Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases

Toxins, Journal Year: 2023, Volume and Issue: 15(3), P. 233 - 233

Published: March 21, 2023

Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, terrestrial ecosystems. The health significance these metabolites, which include genotoxic- neurotoxic agents, is confirmed by continued associations between the occurrence animal human acute toxic events and, long term, cyanobacteria neurodegenerative diseases. Major mechanisms related to neurotoxicity compounds (1) blocking key proteins channels; (2) inhibition essential enzymes mammalian cells such as protein phosphatases phosphoprotein well new molecular targets toll-like receptors 4 8. One widely discussed implicated includes misincorporation cyanobacterial non-proteogenic amino acids. Recent research provides evidence that non-proteinogenic acid BMAA produced have multiple effects on translation process bypasses proof-reading ability aminoacyl-tRNA-synthetase. Aberrant generated non-canonical may be factor neuronal death neurodegeneration. We hypothesize production acids more general mechanism, leading mistranslation, affecting homeostasis, targeting mitochondria eukaryotic cells. It can evolutionarily ancient initially developed control phytoplankton communities during algal blooms. Outcompeting gut symbiotic microorganisms lead dysbiosis, increased permeability, shift blood-brain-barrier functionality, eventually, mitochondrial dysfunction high-energy demanding neurons. A better understanding interaction metabolism nervous system will crucial target or prevent

Language: Английский

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Comparative genomic analysis and functional investigations for MCs catabolism mechanisms and evolutionary dynamics of MCs-degrading bacteria in ecology

Environmental Research, Journal Year: 2024, Volume and Issue: 248, P. 118336 - 118336

Published: Jan. 29, 2024

Language: Английский

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Dynamic characteristics of total and microcystin-producing Microcystis in a large deep reservoir

Environmental Pollution, Journal Year: 2023, Volume and Issue: 335, P. 122256 - 122256

Published: July 26, 2023

Language: Английский

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Innovative approaches for Microcystin removal: Bacterioplankton biodegradation and multi-soil-layering system performance assessment

Journal of Cleaner Production, Journal Year: 2024, Volume and Issue: 452, P. 142187 - 142187

Published: April 15, 2024

Language: Английский

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A critical review of current research on Cyanobacterial cells and associated toxins in aquatic environments: occurrence, impact, and treatment methods

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(5), P. 113931 - 113931

Published: Aug. 26, 2024

Language: Английский

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Impact of algicidal fungus Aspergillus welwitschiae GF6 on harmful bloom-forming cyanobacterium Microcystis aeruginosa: Growth and physiological responses

Chemosphere, Journal Year: 2025, Volume and Issue: 372, P. 144090 - 144090

Published: Jan. 13, 2025

Language: Английский

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Virus Infection of a Freshwater Cyanobacterium Contributes Significantly to the Release of Toxins Through Cell Lysis

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 486 - 486

Published: Feb. 22, 2025

Toxic algal-bloom-forming cyanobacteria are a persistent problem globally for many aquatic environments. Their occurrence is attributed to eutrophication and rising temperatures due climate change. The result of these blooms often the loss biodiversity, economic impacts on tourism fisheries, risks human animal health. Of emerging interest poorly understood interplay between viruses toxic species that form blooms. This because recent studies have suggested may exacerbate harmful effects by contributing release toxins into dissolved phase upon cell lysis. However, date, there no experimental evidence explicitly implicates in microcystin release. Here, we show experimentally virus infection toxin-producing, harmful, cyanobacterium Microcystis aeruginosa results 4-fold increase toxin microcystin-LR two days post-infection (dpi). We also concentrations remain high after culture discoloration host Collectively, our directly implicate as major contributors from emphasize importance taking account predictive models assessment water quality safety.

Language: Английский

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The first eco-assessment of phytoplankton assemblages associated with environmental conditions of different lakes in the Western Black Sea basin of Türkiye

Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

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Assessment of estrogenic potential from exudates of microcystin-producing and non-microcystin-producing Microcystis by metabolomics, machine learning and E-screen assay

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 470, P. 134170 - 134170

Published: April 9, 2024

Cyanobacterial blooms, often dominated by Microcystis aeruginosa, are capable of producing estrogenic effects. It is important to identify specific compounds produced cyanobacteria, though this can prove challenging owing the complexity exudate mixtures. In study, we used untargeted metabolomics compare components exudates from microcystin-producing and non-microcystin-producing M. aeruginosa strains that differed with respect their ability produce microcystins, across two growth phases. We identified 416 chemicals found similar components, mainly organoheterocyclic (20.2%), organic acids derivatives (17.3%), phenylpropanoids polyketides (12.7%), benzenoids (12.0%), lipids lipid-like molecules (11.5%), oxygen (10.1%). then predicted group using random forest machine learning. Six (daidzin, biochanin A, phenylethylamine, rhein, o-Cresol, arbutin) belonging (3), (2), compound (1) were tested exhibited potency based upon E-screen assay. This study confirmed both contain properties, a growing concern in cyanobacteria management.

Language: Английский

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MICROCYSTIN REMOVAL BY MICROBIAL COMMUNITIES FROM A COASTAL LAGOON: INFLUENCE OF ABIOTIC FACTORS, BACTERIOPLANKTON COMPOSITION AND ESTIMATED FUNCTIONS

Harmful Algae, Journal Year: 2024, Volume and Issue: 135, P. 102646 - 102646

Published: May 1, 2024

Language: Английский

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