Toxicological review of micro- and nano-plastics in aquatic environments: Risks to ecosystems, food web dynamics and human health

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116426 - 116426

Published: May 8, 2024

The increase of micro- and nano-plastics (MNPs) in aquatic environments has become a significant concern due to their potential toxicological effects on ecosystems, food web dynamics, human health. These plastic particles emerge from range sources, such as the breakdown larger waste, consumer products, industrial outputs. This review provides detailed report transmission dangers MNPs environmental behavior, interactions within webs, emphasizing toxic impact marine life. It explores relationship between particle size toxicity, distribution different tissues, process trophic transfer through web. MNPs, once consumed, can be found various organs, including digestive system, gills, liver. Their consumption by lower level organisms facilitates progression up chain, potentially leading bioaccumulation biomagnification, thereby posing substantial risks health, reproduction, behavior species. work also how persistence bioaccumulation, pose biodiversity disrupt relationships. addresses implications for particularly contaminated seafood, highlighting direct indirect pathways which humans are exposed these pollutants. Furthermore, highlights recommendations future research directions, integration ecological, toxicological, health studies inform risk assessments develop mitigation strategies address global challenge pollution environments.

Language: Английский

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Health benefits and health risks of contaminated fish consumption: Current research outputs, research approaches, and perspectives

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33905 - e33905

Published: July 1, 2024

BackgroundFish contains high-quality omega-3 fatty acids, protein, vitamins, and minerals due to this it is termed as an essential component of a balanced diet. But there have been concerns raised about the risks consuming fish that contaminated with toxins such methylmercury, polychlorinated biphenyls (PCBs), dioxins, pesticides, plastic waste. Consumption containing these pollutants raising global mortality morbidity rates.Scope approachesThe review examines current research outputs on health benefits potential consumption. The also discusses various approaches mitigating problems caused by consumption, highlights roles balancing when fish.Key findings conclusionDifferent indicated contaminants cause cancer, kidney failure, adverse neurological effect, cardiovascular diseases, so vulnerable groups pregnant, child breast-feeding children. In conclusion, need get more tangible evidence advantages disadvantages consumption safeguard wellbeing society.

Language: Английский

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Ingested Polystyrene Micro-Nanoplastics Increase the Absorption of Co-Ingested Arsenic and Boscalid in an In Vitro Triculture Small Intestinal Epithelium Model

Microplastics, Journal Year: 2025, Volume and Issue: 4(1), P. 4 - 4

Published: Jan. 7, 2025

Micro-nano plastics (MNPs) are emerging environmental and food contaminants that raising serious health concerns. Due to the polycontamination of web with pollutants (EPs), now MNPs, co-ingestion EPs MNPs is likely occur, potential synergistic effects such co-ingestions completely unstudied. In this study, we therefore sought determine two model EPs, arsenic boscalid, on uptake toxicity 25 1000 nm polystyrene (PS-25 PS-1000), vice versa, employing a triculture small intestinal epithelium combined simulated digestion. 24 h exposures, neither nor + caused significant toxicity. The presence PS-25 significantly increased (from 0.0 5.8%, p < 0.001) translocation 5.2 9.8%, 0.05) but had no effect boscalid or translocation, whereas PS-1000 either EP. both PS was also by rising from 10.6 19.5% (p 0.01) for 4.8 8.5% PS-1000. These findings highlight need further studies assess MNP-EP interactions possible adverse impacts.

Language: Английский

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Nanoplastics in focus: Exploring interdisciplinary approaches and future directions

NanoImpact, Journal Year: 2025, Volume and Issue: unknown, P. 100544 - 100544

Published: Jan. 1, 2025

Language: Английский

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Biomarkers of oxidative stress, inflammation, and genotoxicity to assess exposure to micro- and nanoplastics. A literature review

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 267, P. 115645 - 115645

Published: Nov. 1, 2023

The increased awareness about possible health effects arising from micro- and nanoplastics (MNPs) pollution is driving a huge amount of studies. Many international efforts are in place to better understand characterize the hazard MNPs present environment. literature search was performed according Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) methodology two different databases (PubMed Embase). selection articles carried out blind, screening titles abstracts inclusion exclusion criteria. In general, these studies rely on already use assessing nanomaterials particles concern. However, only limited number have so far directly measured human exposure examined relationship between such its impact health. This review aims provide an overview current state research biomarkers oxidative stress, inflammation, genotoxicity that been explored relation exposure, using human, cellular, animal, plant models. Both in-vitro in-vivo models suggest level stress inflammation as main mechanism action (MOA) leading adverse chronic immunotoxicity genotoxicity. With identification biological endpoints, representing critical key initiating events (KIEs) towards adaptive or outcomes, it identify panel surrogate be applied validated especially occupational settings, where higher levels may occur.

Language: Английский

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Nasal instillation of polystyrene nanoplastics induce lung injury via mitochondrial DNA release and activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-signaling cascade

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174674 - 174674

Published: July 11, 2024

Language: Английский

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Micro(nano)plastics: an Emerging Burden for Human Health

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(14), P. 5779 - 5792

Published: Oct. 21, 2024

The escalation of plastic pollution represents a global environmental and health problem. Important toxic effects have been attributed to the increasing diffusion microplastics (MPs) nanoplastics (NPs) derived from degradation plastics. These particles ubiquitously observed in environment, with humans being continuously exposed via ingestion, inhalation skin contact. Nonetheless, cellular homeostasis imbalance induced by micro- nano- plastics (MNPs) human has only recently shown, while most evidence molecular mechanisms studies

Language: Английский

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Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12166 - 12166

Published: Nov. 13, 2024

The widespread use of plastics has increased environmental pollution by micro- and nanoplastics (MNPs), especially polystyrene (PS-MNPs). These particles are persistent, bioaccumulative, linked to endocrine-disrupting toxicity, posing risks reproductive health. This review examines the effects PS-MNPs on mammalian systems, focusing oxidative stress, inflammation, hormonal imbalances. A comprehensive search in Web Science Core Collection, following PRISMA 2020 guidelines, identified studies impact fertility, including oogenesis, spermatogenesis, folliculogenesis. An analysis 194 publications revealed significant harm, such as reduced ovarian size, depleted follicular reserves, apoptosis somatic cells, disrupted estrous cycles females, along with impaired sperm quality imbalances males. were endocrine disruption, leading cellular molecular damage. Further research is urgently needed understand toxicity mechanisms, develop interventions, assess long-term health impacts across generations, highlighting need address these challenges given growing exposure.

Language: Английский

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Microplastic effects on mouse colon in normal and colitis conditions: A literature review

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e18880 - e18880

Published: Feb. 10, 2025

Background Taking into account the global spread of microplastic (MP) pollution, problem MP impact on human health is relevant. enters organism predominantly with water and food, mostly detected in large intestine. Therefore, connection between pollution increase colitis an important question. In order to assess toxic pathogenetic effects MP, experimental studies were actively conducted during recent years, mainly laboratory mice. Objectives The aim our review was summarize systematize data effect mice colon under normal conditions role development intestinal diseases. This manuscript could be relevant for ecologists, biologists, physicians dealing problems related anthropogenic environmental changes inflammatory bowel Survey Methodology search based PubMed about original healthy colitis. Results colon, can cause oxidative stress, increased permeability, immune cell infiltration, production proinflammatory factors, decreased mucus production. affects proliferation, apoptosis, differentiation epithelial cells, expression tight junction components glycocalyx, membrane transport, signaling pathways, metabolome, microflora composition. acute chronic colitis, consumption leads a more pronounced pathological process course. Conclusions may one factors contributing humans. However, further research needed.

Language: Английский

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Strategies for the Remediation of Micro- and Nanoplastics from Contaminated Food and Water: Advancements and Challenges

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 30 - 30

Published: Feb. 9, 2025

Micro- and nanoplastic (MNP) pollution is a significant concern for ecosystems worldwide. The continuous generation extensive utilization of synthetic plastics have led to the widespread contamination water food resources with MNPs. These pollutants originate from daily-use products industrial waste. Remediation such essential protect human health since these ubiquitous contaminants pose serious biological environmental hazards by contaminating chains, sources, air. Various remediation techniques, including physical, chemical, sophisticated filtration, microbial bioremediation, adsorption employing novel materials, provide encouraging avenues tackling this worldwide issue. biotechnological approaches stand out as effective, eco-friendly, sustainable solutions managing toxic pollutants. However, complexity MNP presents challenges in its management regulation. Addressing requires cross-disciplinary research efforts develop implement more efficient, sustainable, scalable techniques mitigating pollution. This review explores various sources micro- resources, their impacts, strategies—including advanced approaches—and treating alleviate effects on health.

Language: Английский

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