Comprehensive Metabolite Profiling and Evaluation of Anti-nociceptive and Anti-inflammatory Potencies of Nypa fruticans (Wurmb.) Leaves: Experimental and In-Silico Approaches.

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e42074 - e42074

Published: Jan. 21, 2025

Globally, inflammation and pain are among the most prevalent health issues. The use of medicinal plants to alleviate these conditions is growing. This study comprehensively investigated analgesic anti-inflammatory properties ethyl-acetate extract Nypa fruticans (EENF) leaves, traditionally used in folk Medicine. High-performance liquid chromatography (HPLC) gas chromatography-mass spectroscopy (GC-MS) were employed identify phytochemicals EENF. In vitro antioxidant studies conducted determine antioxidative Formalin-induced paw edema assay was assess in-vivo activity whereas; acetic acid-induced writhing test, hot plate tail immersion test performed evaluate vivo anti-nociceptive effects. identified compounds subsequently evaluated by computational against cyclooxygenase-2 enzyme. EENF demonstrated significant both DPPH scavenging (IC50: 105.18 μg/mL) reducing power (RC50:1752.76 μg/mL). assay, exhibited highest (50.39 % 67.72 %) inhibition at fourth hour 200 400 mg/kg body weight, accordingly. Moreover, all modulation (p < 0.001) a dose-dependent manner. Among, 23 phytocompounds, promising ones determined be potential agents through molecular docking ADME/T analysis. Molecular dynamics simulations (MDS) confirmed stability protein-ligand complexes. Two phytochemicals, (-) Epicatechin (CID 72276) Quercetin 5280343), outperformed standard drug, diclofenac sodium, MDS studies. Both experimental in-silico have scientifically verified traditional treating inflammatory disease. Overall, possess excellent as natural lead for COX-2 inhibition. Further research, including pure compound isolation biomolecular studies, needed understand underlying mechanisms activities.

Language: Английский

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Toward curing neurological autoimmune disorders: Biomarkers, immunological mechanisms, and therapeutic targets

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Molecular and Cellular Involvement in CIPN

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 751 - 751

Published: March 28, 2024

Many anti-cancer drugs, such as taxanes, platinum compounds, vinca alkaloids, and proteasome inhibitors, can cause chemotherapy-induced peripheral neuropathy (CIPN). CIPN is a frequent harmful side effect that affects the sensory, motor, autonomic nerves, leading to pain, numbness, tingling, weakness, reduced quality of life. The causes are not fully known, but they involve direct nerve damage, oxidative stress, inflammation, DNA microtubule dysfunction, altered ion channel activity. also affected by genetic, epigenetic, environmental factors modulate risk intensity damage. Currently, there no effective treatments or prevention methods for CIPN, symptom management mostly symptomatic palliative. Therefore, high demand better understanding cellular molecular mechanisms involved in well development new biomarkers therapeutic targets. This review gives an overview current knowledge challenges field focusing on biological underlying this disorder.

Language: Английский

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The Utilization of Ultrasound-Guided Regional Nerve Blocks in Anesthetic Management for Fracture Surgery

Journal of Pain Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 353 - 366

Published: Jan. 1, 2025

Fracture surgeries are frequently accompanied by severe pain, necessitating efficacious pain management strategies to enhance postoperative recovery.Nerve block techniques, which critical in mitigating involve the targeted administration of local anesthetics disrupt nerve signal transmission, thereby achieving significant analgesia.Traditionally, these techniques rely on anatomical landmarks and clinician's expertise, can introduce variability potential risks.The adoption ultrasoundguided blocks has increased, facilitated advancements imaging technology.This approach enables precise placement through real-time visualization neural structures adjacent tissues, significantly improving accuracy safety procedure.This review summarizes recent application ultrasound-guided fracture surgeries, particularly for rib, upper limb, thoracic, lumbar, hip fractures.By precisely placing anesthetics, not only improve efficiency but also reduce recovery time.The widespread offers an efficient low-side-effect anesthesia strategy, enhancing post-surgical patient experience quality.

Language: Английский

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Whole Body Cryostimulation: A New Adjuvant Treatment in Central Sensitization Syndromes? An Expert Opinion

Healthcare, Journal Year: 2024, Volume and Issue: 12(5), P. 546 - 546

Published: Feb. 25, 2024

Central sensitisation is defined as a multifactorial etiopathogenetic condition involving an increase in the reactivity of nociceptive neurons and alterations pain transmission perception central nervous system. Patients may present with widespread chronic pain, fatigue, sleep disturbance, dizziness, psychological (e.g., depression, anxiety, anger) social impairment. Pain can be spontaneous onset persistence, characterised by exaggerated response spread beyond site origin, sometimes triggered non-painful stimulus. Whole-body cryostimulation (WBC) could adjuvant therapy management this type because its global anti-inflammatory effect, changes cytokines hormone secretion, reduction nerve conduction velocity, autonomic modulation, release neurotransmitters involved pathway. In several conditions fibromyalgia, rheumatoid arthritis, musculoskeletal pain), WBC affects physical performance, perception, aspects. Given multiple targets effects at different organs levels, appears to versatile treatment for wide range rehabilitation interest. Further research needed fully understand mechanisms analgesic effect potential actions on pathways, well study long-term uses other conditions.

Language: Английский

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Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 537 - 537

Published: May 17, 2024

Inflammation during the perioperative period of joint arthroplasty is a critical aspect patient outcomes, influencing both pathophysiology pain and healing process. This narrative review comprehensively evaluates roles specific cytokines inflammatory biomarkers in this context their implications for management. Inflammatory responses are initiated propagated by cytokines, which pivotal development acute chronic postoperative pain. Pro-inflammatory play essential up-regulating response, which, if not adequately controlled, leads to sustained impaired tissue healing. Anti-inflammatory work dampen promote resolution. Our discussion extends genetic molecular influences on cytokine production, influence perception recovery rates post-surgery. Furthermore, role PAI-1 modulating inflammation through its impact fibrinolytic system highlights potential as therapeutic target. The modulation these various analgesic anesthetic techniques, including fascia iliac compartment block, demonstrates significant reduction markers, thus underscoring importance targeted strategies. analysis suggests that nuanced understanding interplay between pro-inflammatory anti-inflammatory required. Future research should focus individualized management

Language: Английский

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Pain Perception Threshold in Young High-Altitude Natives After Acute Exposure to Severe Hypoxic Conditions

Oxygen, Journal Year: 2025, Volume and Issue: 5(1), P. 1 - 1

Published: Jan. 13, 2025

Previous studies indicate that individuals at high altitudes have a lower pain threshold than those living sea level. This study evaluates the differences in perception among young people an altitude of 3800 m and after acute exposure to severe hypoxic environment more 5100 m. Fourteen (BMI 22.6 ± 1.2 age 23.3 1.9 years) residing city Puno (3825 m) participated ascent Populated Center La Rinconada (>5100 m). The unilateral ischemia provocation test was used, applying pressure with manual sphygmomanometer generate transient arm while patient opens closes their hand. Onset, peak, resolution times pain, heart rate, oxygen saturation were recorded. At residence 3828 m, mean hemoglobin 16.16 2.29, increased 17.57 1.74. average time onset right 30.43 s 14.15 whereas above level, 31.00 19.01. until sensation left 19.93 9.44 23.07 10.83 During environment, similar between

Language: Английский

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Is the Central Sensitization in Chronic Nonspecific Low Back Pain Structural Phenomenon or Psychological Reaction? A Narrative Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 577 - 577

Published: Jan. 17, 2025

Lower back pain (LBP) is a common condition affecting primarily populations in developed countries, placing significant burden on public health systems around the world. A high rate of recurrence increases risk developing chronic syndrome and occurrence complex psychosocial professional problems. Symptoms lasting longer than 12 weeks are associated with sleep problems, depression, anxiety. In 21st century, development knowledge about central sensitization (CS) to allowed for better understanding pathomechanism transformation LBP into form. Patients severe often experience accompanying symptoms such as fatigue, anxiety, disorders, appetite flatulence, dyspepsia, dizziness-these part picture CS. The article presents narrative, chronological review reports covering current state possibility assessing its impact low pain. authors also attempt answer question posed title. CS can be seen an excessive reactivity nociceptive neurons nervous system normal or subthreshold afferent stimuli people certain mental predispositions.

Language: Английский

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Analgesic and Anti-inflammatory Properties of Dendrobium nobile

CABI eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 118 - 142

Published: March 24, 2025

Language: Английский

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The effect of music therapy on treating patients pain and anxiety in emergency department: a randomized controlled trial

International Journal of Emergency Medicine, Journal Year: 2025, Volume and Issue: 18(1)

Published: April 11, 2025

Language: Английский

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