Silver Nanoparticles and Their Antibacterial Applications

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(13), P. 7202 - 7202

Published: July 4, 2021

Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and vivo causing infections. The antibacterial capacity of AgNPs covers Gram-negative Gram-positive bacteria, including multidrug resistant strains. exhibit multiple simultaneous mechanisms action combination with agents organic compounds or antibiotics it has shown synergistic effect against pathogens such Escherichia coli Staphylococcus aureus. characteristics silver make them suitable for their application medical healthcare products where they may treat infections prevent efficiently. With the urgent need new efficient agents, this review aims establish factors affecting cytotoxic effects nanoparticles, well expose advantages using antibiotic, which will reduce dosage needed secondary associated both.

Language: Английский

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Metals to combat antimicrobial resistance

Nature Reviews Chemistry, Journal Year: 2023, Volume and Issue: 7(3), P. 202 - 224

Published: Feb. 8, 2023

Bacteria, similar to most organisms, have a love–hate relationship with metals: specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions long history of antimicrobial activity received increasing attention recent years owing the rise resistance. The search antibacterial agents now encompasses ions, nanoparticles complexes (‘metalloantibiotics’). Although advanced clinic, metalloantibiotics are vast underexplored group compounds that could lead much-needed new class antibiotics. This Review summarizes developments this growing field, focusing on advances development metalloantibiotics, particular, those which mechanism action has been investigated. We also provide an overview alternative uses combat bacterial infections, including photodynamic therapy radionuclide diagnosis infections. Metals their promising source Their 3D geometry potential multiple mechanisms important assets; however, substantial investment research is needed advance them clinic.

Language: Английский

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Current Research on Silver Nanoparticles: Synthesis, Characterization, and Applications

Journal of Nanomaterials, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 23

Published: Feb. 5, 2021

Over the past couple of decades, nanomaterials have advanced research in materials; biomedical, biological, and chemical sciences; etc., owing to their peculiar properties at nanoregime compared bulk composition. Applications nanoparticles fields like medicine agriculture been boosted due development different methodologies developed synthesize specific shapes sizes. Silver tunable physical properties, so it has studied widely improve its applicability. The antimicrobial Ag NPs are finding application enhancing activity drugs (like Amphotericin B, Nystatin, Fluconazole) composite scaffolds for controlled release targeted delivery low toxicity biocompatibility. Similarly, surface plasmon resonance property makes a top-notch material developing (bio)sensors, instance, surface-enhanced Raman spectroscopy, detecting biomarkers, diseases, pollutants, higher catalytic photochemical reactions. Besides these, highly conducting used wearable flexible sensors generate electrocardiographs. Physicochemical or biological approaches prepare NPs; however, each method pros cons. prohibitive cost use hazardous chemicals hinder physicochemical synthesis. Likewise, synthesis is not always reproducible extensive but can be suitable candidate therapeutic activities cancer therapy. Excess cytotoxic, unregulated discharge environment may effects on both aquatic terrestrial biota. driven by need develop technology with potential benefits minimal risk environmental human health. In this review, we attempted provide an insight into various sectors along recent synthetic characterization techniques NPs.

Language: Английский

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An Updated Review on Silver Nanoparticles in Biomedicine

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(11), P. 2318 - 2318

Published: Nov. 23, 2020

Silver nanoparticles (AgNPs) represent one of the most explored categories nanomaterials for new and improved biomaterials biotechnologies, with impressive use in pharmaceutical cosmetic industry, anti-infective therapy wound care, food textile industry. Their extensive versatile applicability relies on genuine easy-tunable properties nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action antitumor activity. Besides commercially available clinically safe AgNPs-based products, a substantial number recent studies assessed nanosilver as therapeutic agents augmented alternative strategies cancer therapy, sensing diagnosis platforms, restorative regenerative biomaterials. Given beneficial interactions AgNPs living structures their nontoxic effects healthy human cells, they an accurate candidate various biomedical products. In present review, important applications products biomedicine are considered.

Language: Английский

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Multifunctional antimicrobial materials: From rational design to biomedical applications

Progress in Materials Science, Journal Year: 2021, Volume and Issue: 125, P. 100887 - 100887

Published: Nov. 11, 2021

Language: Английский

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Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design

Toxicology Mechanisms and Methods, Journal Year: 2019, Volume and Issue: 29(5), P. 378 - 387

Published: Jan. 14, 2019

Nanotoxicology and nanosafety has been a topic of intensive research for about more than 20 years. Nearly 10 000 papers have published on the topic, yet there exists gap in terms understanding ways to harmonize nanorisk assessment. In this review, we revisit critically ignored parameters nanoscale materials (e.g. band factor, phase instability silver leaching problem, defect plasmonic versus inorganic particles) their biological counterparts (cell batch-to-batch heterogeneity, barrier model design, cellular functional characteristics) which yield variability nonuniformity results. We also emphasize system biology approaches integrate high throughput screening methods coupled with vivo silico modeling ensure quality research. highlight recommendation regarding bridging mechanistic gaps fundamental predictive response nanotoxicology. The community develop visions predict unforeseen problems that do not exist context nanotoxicity public health hazards due burgeoning use nanomaterial consumer's product.

Language: Английский

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Unique Properties of Surface-Functionalized Nanoparticles for Bio-Application: Functionalization Mechanisms and Importance in Application

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(8), P. 1333 - 1333

Published: April 13, 2022

This review tries to summarize the purpose of steadily developing surface-functionalized nanoparticles for various bio-applications and represents a fascinating rapidly growing field research. Due their unique properties-such as novel optical, biodegradable, low-toxicity, biocompatibility, size, highly catalytic features-these materials are considered superior, it is thus vital study these systems in realistic meaningful way. However, rapid aggregation, oxidation, other problems encountered with functionalized nanoparticles, inhibiting subsequent utilization. Adequate surface modification organic inorganic compounds results improved physicochemical properties which can overcome barriers. investigates discusses iron oxide gold platinum silver silica-coated how after fabrication allow potential use wide range such nano-based imaging, gene delivery, drug loading, immunoassays. The different groups advantages functionalization applications highlighted here. In recent years, have become important broad bio-applications.

Language: Английский

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An updated overview on metal nanoparticles toxicity

Seminars in Cancer Biology, Journal Year: 2021, Volume and Issue: 76, P. 17 - 26

Published: June 25, 2021

Language: Английский

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Recent Advances and Mechanistic Insights into Antibacterial Activity, Antibiofilm Activity, and Cytotoxicity of Silver Nanoparticles

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(4), P. 1391 - 1463

Published: March 31, 2022

The substantial increase in multidrug-resistant (MDR) pathogenic bacteria is a major threat to global health. Recently, the Centers for Disease Control and Prevention reported possibilities of greater deaths due bacterial infections than cancer. Nanomaterials, especially small-sized (size ≤10 nm) silver nanoparticles (AgNPs), can be employed combat these deadly diseases. However, high reactivity, instability, susceptibility fast oxidation, cytotoxicity remain crucial shortcomings their uptake clinical application. In this review, we discuss various AgNPs-based approaches eradicate provide comprehensive mechanistic insights recent advances antibacterial activity, antibiofilm (both vitro vivo) AgNPs. antimicrobial activity involves four steps: (i) adhesion AgNPs cell wall/membrane its disruption; (ii) intracellular penetration damage; (iii) oxidative stress; (iv) modulation signal transduction pathways. Numerous factors affecting bactericidal such as shape, size, crystallinity, pH, surface coating/charge have also been described detail. review sheds light on photodynamic therapy role versus Ag+ ions release activities. addition, different methods synthesis discussed brief.

Language: Английский

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Metallic nanoparticles as drug delivery system for the treatment of cancer

Expert Opinion on Drug Delivery, Journal Year: 2021, Volume and Issue: 18(9), P. 1261 - 1290

Published: April 1, 2021

Introduction The targeted delivery of anticancer agents to tumor is a major challenge because most the drugs show off-target effect resulting in nonspecific cell death. Multifunctionalized metallic nanoparticles (NPs) are explored as new carrier system era cancer therapeutics. Researchers investigated potential NPs target cells by active and passive mechanisms, thereby reducing effects agents. Moreover, photocatalytic activity upconversion (UCNPs) enhanced permeation retention (EPR) have also gained wide treatment. Recent advancement field nanotechnology highlights their potency for therapy.Areas covered This review summarizes types gold silver with targeting mechanisms potentiality therapy. Expert opinion advances therapy offer high specificity efficiency. Targeting through mechanistic pathways using disruption/alteration molecular profile survival rate has led an effective approach alteration might decrease proliferation more efficient management treatment cancer.

Language: Английский

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