Fiber-Type Shifting in Sarcopenia of Old Age: Proteomic Profiling of the Contractile Apparatus of Skeletal Muscles

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2415 - 2415

Published: Jan. 26, 2023

The progressive loss of skeletal muscle mass and concomitant reduction in contractile strength plays a central role frailty syndrome. Age-related neuronal impairments are closely associated with sarcopenia the elderly, which is characterized by severe muscular atrophy that can considerably lessen overall quality life at old age. Mass-spectrometry-based proteomic surveys senescent human muscles, as well animal models sarcopenia, have decisively improved our understanding molecular cellular consequences fiber-type shifting during aging. This review outlines spectrometric identification proteome-wide changes atrophying focus on proteins potential markers distribution patterns. observed trend fast-to-slow transitions individual muscles aging process most likely linked to preferential susceptibility fast-twitching fibers atrophy. Studies models, including mostly aged rodent confirmed shifting. analysis fast versus slow isoforms key proteins, such myosin heavy chains, light actins, troponins tropomyosins, suggests them suitable bioanalytical tools

Language: Английский

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Diet for the prevention and management of sarcopenia

Metabolism, Journal Year: 2023, Volume and Issue: 146, P. 155637 - 155637

Published: June 21, 2023

Sarcopenia is a geriatric condition characterized by progressive loss of skeletal muscle mass and strength, with an increased risk adverse health outcomes (e.g., falls, disability, institutionalization, reduced quality life, mortality). Pharmacological remedies are currently unavailable for preventing the development sarcopenia, halting its progression, or impeding negative outcomes. The most effective strategies to contrast sarcopenia rely on adoption healthier lifestyle behaviors, including adherence high-quality diets regular physical activity. In this review, role nutrition in prevention management summarized. Special attention given current "blockbuster" dietary regimes agents used counteract age-related wasting, together their putative mechanisms action. Issues related design implementation nutritional discussed, focus unanswered questions appropriate timing interventions preserve function into old age. A brief description also provided new technologies that can facilitate personalized plans sarcopenia.

Language: Английский

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Consumer attitudes and behaviors toward more sustainable diets: a scoping review

Nutrition Reviews, Journal Year: 2023, Volume and Issue: 81(12), P. 1665 - 1679

Published: April 4, 2023

Abstract There is an urgent need to move toward more sustainable diets. Although this will require radical and systemic changes across food systems, altering consumer ideologies practices essential garner support for such actions. In scoping review, the evidence on consumers’ attitudes behaviors diets synthesized a range of factors, considerations, proposed strategies are presented that can contribute building societal-level systems-level changes. The findings suggest consumers, insofar as they interested in sustainability have capacity engage with concept, primarily approach concept diet from human health perspective. However, interconnectedness well-being environmental poorly understood under-researched context This highlights (1) sustained efforts public professionals encourage realignment term its multidimensional meaning by championing ecological all aimed at promoting consumption, awareness raising policy development; (2) broader research lens focused literature exploring behaviors; (3) development multidisciplinary, clear, evidence-based sustainable-eating messages, including holistic dietary guidance, address knowledge gaps, minimize conflicting narratives, build agency. understanding how be generated necessary structural system-level required behavior change.

Language: Английский

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Improving sarcopenia in older adults: a systematic review and meta-analysis of randomized controlled trials of whey protein supplementation with or without resistance training

The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(4), P. 100184 - 100184

Published: Feb. 12, 2024

The aim of the study was to comprehensively analyze effects whey protein (WP)-enriched supplement intake with or without resistance training (RT) in older patients, either from community hospital, who were diagnosed sarcopenia according EWGSOP AWGS criteria.

Language: Английский

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Effect of Plant Versus Animal Protein on Muscle Mass, Strength, Physical Performance, and Sarcopenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Dietary protein is recommended for sarcopenia-a debilitating condition of age-related loss muscle mass and strength that affects 27% older adults. The effects on health may depend quality. aim was to synthesize randomized controlled trial (RCT) data comparing plant with animal health. Forty-three eligible RCTs were sourced from Medline, Embase, Scopus, Web Science, CENTRAL databases. Four reviewers (R.J.R.-M., S.F.B., N.A.W., D.L.) extracted (study setting, population, intervention characteristics, outcomes, summary statistics) conducted quality assessment using the Cochrane Risk Bias 2.0. Standardized mean differences (SMDs) (95% CIs) combined a random-effects meta-analysis forest plots generated. I2 statistics calculated test statistical heterogeneity. Thirty (70%) all examined outcomes. Compared protein, resulted in lower following (SMD = -0.20; 95% CI: -0.37, -0.03; P .02), stronger younger (<60 years; SMD .02) than (≥60 -0.05; -0.32, 0.23; .74) There no pooled effect difference between soy milk -0.02; -0.20, 0.16; .80) (n 17 RCTs), yet improved compared non-soy proteins (rice, chia, oat, potato; -0.58; -1.06, -0.09; 5 RCTs) plant-based diets -0.51; -0.91, -0.11; .01) 7 RCTs). No significant found or 14 physical performance trials sarcopenia as an outcome. Animal have small beneficial over mass; however, research into wider range needed. PROSPERO registration no. CRD42020188658.

Language: Английский

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Sarcopenia, sarcopenic obesity and nonalcoholic fatty liver disease

Metabolism, Journal Year: 2023, Volume and Issue: 147, P. 155676 - 155676

Published: Aug. 4, 2023

Language: Английский

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Age-Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of Sarcopenia

Cells, Journal Year: 2023, Volume and Issue: 12(2), P. 249 - 249

Published: Jan. 7, 2023

Sarcopenia is a debilitating skeletal muscle disease that accelerates in the last decades of life and characterized by marked deficits strength, mass, quality, metabolic health. The multifactorial causes sarcopenia have proven difficult to treat involve complex interplay between environmental factors intrinsic age-associated changes. It generally accepted results progressive loss function exceeds indicating while mass important, quality primary defect with advanced age. Furthermore, preclinical models suggested aged exhibits defects cellular control such as degradation damaged mitochondria. Recent evidence suggests dysregulation proteostasis, an important regulator control, significant contributor aging-associated declines function, mass. Although mammalian target rapamycin 1 (mTORC1) plays critical role including hypertrophy, paradoxically, sustained activation mTORC1 recapitulates several characteristics sarcopenia. Pharmaceutical inhibition well caloric restriction significantly improves animals, however, mechanisms controlling proteostasis are not fully known. This information for developing effective therapeutic strategies mitigate or prevent associated disability. review identifies recent historical understanding molecular driving potential interventions slow

Language: Английский

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Association between oxidative balance score and sarcopenia in older adults

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 4, 2024

Abstract Sarcopenia is a progressive skeletal muscle disease in which oxidative stress has been proposed as one of the primary markers. The balance score (OBS) represents person's dietary pattern using merged intake anti-oxidants and pro-oxidants. Therefore, present study assessed association between OBS sarcopenia Iranian older adults. In current study, 80 people with without it were considered case control groups, respectively. All controls matched by sex cases. To confirm sarcopenia, mass index (SMI), handgrip strength (HGS) measurement, gait speed used. Also, body composition was measured bioelectrical impedance analysis (BIA). A valid reliable food frequency questionnaire (FFQ) used to assess all participants' pro-oxidants anti-oxidants. Conditional logistic regression applied sarcopenia. bivariate model, we observed lower odds second last tertile comparison first (T) (T 2 – ratio (OR) = 0.414, 95% confidence interval (CI) : 0.186–0.918 T 3 OR 0.101, CI: 0.041–0.248). After adjusting for potential confounders, not significant comparision one. study's findings demonstrated that overcoming exposure over pro-oxidants, illustrated higher OBS, related

Language: Английский

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Egg Consumption and Mortality: A Prospective Cohort Study of Australian Community-Dwelling Older Adults

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 323 - 323

Published: Jan. 17, 2025

Egg consumption in adults has been linked with a modestly increased risk of all-cause and CVD mortality. However, evidence on aged 65 y+ is limited. The objective this study was to investigate the association between egg intake mortality community-dwelling older adults. In prospective cohort study, 8756 70+ years, participants ASPirin Reducing Events Elderly (ASPREE) Longitudinal Study Older Persons, self-reported frequency their total intake: never/infrequently (rarely/never, 1-2 times/month), weekly (1-6 times/week), daily (daily/several times per day). All-cause cause-specific (cardiovascular disease [CVD] cancer) established from at least two sources: medical records, death notices, next kin, or registry linkage. assessed using Cox proportional hazards regression analysis, adjusted for socio-demographic, health-related, clinical factors overall dietary quality. Over median 5.9-year follow-up period, 1034 deaths (11.8%) were documented. A 29% lower (HR (95% CI): 0.71 [0.54-0.92]) 17% 0.83 [0.71-0.96]) observed among those who consumed eggs weekly, compared never/infrequently; no statistically significant cancer contrast, that never infrequently eggs, had slightly higher odds mortality, though these results did not reach statistical significance. 1-6 week associated 70 years over. These findings may be important inform development evidence-based guidelines consumption.

Language: Английский

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Eiwitbeperkt dieet bij geriatrische CNI-patiënten: de opinie van geriaters en nefrologen

Tijdschrift voor Geneeskunde, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Low protein diet in geriatric CKD-patients and sarcopenia: current opinion among geriatricians nephrologists Introduction: One of the possible strategies to slow progression chronic kidney disease (CKD) is a low (LPD). Protein supplementation on other hand indicated prevent sarcopenia, common comorbidity CKD. The guidelines suggest higher intake patients with CKD stage 3-5 than nephrology guidelines. effects LPD sarcopenia are unclear. This study explores willingness prescribe about this population geriatricians. Method: A survey was conducted Antwerp. Prescribing behavior compared between them again after raising awareness subject. Results: 32 28 were included. Among 55.6% not willing 33.3% rather LPD. nephrologists, 57.7% 42.3%, respectively (p=0.506). Raising only resulted significant decrease number who concerned (60.0% versus 86.2%, p<0.001). Otherwise, no differences seen within specialties. Kidney function taken into account when prescribing supplements by Discussion conclusion: Both seem equally reluctant 3-5. Consensus optimal reached seems fall their

Language: Английский

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