Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120092 - 120092

Published: Sept. 1, 2024

Language: Английский

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Combined Effects of Social and Behavioral Factors on Stress and Depression

Diseases, Journal Year: 2025, Volume and Issue: 13(2), P. 46 - 46

Published: Feb. 4, 2025

Background: Chronic stress, driven by the persistent activation of body’s stress response system—including sympathetic nervous system and hypothalamic–pituitary–adrenal (HPA) axis—has far-reaching effects on both physical mental health. This study examines combined social behavioral factors a latent variable consisting depressive symptoms, using comprehensive framework to explore complex interactions these factors. Methods: Leveraging data from United States Centers for Disease Control Prevention’s (CDC’s) National Health Nutrition Examination Survey (NHANES), we operationalized allostatic load—a measure cumulative physiological stress—through 10 biomarkers spanning cardiovascular, inflammatory, metabolic systems. Depressive symptoms were measured via Patient Questionnaire-9 (PHQ-9), capturing shared variance between was derived factor analysis. To assess influence (income education) (alcohol consumption smoking) this variable, employed Bayesian Kernel Machine Regression (BKMR), allowing us examine potential non-linear interactive among predictors. Results: Our results revealed significant positive association load across sample, regardless ethnic background. Alcohol emerged as key factor, with associations stress. Conversely, education showed protective effect, higher levels associated decreased symptoms. Conclusions: These findings underscore importance addressing determinants risk in mitigating impacts By highlighting roles alcohol education, provides insights that can inform public health strategies aimed at promoting resilience reducing stress-related disparities.

Language: Английский

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A Review of the Occurrence and Distribution of Per- and Polyfluoroalkyl Substances (PFAS) in Human Organs and Fetal Tissues

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121181 - 121181

Published: Feb. 1, 2025

Language: Английский

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PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties

European journal of ecology, biology and agriculture., Journal Year: 2025, Volume and Issue: 2(2), P. 30 - 46

Published: March 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Language: Английский

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Association of combined lead, cadmium, and mercury with systemic inflammation

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 29, 2024

Background Exposure to environmental metals has been increasingly associated with systemic inflammation, which is implicated in the pathogenesis of various chronic diseases, including those neurodegenerative aspects. However, complexity exposure and response relationships, particularly for mixtures metals, not fully elucidated. Objective This study aims assess individual combined effects lead, cadmium, mercury on inflammation as measured by C-reactive protein (CRP) levels, using data from National Health Nutrition Examination Survey (NHANES) 2017-2018. Methods We employed Bayesian Kernel Machine Regression (BKMR) analyze NHANES 2017-2018 data, allowing evaluation non-linear exposure-response functions interactions between metals. Posterior Inclusion Probabilities (PIP) were calculated determine significance each metal's contribution CRP levels. Results The PIP results highlighted mercury's significant levels (PIP = 1.000), followed cadmium 0.6456) lead 0.3528). Group values confirmed importance considering a collective group relation Our BKMR analysis revealed relationships metal exposures Univariate showed flat relationship CRP, having positive relationship. Mercury exhibited U-shaped association, indicating both low high potential risk factors increased inflammation. Bivariate this when contaminants cadmium. Analysis single-variable suggested that are higher h function, flexible function takes multiple combines them way captures complex potentially nonlinear CRP. overall effect all below 50th percentile level an increase while above 60th linked decrease Conclusions findings suggest mercury, These highlight need public health strategies address cumulative reinforce advanced statistical methods understand impact contaminants. Future research should focus mechanistic pathways metal-induced longitudinal studies ascertain long-term these exposures.

Language: Английский

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Toxic layering and compound extremes: Per- and polyfluoroalkyl substances (PFAS) exposure in rural, environmental justice copper mining communities

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 957, P. 177767 - 177767

Published: Dec. 1, 2024

Language: Английский

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Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117599 - 117599

Published: Dec. 27, 2024

Language: Английский

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Investigating the Interplay of Toxic Metals and Essential Elements in Liver Disease

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(6), P. 762 - 762

Published: June 12, 2024

Liver diseases, including non-alcoholic fatty liver disease (NAFLD), are a growing global health issue. Environmental exposure to toxic metals can harm the liver, increasing risk of NAFLD. Essential elements vital for health, but imbalances or deficiencies contribute development Therefore, understanding interplay between and essential in is important. This study aims assess individual combined effects (lead(Pb), cadmium (Cd), mercury (Hg)), (manganese selenium) on disease. Methods: We assessed Pb, Cd, Hg, manganese (Mn), selenium (Se) using data from National Health Nutrition Examination Survey 2017 2018. performed descriptive statistics linear regression analysis then utilized Bayesian Kernel Machine Regression (BKMR) techniques such as univariate, bivariate, overall effect analysis. BKMR enabled assessment non-linear exposure-response functions interactions elements. Posterior Inclusion Probabilities (PIPs) were calculated determine importance each metal element contributing Regarding our results, injury biomarkers ALT, AST, ALP, GGT, total bilirubin, FLI-an indicator NAFLD-with elements, adjusting covariates age, sex, BMI, alcohol consumption, ethnicity, income, smoking status, demonstrated differential these contaminants markers interest. Our provided further insights. For instance, PIP results underscored Pb's consistent (PIP = 1.000), followed by Hg 0.9512), Cd 0.5796), Se 0.5572), Mn 0.4248). univariate showed positive trend with while other exposures relatively flat. single-variable NAFLD also revealed that Pb significantly affected bivariate found (toxic) when was all together, estimated steady increase 60th 75th percentile. In conclusion, indicates exposure, plays significant role bringing about adverse outcomes.

Language: Английский

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Association between Combined Metals and PFAS Exposure with Dietary Patterns: A Preliminary Study

Environments, Journal Year: 2024, Volume and Issue: 11(6), P. 127 - 127

Published: June 18, 2024

The global burden of chronic diseases has been increasing, with evidence suggesting that diet and exposure to environmental pollutants, such as per- polyfluoroalkyl substances (PFAS) heavy metals, may contribute their development. Dietary Inflammatory Index (DII) assesses the inflammatory potential an individual's diet. However, complex interplay between PFAS, DII remains largely unexplored. goal this cross-sectional study was investigate associations operationalized individual combined lead, cadmium, mercury, perfluorooctanoic acid (PFOA), perfluorooctanesulfonic (PFOS) exposures using data from National Health Nutrition Examination Survey (NHANES) 2017-2018. Descriptive statistics, a correlational analysis, linear regression were initially used assess relationship variables interest. We subsequently employed Bayesian kernel Machine (BKMR) analyze non-linear, non-additive, exposure-response relationships interactions PFAS metals DII. multi-variable revealed significant cadmium mercury. Our BKMR analysis metal exposures, In our univariate function plot, mercury exhibited positive negative relationship, respectively, which indicated across spectrum addition, bivariate two in mixture had robust for different quantiles PFOA, PFOS, indicating increasing levels are associated Mercury's plot demonstrated all pollutants. Furthermore, posterior inclusion probability (PIP) results highlighted consistent importance diet, study, both showing PIP 1.000. This followed by PFOS 0.8524, PFOA at 0.5924, lowest impact among five 0.5596. suggests particularly These findings also provide intricate underscore considering cumulative effects multi-pollutant exposures. Future research should focus on elucidating mechanistic pathways dose-response underlying these examines causality, will enable deeper understanding dietary risks

Language: Английский

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