Critical Reviews in Oncology/Hematology, Journal Year: 2020, Volume and Issue: 157, P. 103182 - 103182
Published: Nov. 24, 2020
Language: Английский
BMC Cancer, Journal Year: 2020, Volume and Issue: 20(1)
Published: Aug. 24, 2020
Abstract Background Curcumin is herbal compound that has been shown to have anti-cancer effects in pre-clinical and clinical studies. The of curcumin include inhibiting the carcinogenesis, angiogenesis, tumour growth. This study aims determine Clinical different types cancers using systematic review approach. Methods A methodology adopted for undertaking detailed analysis cancer therapy. results presented this paper an outcome extracting findings studies selected from articles published international databases including SID, MagIran, IranMedex, IranDoc, Google Scholar, ScienceDirect, Scopus, PubMed Web Science (ISI). These were thoroughly searched, relevant publications based on plausible keywords, accordance with aims, as follows: prevalence, curcumin, features, cancer. Results are derived several consumption chemotherapy drugs, highlighting increases effectiveness radiotherapy which improving patient’s survival time, increasing expression anti-metastatic proteins along reducing their side effects. Conclusion comprehensive confirms reduces or radiotherapy, resulting patients’ quality life. number reported that, increased patient time decreased tumor markers’ level.
Language: Английский
Citations
315
Biomedicines, Journal Year: 2021, Volume and Issue: 9(10), P. 1353 - 1353
Published: Sept. 29, 2021
Cancer is one of the leading causes death globally. The development drug resistance main contributor to cancer-related mortality. cells exploit multiple mechanisms reduce therapeutic effects anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources chemotherapeutic agents. Additionally, they have action inhibit various targets involved in resistance. In this review, we summarized basic research clinical applications natural as possible inhibitors for cancer. molecular each product also explained. Diverse biomarkers were sensitive products. P-glycoprotein breast cancer protein can be targeted by a large number On other hand, kinase C topoisomerases most studied studies discussed review will provide solid ground scientists explore use combination therapies overcome targeting mechanisms.
Language: Английский
Citations
139
Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(10), P. 5856 - 5872
Published: Aug. 31, 2023
Drug resistance to antibacterial and anticancer drugs is one of the most important global problems in treatment field that constantly expanding hinders recovery survival patients. Therefore, it necessary identify compounds have properties or increase effectiveness existing drugs. One these approaches using natural few side effects are effective. Gallic acid (GA) has been identified as plant polyphenols health-promoting various aspects such bacterial viral infections, cancer, inflammatory, neuropsychological, gastrointestinal, metabolic disease. Various studies shown GA inhibits growth by altering membrane structure, metabolism, biofilm formation. Also, cancer cell targeting different signaling pathways apoptosis, increasing reactive oxygen species (ROS) production, cycle, inhibiting oncogenes matrix metalloproteinases (MMPs) expression. Due powerful function against bacteria cells. In this review, we describe latest findings sources chemical GA, its pharmacological bioavailability, activities derivatives alone, combination with other form nanoformulation. This review can be a comprehensive perspective for scientists use medicinal containing future research expand clinical applications.
Language: Английский
Citations
69
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 639 - 639
Published: Feb. 14, 2023
Cancer continues to cause an alarming number of deaths globally, and its burden on the health system is significant. Though different conventional therapeutic procedures are exploited for cancer treatment, prevalence death rates remain elevated. These, therefore, insinuate that novel more efficient treatment needed cancer. Curcumin, a bioactive, natural, phenolic compound isolated from rhizome herbaceous plant turmeric, receiving great interest exciting broad pharmacological properties. Curcumin presents anticancer capacities can be utilized as photosensitizing drug in photodynamic therapy (PDT). Nonetheless, curcumin′s poor bioavailability related pharmacokinetics limit clinical utility treatment. This review looks at physical chemical properties, bioavailability, safety curcumin, while focusing curcumin agent photosensitizer PDT. The possible mechanisms cellular targets PDT highlighted. Furthermore, recent improvements curcumin’s using nanoformulations delivery systems presented.
Language: Английский
Citations
55
Clinical Epigenetics, Journal Year: 2021, Volume and Issue: 13(1)
Published: May 29, 2021
Language: Английский
Citations
70
Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 78, P. 103982 - 103982
Published: Nov. 12, 2022
Language: Английский
Citations
45
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4139 - 4139
Published: April 9, 2024
Bone tumors, particularly osteosarcoma, are prevalent among children and adolescents. This ailment has emerged as the second most frequent cause of cancer-related mortality in Conventional treatment methods comprise extensive surgical resection, radiotherapy, chemotherapy. Consequently, management bone tumors regeneration poses significant clinical challenges. Photothermal tumor therapy attracted considerable attention owing to its minimal invasiveness high selectivity. However, key challenges have limited widespread use. Enhancing specificity photosensitizers through targeting or localized activation holds potential for better outcomes with fewer adverse effects. Combinations chemotherapies immunotherapies also present avenues improvement. In this review, we provide an overview recent strategies aimed at overcoming limitations photothermal (PTT), along current research directions context including (1) target strategies, (2) combined multiple therapies (immunotherapies, chemotherapies, chemodynamic therapies, magnetic, photodynamic therapies), (3) bifunctional scaffolds regeneration. We delve into pros cons these combination explore focal points. Lastly, address prospects therapy.
Language: Английский
Citations
15
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: March 8, 2024
Cancer stands as a prominent global cause of death. One the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse MDR. Discovering novel potential modulators to reduce MDR by has become popular research area across globe. Numerous mainly focus on natural products including flavonoids, alkaloids, terpenoids, polyphenols and coumarins for their modulatory activity. regulating signaling pathways or relevant expressed protein gene. Here we perform deep review previous achievements, advances in development treatment This aims provide some insights study products.
Language: Английский
Citations
14
Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12
Published: Jan. 8, 2025
Chemotherapeutic agents are widely used to combat breast cancer. However, due their non-selective biodistribution, usage is associated with severe adverse effects on healthy tissues. In this study, a chitosan-stabilized nanoemulsion (CSNE) was prepared for the codelivery of curcumin (CUR) and methotrexate (MTX). The mean diameter polydispersity index CUR–MTX–CSNEs were 194.63 ± 6.7 nm 0.27 0.06, respectively. Modifying surface chitosan decreased drug release at pH 7.4 compared 5.8. MTT test demonstrated that more successful in reducing cell viability 4T1 cells than both bare formulation free drugs. Moreover, drug-treated group, 2.6 times reduction relative tumor volume witnessed CUR–MTX–CSNEs-receiving mice. Histopathological studies confirmed substantial inhibitory effect growth pulmonary metastasis developed nanostructures CUR/MTX. While there no noticeable toxicity vital organs mice, drugs resulted liver, kidney, lung spleen. Overall, pH-dependent release, improved anti-tumor activity reduced organ suggest CUR–MTX–CSNE may be promising cancer therapy.
Language: Английский
Citations
1
OpenNano, Journal Year: 2022, Volume and Issue: 7, P. 100055 - 100055
Published: July 1, 2022
Cancer is one of the leading causes mortality worldwide. Currently available anticancer therapeutic strategies are not able to improve survival rate patients over past few decades. Research suggests that cancer cells develop multidrug resistance (MDR) against chemotherapeutics lead enhanced proliferation, epithelial mesenchymal transition (EMT), invasion and metastasis. Hence, there an urgent need for alternative strategy treat this disease. Recently, phytochemicals have gained immense attention as a promising agent by targeting multimodal oncogenic pathways, inducing cell cycle arrest apoptosis in preclinical studies. However, their clinical application limited due poor aqueous solubility, bioavailability, low cellular uptake narrow index. Therefore, address these challenges, phytochemical-based nanomedicine i.e. phytonanomedicine been developed can pharmacokinetics profile vivo systems. In review, we aim summarize challenges treatment status effective
Language: Английский
Citations
37