Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2488 - 2488

Published: Sept. 7, 2023

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated the pathogenesis various brain diseases, including neurodegenerative disorders, stroke, psychiatric illnesses. This review paper provides comprehensive overview intricate relationship between disease, focusing on underlying pathological mechanisms exploring potential therapeutic opportunities. The covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, dynamics, calcium dysregulation, reactive oxygen species generation context disease. Additionally, it discusses emerging strategies targeting dysfunction, protective agents, metabolic modulators, gene therapy approaches. By critically analysing existing literature recent advancements, this aims to enhance our understanding multifaceted disease shed light novel interventions.

Language: Английский

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Navigating the New Normal: Adapting Online and Distance Learning in the Post-Pandemic Era

Education Sciences, Journal Year: 2023, Volume and Issue: 14(1), P. 19 - 19

Published: Dec. 24, 2023

This review examines the transformation of educational practices to online and distance learning during COVID-19 pandemic. It specifically focuses on challenges, innovative approaches, successes this transition, emphasizing integration technology, student well-being, teacher development. The pandemic has significantly transformed landscape, necessitating a rapid shift learning. highlighted key strategies innovations in teaching, importance engaging, adaptable, inclusive practices. underscores need for continuous professional development educators, advanced technological tools, prioritizing well-being academic success digital environments. As we move forward, insights gathered from experience will be invaluable shaping resilient dynamic framework that is well suited post-pandemic era, focusing inclusivity, engagement, effective use technology enhance experiences.

Language: Английский

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Understanding the New Stress Factors Affecting Teachers' Burnout: A Scoping Review

Makara Human Behavior Studies in Asia, Journal Year: 2024, Volume and Issue: 28(1)

Published: July 1, 2024

The teaching profession is extremely vulnerable to burnout. sudden outbreak of the COVID-19 pandemic posed new threats and changed educational environment as well perceptions values teachers. traditional in-person learning approach was quickly replaced by distant online continue education. As schools re-opened, a platform, hybrid model, evolved fusing two models. high expectations on teachers swiftly adopt methods—often without required resources or training—exacerbated their exhaustion. We conducted scoping review determine stress factors causing teachers' burnout following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) 2020 statement. A total 27 studies were systematically reviewed, we identified numerous affecting These stressors increased already existing difficulties, magnifying detrimental impacts. categorized organizational, individual, transactional, emotional, cultural, digital. This suggests additional research understand prevalence teacher how these affect personal professional lives over time. Despite challenges, this study demonstrates need more in-depth future analysis develop interventions lessen support them in maintaining lives.

Language: Английский

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The relationship between role ambiguity, emotional exhaustion and work alienation among chinese nurses two years after COVID-19 pandemic: a cross-sectional study

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 18, 2023

work alienation is receiving increasing attention as a psychological risk at work, and little known about the mechanisms of role ambiguity in nurses context COVID-19 pandemic. This article aims to examine how affects among Chinese during two years after pandemic verify emotional exhaustion mediators.A cross-sectional study design was used recruit 281 nurses. Nurses completed online questionnaires containing demographic characteristics, ambiguity, exhaustion, alienation, SPSS 26.0 AMOS 24.0 were for data analysis structural equation modelling.work scores (34.64 ± 10.09), correlated with (r1 = 0.521, r2 0.755; p < .01), positively (r 0.512; .01). A mediating effect between held (mediating 0.288, 95% CI: 0.221-0.369, accounting 74.8% total effect).Role has significant direct on nurses' feelings exacerbates through exhaustion. Clarifying roles being less emotionally drained are effective ways reduce alienation.

Language: Английский

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Role ambiguity and role conflict effects on employees’ emotional exhaustion in healthcare services in Tanzania

Cogent Business & Management, Journal Year: 2024, Volume and Issue: 11(1)

Published: April 4, 2024

This study investigated the effect of role conflict and ambiguity on emotional exhaustion among healthcare service employees in hospital settings. A questionnaire utilizing a 5-point Likert scale was administered to 181 Kairuki Memorial Hospital. Out these, 131 questionnaires were considered valid for data analysis. Descriptive regression analyses conducted using SPSS software. The findings indicated that had positive significant association with exhaustion. Conversely, between negative but not significant. It should be noted that, unlike previous studies focused specific professionals, this included all professionals working setting, acknowledging exposure stressful environment may differ based one's profession. However, as relied cross-sectional survey single hospital, caution exercised generalizing findings. contributes literature human resources management by shedding light conflict. also offers recommendations managing addressing underlying causes identified study.

Language: Английский

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Prevalence and influencing factors of anxiety, depression, and burnout among teachers in China: a cross-sectional study

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Background Teachers are more likely to experience mental health issues than the general population, yet few studies focus on Chinese teachers. After “Double Reduction” policy, teacher workload and stress have risen significantly. In Dongguan, a city actively implementing educational reforms, may be particularly concerning. Anxiety, depression, burnout prevalent issues. This study examined prevalence factors linked anxiety, among Dongguan Methods A cross-sectional survey evaluated of primary secondary school teachers in China, using two-stage random sampling. Eleven schools were randomly selected, with 30 chosen from each 330 invited participants, 313 completed (94.8% response rate), 259 valid responses retained after excluding incomplete or inconsistent answers. The used Zung Self-Rating Anxiety Scale (SAS), Depression (SDS), Maslach Burnout Inventory-Educators Survey (MBI-ES). Wilcoxon rank-sum Kruskal–Wallis tests identified burnout. Variables p ≤ 0.10 univariate analysis included multivariate logistic regression, cut-offs 50 for SAS, 53 SDS, 27 Emotional Exhaustion (EE), 13 Depersonalization (DP), 31 Personal Accomplishment (PA). threshold was avoid omitting potential predictors. Results found rates 19.3%, 34.7%, 74.5%, respectively (95% CI: 14.5–24.1; 28.9–40.6; 69.2–79.9). Junior high (OR = 0.47) those higher education 0.39) had lower depression risk. Female 1.96) risk emotional exhaustion while older 0.923) reduced personal accomplishment depersonalization (DP) showed no significant associations. Conclusion teachers, influenced by level, type, sex, age. Authorities should address these clarifying responsibilities, providing training, establishing monitoring systems. As study, it cannot determine causality, further longitudinal research is needed confirm findings.

Language: Английский

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Qualitative analysis of negative and positive COVID-19 experiences of frontline client educators in a Canadian maritime province

Social Sciences & Humanities Open, Journal Year: 2025, Volume and Issue: 11, P. 101385 - 101385

Published: Jan. 1, 2025

Language: Английский

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Balancing health and work: Fear predicts gig workers' goals and behaviors during COVID‐19

Applied Psychology, Journal Year: 2025, Volume and Issue: 74(2)

Published: April 1, 2025

Abstract Findings are mixed regarding fear and performance behaviors. Whereas resource‐based theories suggest that impairs performance, perspectives on emotion regulation argue is motivating. It also unclear how independent workers prioritize between potentially competing health work goals. We help reconcile disputes by implicating goal setting for gig workers' effective functioning. studied relationships COVID‐19 fear, preventative goals hour goals, actual behaviors over four weekly surveys with (N = 49) during the summer of 2020. Fear was assessed in a baseline survey, were at Time 1, three days later 2. Supporting predictions, although may prompt greater behaviors, might still undermine these through weakening setting. However, results did not support predictions conflict. Instead, between‐person level, 1 linked to 2 contribute theory relationship motivation, performance. Organizations both crisis.

Language: Английский

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Role stress and burnout among social workers in China: Exploring the impact of job satisfaction and leadership support

Journal of Human Behavior in the Social Environment, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Feb. 21, 2025

Language: Английский

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Interventions to Reduce Burnout Among University Lecturers: A Systematic Literature Review

Behavioral Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 649 - 649

Published: May 10, 2025

The teaching profession is widely recognized as highly challenging due to its intense workload, emotional demands, and ongoing stressors. This Systematic Literature Review (SLR) aims identify evaluate various interventions that have been implemented address lecturer burnout over the past five years. A thorough review of 21 studies published between 2020 2024 was conducted across major databases: Web Science, Scopus, PubMed, ERIC, APA PsycINFO. Relevant search terms were used explore effectiveness different aimed at reducing burnout. Articles extracted, reviewed, collated, thematically analyzed synthesize findings. Seven distinct identified effective in most commonly studied intervention social support, followed by training programs. Other demonstrating positive results include supportive work environments, Rational Emotive Behavior Therapy (REBT), psychological capital. Additionally, balanced life conditions, facilitated transitions, helped lecturers reevaluate encouraged utilization character strengths also found yield beneficial outcomes. implementation targeted, school-based crucial for enhancing overall well-being university lecturers. Policymakers, administrators, educational leaders should prioritize awareness

Language: Английский

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