Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 11, 2023
It
has
been
for
thousands
of
years
in
China
known
medicinal
homologous
foods
that
can
be
employed
both
as
and
medicines
to
benefit
human
animal
health.
These
edible
herbal
materials
perform
divert
roles
the
regulation
metabolic
disorders,
cancers,
immune-related
diseases.
Curcumin,
primary
component
derived
from
like
curcuma
longa
rhizome,
is
reported
play
vital
actions
organic
activities,
such
numerous
pharmacological
functions
including
anti-oxidative
stress,
anti-inflammation
anti/pro-apoptosis
treating
various
However,
potential
mechanisms
curcumin-derived
modulation
still
need
developed
attract
more
attention
worldwide.
Given
these
signal
pathways
are
enrolled
important
bioactive
reactions,
we
collected
curcumin's
last
achievements
predominantly
on
immune-regulation
signals
with
underlying
targetable
strategies
10
years.
This
mini-review
will
helpful
accelerate
curcumin
other
extracts
use
future
clinical
applications.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2021,
Volume and Issue:
2021(1)
Published: Jan. 1, 2021
Due
to
its
vast
therapeutic
potential,
the
plant‐derived
polyphenol
curcumin
is
utilized
in
an
ever‐growing
number
of
health‐related
applications.
Here,
we
report
extraction
methodologies,
properties,
advantages
and
disadvantages
linked
employment,
new
strategies
addressed
improve
effectiveness
by
employing
advanced
nanocarriers.
The
emerging
nanotechnology
applications
used
enhance
CUR
bioavailability
targeted
delivery
specific
pathological
conditions
are
collected
discussed.
In
particular,
aspects
concerning
main
strategic
nanocarriers
employed
for
treating
inflammation
oxidative
stress‐related
diseases
reported
discussed,
with
emphasis
on
those
topically
such
as
wounds,
arthritis,
or
psoriasis
others
pathologies
bowel
(colitis),
neurodegenerative
(Alzheimer’s
dementia),
cardiovascular
(atherosclerosis),
lung
(asthma
chronic
obstructive
pulmonary
disease)
diseases.
A
brief
overview
relevant
clinical
trials
also
included.
We
believe
review
can
provide
readers
nanostrategies
currently
highlighted
conditions.
BMC Pharmacology and Toxicology,
Journal Year:
2020,
Volume and Issue:
21(1)
Published: Aug. 18, 2020
Acrylamide
(ACR)
formed
during
heating
of
tobacco
and
carbohydrate-rich
food
as
well
widely
applied
in
industries
has
been
known
a
well-established
neurotoxic
pollutant.
Although
the
precise
mechanism
is
unclear,
enhanced
apoptosis,
oxidative
stress
inflammation
have
demonstrated
to
contribute
ACR-induced
neurotoxicity.
In
this
study,
we
assessed
possible
anti-apoptotic,
antioxidant
anti-inflammatory
effects
curcumin,
most
active
component
popular
spice
turmeric,
on
neurotoxicity
caused
by
ACR
rats.Curcumin
at
dose
50
100
mg/kg
was
orally
given
ACR-
intoxicated
Sprague-Dawley
rats
exposed
40
for
4
weeks.
All
were
subjected
behavioral
analysis.
The
HE
staining
terminal
deoxynucleotidyl
transferase
mediated
dUTP
nick
end
labelling
(TUNEL)
used
detect
histopathological
changes
apoptotic
cells,
respectively.
mRNA
protein
expressions
apoptosis-related
molecule
telomerase
reverse
transcriptase
(TERT)
detected
using
real-time
PCR
immunohistochemistry,
contents
malondialdehyde
(MDA)
glutathione
(GSH)
activities
superoxide
dismutase
(SOD)
peroxidase
(GSH-Px)
measured
indicators
evaluating
level
brain.
levels
pro-inflammatory
cytokinestumor
necrosis
factor-α
(TNF-α)
interleukin-1β
(IL-1β)
cerebral
homogenates
ELISA
assay.ACR-induced
weigh
loss,
deficits
motor
function
pathological
alterations
brains
significantly
improved
administrated
with
curcumin.
TUNEL-positive
cells
curcumin-treated
less
than
those
model
group.
Curcumin
administration
especially
upregulated
TERT
expression
number
TERT-positive
ACR-intoxicated
cortex
tissues.
Moreover,
curcumin
treatment
reduced
concentrations
TNF-α,
IL-1β
MDA,
while
increased
GSH
SOD
GSH-Px
homogenates,
comparison
control
group.These
data
suggested
rats.
Maintaining
TERT-related
anti-apoptotic
might
be
one
underlying
protective
effect
brains.
Acta Pharmaceutica Sinica B,
Journal Year:
2020,
Volume and Issue:
10(10), P. 1814 - 1834
Published: Jan. 7, 2020
The
Wnt/β-catenin
signaling
is
a
conserved
pathway
that
has
crucial
role
in
embryonic
and
adult
life.
Dysregulation
of
the
been
associated
with
diseases
including
cancer,
components
have
proposed
as
innovative
therapeutic
targets,
mainly
for
cancer
therapy.
attention
worldwide
researchers
paid
to
this
issue
increasing,
also
view
potential
these
agents
diseases,
such
Parkinson's
disease
(PD),
which
no
cure
existing
today.
Much
evidence
indicates
abnormal
involved
tumor
immunology
targeting
an
attractive
strategy
potentiate
immunotherapy.
During
last
decade,
several
products,
naturally
occurring
dietary
well
wide
variety
products
from
plant
sources,
curcumin,
quercetin,
berberin,
ginsenosides,
identified
potent
modulators
gained
interest
promising
candidates
development
chemopreventive
or
drugs
cancer.
In
review
we
make
overview
nature-derived
compounds
reported
antitumor
activity
by
modulating
signaling,
focusing
on
extraction
methods,
chemical
features,
bio-activity
assays
used
screening
compounds.
BMC Complementary Medicine and Therapies,
Journal Year:
2020,
Volume and Issue:
20(1)
Published: March 3, 2020
Osteosarcoma
is
the
most
common
primary
malignant
bone
tumor
in
children
and
adolescents
has
also
been
associated
with
a
high
degree
of
malignancy
enhanced
metastatic
capacity.
Curcumin
(CUR)
well
known
for
its
anti-osteosarcoma
activity.
However,
both
demethoxycurcumin
(DMC),
bisdemethoxycurcumin
(BDMC)
are
natural
curcumin
analogues/congeners
from
turmeric
whose
role
osteosarcoma
development
remains
unknown.To
evaluate
growth
inhibitory
effects
CUR,
DMC
BDMC
on
(HOS
U2OS),
breast
(MDA-MB-231),
melanoma
(A2058)
cancer
cells,
we
employed
MTT
assay,
annexin
V-FITC
/7-AAD
staining,
clonogenic
assay.CUR,DMC,
all
decreased
viability
HOS,
U2OS,
MDA-MB-231,
A2058
cells.
Additionally,
CUR,DMC,
induced
apoptosis
HOS
cells
through
activation
Smad
2/3
or
repression
Akt
signaling
pathway.
Furthermore,
combination
synergistically
reduced
cell
viability,
colony
formation
increased
than
either
two
single
agent
cells.The
these
three
compounds
could
be
used
as
novel
target
treatment
osteosarcoma.
BioFactors,
Journal Year:
2021,
Volume and Issue:
47(6), P. 914 - 932
Published: Aug. 10, 2021
Abstract
The
tumor
microenvironment
(TME)
is
made
up
of
several
cells
and
molecules
that
affect
the
survival
cancer
cells.
Indeed,
certain
(immunosuppressive)
which
promote
tumors
can
growth
by
stimulating
proliferation
promoting
angiogenesis.
During
growth,
antitumoral
immunity
includes
natural
killer
CD8+
T
cannot
overcome
immunosuppressive
responses
cell
proliferation.
In
order
to
achieve
appropriate
therapeutic
response,
we
must
kill
suppress
release
molecules.
balance
between
anti‐tumor
cells,
such
as
regulatory
(Tregs),
cancer‐associated
fibroblasts,
tumor‐associated
macrophages,
myeloid‐derived
suppressor
plays
a
key
role
in
suppression
or
promotion
Curcumin
plant‐derived
agent
has
shown
interesting
properties
for
therapy.
It
not
only
directly
inhibit
but
also
modulate
activity
immunosuppressant
tumor‐promoting
this
review,
explain
how
curcumin
modulates
interactions
within
TME
favor
treatment.
potential
modulating
effects
on
treatment
modalities
immunotherapy
will
be
discussed.
Molecular Therapy — Nucleic Acids,
Journal Year:
2020,
Volume and Issue:
23, P. 169 - 184
Published: Oct. 15, 2020
An
increasing
number
of
studies
have
clarified
the
functional
roles
RNA-binding
proteins
(RBPs)
in
driving
post-transcriptional
mechanisms
cancer
progression.
In
this
study,
we
integrated
data
from
RBP
database
and
Gene
Expression
Omnibus
(GEO)
with
RNA
sequencing
(RNA-seq)
10
ovarian
tissues
8
normal
identified
an
RBP,
CUGBP-
ETR-3-like
family
2
(CELF2).
We
found
that
CELF2
expression
was
downregulated
positively
correlated
overall
survival
(OS)
progression-free
(PFS)
patients
cancer.
Altered
led
to
changes
proliferation,
migration,
invasion
cells
Biomolecules,
Journal Year:
2021,
Volume and Issue:
11(8), P. 1176 - 1176
Published: Aug. 9, 2021
Breast
cancer
(BC)
is
one
of
the
most
common
type
and
an
important
contributor
to
female
mortality.
Several
genes
epigenetic
modifications
are
involved
in
development
progression
BC.
Research
phytochemistry,
nutrigenomics,
nutrigenetics
has
provided
strong
evidence
that
certain
phytonutrients
able
modulate
gene
expression
at
transcriptional
post-transcriptional
levels.
Such
may
also
be
beneficial
prevent
treat
In
this
review,
we
will
focus
on
nutrigenomic
effects
various
phytochemicals
including
polyphenols,
phytosterols,
terpenoids,
alkaloids,
other
compounds
from
different
sources.
Overall,
these
found
inhibit
BC
cell
proliferation,
differentiation,
invasion,
metastasis,
angiogenesis,
induce
apoptotic
death
by
targeting
molecular
pathways.
They
alter
mechanisms
enhance
chemosensitivity
radiosensitivity
cells.
used
for
effective
management
patients
clinical
setting
future.
The
present
article
aims
summarize
specific
pathways
genetic
Coatings,
Journal Year:
2021,
Volume and Issue:
11(5), P. 519 - 519
Published: April 28, 2021
The
recent
development
of
several
methods
for
extracting
curcumin
from
the
root
plant
Curcuma
longa
has
led
to
intensified
research
on
properties
and
its
fields
application.
Following
studies
accreditation
as
a
natural
compound
with
antifungal,
antiviral,
antibacterial
properties,
new
application
have
been
developed
in
two
main
directions—food
medical,
respectively.
This
review
paper
aims
synthesize
an
additive
prevention
spoilage,
safety,
quality
food.
Simultaneously,
it
present
products
bacterial
infections
health
care.
In
both
cases,
types
formulations
form
(nano)emulsions,
(nano)particles,
or
(nano)composites
are
presented,
depending
field
conditions
exploitation
their
be
used.
diversity
composite
materials
that
can
designed,
purpose
use,
leaves
open
conditioning
curcumin.
Various
biomaterials
active
antibiofilm
point
view
intuited
which
acts
potentiates
activities
other
compounds
synergistic
activity
them.
