<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 2555 - 2562

Published: April 1, 2020

Abstract: Nanotechnology has recently emerged as a rapidly growing field with numerous biomedical science applications. At the same time, silver been adopted an antimicrobial material and disinfectant that is relatively free of adverse effects. Silver nanoparticles possess broad spectrum antibacterial, antifungal antiviral properties. have ability to penetrate bacterial cell walls, changing structure membranes even resulting in death. Their efficacy due not only their nanoscale size but also large ratio surface area volume. They can increase permeability membranes, produce reactive oxygen species, interrupt replication deoxyribonucleic acid by releasing ions. Researchers studied agents dentistry. For instance, be incorporated into acrylic resins for fabrication removable dentures prosthetic treatment, composite resin restorative irrigating solution obturation endodontic adhesive materials orthodontic membrane guided tissue regeneration periodontal titanium coating dental implant treatment. Although all authorities acknowledged safety nanoparticles, no systemic toxicity ingested reported. A concern potential hazard if they are released environment. However, interaction toxic organic compounds either or reduce toxicity. This paper provides overview antibacterial use dentistry, highlighting mechanism, applications clinical Keywords: nanotechnology,

Language: Английский

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Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(7), P. 2375 - 2375

Published: March 30, 2020

Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among various ENMs, silver nanoparticles (AgNPs) become one of most explored nanotechnology-derived nanostructures and been intensively investigated for their unique physicochemical properties. The widespread commercial biomedical application nanosilver include its use as a catalyst an optical receptor cosmetics, electronics textile engineering, bactericidal agent, wound dressings, surgical instruments, disinfectants. This, turn, has increased potential interactions AgNPs with terrestrial aquatic environments, well exposure toxicity to human health. In present review, after giving overview we discuss current advances on physiochemical properties specific emphasis biodistribution both vitro vivo following routes exposure. Most studies demonstrated size-, dose- coating-dependent cellular uptake AgNPs. Following NPs exposure, reported Ag accumulation local distant organs. Though there increase number this area, more investigations are required understand mechanisms modes

Language: Английский

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Plasmonic Photothermal Nanoparticles for Biomedical Applications

Advanced Science, Journal Year: 2019, Volume and Issue: 6(17)

Published: July 22, 2019

Recent advances of plasmonic nanoparticles include fascinating developments in the fields energy, catalyst chemistry, optics, biotechnology, and medicine. The photothermal properties metallic are enormous interest biomedical because their strong tunable optical response capability to manipulate effect by an external light source. To date, most applications using have focused on therapy; however, fully realize potential these particles for clinical other applications, fundamental need be better understood controlled, effect-based diagnosis, treatment, theranostics should thoroughly explored. This Progress Report summarizes recent understanding nanoparticles, particularly sensing, imaging, therapy, drug delivery, discusses future directions fields.

Language: Английский

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Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

Materials, Journal Year: 2019, Volume and Issue: 12(16), P. 2540 - 2540

Published: Aug. 9, 2019

Recent data have reported that the burden of infections related to antibiotic-resistant bacteria in European Union and Economic Area (EEA) can be estimated as cumulative tuberculosis, influenza, human immunodeficiency virus (HIV). In wound management, control represents a crucial issue multi-billion dollar industry worldwide. For diabetic wounds ulcers, particular, are majority amputations patients, which today represent an increasing number elderly. The greatest barrier healing is represented by biofilm, organized consortium encapsulated self-produced extracellular polymeric substance with high resistance conventional antimicrobial therapies. There urgent need for novel anti-biofilm strategies agents and, this scenario, silver nanotechnology has received tremendous attention recent years therapeutically enhanced healthcare. Due its intrinsic therapeutic properties broad-spectrum efficacy, nanoparticles opened new horizons towards approaches healing. This review aims at providing reader overview most progress nanotechnology, special focus on role process.

Language: Английский

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Bactericidal activity of silver nanoparticles: A mechanistic review

Materials Science for Energy Technologies, Journal Year: 2020, Volume and Issue: 3, P. 756 - 769

Published: Jan. 1, 2020

Metallic nanoparticles such as silver (AgNPs) have gained lots of attention due to the continuous upsurge in microbial infections and diseases, also inefficient treatment. Also, rapid intensification antibiotic resistance this period has revived consideration researchers scientists explore therapeutic abilities its nanoparticulate systems potential antimicrobial agents. Indeed, numerous studies suggested that AgNPs exhibited significant actions, specifically against bacterial infections. Ample been performed evaluate estimate antibacterial potentials associated products, it was noticed they these Ag-particles triggers oxidative stress, protein dysfunction, membrane DNA damage, leading cell damage. Although activities, but adverse effects over human health a major concern. Further, review we summarized significance AgNPs, various approaches for preparation mechanism probable toxicity environment. Furthermore, focused consider mechanisms behind bactericidal actions nanoparticles-based systems, followed by comprehensive ideas related their toxic potentials. This would open new robust possibilities develop nanoparticle-based with desired properties effective treatment humans.

Language: Английский

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Silver nanoparticles: Toxicity in model organisms as an overview of its hazard for human health and the environment

Journal of Hazardous Materials, Journal Year: 2019, Volume and Issue: 390, P. 121974 - 121974

Published: Dec. 24, 2019

Language: Английский

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Safe Nanoparticles: Are We There Yet?

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 22(1), P. 385 - 385

Published: Dec. 31, 2020

The field of nanotechnology has grown over the last two decades and made transition from benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles, have emerged as promising tools with broad applications in drug delivery, diagnostics, cosmetics several other biological non-biological areas. These advances lead questions about nanoparticle safety. Despite considerable efforts understand toxicity safety these many are not yet fully answered. Nevertheless, identified approaches minimize prevent promote safer nanotechnology. This review summarizes our current knowledge on their toxic effects, interactions mammalian cells finally minimizing toxicity.

Language: Английский

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Edible packaging: Sustainable solutions and novel trends in food packaging

Food Research International, Journal Year: 2020, Volume and Issue: 140, P. 109981 - 109981

Published: Dec. 26, 2020

Language: Английский

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Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens

Microorganisms, Journal Year: 2023, Volume and Issue: 11(2), P. 369 - 369

Published: Feb. 1, 2023

This review highlights the different modes of synthesizing silver nanoparticles (AgNPs) from their elemental state to particle format and mechanism action against multidrug-resistant biofilm-forming bacterial pathogens. Various studies have demonstrated that AgNPs cause oxidative stress, protein dysfunction, membrane disruption, DNA damage in bacteria, ultimately leading death. also been found alter adhesion cells prevent biofilm formation. The benefits using medicine are, some extent, counter-weighted by toxic effect on humans environment. In this review, we compiled recent demonstrating antibacterial activity AgNPs, are discussing known mechanisms Ongoing clinical trials involving briefly presented. A particular focus is placed interaction with biofilms, which a significant pathogenicity determinant. brief overview use other medical applications (e.g., diagnostics, promotion wound healing) non-medical sectors Finally, current drawbacks limitations discussed, perspectives for improved future functionalized

Language: Английский

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Antimicrobial Metal Nanomaterials: From Passive to Stimuli‐Activated Applications

Advanced Science, Journal Year: 2020, Volume and Issue: 7(10)

Published: April 6, 2020

The development of antimicrobial drug resistance among pathogenic bacteria and fungi is one the most significant health issues 21st century. Recently, advances in nanotechnology have led to nanomaterials, particularly metals that exhibit properties. These metal nanomaterials emerged as promising alternatives traditional therapies. In this review, a broad overview their synthesis, properties, interactions with micro-organisms first provided. Secondly, range demonstrate passive properties are outlined in-depth analysis comparison stimuli-responsive provided, which represent next generation microbiocidal nanomaterials. stimulus applied activate such includes light (including photocatalytic photothermal) magnetic fields, can induce hyperthermia kinetically driven activation. Broadly, review aims summarize currently available research provide future scope for nanomaterial-based technologies, those be activated through externally stimuli.

Language: Английский

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