, exploring effects four framing messages that emphasized and/or participants’ willingness receive hypothetical fourth dose. Furthermore, participants asked about level trust scientific community public authorities, as well use different information channels for obtaining COVID-19-related information. Results Our reveals dynamic shift throughout pandemic, potentially compliance. Initially more effective than safe, this assessment reversed by time third Beliefs regarding safety, rather efficacy, played significant anticipating future vaccinations (e.g., booster dose). Safety-focused positively affected intent, while efficacy-focused showed limited impact. also observed changing trend vaccination, decline infection-related increase social related ones. dynamics evolved differently authorities community. Conclusions Vaccine perception is process shaped evolving factors like perceptions, levels, individual motivations. sheds light complex underlie impact vaccinate. discuss these results bounded rationality, loss aversion classic utility theory.

Language: Английский

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Oportunidades y desafíos en la implementación de la vacunación contra COVID-19: una revisión sistemática

Atención Primaria, Journal Year: 2024, Volume and Issue: 56(10), P. 103047 - 103047

Published: July 17, 2024

Language: Английский

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The impact of COVID-19 booster vaccination in the current pregnancy during the Omicron waves on maternal and perinatal outcomes: a multicentre observational study

Italian Journal of Gynaecology and Obstetrics, Journal Year: 2023, Volume and Issue: 35(04), P. 550 - 550

Published: Feb. 14, 2023

Objective.The aim of this study is to investigate the impact COVID-19 booster vaccination received during current pregnancy on maternal and perinatal outcomes. Material Methods.This was an observational multicenter study.Pregnant women who gave birth while infected by SARS CoV2 Omicron waves were included.Patients divided into 2 groups: "booster vaccination" group included pregnant had completed additional dose vaccine pregnancy; "non-booster primary without shots.Data about obstetrical neonatal outcomes in both groups compared.Results.In total, 59 patients included: 41 shots pregnancy, 18 did not.Asymptomatic forms seen 58.5% versus 16.6% "non-boosted with p = 0.003.The need for cesarean delivery reduced from 72.2% 41.4% 0.028.The length hospitalization 4.67 ± 4 days 1.98 0.93 0.001.The allowed rates prematurity 0.011 intensive care admissions 0.007. Conclusions.The seems be beneficial waves.It improved outcomes.So, could advised get a when they pregnant.

Language: Английский

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Humoral Response and Tolerance of Vaccination against SARS-CoV-2 in Adults Senegalese Patients Undergoing Hemodialysis: A Multicenter Prospective Study

Open Journal of Nephrology, Journal Year: 2024, Volume and Issue: 14(01), P. 70 - 80

Published: Jan. 1, 2024

Introduction: Following the COVID-19 pandemic, vaccination has been proposed in several countries as main preventive measure despite very limited data, particularly dialysis patients. We conducted this study to assess immunological response Senegalese hemodialysis Patients and Methods: a prospective study, two centers Dakar from March 30th August 30th, 2021 including patients on for >6 months, vaccinated against SARS-CoV-2 according schedule recommended by WHO. A vaccine was considered positive when seroconversion observed after one dose of vaccine. The clinical efficacy immunization defined absence new infection who received complete vaccination. Results: Among 81 included 7.4% had anti-Spike IgM antibodies before their first Seroprevalence 38.3% month (at M1) 8.6% second M4). Anti-Spike IgG were present 40.3% vaccination, 90.1% at M1, 59.7% M4. previously infected with SARS-CoV-2, 10.2% M0, 31.6% 10.5% M4 post-vaccination. Similarly, seroprevalences subgroup 31.5%, 61.3%, 50.0% respectively comparison rates between M0 showed significant differences only naive Mean duration existence previous associated patients’ vaccinal doses. Age, gender use immunosuppressive treatment did not influence post-vaccinal antibody production. Conclusion: Vaccination induced low rate but it well tolerated. Moreover, protection neither strong nor durable, longer dialysis.

Language: Английский

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Safety monitoring of precautionary third dose of COVID-19 vaccines in a district in Northern India

Journal of Family Medicine and Primary Care, Journal Year: 2024, Volume and Issue: 13(5), P. 1875 - 1880

Published: May 1, 2024

A BSTRACT Background: The World Health Organization (WHO) declared Coronavirus disease-19 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) a pandemic on March 11, 2020. On 16 th January 2021, India began its vaccination programme using two COVID-19 vaccines (Covishield and Covaxin). Precautionary dose (booster shots) was administered to health front-line workers in the beginning then all eligible populations. Material Methods: This descriptive observational study conducted centres of Karnal district ADR monitoring centre, KCGMC, Karnal. During visits centres, beneficiaries precautionary third as well healthcare were sensitized report case any adverse event following part policy run government Pharmacovigilance Programme India. data collected suspected drug reaction (ADR) reporting form version 1.4, causality assessment done per WHO–UMC scale. analysed simple proportions percentages. Results: booster 72,853 individuals, while 1 st 2 nd given 13,30,042 10,73,050, respectively. Only three ADRs reported with 34 district. These classified unlikely hence not included analysis. Conclusion: for prevention has been found be reasonably safe. population who received doses significantly less than populations first second doses, which suggests low acceptance rate.

Language: Английский

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Vaccination with Tozimameran Induces T-Cell Activation, but Not Senescent or Exhaustive Alterations, in Kidney Transplant Recipients

Vaccines, Journal Year: 2024, Volume and Issue: 12(8), P. 877 - 877

Published: Aug. 2, 2024

Multiple vaccinations have potential inimical effects on the immune system aging process. We examined whether response to SARS-CoV-2 vaccination with Tozinameran is associated immunosenescence and immunoexhaustion in kidney transplant recipients (KTRs).

Language: Английский

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I Want To Be Safe: Understanding The Main Drivers Behind Vaccination Choice Throughout The Pandemic

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Background Vaccines are one of the most significant achievements modern medicine. However, vaccine hesitancy and refusal widespread can hamper immunization campaigns. During COVID-19 pandemic, became particularly evident. Beliefs regarding efficacy safety prominent in shaping acceptance rates. This study investigated impact perception on uptake Italy throughout pandemic.Methods We used a 70-item questionnaire distributed to representative sample 600 Italian speakers. The participants were asked rate how effective/safe they perceived each dose their willingness receive potential fourth dose.Results Our findings show that changed during possibly vaccination compliance. If at time first was deemed as more effective than safe, third assessment reversed. Moreover, future vaccination, role beliefs is negligible, whereas appears still significant. results our experimental manipulation (framing effect) highlighted framing vaccine-related information terms much it boosting vaccinate. we retraced diachronic evolution reasons behind choice. detected decrease infection-related corresponding increase social-related ones. Lastly, reported different trust attribution relative public authorities scientific community.Conclusions vaccines constantly evolving process, influenced by various dynamic factors such safety, levels trust, individual motivations. sheds light complex dynamics underlie efficacy, discuss these bounded rationality, loss aversion classic utility theory. traces pandemic history examining beliefs, opinions, population.

Language: Английский

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