Clinical Features, Radiological Findings, and Outcome in Patients with Symptomatic Mild (<50%) Carotid Stenosis: A MUSIC Study DOI Open Access
Daina Kashiwazaki, Kohei Chida, Kazumichi Yoshida

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 4, 2024

Abstract Background and Purpose Plaque composition, but not stenosis degree, may play a key role in the development of recurrent ischemic events patients with symptomatic, mild (<50%) carotid stenosis. This multi-center prospective cohort study was aimed to determine their clinical radiological features evaluate benefits endarterectomy (CEA) for them. Methods included 124 cerebrovascular or retinal ipsilateral Best medical therapy (BMT) administered all participants. CEA artery stenting (CAS) implemented at each institution’s discretion. Baseline 6-, 12-, 24-month follow-up data were collected. Primary endpoint stroke. Secondary endpoints any stroke, TIA, ocular symptoms, death, plaque progression requiring CEA/CAS. Multivariate Cox proportional hazard model used predictors endpoint. Results Of patients, 70 (56.5%) had history stroke 51 (43.5%) been treated antiplatelet agents. Mean degree 22.4±13.7%. composition categorized into fibrous 22 lipid-rich/necrotic core (LR/NC) 25, intraplaque hemorrhage (IPH) 69. BMT indicated 59 while performed 63. The incidence primary significantly higher group than (15.1% vs. 1.7%; HR, 0.18; 95%CI, 0.05–0.84; P=0.03). (HR, P=0.03) IPH 1.92; 1.26–4.28; P=0.04). results on secondary very similar. Conclusion highly predict subsequent events, whereas reduce these risk during 2-year Registration has registered University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) (UMIN000023635). Contributors SK, KO, UM, MS designed study. DK wrote an original draft. All authors recruited patients. DK, KC, KY, MM, SY, SM, MU, MS, SK analyzed imaging as members Central Judgement Committee contributed analysis. takes final responsibility submitted publication.

Language: Английский

Assessing the Relationship between Systemic Immune-Inflammation Index and Metabolic Syndrome in Children with Obesity DOI Open Access
Delia-Maria Nicoară,

Andrei-Ioan Munteanu,

Alexandra-Cristina Scutca

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8414 - 8414

Published: May 8, 2023

Childhood obesity represents a worldwide concern as many countries have reported an increase in its incidence, with possible cardiovascular long-term implications. The mechanism that links disease to is related low-grade inflammation. We designed this study investigate the diagnostic utility of inflammatory indices (NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte SII, systemic immune-inflammation index; SIRI, inflammation response index) obese children metabolic syndrome (MetS) and their relationship cardiometabolic risk biomarkers, such Homeostasis Model Assessment Insulin Resistance (HOMA-IR), triglyceride-to-high-density lipoprotein cholesterol (TG:HDL-C), non-high-density (non-HDL-C). A total 191 from one large Romanian reference center was included study. Patients were classified two groups according presence (MetS group) or absence (non-MetS syndrome. According our results, SII index proved value distinguishing MetS patients among (AUC = 0.843, sensitivity 0.83, specificity 0.63). Furthermore, positively associated biomarkers (HOMA-IR, p < 0.001; TG:HDL-C, 0.002; non-HDL-C, 0.021), highlighting role additional measure instability children.

Language: Английский

Citations

35
Blood Count-Derived Inflammatory Markers and Acute Complications of Ischemic Heart Disease in Elderly Women DOI Open Access
Ewelina A. Dziedzic, Jakub S. Gąsior, Agnieszka Tuzimek

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(4), P. 1369 - 1369

Published: Feb. 8, 2023

Coronary artery disease (CAD) in women occurs later than men. Underlying atherosclerosis, a chronic process of lipoprotein deposition arterial walls with prominent inflammatory component, is influenced by several risk factors. In women, commonly used markers are generally found to be related the occurrence acute coronary syndrome (ACS), as well development other diseases that influence CAD. New derived from total blood count-systemic response index (SII), systemic reaction (SIRI), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte (PLR), and neutrophil-lymphocyte (NLR)-were analyzed group 244 elderly, postmenopausal diagnosis ACS or stable SII, SIRI, MLR, NLR were significantly higher compared those CAD (p < 0.05 for all)-the highest values observed NSTEMI. MLR new markers, HDL, history MI turned out significant factors associated ACS. These results suggest representative count-derived may considered additional CVD suspected

Language: Английский

Citations

23
Advances in magnesium-based bioresorbable cardiovascular stents: Surface engineering and clinical prospects DOI Creative Commons
Ganesh Kumar, Subham Preetam, Arunima Pandey

et al.

Journal of Magnesium and Alloys, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Increased Epicardial Adipose Tissue (EAT), Left Coronary Artery Plaque Morphology, and Valvular Atherosclerosis as Risks Factors for Sudden Cardiac Death from a Forensic Perspective DOI Creative Commons
Timur Hogea, Bogdan Andrei Suciu, Adrian Dumitru Ivănescu

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(1), P. 142 - 142

Published: Jan. 1, 2023

Background: In sudden cardiac deaths (SCD), visceral adipose tissue has begun to manifest interest as a standalone cardiovascular risk factor. Studies have shown that epicardial can be seen viable marker of coronary atherosclerosis. This study aimed evaluate, from forensic perspective, the correlation between body mass index (BMI), heart weight, and valvular atherosclerosis, left ventricular morphology, thickness (EAT) in deaths, establishing an increased EAT novel Methods: is retrospective case–control descriptive included 80 were autopsied, 40 control cases who hanged themselves had unknown pathologies prior their death. all autopsies performed, was measured two regions artery, macro/microscopically quantified weight evaluated. Results: revealed higher age SCD group (58.82 ± 9.67 vs. 53.4 13.00; p = 0.03), well incidence females (p 0.03). terms artery characteristics, there values BMI 0.0009), < 0.0001), circumflex (LCx) anterior descending (LAD) 0.0001). multivariate analysis, high baseline value (OR: 4.05; 0.004), 5.47; 0.001), LCx 23.72; LAD 21.07; 0.001) strong independent predictors SCD. Moreover, over 55 years 2.53; 0.045), type Vb plaque 17.19; mild atherosclerosis 4.88; 0.002), moderate ventricle dilatation 16.71; 0.008) act Conclusions: The data this research BMI, LCx, highly predict Furthermore, above years, plaque, factors for

Language: Английский

Citations

15
Identification of novel hub gene and biological pathways associated with ferroptosis in In-Stent restenosis DOI
Shan Jin,

Meixia Zhang,

Lingli Xu

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149287 - 149287

Published: Jan. 1, 2025

Language: Английский

Citations

0
Intimal CD31-Positive Relative Surfaces Are Associated with Systemic Inflammatory Markers and Maturation of Arteriovenous Fistula in Dialysis Patients DOI Open Access

Réka Kaller,

Eliza Russu,

Emil Marian Arbănași

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(13), P. 4419 - 4419

Published: June 30, 2023

Background: Arteriovenous fistula dysfunction is a widely disputed subject in the scientific literature on end-stage kidney disease (ESKD). The main cause of mortality and morbidity these patients non-maturation or arteriovenous fistula. Despite many complications, native remains gold standard treatment requiring renal replacement. This study aims to discuss predictive role some systemic inflammatory biomarkers (NLR, PLR, SII, IL-6), intimal hyperplasia, neoangiogenesis (characterized by intimal-media CD31-positive relative surface) maturation failure. Methods: present was designed as an observational, analytical, prospective which included diagnosed with ESKD indications radio-cephalic (RCAVF). Demographic data, comorbidities, preoperative laboratory data histological/digital morphometry analysis results were processed. divided into two groups based their AVF status at 8 weeks: “Maturation” (Group 1) “Failed Maturation” 2). Results: There no difference demographic data. In terms second group had greater incidence heart failure (p = 0.03), diabetes 0.04), peripheral artery 0.002), obesity 0.01). Additionally, regarding findings, higher levels serum uric acid 0.0005), phosphates < 0.0001), creatinine 0.02), well lower total calcium 0.0002), monocytes 0.008), lymphocytes 0.0001). Moreover, all markers 0.001; p 0.0001; 0.006, 0.03) Ca-P product 0.0001) baseline values Group 2. Upon immunohistochemical analysis, density neoformed vessels, there surfaces 0.006) 0.001); NLR (r 0.323; PLR 0.381; SII 0.376; IL-6 0.611; 0.001) are significantly correlated vascular density, evidenced CD31. Conclusions: Heart failure, disease, obesity, diabetes, predictors failures.

Language: Английский

Citations

10
The role of inflammation biomarkers in carotid artery stenosis procedures DOI Creative Commons

Enrica Scalise,

Davide Costa, Sorana D. Bolboacă

et al.

Annals of Vascular Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

3
FGF-23 as a Biomarker for Carotid Plaque Vulnerability: A Systematic Review DOI Creative Commons

Joana Oliveira-Sousa,

Mariana Fragão-Marques,

Luís Duarte-Gamas

et al.

Medical Sciences, Journal Year: 2025, Volume and Issue: 13(1), P. 27 - 27

Published: March 10, 2025

Background/Objectives: Carotid artery disease is a condition affecting 3% of the general population which significantly contributes to development cerebrovascular events. Fibroblast Growth Factor-23 (FGF-23) hormone that has been linked atherosclerosis and increased cardiovascular risk, including stroke myocardial infarction. This review explores association FGF-23 with carotid progression in an endarterectomy clinical context. Methods: Based on Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA), search was performed relying MEDLINE, Scopus Web Science, identifying publications focused correlation between serum disease. Assessment study quality made using National Heart, Lung Blood Institute Study Quality Tool (NHLBI). Results: Three observational studies, comprising 1039 participants, were included. There considerable heterogeneity among populations from different studies. Elevated levels consistently associated unstable plaque features, intraplaque neovascularization, as identified through Superb Microvascular Imaging (SMI). Plasma inflammatory mediators, such Interleukin-6 (Il-6), Monocyte Chemoattractant Protein-1 (MCP-1), Osteoprotegerin (OPG), positively correlated disease, but their link plaques conflicting. None studies investigated complications following endarterectomy. Conclusions: potential biomarker vulnerability Despite promising findings, limitations small sample sizes lack longitudinal data suggest need larger more diverse improve risk stratification inform personalized treatment strategies atherosclerosis.

Language: Английский

Citations

0
Polytetrafluorethylene (PTFE) vs. Polyester (Dacron®) Grafts in Critical Limb Ischemia Salvage DOI Open Access

Eliza Russu,

Adrian Vasile Mureșan,

Adrian Dumitru Ivănescu

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(2), P. 1235 - 1235

Published: Jan. 10, 2023

Critical ischemia of the lower limbs refers to last stages peripheral arterial disease. It is characterized by resting discomfort or trophic disorders such as ulceration, skin necrosis, gangrene in limbs. corresponds Leriche-Fontaine (LF) III-IV and Rutherford 4-6. The purpose this study was observe patency postoperative complications patients who have had infra-inguinal surgical revascularization compare results based on kind graft utilized.

Language: Английский

Citations

9
Neutrophil-to-Lymphocyte Ratio as a Predictor of Short-Term Functional Outcomes in Acute Ischemic Stroke Patients DOI Open Access
Min-Su Kim,

Min Young Heo,

Hyo Jin Joo

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(2), P. 898 - 898

Published: Jan. 4, 2023

Background: Neutrophil-to-lymphocyte ratio (NLR), a systemic inflammatory biomarker, has been associated with poorer outcomes in acute ischemic stroke patients. The present study was designed to expand these findings by investigating the association between NLR and short-term functional Methods: This retrospective evaluated patients within 7 days after onset of stroke. Stroke severity on admission measured using National Institutes Health Scale (NIHSS). were assessed Berg Balance (BBS), Manual Function Test (MFT), Korean version modified Barthel Index (K-MBI), Mini-Mental State Examination (K-MMSE) 2 weeks onset. Rankin (mRS) at discharge. Results: included 201 patients, who grouped into three tertiles (<1.84, 1.84−2.71, >2.71) admission. A multivariate analysis showed that top tertile group (NLR > 2.71) had significantly higher risks unfavorable K-MBI (p = 0.010) K-MMSE 0.029) than bottom < 1.84). Based optimal cut-off values from receiver operating characteristic curve analysis, NIHSS scores 0.011) 0.002) 0.001). Conclusions: is

Language: Английский

Citations

8