Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(8), P. 1333 - 1333
Published: April 13, 2022
This
review
tries
to
summarize
the
purpose
of
steadily
developing
surface-functionalized
nanoparticles
for
various
bio-applications
and
represents
a
fascinating
rapidly
growing
field
research.
Due
their
unique
properties-such
as
novel
optical,
biodegradable,
low-toxicity,
biocompatibility,
size,
highly
catalytic
features-these
materials
are
considered
superior,
it
is
thus
vital
study
these
systems
in
realistic
meaningful
way.
However,
rapid
aggregation,
oxidation,
other
problems
encountered
with
functionalized
nanoparticles,
inhibiting
subsequent
utilization.
Adequate
surface
modification
organic
inorganic
compounds
results
improved
physicochemical
properties
which
can
overcome
barriers.
investigates
discusses
iron
oxide
gold
platinum
silver
silica-coated
how
after
fabrication
allow
potential
use
wide
range
such
nano-based
imaging,
gene
delivery,
drug
loading,
immunoassays.
The
different
groups
advantages
functionalization
applications
highlighted
here.
In
recent
years,
have
become
important
broad
bio-applications.
Nanomaterials,
Journal Year:
2020,
Volume and Issue:
10(1), P. 124 - 124
Published: Jan. 9, 2020
This
article
provides
an
overview
of
current
research
into
the
development,
synthesis,
photocatalytic
bacterial
activity,
biocompatibility
and
cytotoxic
properties
various
visible-light
active
titanium
dioxide
(TiO
Frontiers in Microbiology,
Journal Year:
2021,
Volume and Issue:
12
Published: April 22, 2021
The
increasing
number
of
multi-drug-resistant
bacteria
and
cancer
cases,
that
are
a
real
threat
to
humankind,
forces
research
world
develop
new
weapons
deal
with
it.
Biogenic
silver
nanoparticles
(AgNPs)
considered
as
solution
this
problem.
Biosynthesis
AgNPs
is
regarded
green,
eco-friendly,
low-priced
process
provides
small
biocompatible
nanostructures
antimicrobial
anticancer
activities
potential
application
in
medicine.
biocompatibility
these
related
the
coating
biomolecules
natural
origin.
synthesis
from
actinobacterial
strain
was
confirmed
using
UV-Vis
spectroscopy
while
their
morphology,
crystalline
structure,
stability,
were
characterized
using,
transmission
electron
microscopy
(TEM),
X-ray
diffraction
(XRD),
Zeta
Fourier
transform
infrared
(FTIR).
Antibacterial
activity
biogenic
evaluated
by
determination
minimum
inhibitory
biocidal
concentrations
(MIC
MBC)
against
Escherichia
coli
,
Klebsiella
pneumoniae
Pseudomonas
aeruginosa
Staphylococcus
aureus
.
mechanism
antibacterial
action
determined
measurement
ATP
level.
Since
use
biomedical
applications
depend
on
safety,
vitro
cytotoxicity
biosynthesized
MCF-7
human
breast
cell
line
murine
macrophage
RAW
264.7
MTT
[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide]
assay,
lactate
dehydrogenase
(LDH)
release
reactive
oxygen
species
(ROS)
level
assessed.
nanoparticle
protein
capping
agent
can
be
involved
reduction
ions
stabilization
identified
LC-MS/MS.
Nanoparticles
spherical
shape,
size
(mean
13.2
nm),
showed
nature,
good
stability
(−18.7
mV)
presence
agents.
They
exhibited
8–128
μg
ml
−1
MBC
64–256
)
significantly
decreased
levels
bacterial
cells
after
treatment
different
AgNPs.
analysis
demonstrated
dose-dependent
macrophages
but
higher
latter
than
former.
Cell
viability
decrease
found
42.2–14.2
38.0–15.5%
LDH
leakage
14.6–42.7%
19.0–45.0%,
respectively.
IC
50
values
calculated
for
assay
16.3
12.0
102.3
76.2
Moreover,
released
greater
amount
ROS
during
stimulation
all
tested
(1.47–3.13
1.02–2.58
fold
increase,
respectively).
SDS-PAGE
(sodium
dodecyl
sulfate-polyacrylamide
gel
electrophoresis)
revealed
five
bands
at
molecular
weight
between
31.7
280.9
kDa.
These
proteins
highest
homology
hypothetical
porins
E.
Delftia
sp.
rhodesiae
Based
obtained
results
it
concluded
capped
agent.
International Journal of Environmental Research and Public Health,
Journal Year:
2020,
Volume and Issue:
17(13), P. 4657 - 4657
Published: June 28, 2020
This
review
offers
a
systematic
discussion
about
nanotoxicology
and
nanosafety
associated
with
nanomaterials
during
manufacture
further
biomedical
applications.
A
detailed
introduction
on
their
most
frequently
uses,
followed
by
the
critical
risk
aspects
related
to
regulatory
uses
commercialization,
is
provided.
Moreover,
impact
of
in
research
over
last
decades
discussed,
together
currently
available
toxicological
methods
cell
cultures
(in
vitro)
living
organisms
vivo).
special
focus
given
inorganic
nanoparticles
such
as
titanium
dioxide
(TiO2NPs)
silver
(AgNPs).
In
vitro
vivo
case
studies
for
selected
are
discussed.
The
final
part
this
work
describes
significance
nano-security
both
assessment
environmental
nanosafety.
“Safety-by-Design”
defined
starting
point
consisting
implementation
principles
drug
discovery
development.
concept
appears
be
way
“ensure
safety”,
but
superficiality
lack
articulation
which
it
treated
still
raises
many
doubts.
Although
approach
development
has
helped
toxicity
nanomaterials,
combination
scientific
efforts
constantly
urgent
ensure
consistency
processes.
will
that
quality
controlled
safe
promoted.
Safety
issues
considered
strategies
discovering
novel
toxicological-related
mechanisms
needed
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(18)
Published: July 22, 2021
Intestinal
immune
homeostasis
and
microbiome
structure
play
a
critical
role
in
the
pathogenesis
progress
of
inflammatory
bowel
disease
(IBD),
whereas
IBD
treatment
remains
challenge
as
first-line
drugs
show
limited
therapeutic
efficiency
great
side
effect.
In
this
study,
colon-targeted
adhesive
core-shell
hydrogel
microsphere
is
designed
fabricated
by
ingenious
combination
advanced
gas-shearing
technology
ionic
diffusion
method,
which
can
congregate
on
colon
tissue
regulating
gut
immune-microbiota
microenvironment
treatment.
The
degradation
experiment
indicates
anti-acid
property
alginate
shell,
vivo
imaging
shows
mucoadhesive
ability
thiolated-hyaluronic
acid
core
microsphere,
reduces
systematic
exposure
prolongs
local
drug
dwell
time.
addition,
both
vitro
study
demonstrate
that
significantly
secretion
pro-inflammatory
cytokines,
induces
specific
type
2
macrophage
differentiation,
remarkably
alleviates
colitis
mice
model.
Moreover,
16S
ribosomal
RNA
sequencing
reveals
an
optimized
flora
composition,
probiotics
including
Bifidobacterium
Lactobacillus
augment,
while
detrimental
communities
are
inhibited,
benefits
intestinal
homeostasis.
This
finding
provides
ideal
clinical
candidate
for
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(8), P. 1333 - 1333
Published: April 13, 2022
This
review
tries
to
summarize
the
purpose
of
steadily
developing
surface-functionalized
nanoparticles
for
various
bio-applications
and
represents
a
fascinating
rapidly
growing
field
research.
Due
their
unique
properties-such
as
novel
optical,
biodegradable,
low-toxicity,
biocompatibility,
size,
highly
catalytic
features-these
materials
are
considered
superior,
it
is
thus
vital
study
these
systems
in
realistic
meaningful
way.
However,
rapid
aggregation,
oxidation,
other
problems
encountered
with
functionalized
nanoparticles,
inhibiting
subsequent
utilization.
Adequate
surface
modification
organic
inorganic
compounds
results
improved
physicochemical
properties
which
can
overcome
barriers.
investigates
discusses
iron
oxide
gold
platinum
silver
silica-coated
how
after
fabrication
allow
potential
use
wide
range
such
nano-based
imaging,
gene
delivery,
drug
loading,
immunoassays.
The
different
groups
advantages
functionalization
applications
highlighted
here.
In
recent
years,
have
become
important
broad
bio-applications.
