Characteristics and Pleiotropic Effects of Ashwagandha – A Literature Review DOI

Urszula Miłkowska,

Piotr Franciszek Kurzyna, Klaudia Kołakowska

et al.

Published: Dec. 1, 2024

Abstract Ashwagandha, also known as Winter Cherry ( Withania somnifera ), is one of the most important plants used in traditional Indian medicine. In our study, we focused on presenting comprehensive effects ashwagandha, which exhibits numerous health benefits, including anti-stress, hypoglycemic, cardioprotective, anti-inflammatory, neuroprotective, and anti-cancer properties. It has been shown that ashwagandha supports stress reduction, enhances physical endurance, lowers glucose levels improves blood lipid profiles, can be beneficial treatment diabetes. Extracts from this plant contribute to heart by reducing oxidative markers supporting tissue regeneration. Additionally, studies indicate its properties due presence withaferin A, activates apoptosis processes cancer cells. The paper discusses hormones fertility, highlighting improvements semen quality men. Although generally well-tolerated, literature presents some side effects, incidental cases hepatotoxicity thyrotoxicosis, necessitate caution use. conclusion, a broad therapeutic potential; however, further clinical are essential better understand mechanisms action establish safe dosing guidelines.

Language: Английский

Ashwagandha-induced liver injury—A case series from India and literature review DOI Creative Commons
Cyriac Abby Philips, Arun Valsan, Arif Hussain Theruvath

et al.

Hepatology Communications, Journal Year: 2023, Volume and Issue: 7(10)

Published: Sept. 27, 2023

Background: Ashwagandha herb is commonly used in Ayurveda and a “fad” dietary supplement for host of indications based on low levels evidence. Recently, ashwagandha was implicated multiple reports herb-induced liver injury (HILI), mainly from the United States. We present first, currently largest, series ashwagandha-HILI centers India. Methods: retrospectively analyzed respective institutional electronic medical records ashwagandha-HILI. Patients consuming as part multiherbal formulations or along with other known hepatotoxic supplements medicines were excluded. All patients underwent detailed diagnostic workup to exclude competing causes reasonably. Where possible, herbal formulation retrieved subjected chemical analysis. Results: Out 23 (January 2019 December 2022), we report 8 single-ingredient formulation-related HILI. Study cohort male predominant, cholestatic hepatitis commonest presentation. Five had underlying chronic disease; 3 presented acute-on-chronic failure, all died follow-up. In others, prolonged, nonetheless self-limiting. Liver biopsy revealed features predominantly hepatocellular necrosis lymphocyte/eosinophil predominant portal-based inflammation. One patient progressed Chemical analysis only natural phytochemicals without adulteration contamination. Conclusions: Ashwagandha-HILI presents can lead syndrome failure high mortality those pre-existing disease. Educating public avoiding use potentially toxic unrecommended help mitigate avoidable disease burden community.

Language: Английский

Citations

24
A comprehensive review on the hepatotoxicity of herbs used in the Indian (Ayush) systems of alternative medicine DOI Creative Commons
Cyriac Abby Philips, Arif Hussain Theruvath

Medicine, Journal Year: 2024, Volume and Issue: 103(16), P. e37903 - e37903

Published: April 19, 2024

Complementary and alternative medicine-related liver injuries are increasing globally. Alternative medicine, as an inclusive healthcare practice, is widely accepted in developing underdeveloped countries. In this context, the traditional systems of medicine India have been at forefront, catering to preventive therapeutic spectrum absence conclusive evidence for benefits lack data on safety. Contrary popular belief, it evident that apart from adverse events caused by contamination adulteration medicines, certain commonly used herbal components inherent hepatotoxicity. This narrative review updates our current understanding publications toxicity potential herbs Indian (Ayush), such Tinospora cordifolia (Willd.) Hook.f. & Thomson (Giloy/Guduchi), Withania somnifera (L.) Dunal (Ashwagandha), Curcuma longa L. (Turmeric), Psoralea corylifolia (Bakuchi/Babchi). also highlights importance upcoming profiles associated with other dietary supplements, Centella asiatica Urb., Garcinia cambogia Desr., Cassia angustifolia Vahl (Indian senna), Morinda citrofolia (Noni fruit). Fortunately, most reported due these self-limiting, but can lead progressive dysfunction, leading acute failure or chronic a high mortality rate. aims provide adequate knowledge regarding herbalism practices, pertinent medical doctors diagnose, treat, prevent avoidable disease burdens within communities, improve public health education.

Language: Английский

Citations

6
Agricultural-based challenges, genetic enhancement, and obstacles to an industrially important medicinal plant, ashwagandha (Withania somnifera (L.) Dunal): A review DOI
Anuj Kumar,

S. Venugopal,

A.C. Jnanesha

et al.

Ecological Genetics and Genomics, Journal Year: 2023, Volume and Issue: 28, P. 100183 - 100183

Published: June 16, 2023

Language: Английский

Citations

13
Current issues in phytomedicine research - Conundrum on the chemistry of ashwagandha and its biological effects DOI
Amar G. Chittiboyina, Ikhlas A. Khan

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117871 - 117871

Published: Feb. 5, 2024

Language: Английский

Citations

5
Use of herbal medication in the perioperative period: Potential adverse drug interactions DOI Creative Commons
Ofelia Loani Elvir-Lazo, Paul F. White, Carol Lee

et al.

Journal of Clinical Anesthesia, Journal Year: 2024, Volume and Issue: 95, P. 111473 - 111473

Published: April 12, 2024

Use of herbal medications and supplements has experienced immense growth over the last two decades, with retail sales in USA exceeding $13 billion 2021. Since Dietary Supplement Health Education Act (DSHEA) 1994 reduced FDA oversight, these products have become less regulated. Data from 2012 shows 18% U.S. adults used non-vitamin, non-mineral natural products. Prevalence varies regionally, higher use Western states. Among preoperative patients, most commonly included garlic, ginseng, ginkgo, St. John's wort, echinacea. However, 50–70% surgical patients fail to disclose their physicians, discontinue them preoperatively. can interact anesthetic administered during surgery, American Society Anesthesiologists (ASA) Association Nurse Anesthetists (AANA) recommend stopping 1–2 weeks before elective procedures. Potential adverse drug effects related involve coagulation system (e.g., increasing risk perioperative bleeding), cardiovascular arrhythmias, hypotension, hypertension), central nervous sedation, confusion, seizures), pulmonary coughing, bronchospasm), renal diuresis) endocrine-metabolic hepatic dysfunction, altered metabolism drugs). During evaluation, anesthesiologists should inquire about anticipate potential interactions period.

Language: Английский

Citations

4
Drug induced cholestatic liver diseases DOI
Einar S. Björnsson, Harshad Devarbhavi

Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Cholestatic DILI is an important and frequently challenging differential diagnosis in patients presenting with elevated liver tests predominant elevation alkaline phosphatase. A number of competing etiologies need to be ruled out, such as hepatobiliary malignancy, choledocholithiasis, cholestatic forms viral hepatitis, cholestasis sepsis, primary secondary cholangitis, right-sided cardiac failure name a few. Important advances have occurred the understanding knowledge clinical phenotypes, new etiological agents, risk factors, pathophysiology, genetic determinants drug-induced since last review on was published Hepatology 2011. Secondary sclerosing cholangitis (SSC) due drugs has been well documented for several different drugs. Checkpoint inhibitors are one types shown lead cholangitis. Several herbal dietary supplements recently injury. factors identified decade, pathogenesis behind injury better defined. In this review, focus diagnostic approach description phenotypes vanishing bile duct syndrome. Furthermore, provides overview determinants, pathophysiology transporters leading cholestasis. Management, areas uncertainty, future direction also presented.

Language: Английский

Citations

4
Assessment of the Use of Herbal Supplements and Attitudes of Adults Taking Medication DOI Creative Commons
Rahime Evra Karakaya

Journal of Contemporary Medicine, Journal Year: 2025, Volume and Issue: 15(1), P. 45 - 50

Published: Jan. 31, 2025

Aim: The use of herbal supplements is increasing today, and these products have a significant impact on individuals' health. aim this study to examine the reasons for using supplements, as well determine attitudes towards products. Materials Methods: was conducted with individuals aged 19-65 who medications. A questionnaire containing questions about participants' demographic characteristics, supplement usage, administered by researcher through face-to-face interviews. Results: Of 274 participants in study, 10.6% most preferred being ginseng, St. John's wort, garlic (20.7%, 27.6%, 37.9%, respectively). It found that consume alcohol 3.188 times more, those exercise them 3.470 more than do not (p=0.043, p=0.015, Most users agreed statement, "Herbal can be used immediately when experiencing symptoms related illness," while non-users disagreed (p

Language: Английский

Citations

0
Etiopathogenic and Therapeutic Considerations in a Multiple Sclerosis Case with Acute Toxic Hepatitis DOI Creative Commons

Maria-Melania Dumitru-Martoiu,

Simona Petrescu,

Cristina Panea

et al.

Reports — Medical Cases Images and Videos, Journal Year: 2025, Volume and Issue: 8(2), P. 38 - 38

Published: March 26, 2025

Background and Clinical Significance: In multiple sclerosis (MS), there are many therapeutic options, but most of the available drugs can cause drug-induced liver injury (DILI) after first infusions. A wide group other may induce injury, from simple anti-pyretic medication like Acetaminophen to various dietary herb supplements Ashwagandha. Case Presentation: 39-year-old female patient, diagnosed with MS, has been previously treated Glatiramer Acetate interferon-beta, is currently undergoing immunomodulatory treatment natalizumab (infusion no. 81). She had a recent history an airway infection for which she took 4–5 capsules per day 7 days, along consumption supplement Ashwagandha herb. presented jaundice, pruritus, lower limb ecchymoses. The laboratory results revealed higher aminotransferase levels, total bilirubin, alkaline phosphatase. screening autoimmune infectious hepatitis was negative. scenario toxic induced by recently used (Ashwagandha Acetaminophen) adequate start therapy oral cortisone. clinical gradually improved, normal levels enzymes no further increase discontinuation corticosteroid supplements. Conclusions: This case highlights challenges in determining etiologies managing acute MS patient on natalizumab, drug that infusions, especially context ingestion hepatotoxic drugs.

Language: Английский

Citations

0
Extraction of Bioactive Compounds From Withania somnifera: The Biological Activities and Potential Application in the Food Industry: A Review DOI Creative Commons

Siva Karthikeyan Singirala,

P. K. Dubey, Swarup Roy

et al.

International Journal of Food Science, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

As awareness of the link between diet and health grows, people are increasingly prioritizing functional foods that offer additional benefits beyond basic nutrition. Ashwagandha, scientifically known as Withania somnifera (WS) , is a perennial plant which belongs to family Solanaceae, grows abundantly in subtropical regions world. Ashwagandha renowned Ayurvedic herb with diverse applications global dietary supplements traditional medicines. It has extensive medicinal potential Indian systems such (Ayurvedic, Unani, Siddha) contemporary medicine, recognized “Indian ginseng.” WS additive composed various phytochemicals active compounds withanolides, polyphenols, flavonoids, alkaloids, exhibit therapeutic properties, including anti‐inflammatory, anticancer, antistress, antioxidant, antimicrobial, antidiabetic, cardioprotective, hypoglycemic, hepatoprotective, immunomodulatory, rejuvenating effects. been proven be highly effective against numerous neurological psychological disorders. The incorporation ashwagandha into food enhances biological activity well making it valuable benefits. This review provides an updated analysis emphasizing its bioactive compounds, extraction techniques, applications. Unlike previous studies primarily focused on this highlights integration systems, addressing technological challenges, stability, commercial viability. Additionally, compiles advancements analytical offering insights enhancing bioavailability sensory optimization, thereby bridging herbal use modern science.

Language: Английский

Citations

0
Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause DOI Creative Commons
Goran Bokan,

Tanja Glamočanin,

Zoran Mavija

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1129 - 1129

Published: Aug. 10, 2023

Herb-induced liver injury (HILI) caused by herbal supplements, natural products, and products used in traditional medicine are important for differential diagnoses patients with acute without an obvious etiology. The root of Withania somnifera (L.) Dunal, commonly known as ashwagandha, has been Ayurvedic thousands years to promote health longevity. Due various biological activities, ashwagandha its extracts became widespread supplements on the global market. Although it is generally considered safe, there several reported cases ashwagandha-related injury, one case ended transplantation. In this paper, we review all so far. Additionally, describe two new hepatotoxicity. first case, a 36-year-old man capsules (450 mg, three times daily) 6 months before he developed nausea, pruritus, dark-colored urine. second 30-year-old woman pruritus after 45 days using mg). both cases, serum bilirubin enzymes (aspartate transaminase (AST), alanine (ALT), alkaline phosphatase (ALP) were increased. pattern was hepatocellular (R-value 11.1) mixed 2.6), respectively. updated Roussel Uclaf Causality Assessment Method (RUCAM) (both score seven) indicated "probable" relationship ashwagandha. Clinical function improvements observed discontinuation supplement use. By increasing data related ashwagandha-induced these reports support that consuming not safety concerns.

Language: Английский

Citations

9