Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation DOI Creative Commons
Jessy Etienne, Chao Liu, Colin M. Skinner

et al.

Skeletal Muscle, Journal Year: 2020, Volume and Issue: 10(1)

Published: Feb. 7, 2020

Abstract Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes its resident stem cells (i.e., satellite cells, SCs), differentiated myofibers), and extracellular matrix cause a decline tissue homeostasis, function, regenerative capacity. Based on conservation of aging across taking advantage relatively well-characterization myofibers associated SCs, skeletal emerged as an experimental system to study function maintenance old explore rejuvenation strategies. In this review, we summarize approaches for understanding process assaying success that use choice. We further discuss (and exemplify with studies muscle) how conflicting results might be due variations techniques cell isolation, differences assays functional rejuvenation, or deciding numbers replicates cohorts.

Language: Английский

The blood-brain barrier in aging and neurodegeneration DOI Creative Commons
Emily G. Knox, María R. Aburto, Gerard Clarke

et al.

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(6), P. 2659 - 2673

Published: March 31, 2022

Abstract The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange compounds between the blood and parenchyma. Moreover, BBB prevents unwanted toxins pathogens from entering brain. This barrier, however, breaks down with age further disruption a hallmark many age-related disorders. Several drugs have been explored, thus far, to protect or restore function. With recent connection gut microbiota, microbial-derived metabolites explored their capabilities physiology. review, will focus on components that make up BBB, dissect levels discuss current therapeutics maintain integrity discoveries effects

Language: Английский

Citations

380
Healthy aging and the blood–brain barrier DOI Open Access
William A. Banks, May J. Reed,

Aric F. Logsdon

et al.

Nature Aging, Journal Year: 2021, Volume and Issue: 1(3), P. 243 - 254

Published: March 15, 2021

Language: Английский

Citations

199
Hemorrhagic Transformation in Ischemic Stroke and the Role of Inflammation DOI Creative Commons

Elena Spronk,

Gina Sykes,

Sarina Falcione

et al.

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: May 14, 2021

Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic stroke. It occurs when peripheral blood extravasates across disrupted brain barrier (BBB) into the following Preventing HT important as it worsens stroke outcome and increases mortality. Factors associated increased risk of include severity, reperfusion therapy (thrombolysis thrombectomy), hypertension, hyperglycemia, age. Inflammation immune system are contributors to BBB disruption many factors for HT. In this review, we present relationship inflammation activation context therapy, Differences inflammatory pathways relating discussed. The role stratify therapies targeting reduce presented.

Language: Английский

Citations

156
Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health DOI Open Access

Brigitte M. González Olmo,

Michael J. Butler, Ruth M. Barrientos

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 196 - 196

Published: Jan. 10, 2021

The relatively rapid shift from consuming preagricultural wild foods for thousands of years, to postindustrial semi-processed and ultra-processed endemic the Western world less than 200 years ago did not allow evolutionary adaptation commensal microbial species that inhabit human gastrointestinal (GI) tract, this has significantly impacted gut health. microbiota, diverse dynamic population microbes, been demonstrated have extensive important interactions with digestive, immune, nervous systems. diet-induced dysbiosis microbiota shown negatively impact digestive physiology, pathogenic effects on immune system, and, in turn, cause exaggerated neuroinflammation. Given tremendous amount evidence linking neuroinflammation neural dysfunction, it is no surprise diet implicated development many diseases disorders brain, including memory impairments, neurodegenerative disorders, depression. In review, we discuss each these concepts understand how what eat can lead cognitive psychiatric diseases.

Language: Английский

Citations

113
An Insight into Cellular and Molecular Mechanisms Underlying the Pathogenesis of Neurodegeneration in Alzheimer’s Disease DOI Creative Commons
Yashumati Ratan, Aishwarya Rajput,

Sushmita Maleysm

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1398 - 1398

Published: May 8, 2023

Alzheimer’s disease (AD) is the most prominent neurodegenerative disorder in aging population. It characterized by cognitive decline, gradual neurodegeneration, and development of amyloid-β (Aβ)-plaques neurofibrillary tangles, which constitute hyperphosphorylated tau. The early stages neurodegeneration AD include loss neurons, followed synaptic impairment. Since discovery AD, substantial factual research has surfaced that outlines disease’s causes, molecular mechanisms, prospective therapeutics, but a successful cure for not yet been discovered. This may be attributed to complicated pathogenesis absence well-defined mechanism, constrained diagnostic resources treatment options. To address aforementioned challenges, extensive modeling essential fully comprehend underlying mechanisms making it easier design develop effective strategies. Emerging evidence over past few decades supports critical role Aβ tau participation glial cells different cellular pathways. review extensively discusses current understanding concerning Aβ- tau-associated dysfunction AD. Moreover, risk factors associated with including genetics, aging, environmental variables, lifestyle habits, medical conditions, viral/bacterial infections, psychiatric have summarized. present study will entice researchers more thoroughly explore status mechanism assist drug forthcoming era.

Language: Английский

Citations

49
Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons DOI
Wenchao Gu, Sijin Luozhong, Simian Cai

et al.

Nature Biomedical Engineering, Journal Year: 2024, Volume and Issue: 8(4), P. 415 - 426

Published: Feb. 19, 2024

Language: Английский

Citations

28
The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle DOI Creative Commons
Yu Cai, Yin Zhang,

Shuo Leng

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 192, P. 106426 - 106426

Published: Feb. 6, 2024

The term "glymphatic" emerged roughly a decade ago, marking pivotal point in neuroscience research. glymphatic system, glial-dependent perivascular network distributed throughout the brain, has since become focal of investigation. There is increasing evidence suggesting that impairment system appears to be common feature neurodegenerative disorders, and this exacerbates as disease progression. Nevertheless, factors contributing dysfunction across most disorders remain unclear. Inflammation, however, suspected play role. Dysfunction can lead significant accumulation protein waste products, which trigger inflammation. interaction between inflammation cyclical potentially synergistic. Yet, current research limited, there lack comprehensive models explaining association. In perspective review, we propose novel model inflammation, impaired function, interconnected vicious cycle. By presenting experimental from existing literature, aim demonstrate that: (1) aggravates dysfunction, (2) exacerbated progression, (3) progression promotes Finally, implication proposed discussed.

Language: Английский

Citations

17
The extracellular matrix of the blood–brain barrier: structural and functional roles in health, aging, and Alzheimer’s disease DOI Open Access
May J. Reed, Mamatha Damodarasamy, William A. Banks

et al.

Tissue Barriers, Journal Year: 2019, Volume and Issue: 7(4), P. 1651157 - 1651157

Published: Sept. 11, 2019

There is increasing interest in defining the location, content, and role of extracellular matrix (ECM) components brain structure function during development, aging, injury, neurodegeneration. Studies vivo confirm ECM has a dynamic composition with constitutive induced alterations that impact subsequent cell-cell cell-matrix interactions. Moreover, it clear for any given component, region, cell type within determines direction, magnitude, those changes. This review will examine at neurovascular unit (NVU) blood–brain barrier (BBB) NVU. The discussion begin glycocalyx on luminal surface vasculature, progress to abluminal side focus changes basement membrane aging

Language: Английский

Citations

116
Age‐related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review DOI Creative Commons
Benjamin Zimmerman, Bart Rypma, Gabriele Gratton

et al.

Psychophysiology, Journal Year: 2021, Volume and Issue: 58(7)

Published: March 16, 2021

Abstract The process of aging includes changes in cellular biology that affect local interactions between cells and their environments eventually propagate to systemic levels. In the brain, where neurons critically depend on an efficient dynamic supply oxygen glucose, age‐related complex interaction brain parenchyma cerebrovasculature have effects health functioning negatively impact cognition play a role pathology. Thus, cerebrovascular is considered one main mechanisms by which healthy lifestyle, such as habitual cardiorespiratory exercise healthful diet, could lead improved cognitive outcomes with aging. This review aims at detailing how physiology cerebral vascular system age these differential trajectories maintenance or decline. provides framework for generating specific mechanistic hypotheses about efficacy proposed interventions lifestyle covariates contribute enhanced well‐being. Finally, we discuss methodological implications vasculature human neuroscience research propose directions future experiments aimed investigating relationship mechanisms.

Language: Английский

Citations

101
Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease DOI Creative Commons
Zixuan Lin, Sandeepa Sur, Peiying Liu

et al.

Annals of Neurology, Journal Year: 2021, Volume and Issue: 90(2), P. 227 - 238

Published: May 27, 2021

Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early biomarker in human cognitive impairment. However, the relationship between BBB and brain pathology, most commonly Alzheimer disease (AD) vascular disease, is still poorly understood. The present study measured function mild impairment (MCI) patients on 2 molecular scales, specifically BBB's permeability water albumin molecules. Methods Fifty‐five elderly participants were enrolled, including 33 MCI 22 controls. was with a new magnetic resonance imaging technique, extraction phase contrast arterial spin tagging. determined using cerebrospinal fluid (CSF)/serum ratio. Cognitive performance assessed by domain‐specific composite scores. AD pathology (including CSF Aβ ptau) risk factors examined. Results Compared cognitively normal subjects, manifested increased small molecules such as but no more permeable large albumin. found related markers of ptau. On other hand, factors, especially hypercholesterolemia, not pathology. molecules, predictive function. Interpretation These findings provide evidence that both risks, their effects can differentiated spatial scales. greater impact performance. ANN NEUROL 2021;90:227–238

Language: Английский

Citations

100