The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175275 - 175275
Published: Aug. 5, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3447 - 3447
Published: Oct. 11, 2024
The gut microbiota, a complex ecosystem of microorganisms in the human gastrointestinal tract (GI), plays crucial role maintaining metabolic health and influencing disease susceptibility. Dysbiosis, or an imbalance has been linked to development type 2 diabetes mellitus (T2DM) through mechanisms such as reduced glucose tolerance increased insulin resistance. A balanced eubiosis, is associated with improved metabolism sensitivity, potentially reducing risk diabetes-related complications. Various strategies, including use prebiotics like inulin, fructooligosaccharides, galactooligosaccharides, resistant starch, pectic oligosaccharides, polyphenols, β-glucan, Dendrobium officinale have shown improve microbial composition support glycemic control T2DM patients. These can directly impact blood sugar levels while promoting growth beneficial bacteria, thus enhancing control. Studies that patients often exhibit decrease butyrate-producing Roseburia Faecalibacterium, increase harmful Escherichia Prevotella. This review aims explore effects different on T2DM, their microbiota composition, potential for personalized dietary interventions optimize management overall outcomes.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4817 - 4817
Published: April 28, 2024
The gut microbiota and short chain fatty acids (SCFA) have been associated with immune regulation autoimmune diseases. Autoimmune kidney diseases arise from a loss of tolerance to antigens, often unclear triggers. In this review, we explore the role microbiome how disease, diet, therapy can alter consortium. Perturbations in may systemically induce translocation microbiota-derived inflammatory molecules such as liposaccharide (LPS) other toxins by penetrating epithelial barrier. Once blood stream, these pro-inflammatory mediators activate cells, which release molecules, many are antigens ratio bacteria Bacteroidetes/Firmicutes is worse outcomes multiple including lupus nephritis, MPO-ANCA vasculitis, Goodpasture’s syndrome. Therapies that enhance SCFA-producing powerful therapeutic potential. Dietary fiber fermented turn SCFAs protect barrier, well modulating responses towards tolerogenic anti-inflammatory state. Herein, describe where current field research strategies harness potential therapy.
Language: Английский
Citations
2
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 18, 2024
The progressive globalization of sedentary lifestyles and diets rich in lipids processed foods has caused two major public health hazards-diabetes obesity. strong interlink between obesity type 2 diabetes mellitus their combined burden encompass them into a single term 'Diabesity'. They have also been tagged as the drivers for onset cancer. clinical association diabetes, obesity, several types human cancer demands an assessment vital junctions correlating three. This review focuses on revisiting molecular axis linking to through pathways that get imbalanced owing metabolic upheaval. We attempt describe functional disruptions DNA repair mechanisms due overwhelming oxidative damage by diabesity. Genomic instability, known hallmark results when does not work optimally, will be inferred from this obtruded homeostasis creates favorable microenvironment supporting reprogramming enabling malignancies. Altered hormonal landscapes these morbidities provide novel connection metabolomics oncogenesis. Understanding various aspects tumorigenic process diabesity-induced cancers might help discovery new biomarkers prompt targeted therapeutic interventions.
Language: Английский
Citations
2
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: Aug. 2, 2023
Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease that causes multi-organ complications, seriously affecting patients' quality of life and survival. Understanding its pathogenesis remains challenging, with current clinical treatment regimens often proving ineffective.In this study, we established mouse model T2DM employed 16s rDNA sequencing to detect changes in the species structure gut flora. Additionally, used UPLC-Q-TOF-MS identify urinary metabolites mice, analyzed differential constructed pathways. Finally, Pearman correlation analysis investigate relationship between intestinal flora aiming elucidate provide an experimental basis for treatment.Our findings revealed reduction both diversity abundance significantly decreased levels beneficial bacteria such as Lactobacillus increased harmful Helicobacter pylori. Urinary metabolomics results identified 31 control including Phosphatidylcholine, CDP-ethanolamine Leukotriene A4, which may be closely associated glycerophospholipid arachidonic acid showed strong dopamine gonadal, estradiol microbiota, novel direction underlying T2DM.In conclusion, our study suggests alterations microbiota are characteristic features mice. Furthermore, dopamine, T2DM, aim new ideas basic research.
Language: Английский
Citations
5
Foods, Journal Year: 2023, Volume and Issue: 12(21), P. 4006 - 4006
Published: Nov. 2, 2023
Type 2 diabetes mellitus is a disease caused by hyperglycemia, an imbalance in the intestinal flora and disruption of endocrine system. At present, it primarily controlled through drug treatment improved diet. Mulberry leaf fu brick tea were considered to have excellent hypoglycemic effects. This study used mulberry leaves as raw materials develop dietary regulator that can assist prevention alleviation diabetes. The experiment Goto-Kakizaki (GK) rat model investigate effect (MFT) its influence on diabetic rats methods including ELISA, tissue section observation 16S RNA microbial sequencing. results showed that, compared with GK group, intervention significantly reduced activities α-glucosidase (p < 0.05) α-amylase duodenum rats. height duodenal villi was 0.001), leading decreased sugar absorption. same time, MFT alleviates high blood sugar, promotes growth beneficial bacteria (Lactobacillus, Bifidobacterium, etc.), inhibits reproduction harmful (Blautia, Klebsiella, Helicobacter, Alistipes, etc.). helps reduce secretion toxic substances (lipopolysaccharide, p decreases oxidative stress inflammation, mitigates organ damage, improves symptoms Finally, random glucose value dropped from 22.79 mmol/L 14.06 mmol/L. In summary, lower absorption rats, body's inflammatory response, regulate flora, levels It hinted could be functional drink help prevent occurrence
Language: Английский
Citations
5
Published: March 25, 2024
Autoimmune kidney diseases arise from a loss of tolerance to antigens, often with unclear triggers. In this review we explore the role gut microbiome and how disease, diet therapy can alter microbiota consortium. Perturbations in may induce translocation microbiota-derived inflammatory molecules such as liposaccharide (LPS) other toxins systemically by penetrating epithelial barrier. Once blood stream these pro-inflammatory mediators activate immune cells which release many are antigens autoimmune diseases. The ratio bacteria Bacteroidetes:Firmicutes is associated worse outcomes multiple including Lupus nephritis, MPO-ANCA vasculitis Goodpasture’s syndrome. Therapies enhance short chain fatty acid (SCFA)-producing have powerful therapeutic potential. Dietary fibre fermented turn SCFAs protect barrier well modulate responses towards tolerogenic anti-inflammatory state. Herein, describe where current field research strategies harness potential therapy.
Language: Английский
Citations
1
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10
Published: July 27, 2023
This study aimed to investigate the effects of two types peanuts, regular Hanoch (HN) and a new high-oleic cultivar., Hanoch-Oleic (HO), on metabolic parameters gut microbiota composition. Male C57BL/6 mice were fed with normal diet (ND) or ND supplemented HN (NDh) HO (NDo). Following 18 weeks regimen, NDo group exhibited reduced body weight peri-gonadal adipose-to-body ratio, paralleled lesser food consumption. Although blood levels total cholesterol, HDL-cholesterol, free fatty acids, liver enzyme did not differ between groups, decreased insulin sensitivity was found in NDh group. Within adipose tissue, expression lipolytic lipogenic enzymes higher, while those related lipid oxidation lower compared Additionally, peanuts consumption promoted establishment healthy microbiota, an enhanced abundance Bifidobacterium, Lactobacillus, Coprococcus genera. In conclusion, inclusion peanut rather than conventional balanced better outcomes linked favorable profile.
Language: Английский
Citations
2
Advances in Public Health, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 14
Published: Feb. 14, 2024
Gut
microbiome
analysis
is
costly
and
poses
a
significant
challenge
for
determining
the
gut
microbiota
composition
to
facilitate
adoption
of
personalized
nutritional
interventions.
Emerging
evidence
suggests
dysbiosis
as
contributor
irritable
bowel
syndrome
(IBS),
but
results
remain
uncertain.
Moreover,
IBS
prevalence
becoming
public
health
problem
in
adult
Lebanese
population.
This
study
aimed
at
estimating
microbiota’s
using
Food
Frequency
Questionnaire
(FFQ)
exploring
its
correlation
with
among
adults.
A
cross-sectional
was
conducted
388
adults
during
summer
2023.
An
online
questionnaire
collected
information
about
sociodemographic
characteristics,
anthropometric
measures,
status,
dietary
habits
through
semiquantitative
FFQ.
We
observed
influence
Western
diet
three
patterns
that
were
identified.
Participants
clustered
into
two
groups
based
on
their
estimated
(poor
or
good)
composition,
EPMC
EGMC,
respectively.
inverse
relationship
between
symptoms
EGMC.
experiencing
less
likely
exhibit
good
compared
those
without
any
(AOR
=
0.614,
95%
CI
(0.402–0.937),
),
higher
adherence
Mediterranean
significantly
associated
lower
odds
having
0.786,
(0.635–0.973),
id="M2">
Language: Английский
Citations
0
Eurasian Journal of Medicine and Oncology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8
Published: Jan. 1, 2024
[6] Despite the strides made in diabetes research and medical innovations, a definitive treatment for T2DM has remained elusive, necessitating ongoing exploration of novel therapeutic avenues. [2,7] mid this persistent challenge, promising frontier emerged form sodium-glucose co-transporter 2 (SGLT2) inhibitors, which represent paradigm shift management.SGLT2 inhibitors modulate renal glucose reabsorption have demonstrated remarkable efficacy improving glycemic control addressing cardiovascular risk factors. [8,9] owever, story does not end with their direct impact on metabolism; an intriguing relatively uncharted path is revealed when we consider interplay between SGLT2 human gut microbiota.Amid quest interventions, attention increasingly turned to microbiota, dynamic intricate community microorganisms residing gastrointestinal tract.From 2013 2017, there was notable surge number publications devoted microbiota studiesa staggering 12,900 publications. [10]This accounted four-fifths all conducted topic over preceding 40 years reflected expansive territory microbiome re-The microecosystem within us that actively influences health beyond digestion.It impacts energy regulation, immune response, even drug metabolism.People type mellitus (T2DM) exhibit variations linking dysbiosis metabolic dysfunction.In pursuit strategies T2DM, emerges as frontier.Renowned effectiveness control, range benefits, including renoprotection, weight loss, blood pressure reduction, protection.Although exact mechanisms responsible these multifaceted advantages remain unclear, recent evidence indicates potentially affect microbiota.This review sheds light potential benefits mediated by influence management examining current understanding developments field research.
Language: Английский
Citations
0
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175275 - 175275
Published: Aug. 5, 2024
Language: Английский
Citations
0