Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(16), P. 10362 - 10362

Published: Aug. 19, 2022

The physio-affective phenome of Long COVID-19 is predicted by (a) immune-inflammatory biomarkers the acute infectious phase, including peak body temperature (PBT) and oxygen saturation (SpO2), (b) subsequent activation immune oxidative stress pathways during COVID. purpose this study was to delineate effects PBT SpO2 infection, as well increased neurotoxicity on physical, psychological, social environmental domains health-related quality life (HR-QoL) in people with We recruited 86 participants COVID 39 normal controls, assessed WHO-QoL-BREF (World Health Organization Quality Life Instrument-Abridged Version, Geneva, Switzerland) (comprising depression, anxiety fibromyalgia-fatigue rating scales) measured (NT, comprising serum interleukin (IL)-1β, IL-18 caspase-1, advanced oxidation protein products myeloperoxidase, calcium insulin resistance) found that 70.3% variance HR-QoL explained regression phenome, lowered NT, whilst 61.5% calcium, PBT, SpO2, female sex vaccination AstraZeneca Pfizer. were mediated NT yielding severity which largely affects HR-QoL. In conclusion, HR-Qol neuro-immune neuro-oxidative

Language: Английский

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Major neurocognitive psychosis: a novel schizophrenia endophenotype class that is based on machine learning and resembles Kraepelin’s and Bleuler’s conceptions

Acta Neuropsychiatrica, Journal Year: 2022, Volume and Issue: 35(3), P. 123 - 137

Published: Nov. 14, 2022

The purpose of this study is to describe how use the precision nomothetic psychiatry approach (a) delineate associations between schizophrenia symptom domains, including negative symptoms, psychosis, hostility, excitation, mannerism, formal thought disorders, psychomotor retardation (PHEMFP), and cognitive dysfunctions neuroimmunotoxic neuro-oxidative pathways (b) create a new endophenotype class based on these features. We show that all domains (negative PHEMFP) may be used derive single latent trait called overall severity (OSOS). In addition, neurocognitive test results extract general decline (G-CoDe) index, executive function, attention, semantic episodic memory, delayed recall scores. According partial least squares analysis, impacts adverse outcome (AOPs) OSOS are partially mediated by increasing G-CoDe severity. AOPs include neurotoxic cytokines chemokines, oxidative damage proteins lipids, IgA responses tryptophan catabolites, breakdown vascular paracellular with translocation Gram-negative bacteria, insufficient protection through lowered antioxidant levels impairments in innate immune system. Unsupervised machine learning identified class, named major psychosis (MNP), which characterised increased symptoms PHEMFP, above-mentioned AOPs. Based phenome features, MNP distinct qualitatively different from simple (SP). It impossible draw any valid conclusions research ignores SP distinctions.

Language: Английский

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Changes in Inflammatory Biomarkers in Patients with Schizophrenia: A 3-Year Retrospective Study

Neuropsychiatric Disease and Treatment, Journal Year: 2023, Volume and Issue: Volume 19, P. 1597 - 1604

Published: July 1, 2023

Accumulating evidence suggested that immune system activation might be involved in the pathophysiology of schizophrenia. The neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte (MLR), platelet/lymphocyte (PLR) and systemic immune-inflammation index (SII) can measure inflammation. This study aimed to investigate inflammatory state patients with schizophrenia by using these indicators.

Language: Английский

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Elevated serum IL-17 A and CCL20 levels as potential biomarkers in major psychotic disorders: a case-control study

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 11, 2024

Major psychotic disorders (MPD), including schizophrenia (SCZ) and schizoaffective disorder (SAD), are severe neuropsychiatric conditions with unclear causes. Understanding their pathophysiology is essential for better diagnosis, treatment, prognosis. Recent research highlights the role of inflammation immune system, particularly Interleukin 17 (IL-17) family, in these disorders. Elevated IL-17 levels have been found MPD, human A antibodies available. Changes chemokine levels, such as CCL20, also noted SCZ. This study investigates relationship between serum CCL20 MPD patients clinical characteristics. We conducted a case-control at Ibn Sina Psychiatric Hospital (Mashhad, Iran) 2023. The involved 101 participants, which 71 were 30 healthy controls (HC). Positive Negative Symptom Scale (PANSS) was utilized to assess symptoms patients. Serum measured using Enzyme-Linked Immunosorbent Assay (ELISA) kits. gathered data on lipid profiles Fasting Blood Glucose (FBS). mean age 41.04 ± 9.93 years. median significantly elevated compared HC (5.8 (4.1–15.3) pg/mL 4.2 (3–5) pg/mL, respectively; p < 0.001). Furthermore, showed positive correlation severity MPD. had higher FBS, cholesterol, Low-Density Lipoprotein (LDL) lower High-Density (HDL) HC. No significant PANSS components blood IL17 CCL20. current revealed that than those control group. Metabolic factors HDL, LDL differences In conclusion, findings suggest two inflammatory could serve potential therapeutic targets prognostic biomarkers schizophrenia.

Language: Английский

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Pterin metabolism, inflammation and oxidative stress biochemical markers in schizophrenia: Factor analysis and assessment of clinical symptoms associations

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 127, P. 110823 - 110823

Published: July 13, 2023

Language: Английский

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A further examination of growth factors, T helper 1 polarization, and the gut microbiome in major depression: Associations with reoccurrence of illness, cognitive functions, suicidal behaviors, and quality of life

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 176, P. 430 - 441

Published: June 29, 2024

Language: Английский

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Increased AGE–RAGE axis stress in methamphetamine abuse and methamphetamine‐induced psychosis: Associations with oxidative stress and increased atherogenicity

Addiction Biology, Journal Year: 2023, Volume and Issue: 28(10)

Published: Sept. 21, 2023

Methamphetamine (MA)-induced psychosis (MIP) is associated with increased oxidative toxicity (especially lipid peroxidation) and lowered antioxidant defences. Advanced glycation end products (AGEs) cause stress upon ligand binding to AGE receptors (RAGEs). There no data on whether MA use may AGE-RAGE or the latter MIP. This case-control study recruited 60 patients disorder 30 normal controls measured serum levels of (OSTOX, peroxidation), defences (ANTIOX), magnesium, copper, atherogenicity, soluble RAGE (sRAGE) computed a composite reflecting axis activity. dependence were elevated AGE, sRAGE, OSTOX/ANTIOX, Castelli Risk Index 1 atherogenic index plasma. Increased sRAGE concentrations strongly correlated severity dose. was OSTOX, OSTOX/ANTIOX MA-induced intoxication symptoms, psychosis, hostility, excitement formal thought disorders. The regression AGE-RAGE, ratio, decreased magnesium copper explained 54.8% variance in MIP these biomarkers mediated effects increasing symptoms. insufficient found explain 36.0% atherogenicity indices. causes intertwined increases damage, which together predict symptoms atherogenicity.

Language: Английский

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The General Neurocognitive Decline in Patients with Methamphetamine Use and Transient Methamphetamine-induced Psychosis is Primarily Determined by Oxidative and AGE-RAGE Stress

Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(20), P. 1816 - 1828

Published: July 10, 2024

Chronic Methamphetamine (MA) usage is linked to oxidative and AGE (advanced glycation end products) - RAGE (receptors for AGEs) stress, changes in magnesium, calcium, copper, increased psychotic symptoms, neurocognitive deficits. Nevertheless, it still unclear whether these biological pathways mediate the latter impairments.

Language: Английский

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The novel schizophrenia subgroup “major neurocognitive psychosis” is validated as a distinct class through the analysis of immune-linked neurotoxicity biomarkers and neurocognitive deficits

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 40, P. 100842 - 100842

Published: Aug. 14, 2024

Using machine learning methods based on neurocognitive deficits and neuroimmune biomarkers, two distinct classes were discovered within schizophrenia patient samples. Increased frequency of psychomotor retardation, formal thought disorders, mannerisms, psychosis, hostility, excitation, negative symptoms defined the first subgroup, major psychosis (MNP). Cognitive in executive functions memory diverse aberrations other MNP features. Simple (SNP) was less severe phenotype.

Language: Английский

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Increased AGE-RAGE axis stress in methamphetamine (MA) abuse and MA-induced psychosis: associations with oxidative stress and increased atherogenicity

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 23, 2023

Abstract Background and aims Methamphetamine (MA)-induced psychosis (MIP) is associated with increased oxidative toxicity (especially lipid peroxidation) lowered antioxidant defenses. Advanced glycation end products (AGEs) cause stress upon ligand binding to AGE receptors (RAGE). There are no data on whether MA use may AGE-RAGE stress, the latter MIP. Methods This case-control study recruited 60 patients disorder 30 normal controls measured serum levels of (OSTOX, peroxidation), defenses (ANTIOX), magnesium, copper, atherogenicity, AGE, soluble RAGE (sRAGE), computed a composite reflecting axis activity. Findings dependence were accompanied by sRAGE, AGE-RAGE, OSTOX/ANTIOX, Castelli risk index 1 atherogenic plasma, indicating that causes damage, atherogenicity. The severity dose strongly correlated sRAGE concentrations. Increased was OSTOX, MA-induced intoxication symptoms, psychosis, hostility, excitation, formal thought disorders. We found 54.8% variance in MIP symptoms explained regression OSTOX/ANTIOX ratio, these biomarkers mediated effects increasing doses symptoms. 36.0% atherogenicity indices magnesium. Conclusions intertwined increases which together predict

Language: Английский

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