Nutrients and amyloid β status in the brain: A narrative review DOI Creative Commons
Gustavo Díaz, Laetitia Lengelé,

Sandrine Sourdet

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 81, P. 101728 - 101728

Published: Aug. 30, 2022

Amyloid beta (Aβ) is a peptide and hallmark of Alzheimer's disease (AD). Emerging evidence suggests that Aβ levels could be influenced by diet. However, the sparse for some nutrients, controversial. The aim this narrative review to gather findings observational clinical trials involving human participants on relationships between nutrients brain status. Some dietary patterns are associated reduced in brain, such as Mediterranean diet, ketogenic diet well low intake saturated fat, high-glycemic-index food, sodium, junk/fast food. Low status was also with higher density lipoproteins (HDL) cholesterol polyunsaturated fatty acids consumption. Data alcohol not conclusive. On contrary, high were related total cholesterol, triglycerides, low-density (LDL) sucrose, fructose. Folic acid, cobalamin, vitamin E, D status, while blood concentrations Calcium, Aluminum, Zinc, Copper, Manganese decreased but cerebral spinal fluid (CSF) concentrations. In conclusion, certain Further research association needed order pave way use nutritional interventions efficacious strategies prevent disturbance potentially AD.

Language: Английский

Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review DOI Open Access
Vicente Javier Clemente‐Suárez, Ana Isabel Beltrán-Velasco, Laura Redondo-Flórez

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2749 - 2749

Published: June 14, 2023

The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged foods, refined grains, red meat, processed high-sugar drinks, candy, sweets, fried conventionally raised animal products, high-fat dairy and high-fructose products. present review aims to describe the effect on metabolism, inflammation, antioxidant status; impact gut microbiota mitochondrial fitness; cardiovascular health, mental cancer; sanitary cost diet. To achieve this goal, consensus critical was conducted using primary sources, such as scientific articles, secondary including bibliographic indexes, databases, web pages. Scopus, Embase, Science Direct, Sports Discuss, ResearchGate, Web were used complete assignment. MeSH-compliant keywords “Western diet”, “inflammation”, “metabolic health”, fitness”, “heart disease”, “cancer”, “oxidative stress”, “mental “metabolism” used. following exclusion criteria applied: (i) studies with inappropriate or irrelevant topics, not germane review’s focus; (ii) Ph.D. dissertations, proceedings conferences, unpublished studies. This information will allow for better comprehension nutritional behavior its an individual’s metabolism well national systems. Finally, practical applications derived from are made.

Language: Английский

Citations

292
Interactive Relationships between Intestinal Flora and Bile Acids DOI Open Access

Xiaohua Guo,

Edozie Samuel Okpara,

Wanting Hu

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(15), P. 8343 - 8343

Published: July 28, 2022

The digestive tract is replete with complex and diverse microbial communities that are important for the regulation of multiple pathophysiological processes in humans animals, particularly those involved maintenance intestinal homeostasis, immunity, inflammation, tumorigenesis. diversity bile acids a result joint efforts host microflora. There bidirectional relationship between community that, while flora tightly modulates metabolism synthesis acids, acid pool composition affect homeostasis flora. Homeostatic imbalances systems may lead to development variety diseases, such as inflammatory bowel disease (IBD), colorectal cancer (CRC), hepatocellular carcinoma (HCC), type 2 diabetes (T2DM), polycystic ovary syndrome (PCOS). interactions be (in)directly pathogenesis these diseases.

Language: Английский

Citations

95
The gut microbiome, mild cognitive impairment, and probiotics: A randomized clinical trial in middle-aged and older adults DOI
Mashael R. Aljumaah, Urja Bhatia, Jeffrey Roach

et al.

Clinical Nutrition, Journal Year: 2022, Volume and Issue: 41(11), P. 2565 - 2576

Published: Sept. 28, 2022

Language: Английский

Citations

73
Moringa (Moringa oleifera Lam.) polysaccharides: Extraction, characterization, bioactivities, and industrial application DOI
Kanika Sharma, Manoj Kumar, Roji Waghmare

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 209, P. 763 - 778

Published: April 11, 2022

Language: Английский

Citations

71
Mediation Role of Recreational Physical Activity in the Relationship between the Dietary Intake of Live Microbes and the Systemic Immune-Inflammation Index: A Real-World Cross-Sectional Study DOI Open Access
Yanwei You, Yuquan Chen,

Mengxian Wei

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 777 - 777

Published: March 8, 2024

The main topic of this research is the relationship between dietary intake live microbe-containing (LMC) foods, recreational physical activity (RPA), and systemic immune-inflammation index (SII). This study presented a cohort 26,254 individuals in National Health Nutrition Examination Survey (NHANES), representing an estimated weighted population 193,637,615 United States. Weighted multivariable linear regression models were used consideration multi-stage sampling design. Results: found that medium-LMC foods negatively associated with SII [β (95% CI): −4.807 (−7.752, −1.862), p = 0.002], indicating their was correlated lower levels SII. However, no significant associations low- or high-LMC foods. also explored RPA SII, finding more time spent −0.022 (−0.034, −0.011), < 0.001]. A mediation analysis conducted to investigate role food revealed had notable indirect effect, contributing 6.7% overall change Overall, suggests may have beneficial effects on immune inflammation.

Language: Английский

Citations

65
Association of the newly proposed dietary index for gut microbiota and depression: the mediation effect of phenotypic age and body mass index DOI
Xuan Zhang,

Qinglong Yang,

Jingtao Huang

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Language: Английский

Citations

17
The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis DOI Creative Commons
Ruyi Zhang,

Ning Ding,

X. Feng

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

The gut microbiome has emerged as a pivotal area of research due to its significant influence on the immune system and cognitive functions. Cognitive disorders, including dementia Parkinson’s disease, represent substantial global health challenges. This review explores relationship between microbiota, modulation, decline, with particular focus gut-brain axis. Research indicates that bacteria produce metabolites, short-chain fatty acids (SCFAs), which affect mucosal immunity, antigen presentation, responses, thereby influencing A noteworthy correlation been identified imbalances in impairments, suggesting novel pathways for treatment disorders. Additionally, factors such diet, environment, pharmaceuticals play role shaping composition microbiome, subsequently impacting both health. article aims clarify complex interactions among regulation, evaluating their potential therapeutic targets. goal is promote microbiome-based treatments lay groundwork future this field.

Language: Английский

Citations

5
The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier DOI Open Access
D. Rondinella, Pauline Raoul,

Eleonora Valeriani

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 859 - 859

Published: Feb. 28, 2025

Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs the microbiome and barrier, emphasizing dysbiosis increased permeability. UPFs, characterized by high content of synthetic additives emulsifiers, low fiber content, are associated with decrease microbial diversity, lower levels beneficial bacteria like Akkermansia muciniphila Faecalibacterium prausnitzii, an increase pro-inflammatory microorganisms. These alterations community contribute to persistent inflammation, which various chronic disorders including metabolic syndrome, irritable bowel type 2 diabetes, colorectal cancer. In addition, may alter gut-brain axis, potentially affecting cognitive function mental health. Dietary modifications incorporating fiber, fermented foods, probiotics can help mitigate effects UPFs. Furthermore, public needs stricter regulations for banning along well-defined labels. Further studies necessary elucidate mechanisms connecting systemic illnesses, thereby informing evidence-based dietary guidelines.

Language: Английский

Citations

2
Bacillus subtilis-Based Probiotic Improves Skeletal Health and Immunity in Broiler Chickens Exposed to Heat Stress DOI Creative Commons
Sha Jiang, Feifei Yan, Jiaying Hu

et al.

Animals, Journal Year: 2021, Volume and Issue: 11(6), P. 1494 - 1494

Published: May 21, 2021

The elevation of ambient temperature beyond the thermoneutral zone leads to heat stress, which is a growing health and welfare issue for homeothermic animals aiming maintain relatively constant reproducibility survivability. Particularly, global warming over past decades has resulted in more hot days with intense, frequent, long-lasting waves, resulting surge suffering from stress. Heat stress causes pathophysiological changes animals, increasing sensitivity immunosuppression, consequently leading increased intestinal permeability (leaky gut) related neuroinflammation. Probiotics, as well prebiotics synbiotics, have been used prevent or reduce stress-induced negative effects on physiological behavioral homeostasis humans various animals. current data indicate dietary supplementation Bacillus subtilis-based probiotic similar functions poultry. This review highlights recent findings subtilis skeletal broiler chickens exposed It provides insights aid development practical strategies improving performance

Language: Английский

Citations

70
The Obese Brain: Mechanisms of Systemic and Local Inflammation, and Interventions to Reverse the Cognitive Deficit DOI Creative Commons
Verónica Salas-Venegas, Rosa Pamela Flores-Torres, Yesica María Rodríguez-Cortés

et al.

Frontiers in Integrative Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: March 29, 2022

Overweight and obesity are now considered a worldwide pandemic growing public health problem with severe economic social consequences. Adipose tissue is an organ neuroimmune-endocrine functions, which participates in homeostasis. So, adipocyte hypertrophy hyperplasia induce state of chronic inflammation that causes changes the brain neuroinflammation. Studies obese animal models patients have shown relationship between diet cognitive decline, especially working memory learning deficiencies. Here we analyze how obesity-related peripheral can affect central nervous system physiology, generating Given blood-brain barrier interface periphery system, its altered physiology may mediate consequences on various processes. Finally, several interventions, use natural compounds exercise to prevent adverse effects also discussed.

Language: Английский

Citations

64