Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: March 2, 2022
Curcumin
(CUR)
has
demonstrated
promising
potential
as
a
therapeutic
agent
against
colorectal
cancer
(CRC).
However,
its
intrinsic
shortcomings,
including
oxidative
instability,
sensitivity
to
gastrointestinal
(GI)
hydrolytic/enzymatic
action,
and
susceptibility
biotransformation
systemic
elimination,
have
greatly
undermined
value
for
application
in
clinical
settings.
The
development
of
carriers,
particular
oral
formulations,
efficient
delivery
remained
an
important
direction
nutraceutical
research.
In
the
present
work,
CUR-encapsulated
nanoparticles
were
fabricated
with
zein
alone
(Zein-CUR)
polysaccharide
(PS)
[gum
Arabic
(GA),
hyaluronic
acid
(HA)
pectin
(PC),
respectively]
(PS-Zein-CUR).
Their
physicochemical
biological
properties
evaluated
series
Biomolecules,
Journal Year:
2021,
Volume and Issue:
11(9), P. 1295 - 1295
Published: Aug. 31, 2021
Nicotinamide
N-methyltransferase
(NNMT)
plays
multiple
roles
in
improving
the
aggressiveness
of
colorectal
cancer
(CRC)
and
enhancing
resistance
to
5-Fluorouracil
(5-FU),
making
it
an
attractive
therapeutic
target.
Curcumin
(Cur)
is
a
promising
natural
compound,
exhibiting
antitumor
effects
potentiating
effect
5-FU.
The
aim
present
study
explore
Cur
on
attenuating
NNMT-induced
5-FU
CRC.
A
panel
CRC
cell
lines
with
different
NNMT
expressions
are
used
characterize
Cur.
Herein,
observed
that
can
depress
expression
p-STAT3
cells.
Furthermore,
induce
inhibition
proliferation,
G2/M
phase
cycle
arrest,
reactive
oxygen
species
(ROS)
generation,
especially
high-NNMT-expression
lines.
also
re-sensitize
cells
both
vitro
vivo.
In
summary,
proposed
reverse
proliferation
through
ROS
generation
arrest.
Given
has
long
been
used,
we
suppose
anticancer
drug
candidate
minimal
side
for
human
therapy
attenuate
Phytotherapy Research,
Journal Year:
2020,
Volume and Issue:
34(10), P. 2534 - 2556
Published: April 19, 2020
Chemotherapy
is
one
of
the
main
methods
for
cancer
treatment.
However,
despite
many
advances
in
design
anticancer
drugs,
their
efficiency
limited
due
to
high
toxicity
and
resistance
cells
chemotherapeutic
drugs.
In
order
improve
therapy,
it
essential
use
compounds
that
can
overcome
drug
increase
treatment
efficiency.
Researchers
have
studied
effects
natural
controlling
various
mechanisms.
Curcumin
a
phenolic
compound
which
shows
potent
activities
different
tumors,
alone
or
as
an
adjuvant
with
other
antitumor
drugs
prevent
inhibit
survival
progression
by
The
role
curcumin
overcoming
was
followed
reviewing
applications
therapy.
Afterward,
clinical
impacts
curcumin,
decreasing
its
mechanisms
were
discussed.
It
has
been
demonstrated
regulates
signaling
pathways
cells,
reduces
expression
proteins
related
resistance,
increases
performance
at
levels.
reverses
multidrug
sensitivity
chemotherapy.
This
review
mainly
focuses
on
nontoxic
substance
eliminate
through
modulation
cell
eventually
suggests
chemosensitizer
cancers.
Oncotarget,
Journal Year:
2021,
Volume and Issue:
12(16), P. 1615 - 1626
Published: July 26, 2021
Cancer
is
a
global
public
health
concern
that
characterized
by
the
uncontrolled
growth
of
tumor
cells.
It
regarded
as
subsequent
cause
death
after
cardiovascular
disease.
The
most
common
types
cancer
include
breast,
colorectal,
lung,
and
prostate.
risk
factors
attributed
to
development
are
tobacco
smoking,
excessive
alcohol
consumption,
dietary
factors,
ultraviolet
radiation
(UV),
lack
physical
activities.
Two
major
cellular
apoptotic
pathways
targeted
in
therapies
intrinsic
extrinsic.
These
two
regulated
different
proteins,
multidomain
pro-apoptotic
proteins
(Bak,
Bax,
Bok),
BH3-only
(Bid,
Bim,
Bad,
Noxa,
Puma),
anti-apoptotic
(Mcl-1,
Bfl-1,
Bcl-XL,
Bcl-2,
Bcl-w,
Bcl-B).
Other
significant
molecules/factors
known
execute
bioactive
compounds,
reactive
oxygen
species
(ROS).
Proteolytic
caspases
play
vital
role
initiation
activities
cancerous
Based
on
their
functions,
they
categorized
into
initiators
executioners.
Nanotechnology
has
produced
novel
outcomes
modern
medicine.
green
synthesis
nanoparticles
demonstrated
prospective
improvements
combination
with
existing
including
photodynamic
therapy.
This
review
aims
at
highlighting
association
between
significance
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: March 2, 2022
Curcumin
(CUR)
has
demonstrated
promising
potential
as
a
therapeutic
agent
against
colorectal
cancer
(CRC).
However,
its
intrinsic
shortcomings,
including
oxidative
instability,
sensitivity
to
gastrointestinal
(GI)
hydrolytic/enzymatic
action,
and
susceptibility
biotransformation
systemic
elimination,
have
greatly
undermined
value
for
application
in
clinical
settings.
The
development
of
carriers,
particular
oral
formulations,
efficient
delivery
remained
an
important
direction
nutraceutical
research.
In
the
present
work,
CUR-encapsulated
nanoparticles
were
fabricated
with
zein
alone
(Zein-CUR)
polysaccharide
(PS)
[gum
Arabic
(GA),
hyaluronic
acid
(HA)
pectin
(PC),
respectively]
(PS-Zein-CUR).
Their
physicochemical
biological
properties
evaluated
series
