Aging Clinical and Experimental Research,
Journal Year:
2023,
Volume and Issue:
35(12), P. 3073 - 3083
Published: Nov. 9, 2023
Abstract
Background
Glucocorticoids
play
a
significant
role
in
metabolic
processes
and
pathways
that
impact
muscle
size,
mass,
function.
The
expression
of
11-beta-hydroxysteroid
dehydrogenase
type
1
(HSD11B1)
has
been
previously
described
as
major
regulator
skeletal
function
glucocorticoid-induced
atrophy
aging
humans.
Our
study
aimed
to
investigate
glucocorticoid
metabolism,
including
the
HSD11B1
muscle,
patients
with
sarcopenia.
Methods
Muscle
biopsies
were
taken
from
vastus
lateralis
thirty-three
over
60
years
age
hip
fractures.
Sarcopenia
status
was
assessed
according
criteria
European
Working
Group
on
Older
People
2.
Skeletal
mass
measured
by
bioelectrical
impedance
analysis.
Cortisol
cortisone
concentrations
serum.
Gene
analysis
HSD11B1,
NR3C1
,
FBXO32,
TRIM63
performed.
Serial
cross
sections
labeled
myosin
heavy
chain
slow
(fiber
type-1)
fast
type-2)
antibodies.
Results
included
33
(21
women)
mean
82.5
±
6.3
years,
17
revealed
sarcopenic
(
n
=
16
non-sarcopenic).
Serum
negatively
correlated
ß
−
0.425;
p
0.034)
type-2
fiber
diameter
0.591;
0.003).
0.673;
0.008)
showed
negative
correlation
group.
A
found
for
non-sarcopenic
group
0.548;
0.028)
mass.
Conclusion
These
findings
suggest
pathogenetic
muscle.
Clinical Science,
Journal Year:
2023,
Volume and Issue:
137(22), P. 1721 - 1751
Published: Nov. 1, 2023
Abstract
Ageing
is
a
complex
biological
process
associated
with
increased
morbidity
and
mortality.
Nine
classic,
interdependent
hallmarks
of
ageing
have
been
proposed
involving
genetic
biochemical
pathways
that
collectively
influence
trajectories
susceptibility
to
pathology
in
humans.
skeletal
muscle
undergoes
profound
morphological
physiological
changes
loss
strength,
mass,
function,
condition
known
as
sarcopenia.
The
aetiology
sarcopenia
whilst
research
this
area
growing
rapidly,
there
relative
paucity
human
studies,
particularly
older
women.
Here,
we
evaluate
how
the
nine
classic
ageing:
genomic
instability,
telomere
attrition,
epigenetic
alterations,
proteostasis,
deregulated
nutrient
sensing,
mitochondrial
dysfunction,
cellular
senescence,
stem
cell
exhaustion,
altered
intercellular
communication
contribute
pathophysiology
We
also
highlight
five
novel
particular
significance
inflammation,
neural
extracellular
matrix
reduced
vascular
perfusion,
ionic
dyshomeostasis,
discuss
are
interconnected.
Their
clinical
relevance
translational
potential
considered.
Aging,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 19, 2024
Aging
|
doi:10.18632/aging.205751.
Michael
D.
Roberts,
Bradley
A.
Ruple,
Joshua
S.
Godwin,
Mason
C.
McIntosh,
Shao-Yung
Chen,
Nicholas
J.
Kontos,
Anthony
Agyin-Birikorang,
Max
Michel,
Daniel
L.
Plotkin,
Madison
Mattingly,
Brooks
Mobley,
Tim
N.
Ziegenfuss,
Andrew
Fruge,
Andreas
Kavazis
Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
134(16)
Published: June 11, 2024
Our
study
was
to
characterize
sarcopenia
in
C57BL/6J
mice
using
a
clinically
relevant
definition
investigate
the
underlying
molecular
mechanisms.
Aged
male
(23-32
months
old)
and
female
(27-28
were
classified
as
non-,
probable-,
or
sarcopenic
based
on
assessments
of
grip
strength,
muscle
mass,
treadmill
running
time,
2
SDs
below
mean
their
young
counterparts
cutoff
points.
A
9%-22%
prevalence
identified
23-26
month-old
mice,
with
more
severe
age-related
declines
function
than
mass.
Females
aged
27-28
showed
fewer
but
probable
cases
compared
males.
As
progressed,
decrease
contractility
trend
toward
lower
type
IIB
fiber
size
observed
Mitochondrial
biogenesis,
oxidative
capacity,
AMPK-autophagy
signaling
decreased
progressed
males,
pathways
linked
mitochondrial
metabolism
positively
correlated
No
age-
sarcopenia-related
changes
OXPHOS
complexes,
AMPK
signaling,
mitophagy,
atrogenes
females.
results
highlight
different
trajectories
mass
function,
providing
insights
into
sex-dependent
associated
progression,
which
may
inform
future
development
novel
therapeutic
interventions.
Free Radical Biology and Medicine,
Journal Year:
2024,
Volume and Issue:
213, P. 409 - 425
Published: Jan. 29, 2024
Skeletal
muscle
is
a
heterogeneous
tissue
composed
of
different
types
fibers,
demonstrating
substantial
plasticity.
Physiological
or
pathological
stimuli
can
induce
transitions
in
fiber
types.
However,
the
precise
regulatory
mechanisms
behind
these
remains
unclear.
This
paper
reviews
classification
and
characteristics
along
with
classical
type
transitions.
Additionally,
role
exercise-induced
disease
intervention
reviewed.
Epigenetic
pathways
mediate
cellular
adaptations
thus
represent
potential
targets
for
regulating
focuses
on
by
which
epigenetic
modifications
couple
mitochondrial
function
contraction
characteristics.
Reactive
Oxygen
Species
(ROS)
are
critical
signaling
regulators
health-promoting
effects
exercise.
Finally,
we
discuss
ROS
transition
Autophagy,
Journal Year:
2024,
Volume and Issue:
20(10), P. 2121 - 2132
Published: July 15, 2024
Skeletal
muscle
plays
a
crucial
role
in
generating
force
to
facilitate
movement.
is
heterogenous
tissue
composed
of
diverse
fibers
with
distinct
contractile
and
metabolic
profiles.
The
intricate
classification
skeletal
exists
on
continuum
ranging
from
type
I
(slow-twitch,
oxidative)
II
(fast-twitch,
glycolytic).
distribution
characteristics
within
between
muscles
profoundly
influences
cellular
signaling;
however,
this
has
not
been
broadly
discussed
as
it
relates
macroautophagy/autophagy.
growing
interest
autophagy
research
underscores
the
necessity
comprehending
interplay
autophagic
responses
among
different
properties,
profiles,
other
related
signaling
processes.
We
recommend
approaching
interpretation
findings
careful
consideration
for
two
key
reasons:
1)
behaviors
or
various
perturbations,
2)
potential
impact
alterations
fiber
profile
observed
outcomes.
This
review
provides
an
overview
response
muscles/fibers
types
Further,
discusses
conditions
diseases
that
may
differentially
affect
muscle.
Finally,
we
provide
points
better
enable
researchers
fine-tune
design
experiments.
European Journal of Translational Myology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 2, 2024
During
the
2023
Padua
Days
on
Muscle
and
Mobility
Medicine
2024
meeting
was
scheduled
from
28
February
to
2
March
(2024Pdm3).
autumn
program
expanded
with
Scientific
Sessions
which
will
take
place
over
five
days
(in
this
includes
29),
starting
afternoon
of
27
in
Conference
Rooms
Hotel
Petrarca,
Thermae
Euganean
Hills
(Padua),
Italy.
As
per
consolidated
tradition,
second
day
Padua,
for
occasion
Sala
San
Luca
Monastery
Santa
Giustina
Prato
della
Valle,
Confirming
attractiveness
Medicine,
100
titles
were
accepted
until
15
December
(many
more
than
expected),
forcing
organization
parallel
sessions
both
1
2024.
The
include
lectures
oral
presentations
scientists
clinicians
Argentina,
Austria,
Belgium,
Brazil,
Bulgaria,
Canada,
Denmark,
Egypt,
France,
Germany,
Iceland,
Ireland,
Italy,
Romania,
Russia,
Slovenia,
Switzerland,
UK
USA.
Only
Australia,
China,
India
Japan
are
missing
edition.
But
we
confident
that
authors
those
countries
who
publish
articles
PAGEpress:
European
Journal
Translational
Myology
(EJTM:
2022
ESCI
Clarivate's
Impact
Factor:
2.2;
SCOPUS
Cite
Score:
3.2)
decide
join
us
coming
years.
Together
established
by
31
January
2024,
abstracts
circulate
during
only
electronic
version
EJTM
Issue
34
(1)
See
you
soon
person
at
Petrarca
Montegrotto
Terme,
inauguration
or
on-line
free
via
Zoom.
Send
your
email
address
if
not
traditional
participants
listed
Pdm3
books.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
Sarcopenia,
or
age-related
muscle
dysfunction,
contributes
to
morbidity
and
mortality.
Besides
decreases
in
force,
sarcopenia
is
associated
with
atrophy
fast-to-slow
fiber
type
switching,
which
typically
secondary
denervation
humans
rodents.
However,
very
little
known
about
cellular
changes
preceding
these
important
(mal)adaptations.
To
this
matter,
mitochondria
the
sarcoplasmic
reticulum
are
critical
for
tension
generation
myofibers.
They
physically
interact
at
boundaries
of
sarcomeres
forming
subcellular
hubs
called
mitochondria-endo/sarcoplasmic
contacts
(MERCs).
Yet,
whether
MERCs
ultrastructure
proteome
occur
early
aging
unknown.
Here,
studying
young
adult
older
mice
we
reveal
that
slows
relaxation
leading
longer
excitation-contraction-relaxation
(ECR)
cycles
before
maximal
force
switching
takes
place.
We
MERC
mitochondria-associated
ER
membrane
(MAM)
protein
composition
also
affected
closely
rate
relaxation.
Additionally,
demonstrate
regular
exercise
preserves
aging.
Finally,
profile
a
set
MAM
proteins
involved
energy
metabolism,
quality
control,
Ca
2+
homeostasis,
cytoskeleton
integrity
redox
balance
inversely
regulated
by
exercise.
These
may
represent
new
targets
preserve
function
individuals.
The FASEB Journal,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Jan. 20, 2025
Abstract
Skeletal
muscle
function
gradually
declines
with
aging,
presenting
substantial
health
and
societal
challenges.
Comparative
analysis
of
how
aging
affects
fast‐
slow‐twitch
muscles
remains
lacking.
We
utilized
20‐month‐old
mice
to
reveal
the
effects
on
structure
fiber
composition,
followed
by
bulk
RNA
sequencing
for
integration
human
single‐cell
dataset
providing
a
comparative
across
species.
In
mouse
muscles,
induced
switch
from
fast
slow
fibers
distinctively
altered
lipid
metabolism
in
ceramide
triglyceride,
upregulation
regulatory
genes
Gk
Ppargc1a
also
observed
fibers.
Additionally,
both
types
exhibited
common
collagen
deposition
fibrosis,
possibly
due
imbalance
between
synthesis
degradation.
The
extracellular
matrix
gene
changes
substantially
overlapped
humans
yet
highlighted
clear
differences.
This
integrative
provides
further
understanding
aged
offers
new
insights
into
molecular
aging.
