Antibacterial lignin-based nanoparticles and their use in composite materials

Nanoscale Advances, Journal Year: 2022, Volume and Issue: 4(21), P. 4447 - 4469

Published: Jan. 1, 2022

Lignin, one of the most abundant biopolymers on earth, has been traditionally considered a low-value by-product pulp and paper industries. This renewable raw material, besides being source valuable molecules for chemical industry, also antioxidant, UV-absorbing, antibacterial properties in its macromolecular form. Moreover, lignin form nanoparticles (LigNPs) presents advantages over bulk lignin, such as higher reactivity due to larger surface-to-volume ratio. In view rapid surge antimicrobial resistance (AMR), caused by overuse antibiotics, continuous development novel agents is needed. The use LigNPs suitable alternative conventional antibiotics topical application or disinfectants surfaces packaging. Besides, their multiple unspecific targets bacterial cell may prevent emergence AMR. review summarizes latest developments nano-formulated both dispersion embedded materials. following roles formulation NPs have analyzed: (i) an active nanoformulations, (ii) reducing capping agent metals, (iii) carrier other agents. Finally, covers inclusion films, fibers, hydrogels, foams, obtaining lignin-based nanocomposites variety applications, including food packaging, wound healing, medical coatings.

Language: Английский

---

Recent advances in lignin antioxidant: Antioxidant mechanism, evaluation methods, influence factors and various applications

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 251, P. 125992 - 125992

Published: Aug. 4, 2023

Language: Английский

---

Unlocking the potential: Evolving role of technical lignin in diverse applications and overcoming challenges

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133506 - 133506

Published: June 27, 2024

Language: Английский

---

Techno-Economic Assessment, Scalability, and Applications of Aerosol Lignin Micro- and Nanoparticles

ACS Sustainable Chemistry & Engineering, Journal Year: 2018, Volume and Issue: 6(9), P. 11853 - 11868

Published: July 13, 2018

Lignin micro- and nanoparticles (LMNPs) synthesized from side-streams of pulp paper biorefinery operations have been proposed for the generation new, high-value materials. As sustainable alternatives to particles synthetic or mineral origins, LMNPs viability depends on scale-up, manufacturing cost, applications. By using experimental data as primary source information, along with industrial know-how, we analyze dry spherical obtained by our recently reported aerosol/atomization method. First, a preliminary evaluation toward commercial production lignin precursors is presented. Following, introduce potential applications financial perspective. Mass energy balances, operating costs, capital investment are estimated discussed in view scalability prospects. The main market segments identified (from perspective) include composite nanofillers, solid foams, emulsion stabilizers, chelating agents, UV protection. Our technical, financial, assessment represent basis R&D planning efforts lower risk related expected industrialization efforts. Manufacturing costs were between 870 1170 USD/t; also, minimum selling prices varied 1240 1560 USD/t, depending raw materials used. Sensitivity analysis indicated that cost can be low 600 process conditions considered. Finally, based assessment, identified.

Language: Английский

---

Lignin for polymer and nanoparticle production: Current status and challenges

The Canadian Journal of Chemical Engineering, Journal Year: 2019, Volume and Issue: 97(11), P. 2827 - 2842

Published: Aug. 8, 2019

Abstract In pulp production processes, lignin is generated in large quantities as a by‐product. It often burned to generate heat and electricity. Despite the large‐scale of lignin, its utilization high‐value applications has remained challenge. Recently, nanoparticles (LNP) polymers gathered attention. The potential use LNPs reinforcement filler, UV absorbent, antioxidant, drug carrier been reported, while might be suitable for composites, hydrogels, flocculants, coagulants. This review paper provides insights into application LNP polymers. addition, challenges associated with characterization these products are comprehensively reviewed.

Language: Английский

---

Preparation and properties of adhesives based on phenolic resin containing lignin micro and nanoparticles: A comparative study

Materials & Design, Journal Year: 2018, Volume and Issue: 161, P. 55 - 63

Published: Nov. 14, 2018

This work investigated, for the first time, role of nanosized lignin (LNP), in comparison with microlignin (LMP), when introduced at two different weight amounts (5% and 10 wt%) bulk phenol–formaldehyde resol as adhesive. Morphological analysis was performed to check out dispersion interfacial bonding phenolic resin. The curing process has been examined by differential scanning calorimetry (DSC), while thermal stability composites evaluated using thermogravimetric (TGA) thermo-mechanical (TMA) analysis. Results exhibited that small amount could both favor cure reaction, due its abundance phenylpropane units, initial resistance be consequently improved, especially nano-sized used. Meanwhile, effect micro- nano-modification on tensile shear strength wood lap joints based lignin-phenol–formaldehyde adhesives also analyzed. showed 5 wt% LNP positively increase from 8.7 10.9 MPa, opening possibility environmental friendly nanoscale cross linked traditional phenol enhanced adhesion performance, strongly related nanoparticles higher specific surface area reactivity.

Language: Английский

---

Nanocomposites Based on Biodegradable Polymers

Materials, Journal Year: 2018, Volume and Issue: 11(5), P. 795 - 795

Published: May 15, 2018

In the present review paper, our main results on nanocomposites based biodegradable polymers (on a time scale from 2010 to 2018) are reported. We mainly focused attention commercial polymers, which we mixed with different nanofillers and/or additives final aim of developing new materials tunable specific properties. A wide list have been considered according their shape, properties, and functionalization routes, discussed looking at roles basis adopted processing routes (solvent-based or melt-mixing processes). Two application fields nanocomposite considered: interaction stem cells in regenerative medicine applications as antimicrobial active role selected food packaging critically revised, providing an overview authors’ contribution state art field polymeric nanocomposites.

Language: Английский

---

Role of lignin nanoparticles in UV resistance, thermal and mechanical performance of PMMA nanocomposites prepared by a combined free-radical graft polymerization/masterbatch procedure

Composites Part A Applied Science and Manufacturing, Journal Year: 2017, Volume and Issue: 107, P. 61 - 69

Published: Dec. 29, 2017

Language: Английский

---

Rapid and Direct Preparation of Lignin Nanoparticles from Alkaline Pulping Liquor by Mild Ultrasonication

ACS Sustainable Chemistry & Engineering, Journal Year: 2019, Volume and Issue: 7(24), P. 19925 - 19934

Published: Nov. 13, 2019

The production of lignin nanoparticles (LNPs) has opened new routes to the utilization in advanced applications. existing challenge, however, is develop a method that can easily be adapted on an industrial scale. In this study, we demonstrated green and rapid preparing LNPs directly from sulfur-free alkaline pulping liquor by combining acid precipitation ultrasonication. combined produced spherical LNPs, with hierarchical nanostructure highly negative surface charge, within only 5 min sonication. mild, sonication was achieved sonicating without prior drying acid-precipitated dialyzed lignin. Optimization revealed potential for minimizing consumption, shortening dialysis time, processing as much 20 wt % isolated were stable during storage 180 days, at pH range 4–7, dispersing medium below 0.1 M NaCl. also displayed excellent emulsifying properties, stabilizing oil-in-water emulsions. Thus, simple energy-efficient opens sustainable, straightforward, scalable route organic solvent-free high interface stabilizers multiphase systems food medical industries.

Language: Английский

---

Chitin Nanofibrils and Nanolignin as Functional Agents in Skin Regeneration

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(11), P. 2669 - 2669

Published: May 30, 2019

Chitin and lignin, by-products of fishery plant biomass, can be converted to innovative high value bio- eco-compatible materials. On the nanoscale, antibacterial, anti-inflammatory, cicatrizing anti-aging activity is obtained by controlling their crystalline structure purity. Moreover, electropositive chitin nanofibrlis (CN) combined with electronegative nanolignin (NL) leading microcapsule-like systems suitable for entrapping both hydrophilic lipophilic molecules. The aim this study was provide morphological, physico-chemical, thermogravimetric biological characterization CN, NL, CN-NL complexes, which were also loaded glycyrrhetinic acid (GA) as a model bioactive molecule. CN-NL/GA thermally stable up 114 °C 127 °C, respectively. compounds administered in vitro cultures human keratinocytes (HaCaT cells) mesenchymal stromal cells (hMSCs) potential use skin contact applications. Cell viability, cytokine expression effects on hMSC multipotency studied. For each component, CN-NL/GA, non-toxic concentrations towards HaCaT identified. In keratinocyte model, proinflammatory cytokines IL-1α, IL-1 β, IL-6, IL-8 TNF-α that resulted downregulated, whereas antimicrobial peptide β defensin-2 upregulated CN-LN. hMSCs viable, these complexes did not modify osteo-differentiation capability cells. findings demonstrate biocomponents are cytocompatible, show anti-inflammatory may serve delivery biomolecules care regeneration.

Language: Английский

---