Poultry Science,
Journal Year:
2022,
Volume and Issue:
101(5), P. 101715 - 101715
Published: Jan. 12, 2022
This
review
provides
insight
into
the
effects
of
branched-chain
amino
acids
(BCAA:
leucine,
isoleucine,
and
valine)
on
growth,
production
performance,
immunity,
intestinal
health
poultry.
Besides
providing
nitrogen
substrates
carbon
framework
for
energy
homeostasis
transamination,
BCAA
also
function
as
signaling
molecules
in
regulation
glucose,
lipid,
protein
synthesis
via
kinase
B
a
mechanistic
target
rapamycin
(AKT-mTOR)
pathway
that
is
important
muscle
accretion.
The
level
leucine
generally
high
cereals
an
imbalance
ratio
among
3
low
diet
would
produce
negative
effect
poultry
growth
performance.
occurs
due
to
structural
similarity
BCAA,
which
leads
metabolic
competition
interference
with
enzymatic
degradation
pathway.
Emerging
evidence
shows
inclusion
essential
proper
functioning
innate
adaptive
immune
system
maintenance
mucosal
integrity.
recommended
levels
are
outlined
by
NRC
(1994),
but
commercial
broilers
laying
hen
breed
standards
determine
their
own
levels.
In
this
review,
it
has
been
noted
requirement
influenced
type,
breed,
age
birds.
Additionally,
several
studies
focused
diets
strategy
reduce
excretion.
Notably,
there
limited
research
supplemental
form
compared
ingredient-bound
affect
dynamics
utilization
different
disease-challenged
conditions,
especially
those
affecting
digesta
passage
ratio.
summary,
encompasses
role
functional
AA
discusses
physiological
productivity
observations
interpretations
can
guide
future
adjust
feeding
programs
absence
subtherapeutic
antibiotics
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
8
Published: Jan. 12, 2021
Metabolic
reprogramming
has
been
widely
recognized
as
a
hallmark
of
malignancy.
The
uptake
and
metabolism
amino
acids
are
aberrantly
upregulated
in
many
cancers
that
display
addiction
to
particular
acids.
Amino
facilitate
the
survival
proliferation
cancer
cells
under
genotoxic,
oxidative,
nutritional
stress.
Thus,
targeting
acid
is
becoming
potential
therapeutic
strategy
for
patients.
In
this
review,
we
will
systematically
summarize
recent
progress
malignancy
discuss
their
interconnection
with
mammalian
target
rapamycin
complex
1
(mTORC1)
signaling,
epigenetic
modification,
tumor
growth
immunity,
ferroptosis.
Finally,
highlight
applications.
Nutrients,
Journal Year:
2019,
Volume and Issue:
11(4), P. 923 - 923
Published: April 24, 2019
The
gut
microbiota
is
a
highly
complex
community
which
evolves
and
adapts
to
its
host
over
lifetime.
It
has
been
described
as
virtual
organ
owing
the
myriad
of
functions
it
performs,
including
production
bioactive
metabolites,
regulation
immunity,
energy
homeostasis
protection
against
pathogens.
These
activities
are
dependent
on
quantity
quality
alongside
metabolic
potential,
dictated
by
number
factors,
diet
genetics.
In
this
regard,
microbiome
malleable
varies
significantly
from
host.
two
features
render
candidate
‘organ’
for
possibility
precision
microbiomics—the
use
biomarker
predict
responsiveness
specific
dietary
constituents
generate
diets
interventions
optimal
health.
With
in
mind,
two-part
review
investigates
current
state
science
terms
influence
components
subsequent
consequences
health
status,
along
with
opportunities
modulate
improved
potential
components.
particular,
Part
I,
we
examine
development
birth
role
We
investigate
poor-quality
relation
infection
inflammation
discuss
diet-derived
microbial
metabolites
negatively
impact
look
at
shaping
components,
namely
protein,
fat
carbohydrates,
composition.
Nutrients,
Journal Year:
2020,
Volume and Issue:
12(8), P. 2236 - 2236
Published: July 27, 2020
The
search
for
a
quality
diet
has
grown
over
the
past
decade.
Diet
is
considered
one
of
pillars
prevention
and
progression
several
diseases,
among
them:
diabetes.
Type
2
diabetes
(T2D)
an
epidemic
western
countries
that
increases
vulnerability
other
such
as
cardiovascular
cancer.
T2D
associated
with
lifestyle
diet.
traditional
Mediterranean
proven
its
benefits
risk
factors,
specifically
on
This
review
compiles
recent
published
evidence
effects
incidence
type
relation
healthy
diets.
We
will
also
focus
how
could
play
role
in
T2D-related
mechanisms,
anti-inflammatory
or
antioxidant
compounds,
glucagon-like
peptide
agonist
changes
gut
microbiota.
Each
component
be
involved
processes
related
to
homeostasis,
many
them
sharing
common
physio-pathological
pathways.
importance
this
within
set
habits
must
emphasized.
Foods,
Journal Year:
2019,
Volume and Issue:
8(8), P. 347 - 347
Published: Aug. 15, 2019
Cheese
whey
constitutes
one
of
the
most
polluting
by-products
food
industry,
due
to
its
high
organic
load.
Thus,
in
order
mitigate
environmental
concerns,
a
large
number
valorization
approaches
have
been
reported;
mainly
targeting
recovery
proteins
and
lactose
from
cheese
for
further
exploitation
as
renewable
resources.
Most
studies
are
predominantly
focused
on
separate
implementation,
either
protein
or
lactose,
configure
processes
that
will
formulate
value-added
products.
Likewise,
valorization,
so
far,
do
not
exploit
full
potential
whey,
particularly
with
respect
applications.
Nonetheless,
within
concept
integrated
biorefinery
design
transition
circular
economy,
it
is
imperative
develop
consolidated
bioprocesses
foster
holistic
whey.
Therefore,
aim
this
article
elaborate
recent
advances
regarding
conversion
products,
focusing
Moreover,
novel
biorefining
concepts
proposed,
inaugurate
complete
products
diversified
end
Within
context
envisaged
be
reintroduced
supply
chain,
thereby
enhancing
sustainability
creating
"zero
waste"
processes.
Nutrition and Diabetes,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Aug. 5, 2022
Abstract
Branched-chain
amino
acid
(BCAA)
catabolism
has
been
considered
to
have
an
emerging
role
in
the
pathogenesis
of
metabolic
disturbances
obesity
and
type
2
diabetes
(T2D).
Several
studies
showed
elevated
plasma
BCAA
levels
humans
with
insulin
resistance
patients
T2D,
although
underlying
reason
is
unknown.
Dysfunctional
could
theoretically
be
factor.
In
vitro
animal
work
collectively
show
that
modulation
catabolic
pathway
alters
key
processes
affecting
glucose
homeostasis,
integrated
understanding
tissue-specific
remains
largely
unknown,
especially
humans.
Proof-of-concept
rodents
-and
a
lesser
extent
–
strongly
suggest
enhancing
improves
homeostasis
disorders,
such
as
T2D.
this
review,
we
discuss
several
hypothesized
mechanistic
links
between
overview
current
available
tools
modulate
vivo.
Furthermore,
review
considers
whether
forms
potential
future
treatment
strategy
promote
health
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(8), P. 2592 - 2592
Published: July 28, 2021
Threonine
(Thr),
an
essential
amino
acid
for
animals
and
the
limiting
in
swine
poultry
diets,
which
plays
a
vital
role
modulation
of
nutritional
metabolism,
macromolecular
biosynthesis,
gut
homeostasis.
Current
evidence
supports
that
supplementation
Thr
leads
to
benefits
terms
energy
metabolism.
is
not
only
important
component
gastrointestinal
mucin,
but
also
acts
as
modulator
influences
intestinal
immune
system
via
complex
signaling
networks,
particularly
mitogen-activated
protein
kinase
(MAPK)
target
rapamycin
(TOR)
signal
pathway.
recognized
indispensable
nutrient
cell
growth
proliferation.
Hence,
optimization
requirement
may
exert
favorable
impact
on
factors
linked
health
diseases
animals.
This
review
focuses
latest
reports
metabolic
pathways
regulation,
well
relationship
between
relevant
physiological
functions.
