How Curcumin Targets Inflammatory Mediators in Diabetes: Therapeutic Insights and Possible Solutions

Molecules, Journal Year: 2022, Volume and Issue: 27(13), P. 4058 - 4058

Published: June 24, 2022

Diabetes mellitus is a multifactorial chronic metabolic disorder, characterized by altered metabolism of macro-nutrients, such as fats, proteins, and carbohydrates. Diabetic retinopathy, diabetic cardiomyopathy, encephalopathy, periodontitis, nephropathy are the prominent complications diabetes. Inflammatory mediators primarily responsible for these complications. Curcumin, polyphenol derived from turmeric, well known its anti-oxidant, anti-inflammatory, anti-apoptotic properties. The regulation several signaling pathways effectively targets inflammatory in Curcumin's anti-inflammatory anti-oxidative activities against wide range molecular have been shown to therapeutic potential variety disorders, including biological examination has that it powerful anti-oxidant stops cells growing releasing active free thiol groups at target location. Curcumin agent diabetes, resistant form leads better outcomes diabetes Moreover, an NF-B inhibitor may be useful treating inhibit diabetes-related enzymes, a-glucosidase, aldose reductase inhibitors. Through effects, suppression vascular endothelial development nuclear transcription factors, curcumin ability prevent, or reduce, course retinopathy. improves insulin sensitivity suppressing phosphorylation ERK/JNK HG-induced insulin-resistant strengthening PI3K-AKT-GSK3B pathway. In present article, we aimed discuss mechanisms regulated various pathways.

Language: Английский

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Role of pyroptosis in the pathogenesis and treatment of diseases

MedComm, Journal Year: 2023, Volume and Issue: 4(3)

Published: April 25, 2023

Abstract Programmed cell death (PCD) is regarded as a pathological form of with an intracellular program mediated, which plays pivotal role in maintaining homeostasis and embryonic development. Pyroptosis new paradigm PCD, has received increasing attention due to its close association immunity disease. inflammatory mediated by gasdermin that promotes the release proinflammatory cytokines contents induced inflammasome activation. Recently, evidence studies shows pyroptosis crucial conditions like cardiovascular diseases (CVDs), cancer, neurological (NDs), metabolic (MDs), suggesting targeting potential intervention for treatment these diseases. Based on this, review aims identify molecular mechanisms signaling pathways related activation summarizes current insights into complicated relationship between multiple human (CVDs, NDs, MDs). We also discuss promising novel strategy method treating focus pathway application clinics.

Language: Английский

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Enhanced anti-cancer effect of curcumin loaded-niosomal nanoparticles in combination with heat-killed Saccharomyces cerevisiae against human colon cancer cells

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 80, P. 104167 - 104167

Published: Jan. 11, 2023

Language: Английский

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Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 235, P. 123827 - 123827

Published: Feb. 27, 2023

Colon cancer (CRC) is the second leading cause of death and third most diagnosed worldwide. Although curcumin (CUR) has demonstrated a potent anticancer activity, it characterized by its poor solubility, low bioavailability, instability. This study projection from previous investigation where CUR succinylated (CUR.SA) were separately encapsulated in mannosylated-chitosan nanoparticles (CM-NPs) to form CUR-NPs CUR.SA-NPs, respectively. Here, we aim assess anti-CRC activity these two nanoformulations. Cytotoxicity studies using CCK-8 assay indicated that both CUR.SA-NPs have dose time-dependent toxicity towards CRC human cell-lines (HCT116 SW480), more cytotoxic compared free or CUR-SA manner. A significant induction early late apoptosis treated cell lines untreated cells was observed. Western blotting analyses confirmed through activation Caspase signaling cells. Based on physicochemical properties along with data vitro studies, may conclude nanoparticle formulations hold very promising attributes, worthy further investigations for role management CRC.

Language: Английский

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Bifidobacterium longum SX-1326 ameliorates gastrointestinal toxicity after irinotecan chemotherapy via modulating the P53 signaling pathway and brain-gut axis

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 3, 2024

Abstract Background Colorectal cancer (CRC) is a prevalent malignant malignancy affecting the gastrointestinal tract that usually treated clinically with chemotherapeutic agents, whereas agents can cause severe toxicity, which brings great pain to patients. Therefore, finding effective adjuvant for chemotherapy crucial. Methods In this study, CRC mouse model was successfully constructed using AOM/DSS, and treatment carried out by probiotic Bifidobacterium longum SX-1326 ( B. SX-1326) in combination irinotecan. Combining various techniques of modern biomedical research, such as Hematoxylin Eosin (H&E), Immunohistochemistry (IHC), Western blotting 16S rDNA sequencing, we intend elucidate effect mechanism improving anticancer efficacy reducing side effects on different levels molecules, animals, bacteria. Results Our results showed enhanced expression Cleaved Caspase-3 (M vs. U = p < 0.01) down-regulated level B-cell lymphoma-2 (Bcl-2) through up-regulation p53 signaling pathway mice, resulted an Moreover, also able regulate gut-brain-axis (GBA) restoring damaged enterochromaffin cells, release 5-hydroxytryptamine (5-HT) brain tissue (I 89.26 75.03, 0.05), further alleviating adverse nausea vomiting. addition, reversed dysbiosis mice increasing Dehalobacterium , Ruminnococcus Mucispirillum . And alleviated colorectal inflammation downregulating TLR4/MyD88/NF-κB pathway. Conclusions conclusion, our work reveals has favorable irinotecan amelioration post-chemotherapy effects, provides theoretical basis data safe efficient adjuvant.

Language: Английский

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Turmeric (Curcuma longa): an insight into its food applications, phytochemistry and pharmacological properties

Vegetos, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

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Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 177 - 177

Published: Jan. 26, 2024

Curcumin is a natural compound that has been widely investigated thanks to its various biological properties, including antiproliferative. This molecule acts on different cancers such as lung, breast, pancreatic, colorectal, etc. However, the bioactive actions of curcumin have limitations when physicochemical properties compromise pharmacological potential. As therapeutic strategy against cancer, associated with inorganic nanoparticles. These nanocarriers are capable delivering and offering synergistically enhance anticancer properties. review highlights types curcumin-based nanoparticles discusses their in vivo activity models cancer.

Language: Английский

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Natural Compounds for Preventing Age-Related Diseases and Cancers

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530

Published: July 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Language: Английский

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From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9463 - 9463

Published: Aug. 30, 2024

Colorectal cancer (CRC) represents a significant global health burden, with high incidence and mortality rates worldwide. Recent progress in research highlights the distinct clinical molecular characteristics of colon versus rectal cancers, underscoring tumor location's importance treatment approaches. This article provides comprehensive review our current understanding CRC epidemiology, risk factors, pathogenesis, management strategies. We also present intricate cellular architecture colonic crypts their roles intestinal homeostasis. carcinogenesis multistep processes are described, covering conventional adenoma-carcinoma sequence, alternative serrated pathways, influential Vogelstein model, which proposes sequential

Language: Английский

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Effect of Drying Methods on the Phenolic Profile and Antioxidant Capacity of Pithecellobium dulce (Roxb.) Benth. Aril and Its Inhibitory Properties on Human SW480 Colon Adenocarcinoma Cells

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 233 - 233

Published: Jan. 9, 2025

Pithecellobium dulce (P. dulce) is a Mexican plant that consumed raw or in different preparations, and its anti-inflammatory antioxidant properties have traditionally been useful treating several conditions. However, the post-harvest drying process can alter content of bioactive compounds P. dulce. This study aims to evaluate impact methods on phenolic profile capacity this plant, as well inhibitory effect human SW480 colon adenocarcinoma cells. After oven drying, samples showed higher amount (p < 0.05) compounds, up 1149.45 ± 69.27 mg GAE/100 g LE, which 80% more than freeze-dried samples. Also, was oven-dried samples, with 44.63 2.00 µmol Trolox equivalents/g 108% method. Methanolic extraction, turn, yielded better results aqueous ethanolic extractions. Up 14 polyphenolic were detected For vitro assays cells, 50% v/v methanolic extract used. From extract, median lethal concentration (LC50) determined be 13.76 mg/mL, represents necessary inhibit growth half cancer cells cell line. The led cycle arrest G1 phase an increase apoptosis-induced death. augmented p53 decreased KRAS gene expressions. Results suggested pro-apoptotic mechanisms linked are preserved when plants subjected extraction.

Language: Английский

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